YLR262C-A / TMA7

Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR262C-A / TMA7

Click on Significant Values for Screen Details ID:SGTC_124|Compound:0136-0217|FD-Score:3.76|P-value:7.09E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:4.02|P-value:2.37E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:3.84|P-value:5.19E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.43|P-value:3.55E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-5.17|P-value:1.53E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.18|P-value:8.81E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:7.25|P-value:1.49E-13 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.52|P-value:1.84E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.41|P-value:3.89E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.05|P-value:9.75E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.41|P-value:4.15E-6 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.96|P-value:3.12E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.46|P-value:2.31E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.56|P-value:2.20E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.30|P-value:7.00E-6 ID:SGTC_1275|Compound:0867-0008|FD-Score:5.04|P-value:1.90E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.62|P-value:1.26E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.14|P-value:7.30E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.16|P-value:6.87E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.75|P-value:1.07E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.30|P-value:5.79E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.43|P-value:3.56E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.28|P-value:6.11E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.36|P-value:3.36E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.33|P-value:3.78E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.61|P-value:1.63E-6 ID:SGTC_1809|Compound:st050081|FD-Score:3.11|P-value:7.97E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.68|P-value:9.97E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.48|P-value:3.02E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-4.00|P-value:3.83E-5 ID:SGTC_1956|Compound:st077085|FD-Score:3.89|P-value:4.14E-5 ID:SGTC_1958|Compound:st076513|FD-Score:4.22|P-value:1.02E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.33|P-value:5.07E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-3.37|P-value:4.42E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.05|P-value:9.75E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.12|P-value:7.92E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.57|P-value:1.49E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.12|P-value:7.68E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.67|P-value:1.02E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.82|P-value:5.53E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.59|P-value:1.42E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.12|P-value:1.56E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:6.98|P-value:1.13E-12 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.84|P-value:8.31E-7 ID:SGTC_2900|Compound:5328528|FD-Score:3.22|P-value:5.44E-4 ID:SGTC_2944|Compound:9067346|FD-Score:15.50|P-value:2.17E-54 ID:SGTC_3136|Compound:9095672|FD-Score:3.93|P-value:3.62E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.06|P-value:9.68E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.76|P-value:7.09E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:4.02|P-value:2.37E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:3.84|P-value:5.19E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.43|P-value:3.55E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-5.17|P-value:1.53E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.18|P-value:8.81E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:7.25|P-value:1.49E-13 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.52|P-value:1.84E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.41|P-value:3.89E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.05|P-value:9.75E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.41|P-value:4.15E-6 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.96|P-value:3.12E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.46|P-value:2.31E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.56|P-value:2.20E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.30|P-value:7.00E-6 ID:SGTC_1275|Compound:0867-0008|FD-Score:5.04|P-value:1.90E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.62|P-value:1.26E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.14|P-value:7.30E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.16|P-value:6.87E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.75|P-value:1.07E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.30|P-value:5.79E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.43|P-value:3.56E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.28|P-value:6.11E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.36|P-value:3.36E-4 ID:SGTC_1700|Compound:st030840|FD-Score:3.33|P-value:3.78E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.61|P-value:1.63E-6 ID:SGTC_1809|Compound:st050081|FD-Score:3.11|P-value:7.97E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.68|P-value:9.97E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.48|P-value:3.02E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-4.00|P-value:3.83E-5 ID:SGTC_1956|Compound:st077085|FD-Score:3.89|P-value:4.14E-5 ID:SGTC_1958|Compound:st076513|FD-Score:4.22|P-value:1.02E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.30|P-value:4.20E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.07|P-value:9.18E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.33|P-value:5.07E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-3.37|P-value:4.42E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.05|P-value:9.75E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.12|P-value:7.92E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.57|P-value:1.49E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.12|P-value:7.68E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.67|P-value:1.02E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.82|P-value:5.53E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.59|P-value:1.42E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.12|P-value:1.56E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:6.98|P-value:1.13E-12 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.84|P-value:8.31E-7 ID:SGTC_2900|Compound:5328528|FD-Score:3.22|P-value:5.44E-4 ID:SGTC_2944|Compound:9067346|FD-Score:15.50|P-value:2.17E-54 ID:SGTC_3136|Compound:9095672|FD-Score:3.93|P-value:3.62E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.06|P-value:9.68E-4

Top fitness defect scores for YLR262C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2944 9067346 15.50 25.6 µM 2.17E-54 1 3.75E-54
2 SGTC_919 tnp00227 7.25 403.6 nM 1.49E-13 RNA pol III & RNase P/MRP 2 2.02E-13
3 SGTC_2612 dictamnine 6.98 15.5 µM 1.13E-12 RNA pol III & RNase P/MRP 9 1.51E-12
4 SGTC_1275 0867-0008 5.04 21.1 µM 1.90E-7 3 2.37E-7
5 SGTC_1720 st037298 4.61 9.5 µM 1.63E-6 26 2.01E-6
6 SGTC_1058 3448-5425 4.41 97.3 µM 4.15E-6 28 5.06E-6
7 SGTC_1251 0490-5699 4.30 265.0 µM 7.00E-6 23 8.50E-6
8 SGTC_1958 st076513 4.22 41.9 µM 1.02E-5 60S ribosome export 24 1.23E-5
9 SGTC_2610 ononetin 4.12 44.2 µM 1.56E-5 37 1.89E-5
10 SGTC_686 1319-0111 4.02 510.0 µM 2.37E-5 60S ribosome export 30 2.85E-5
11 SGTC_1167 k781-0610 3.96 148.0 µM 3.12E-5 RNA processing & uracil transport 25 3.73E-5
12 SGTC_3136 9095672 3.93 49.5 µM 3.62E-5 25 4.33E-5
13 SGTC_1956 st077085 3.89 54.0 µM 4.14E-5 19 4.95E-5
14 SGTC_792 4534-1957 3.84 155.0 µM 5.19E-5 36 6.19E-5
15 SGTC_2488 5268135 3.82 45.7 µM 5.53E-5 54 6.59E-5
16 SGTC_124 0136-0217 3.76 7.1 µM 7.09E-5 mitochondrial stress 65 8.44E-5
17 SGTC_1920 st075728 3.68 45.7 µM 9.97E-5 31 1.18E-4
18 SGTC_2326 6164455 3.67 177.6 µM 1.02E-4 mitochondrial processes 31 1.20E-4
19 SGTC_1280 0880-0253 3.62 10.1 µM 1.26E-4 27 1.49E-4
20 SGTC_2569 tetrandrine 3.59 100.0 µM 1.42E-4 34 1.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.75E-15 YBR057C MUM2 hom Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
0.133 9.50E-15 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.130 3.65E-14 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.123 7.61E-13 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.123 9.46E-13 YIR022W SEC11 het 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum
0.117 9.09E-12 YLR071C RGR1 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
0.114 3.05E-11 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.114 3.58E-11 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.113 5.93E-11 YIL029C_p YIL029C_p hom Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W
0.112 8.50E-11 YIL156W UBP7 hom Ubiquitin-specific protease that cleaves ubiquitin-protein fusions
0.110 1.83E-10 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.109 2.22E-10 YPL220W RPL1A hom Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.106 8.70E-10 YNL202W SPS19 hom Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
0.105 1.23E-9 YHR158C KEL1 hom Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
0.104 1.66E-9 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination