YLR263W / RED1

Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR263W / RED1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.47|P-value:1.05E-9 ID:SGTC_66|Compound:0109-0187|FD-Score:-8.81|P-value:5.75E-22 ID:SGTC_130|Compound:0136-0219|FD-Score:3.57|P-value:4.56E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:2.90|P-value:7.15E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.89|P-value:9.71E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:3.12|P-value:3.08E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.63|P-value:4.45E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:3.48|P-value:6.57E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.56|P-value:4.60E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.18|P-value:2.35E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.64|P-value:1.82E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.20|P-value:2.23E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:2.90|P-value:7.22E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:6.89|P-value:2.45E-14 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.07|P-value:4.66E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.98|P-value:5.26E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:2.83|P-value:9.31E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:2.87|P-value:7.97E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.40|P-value:9.66E-5 ID:SGTC_1713|Compound:st033146|FD-Score:2.95|P-value:5.92E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.29|P-value:1.51E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.71|P-value:2.34E-5 ID:SGTC_1776|Compound:st049249|FD-Score:-3.31|P-value:1.78E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-3.13|P-value:3.61E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.49|P-value:6.39E-5 ID:SGTC_2118|Compound:5526350|FD-Score:-3.87|P-value:1.41E-5 ID:SGTC_2269|Compound:7935389|FD-Score:-3.10|P-value:4.17E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.46|P-value:7.35E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-3.03|P-value:5.31E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.90|P-value:1.27E-5 ID:SGTC_2401|Compound:5128683|FD-Score:-3.26|P-value:2.15E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.15|P-value:2.64E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.41|P-value:8.90E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.39|P-value:9.81E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:2.97|P-value:5.49E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.09|P-value:3.37E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:2.88|P-value:7.67E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-5.26|P-value:5.90E-9 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.43|P-value:5.98E-7 ID:SGTC_2699|Compound:st077704|FD-Score:3.08|P-value:3.62E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-2.94|P-value:7.70E-4 ID:SGTC_2703|Compound:st077852|FD-Score:2.92|P-value:6.74E-4 ID:SGTC_2704|Compound:st078022|FD-Score:5.92|P-value:4.74E-11 ID:SGTC_2707|Compound:st078556|FD-Score:-3.71|P-value:3.05E-5 ID:SGTC_2813|Compound:7971799|FD-Score:2.99|P-value:5.16E-4 ID:SGTC_2816|Compound:7982706|FD-Score:2.99|P-value:5.13E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.03|P-value:6.60E-6 ID:SGTC_2830|Compound:7992007|FD-Score:2.95|P-value:5.98E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.95|P-value:7.24E-6 ID:SGTC_2894|Compound:9048625|FD-Score:4.22|P-value:1.87E-6 ID:SGTC_2895|Compound:9054447|FD-Score:3.76|P-value:1.83E-5 ID:SGTC_2943|Compound:9068529|FD-Score:4.36|P-value:9.05E-7 ID:SGTC_3002|Compound:9075603|FD-Score:-3.47|P-value:8.86E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.20|P-value:2.22E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.18|P-value:2.94E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.08|P-value:3.62E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.75|P-value:9.79E-8 ID:SGTC_3135|Compound:9127742|FD-Score:3.04|P-value:4.11E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.38|P-value:1.02E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.82|P-value:1.80E-5 ID:SGTC_3270|Compound:9137563|FD-Score:-2.91|P-value:8.62E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.55|P-value:6.27E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.02|P-value:5.67E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:5.47|P-value:1.05E-9 ID:SGTC_66|Compound:0109-0187|FD-Score:-8.81|P-value:5.75E-22 ID:SGTC_130|Compound:0136-0219|FD-Score:3.57|P-value:4.56E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:2.90|P-value:7.15E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.89|P-value:9.71E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:3.12|P-value:3.08E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.63|P-value:4.45E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:3.48|P-value:6.57E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.56|P-value:4.60E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.18|P-value:2.35E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:4.64|P-value:1.82E-7 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.20|P-value:2.23E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:2.90|P-value:7.22E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:6.89|P-value:2.45E-14 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.07|P-value:4.66E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.98|P-value:5.26E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:2.83|P-value:9.31E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:2.87|P-value:7.97E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.40|P-value:9.66E-5 ID:SGTC_1713|Compound:st033146|FD-Score:2.95|P-value:5.92E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.29|P-value:1.51E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.71|P-value:2.34E-5 ID:SGTC_1776|Compound:st049249|FD-Score:-3.31|P-value:1.78E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-3.13|P-value:3.61E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.49|P-value:6.39E-5 ID:SGTC_2118|Compound:5526350|FD-Score:-3.87|P-value:1.41E-5 ID:SGTC_2269|Compound:7935389|FD-Score:-3.10|P-value:4.17E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.46|P-value:7.35E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-3.03|P-value:5.31E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.90|P-value:1.27E-5 ID:SGTC_2401|Compound:5128683|FD-Score:-3.26|P-value:2.15E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.15|P-value:2.64E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.41|P-value:8.90E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.39|P-value:9.81E-5 ID:SGTC_2516|Compound:gossypol|FD-Score:2.97|P-value:5.49E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.09|P-value:3.37E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:2.88|P-value:7.67E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-5.26|P-value:5.90E-9 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.43|P-value:5.98E-7 ID:SGTC_2699|Compound:st077704|FD-Score:3.08|P-value:3.62E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-2.94|P-value:7.70E-4 ID:SGTC_2703|Compound:st077852|FD-Score:2.92|P-value:6.74E-4 ID:SGTC_2704|Compound:st078022|FD-Score:5.92|P-value:4.74E-11 ID:SGTC_2707|Compound:st078556|FD-Score:-3.71|P-value:3.05E-5 ID:SGTC_2813|Compound:7971799|FD-Score:2.99|P-value:5.16E-4 ID:SGTC_2816|Compound:7982706|FD-Score:2.99|P-value:5.13E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.03|P-value:6.60E-6 ID:SGTC_2830|Compound:7992007|FD-Score:2.95|P-value:5.98E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.95|P-value:7.24E-6 ID:SGTC_2894|Compound:9048625|FD-Score:4.22|P-value:1.87E-6 ID:SGTC_2895|Compound:9054447|FD-Score:3.76|P-value:1.83E-5 ID:SGTC_2943|Compound:9068529|FD-Score:4.36|P-value:9.05E-7 ID:SGTC_3002|Compound:9075603|FD-Score:-3.47|P-value:8.86E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.20|P-value:2.22E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.18|P-value:2.94E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.08|P-value:3.62E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.75|P-value:9.79E-8 ID:SGTC_3135|Compound:9127742|FD-Score:3.04|P-value:4.11E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.38|P-value:1.02E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.82|P-value:1.80E-5 ID:SGTC_3270|Compound:9137563|FD-Score:-2.91|P-value:8.62E-4 ID:SGTC_3284|Compound:9108171|FD-Score:-3.55|P-value:6.27E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-3.02|P-value:5.67E-4

Top fitness defect scores for YLR263W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1225 1216-0074 6.89 20.6 µM 2.45E-14 7 2.77E-12
2 SGTC_2704 st078022 5.92 71.1 µM 4.74E-11 3 1.63E-9
3 SGTC_6 0844-0013 5.47 19.8 µM 1.05E-9 22 2.21E-8
4 SGTC_3123 9126162 4.75 49.5 µM 9.79E-8 8 1.02E-6
5 SGTC_1071 trifluoperazine 4.64 6.3 µM 1.82E-7 16 1.71E-6
6 SGTC_2635 hydroquinidine 4.43 100.0 µM 5.98E-7 13 4.68E-6
7 SGTC_2943 9068529 4.36 45.3 µM 9.05E-7 10 6.64E-6
8 SGTC_2894 9048625 4.22 32.5 µM 1.87E-6 7 1.22E-5
9 SGTC_2893 9048488 3.95 26.0 µM 7.24E-6 fatty acid desaturase (OLE1) 21 3.84E-5
10 SGTC_451 chloral hydrate 3.89 100.0 µM 9.71E-6 54 4.92E-5
11 SGTC_2895 9054447 3.76 58.4 µM 1.83E-5 10 8.42E-5
12 SGTC_1725 st036284 3.71 20.6 µM 2.34E-5 35 1.04E-4
13 SGTC_130 0136-0219 3.57 337.7 µM 4.56E-5 33 1.82E-4
14 SGTC_964 1287-0107 3.56 19.4 µM 4.60E-5 cell wall 61 1.83E-4
15 SGTC_2099 5377090 3.49 177.4 µM 6.39E-5 43 2.42E-4
16 SGTC_960 1222-0186 3.48 7.7 µM 6.57E-5 47 2.48E-4
17 SGTC_2394 5221648 3.46 200.0 µM 7.35E-5 39 2.72E-4
18 SGTC_2468 5987765 3.41 72.9 µM 8.90E-5 33 3.20E-4
19 SGTC_1628 st004252 3.40 77.7 µM 9.66E-5 40 3.43E-4
20 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.39 3.7 µM 9.81E-5 141 3.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.257 8.87E-52 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.233 1.83E-42 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.166 3.13E-22 YDL184C RPL41A hom Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication
0.148 6.34E-18 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.147 8.59E-18 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.146 1.74E-17 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.145 3.17E-17 YLR398C SKI2 hom Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.133 1.00E-14 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.133 1.33E-14 YLR329W REC102 hom Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
0.132 1.43E-14 YBL028C YBL028C hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.132 1.52E-14 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.131 2.40E-14 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.120 3.63E-12 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.118 6.65E-12 YGR139W_d YGR139W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.117 1.14E-11 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress