YLR262C / YPT6

Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR262C / YPT6

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:-6.01|P-value:5.05E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:8.87|P-value:6.90E-9 ID:SGTC_39|Compound:0986-0283|FD-Score:-4.89|P-value:7.63E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:5.92|P-value:7.88E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:-5.43|P-value:2.20E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-5.37|P-value:2.52E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-5.83|P-value:8.11E-5 ID:SGTC_281|Compound:1672-3440|FD-Score:4.99|P-value:7.24E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.87|P-value:9.49E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.85|P-value:9.87E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:5.65|P-value:1.53E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-5.71|P-value:1.08E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.88|P-value:8.67E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-4.86|P-value:8.17E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.29|P-value:1.22E-6 ID:SGTC_455|Compound:paf C-16|FD-Score:-5.42|P-value:2.27E-4 ID:SGTC_459|Compound:nigericin|FD-Score:8.63|P-value:1.65E-8 ID:SGTC_481|Compound:bay k-8644|FD-Score:8.07|P-value:1.19E-7 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.91|P-value:8.72E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-5.18|P-value:3.94E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.93|P-value:8.27E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-7.41|P-value:8.32E-7 ID:SGTC_590|Compound:k048-0076|FD-Score:5.56|P-value:1.90E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:4.93|P-value:8.34E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-4.80|P-value:9.24E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.92|P-value:8.48E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:11.70|P-value:3.77E-14 ID:SGTC_788|Compound:1182-0090|FD-Score:-5.33|P-value:2.77E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:6.60|P-value:1.23E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-5.98|P-value:5.49E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:-4.87|P-value:7.93E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-5.10|P-value:4.81E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.96|P-value:7.79E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:6.74|P-value:8.10E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-5.57|P-value:1.54E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-5.06|P-value:5.21E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:5.01|P-value:6.94E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:5.67|P-value:1.45E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.95|P-value:7.92E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:10.40|P-value:1.24E-11 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.26|P-value:3.92E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:9.14|P-value:2.37E-9 ID:SGTC_1384|Compound:3089-0840|FD-Score:5.75|P-value:1.21E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-6.28|P-value:2.39E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:-6.28|P-value:2.42E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:-4.80|P-value:9.29E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.84|P-value:9.62E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:6.31|P-value:2.79E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-6.84|P-value:4.90E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:-6.98|P-value:3.24E-6 ID:SGTC_1638|Compound:st008370|FD-Score:-5.93|P-value:6.21E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-5.00|P-value:5.92E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.58|P-value:1.96E-8 ID:SGTC_1708|Compound:st033234|FD-Score:4.93|P-value:8.26E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-5.08|P-value:4.98E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.44|P-value:2.15E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-6.49|P-value:1.36E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-5.43|P-value:2.17E-4 ID:SGTC_1760|Compound:st045453|FD-Score:-7.28|P-value:1.25E-6 ID:SGTC_1773|Compound:st048542|FD-Score:-5.23|P-value:3.55E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-5.46|P-value:2.02E-4 ID:SGTC_1838|Compound:st055369|FD-Score:5.96|P-value:7.02E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.45|P-value:2.08E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-6.29|P-value:2.33E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-8.40|P-value:2.85E-8 ID:SGTC_2006|Compound:4011487|FD-Score:-6.43|P-value:1.61E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-5.03|P-value:5.55E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-5.68|P-value:1.18E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-5.55|P-value:1.62E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-6.66|P-value:8.20E-6 ID:SGTC_2187|Compound:6125751|FD-Score:5.62|P-value:1.67E-4 ID:SGTC_2201|Compound:6605497|FD-Score:-5.85|P-value:7.68E-5 ID:SGTC_2242|Compound:6630449|FD-Score:6.02|P-value:6.07E-5 ID:SGTC_2374|Compound:9071832|FD-Score:-5.69|P-value:1.16E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-4.84|P-value:8.48E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-4.90|P-value:7.54E-4 ID:SGTC_2385|Compound:9074692|FD-Score:5.03|P-value:6.66E-4 ID:SGTC_2478|Compound:5763493|FD-Score:8.51|P-value:2.55E-8 ID:SGTC_2483|Compound:5729050|FD-Score:7.39|P-value:1.15E-6 ID:SGTC_2486|Compound:5283202|FD-Score:-5.51|P-value:1.79E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:6.01|P-value:6.10E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:5.67|P-value:1.47E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-5.95|P-value:5.84E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-4.98|P-value:6.19E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.93|P-value:8.26E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-5.54|P-value:1.67E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-6.04|P-value:4.60E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-5.78|P-value:9.17E-5 ID:SGTC_2838|Compound:9002687|FD-Score:-6.71|P-value:7.13E-6 ID:SGTC_2867|Compound:9039098|FD-Score:4.91|P-value:8.69E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-4.89|P-value:7.68E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-8.39|P-value:2.93E-8 ID:SGTC_2986|Compound:9022445|FD-Score:5.93|P-value:7.48E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-6.60|P-value:9.83E-6 ID:SGTC_2993|Compound:9054257|FD-Score:-5.84|P-value:7.85E-5 ID:SGTC_3033|Compound:9090887|FD-Score:-6.62|P-value:9.15E-6 ID:SGTC_3071|Compound:9117417|FD-Score:-5.73|P-value:1.05E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-5.98|P-value:5.44E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-8.58|P-value:1.47E-8 ID:SGTC_3152|Compound:9099253|FD-Score:-5.50|P-value:1.85E-4 ID:SGTC_3160|Compound:9100216|FD-Score:-5.83|P-value:8.13E-5 ID:SGTC_3166|Compound:9102297|FD-Score:6.28|P-value:2.98E-5 ID:SGTC_3177|Compound:9107506|FD-Score:-5.53|P-value:1.73E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-5.93|P-value:6.27E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-5.20|P-value:3.80E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-4.78|P-value:9.80E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-6.13|P-value:3.68E-5 ID:SGTC_12|Compound:0849-0099|FD-Score:-6.01|P-value:5.05E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:8.87|P-value:6.90E-9 ID:SGTC_39|Compound:0986-0283|FD-Score:-4.89|P-value:7.63E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:5.92|P-value:7.88E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:-5.43|P-value:2.20E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-5.37|P-value:2.52E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-5.83|P-value:8.11E-5 ID:SGTC_281|Compound:1672-3440|FD-Score:4.99|P-value:7.24E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.87|P-value:9.49E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.85|P-value:9.87E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:5.65|P-value:1.53E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-5.71|P-value:1.08E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.88|P-value:8.67E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:-4.86|P-value:8.17E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.29|P-value:1.22E-6 ID:SGTC_455|Compound:paf C-16|FD-Score:-5.42|P-value:2.27E-4 ID:SGTC_459|Compound:nigericin|FD-Score:8.63|P-value:1.65E-8 ID:SGTC_481|Compound:bay k-8644|FD-Score:8.07|P-value:1.19E-7 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.91|P-value:8.72E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-5.18|P-value:3.94E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.93|P-value:8.27E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-7.41|P-value:8.32E-7 ID:SGTC_590|Compound:k048-0076|FD-Score:5.56|P-value:1.90E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:4.93|P-value:8.34E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-4.80|P-value:9.24E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.92|P-value:8.48E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:11.70|P-value:3.77E-14 ID:SGTC_788|Compound:1182-0090|FD-Score:-5.33|P-value:2.77E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:6.60|P-value:1.23E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-5.98|P-value:5.49E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:-4.87|P-value:7.93E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-5.10|P-value:4.81E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.96|P-value:7.79E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:6.74|P-value:8.10E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-5.57|P-value:1.54E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-5.06|P-value:5.21E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:5.01|P-value:6.94E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:5.67|P-value:1.45E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.95|P-value:7.92E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:10.40|P-value:1.24E-11 ID:SGTC_1360|Compound:1598-0022|FD-Score:5.26|P-value:3.92E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:9.14|P-value:2.37E-9 ID:SGTC_1384|Compound:3089-0840|FD-Score:5.75|P-value:1.21E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-6.28|P-value:2.39E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:-6.28|P-value:2.42E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:-4.80|P-value:9.29E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:5.84|P-value:9.62E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:6.31|P-value:2.79E-5 ID:SGTC_1547|Compound:harmine|FD-Score:-6.84|P-value:4.90E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:-6.98|P-value:3.24E-6 ID:SGTC_1638|Compound:st008370|FD-Score:-5.93|P-value:6.21E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-5.00|P-value:5.92E-4 ID:SGTC_1687|Compound:st020778|FD-Score:8.58|P-value:1.96E-8 ID:SGTC_1708|Compound:st033234|FD-Score:4.93|P-value:8.26E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-5.08|P-value:4.98E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.44|P-value:2.15E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-6.49|P-value:1.36E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-5.43|P-value:2.17E-4 ID:SGTC_1760|Compound:st045453|FD-Score:-7.28|P-value:1.25E-6 ID:SGTC_1773|Compound:st048542|FD-Score:-5.23|P-value:3.55E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-5.46|P-value:2.02E-4 ID:SGTC_1838|Compound:st055369|FD-Score:5.96|P-value:7.02E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.45|P-value:2.08E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-6.29|P-value:2.33E-5 ID:SGTC_1934|Compound:st074720|FD-Score:-8.40|P-value:2.85E-8 ID:SGTC_2006|Compound:4011487|FD-Score:-6.43|P-value:1.61E-5 ID:SGTC_2038|Compound:4100038|FD-Score:-5.03|P-value:5.55E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-5.68|P-value:1.18E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-5.55|P-value:1.62E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-6.66|P-value:8.20E-6 ID:SGTC_2187|Compound:6125751|FD-Score:5.62|P-value:1.67E-4 ID:SGTC_2201|Compound:6605497|FD-Score:-5.85|P-value:7.68E-5 ID:SGTC_2242|Compound:6630449|FD-Score:6.02|P-value:6.07E-5 ID:SGTC_2374|Compound:9071832|FD-Score:-5.69|P-value:1.16E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-4.84|P-value:8.48E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-4.90|P-value:7.54E-4 ID:SGTC_2385|Compound:9074692|FD-Score:5.03|P-value:6.66E-4 ID:SGTC_2478|Compound:5763493|FD-Score:8.51|P-value:2.55E-8 ID:SGTC_2483|Compound:5729050|FD-Score:7.39|P-value:1.15E-6 ID:SGTC_2486|Compound:5283202|FD-Score:-5.51|P-value:1.79E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:6.01|P-value:6.10E-5 ID:SGTC_2661|Compound:dactinomycin|FD-Score:5.67|P-value:1.47E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-5.95|P-value:5.84E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-4.98|P-value:6.19E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.93|P-value:8.26E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-5.54|P-value:1.67E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-6.04|P-value:4.60E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-5.78|P-value:9.17E-5 ID:SGTC_2838|Compound:9002687|FD-Score:-6.71|P-value:7.13E-6 ID:SGTC_2867|Compound:9039098|FD-Score:4.91|P-value:8.69E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-4.89|P-value:7.68E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-8.39|P-value:2.93E-8 ID:SGTC_2986|Compound:9022445|FD-Score:5.93|P-value:7.48E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-6.60|P-value:9.83E-6 ID:SGTC_2993|Compound:9054257|FD-Score:-5.84|P-value:7.85E-5 ID:SGTC_3033|Compound:9090887|FD-Score:-6.62|P-value:9.15E-6 ID:SGTC_3071|Compound:9117417|FD-Score:-5.73|P-value:1.05E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-5.98|P-value:5.44E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-8.58|P-value:1.47E-8 ID:SGTC_3152|Compound:9099253|FD-Score:-5.50|P-value:1.85E-4 ID:SGTC_3160|Compound:9100216|FD-Score:-5.83|P-value:8.13E-5 ID:SGTC_3166|Compound:9102297|FD-Score:6.28|P-value:2.98E-5 ID:SGTC_3177|Compound:9107506|FD-Score:-5.53|P-value:1.73E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-5.93|P-value:6.27E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-5.20|P-value:3.80E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-4.78|P-value:9.80E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-6.13|P-value:3.68E-5

Top fitness defect scores for YLR262C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_732 3970-1727 11.70 52.7 µM 3.77E-14 1 9.28E-32
2 SGTC_1313 1220-0047 10.40 237.0 µM 1.24E-11 4 1.03E-25
3 SGTC_1374 2889-5571 9.14 141.0 µM 2.37E-9 RSC complex & mRNA processing 1 2.98E-20
4 SGTC_22 0964-0034 8.87 14.5 µM 6.90E-9 unfolded protein response 9 3.81E-19
5 SGTC_459 nigericin 8.63 15.3 µM 1.65E-8 9 3.04E-18
6 SGTC_1687 st020778 8.58 55.4 µM 1.96E-8 58 4.61E-18
7 SGTC_2478 5763493 8.51 32.3 µM 2.55E-8 8 8.69E-18
8 SGTC_481 bay k-8644 8.07 50.0 µM 1.19E-7 3 3.38E-16
9 SGTC_2483 5729050 7.39 27.2 µM 1.15E-6 4 7.57E-14
10 SGTC_1060 3448-7350 6.74 82.0 µM 8.10E-6 Golgi 10 7.71E-12
11 SGTC_830 4076-0286 6.60 57.8 µM 1.23E-5 translation 7 2.08E-11
12 SGTC_1542 7-hydroxy-3'-methoxyflavone 6.31 49.7 µM 2.79E-5 2 1.44E-10
13 SGTC_3166 9102297 6.28 49.5 µM 2.98E-5 Golgi 12 1.68E-10
14 SGTC_2242 6630449 6.02 61.3 µM 6.07E-5 Golgi 18 8.98E-10
15 SGTC_2532 xanthone 6.01 78.9 µM 6.10E-5 7 9.08E-10
16 SGTC_1838 st055369 5.96 84.5 µM 7.02E-5 5 1.27E-9
17 SGTC_2986 9022445 5.93 71.4 µM 7.48E-5 3 1.47E-9
18 SGTC_185 k048-0037 5.92 25.5 µM 7.88E-5 RSC & ERG11 1 1.66E-9
19 SGTC_445 e6 berbamine 5.88 66.0 µM 8.67E-5 NEO1-PIK1 34 2.08E-9
20 SGTC_1495 4469-0029 5.84 237.0 µM 9.62E-5 55 2.66E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.508 2.94E-218 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.497 8.94E-208 YDR136C_d VPS61_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
0.445 5.43E-162 YLR261C_d VPS63_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
0.400 2.08E-128 YLR039C RIC1 hom Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
0.320 4.79E-80 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.309 4.59E-75 YNL041C COG6 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.298 3.09E-69 YKR019C IRS4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
0.297 4.52E-69 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.296 7.61E-69 YML071C COG8 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.281 5.92E-62 YDR320C SWA2 hom Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
0.216 2.05E-36 YOL018C TLG2 hom Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
0.215 2.25E-36 YGL223C COG1 hom Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.211 4.03E-35 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.193 2.11E-29 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.175 1.91E-24 YKR020W VPS51 hom Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p