Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR263W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.257 | 8.87E-52 | YLR414C | PUN1 | hom | Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress |
0.233 | 1.83E-42 | YGL004C | RPN14 | hom | Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p |
0.166 | 3.13E-22 | YDL184C | RPL41A | hom | Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication |
0.148 | 6.34E-18 | YLR405W | DUS4 | hom | Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p |
0.147 | 8.59E-18 | YJL058C | BIT61 | hom | Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication |
0.146 | 1.74E-17 | YKL102C_d | YKL102C_d | hom | Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site |
0.145 | 3.17E-17 | YLR398C | SKI2 | hom | Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay |
0.133 | 1.00E-14 | YPR151C | SUE1 | hom | Mitochondrial protein required for degradation of unstable forms of cytochrome c |
0.133 | 1.33E-14 | YLR329W | REC102 | hom | Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination |
0.132 | 1.43E-14 | YBL028C | YBL028C | hom | Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis |
0.132 | 1.52E-14 | YOR155C | ISN1 | hom | Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms |
0.131 | 2.40E-14 | YKR102W | FLO10 | hom | Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth |
0.120 | 3.63E-12 | YOR252W | TMA16 | hom | Protein of unknown function that associates with ribosomes |
0.118 | 6.65E-12 | YGR139W_d | YGR139W_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.117 | 1.14E-11 | YNL242W | ATG2 | hom | Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress |