HIPHOP chemogenomics database

YLR263W / RED1

Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR263W / RED1

Click on Significant Values for Screen Details

Top fitness defect scores for YLR263W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1225	1216-0074	6.89	20.6 µM	2.45E-14		7	2.77E-12
2	SGTC_2704	st078022	5.92	71.1 µM	4.74E-11		3	1.63E-9
3	SGTC_6	0844-0013	5.47	19.8 µM	1.05E-9		22	2.21E-8
4	SGTC_3123	9126162	4.75	49.5 µM	9.79E-8		8	1.02E-6
5	SGTC_1071	trifluoperazine	4.64	6.3 µM	1.82E-7		16	1.71E-6
6	SGTC_2635	hydroquinidine	4.43	100.0 µM	5.98E-7		13	4.68E-6
7	SGTC_2943	9068529	4.36	45.3 µM	9.05E-7		10	6.64E-6
8	SGTC_2894	9048625	4.22	32.5 µM	1.87E-6		7	1.22E-5
9	SGTC_2893	9048488	3.95	26.0 µM	7.24E-6	fatty acid desaturase (OLE1)	21	3.84E-5
10	SGTC_451	chloral hydrate	3.89	100.0 µM	9.71E-6		54	4.92E-5
11	SGTC_2895	9054447	3.76	58.4 µM	1.83E-5		10	8.42E-5
12	SGTC_1725	st036284	3.71	20.6 µM	2.34E-5		35	1.04E-4
13	SGTC_130	0136-0219	3.57	337.7 µM	4.56E-5		33	1.82E-4
14	SGTC_964	1287-0107	3.56	19.4 µM	4.60E-5	cell wall	61	1.83E-4
15	SGTC_2099	5377090	3.49	177.4 µM	6.39E-5		43	2.42E-4
16	SGTC_960	1222-0186	3.48	7.7 µM	6.57E-5		47	2.48E-4
17	SGTC_2394	5221648	3.46	200.0 µM	7.35E-5		39	2.72E-4
18	SGTC_2468	5987765	3.41	72.9 µM	8.90E-5		33	3.20E-4
19	SGTC_1628	st004252	3.40	77.7 µM	9.66E-5		40	3.43E-4
20	SGTC_2494	18-aminoabieta-8,11,13-triene sulfate	3.39	3.7 µM	9.81E-5		141	3.47E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.257	8.87E-52	YLR414C	PUN1	hom	Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.233	1.83E-42	YGL004C	RPN14	hom	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.166	3.13E-22	YDL184C	RPL41A	hom	Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication
0.148	6.34E-18	YLR405W	DUS4	hom	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.147	8.59E-18	YJL058C	BIT61	hom	Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.146	1.74E-17	YKL102C_d	YKL102C_d	hom	Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.145	3.17E-17	YLR398C	SKI2	hom	Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.133	1.00E-14	YPR151C	SUE1	hom	Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.133	1.33E-14	YLR329W	REC102	hom	Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
0.132	1.43E-14	YBL028C	YBL028C	hom	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.132	1.52E-14	YOR155C	ISN1	hom	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.131	2.40E-14	YKR102W	FLO10	hom	Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.120	3.63E-12	YOR252W	TMA16	hom	Protein of unknown function that associates with ribosomes
0.118	6.65E-12	YGR139W_d	YGR139W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.117	1.14E-11	YNL242W	ATG2	hom	Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress