YLR264C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR264C-A / YLR264C-A

Click on Significant Values for Screen Details ID:SGTC_84|Compound:0443-0269|FD-Score:4.13|P-value:2.20E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.28|P-value:5.75E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.58|P-value:1.96E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.00|P-value:1.49E-9 ID:SGTC_309|Compound:k408-0051|FD-Score:4.80|P-value:1.03E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:3.64|P-value:1.59E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.18|P-value:8.17E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.38|P-value:4.13E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.68|P-value:1.35E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.16|P-value:8.84E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.39|P-value:3.94E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.56|P-value:1.94E-8 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.44|P-value:3.64E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.16|P-value:8.66E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.40|P-value:4.12E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.56|P-value:2.18E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.75|P-value:1.32E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.53|P-value:3.66E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:3.52|P-value:2.50E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-4.03|P-value:3.60E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.54|P-value:3.65E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:3.53|P-value:2.38E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-4.51|P-value:4.50E-6 ID:SGTC_1092|Compound:toremifene|FD-Score:4.07|P-value:2.84E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.20|P-value:7.63E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.10|P-value:2.35E-7 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.17|P-value:8.41E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.80|P-value:8.36E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.62|P-value:2.45E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.66|P-value:1.48E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.21|P-value:7.43E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.66|P-value:1.46E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.96|P-value:4.92E-5 ID:SGTC_1814|Compound:st052110|FD-Score:-3.43|P-value:3.68E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.52|P-value:4.00E-6 ID:SGTC_1960|Compound:st011366|FD-Score:4.13|P-value:2.21E-5 ID:SGTC_1990|Compound:st072050|FD-Score:3.18|P-value:8.14E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.60|P-value:1.86E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.36|P-value:4.79E-4 ID:SGTC_2288|Compound:7946289|FD-Score:5.63|P-value:1.31E-8 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.98|P-value:4.16E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.69|P-value:9.43E-9 ID:SGTC_2699|Compound:st077704|FD-Score:3.70|P-value:1.27E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.26|P-value:1.28E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.32|P-value:5.09E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.25|P-value:6.51E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.37|P-value:4.19E-4 ID:SGTC_2891|Compound:9063876|FD-Score:4.00|P-value:3.86E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.21|P-value:1.72E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-4.04|P-value:3.50E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.46|P-value:3.08E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.38|P-value:4.49E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.50|P-value:2.66E-8 ID:SGTC_84|Compound:0443-0269|FD-Score:4.13|P-value:2.20E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.28|P-value:5.75E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.58|P-value:1.96E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.00|P-value:1.49E-9 ID:SGTC_309|Compound:k408-0051|FD-Score:4.80|P-value:1.03E-6 ID:SGTC_335|Compound:4077-0256|FD-Score:3.64|P-value:1.59E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.18|P-value:8.17E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.38|P-value:4.13E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.68|P-value:1.35E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.16|P-value:8.84E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.39|P-value:3.94E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.56|P-value:1.94E-8 ID:SGTC_689|Compound:0833-0039|FD-Score:-3.44|P-value:3.64E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.16|P-value:8.66E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.40|P-value:4.12E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.56|P-value:2.18E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.75|P-value:1.32E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.53|P-value:3.66E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:3.52|P-value:2.50E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-4.03|P-value:3.60E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.54|P-value:3.65E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:3.53|P-value:2.38E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-4.51|P-value:4.50E-6 ID:SGTC_1092|Compound:toremifene|FD-Score:4.07|P-value:2.84E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.20|P-value:7.63E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:5.10|P-value:2.35E-7 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.17|P-value:8.41E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.80|P-value:8.36E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.62|P-value:2.45E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.66|P-value:1.48E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.21|P-value:7.43E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.66|P-value:1.46E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.96|P-value:4.92E-5 ID:SGTC_1814|Compound:st052110|FD-Score:-3.43|P-value:3.68E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.52|P-value:4.00E-6 ID:SGTC_1960|Compound:st011366|FD-Score:4.13|P-value:2.21E-5 ID:SGTC_1990|Compound:st072050|FD-Score:3.18|P-value:8.14E-4 ID:SGTC_2075|Compound:5212009|FD-Score:3.60|P-value:1.86E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.36|P-value:4.79E-4 ID:SGTC_2288|Compound:7946289|FD-Score:5.63|P-value:1.31E-8 ID:SGTC_2543|Compound:pimpinellin|FD-Score:4.98|P-value:4.16E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.69|P-value:9.43E-9 ID:SGTC_2699|Compound:st077704|FD-Score:3.70|P-value:1.27E-4 ID:SGTC_2716|Compound:st080858|FD-Score:4.26|P-value:1.28E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.32|P-value:5.09E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.25|P-value:6.51E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.37|P-value:4.19E-4 ID:SGTC_2891|Compound:9063876|FD-Score:4.00|P-value:3.86E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.21|P-value:1.72E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-4.04|P-value:3.50E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.46|P-value:3.08E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.38|P-value:4.49E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.50|P-value:2.66E-8

Top fitness defect scores for YLR264C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_118 0083-0097 6.00 135.3 µM 1.49E-9 translation 24 9.68E-10
2 SGTC_2688 kanamycin b 5.69 96.7 µM 9.43E-9 calcium & mitochondrial duress 182 6.43E-9
3 SGTC_2288 7946289 5.63 167.3 µM 1.31E-8 7 8.99E-9
4 SGTC_625 k213-0058 5.56 121.0 µM 1.94E-8 translation 47 1.34E-8
5 SGTC_3211 9128781 5.50 49.5 µM 2.66E-8 24 1.86E-8
6 SGTC_1252 0493-0875 5.10 34.8 µM 2.35E-7 11 1.73E-7
7 SGTC_2543 pimpinellin 4.98 60.7 µM 4.16E-7 Golgi 2 3.12E-7
8 SGTC_309 k408-0051 4.80 1.5 µM 1.03E-6 33 7.89E-7
9 SGTC_791 1348-1292 4.75 225.0 µM 1.32E-6 19 1.02E-6
10 SGTC_1454 4239-0054 4.62 42.6 µM 2.45E-6 16 1.91E-6
11 SGTC_874 0599-0792 4.54 117.0 µM 3.65E-6 15 2.88E-6
12 SGTC_831 k061-1017 4.53 217.0 µM 3.66E-6 translation 35 2.88E-6
13 SGTC_1912 st060209 4.52 90.8 µM 4.00E-6 26 3.16E-6
14 SGTC_2716 st080858 4.26 38.6 µM 1.28E-5 60S ribosome export 12 1.04E-5
15 SGTC_84 0443-0269 4.13 128.8 µM 2.20E-5 19 1.81E-5
16 SGTC_1960 st011366 4.13 51.8 µM 2.21E-5 7 1.82E-5
17 SGTC_1092 toremifene 4.07 6.3 µM 2.84E-5 17 2.36E-5
18 SGTC_2891 9063876 4.00 19.5 µM 3.86E-5 6 3.22E-5
19 SGTC_1313 1220-0047 3.80 237.0 µM 8.36E-5 45 7.10E-5
20 SGTC_1887 st057648 3.75 70.8 µM 1.05E-4 21 8.93E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 6.38E-25 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.167 1.99E-22 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.161 7.14E-21 YBL071C-B_p YBL071C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.153 6.28E-19 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.152 9.76E-19 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.138 1.13E-15 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.137 1.40E-15 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.131 2.13E-14 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.129 5.55E-14 YNL248C RPA49 hom RNA polymerase I subunit A49
0.128 9.97E-14 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.127 1.29E-13 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.127 1.39E-13 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.127 1.50E-13 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.127 1.48E-13 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.122 1.42E-12 YER122C GLO3 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p