YLR266C / PDR8

Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR266C / PDR8

Click on Significant Values for Screen Details ID:SGTC_208|Compound:k072-0098|FD-Score:3.53|P-value:1.22E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.09|P-value:6.45E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:4.26|P-value:4.97E-6 ID:SGTC_379|Compound:3970-0972|FD-Score:3.19|P-value:4.54E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.12|P-value:6.97E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.47|P-value:1.57E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.08|P-value:6.77E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.88|P-value:2.83E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.30|P-value:3.70E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.76|P-value:4.66E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.16|P-value:5.12E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.18|P-value:5.81E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.31|P-value:2.87E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.34|P-value:2.60E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.04|P-value:1.36E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:3.38|P-value:2.22E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.00|P-value:8.96E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.59|P-value:9.70E-5 ID:SGTC_1158|Compound:4092-0494|FD-Score:-3.40|P-value:2.54E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.20|P-value:4.34E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:6.51|P-value:7.75E-12 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.63|P-value:7.58E-7 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.39|P-value:2.56E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.32|P-value:3.46E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.34|P-value:2.54E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.62|P-value:8.34E-7 ID:SGTC_1472|Compound:k841-0093|FD-Score:4.24|P-value:5.43E-6 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.09|P-value:7.96E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.19|P-value:4.56E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.82|P-value:4.60E-5 ID:SGTC_1820|Compound:st053765|FD-Score:-3.11|P-value:7.48E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:5.54|P-value:4.72E-9 ID:SGTC_1901|Compound:st060216|FD-Score:-3.43|P-value:2.21E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.92|P-value:1.68E-7 ID:SGTC_2104|Compound:5389443|FD-Score:3.34|P-value:2.56E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.11|P-value:5.97E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.24|P-value:3.76E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.42|P-value:2.33E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.41|P-value:2.45E-4 ID:SGTC_2402|Compound:5553605|FD-Score:4.72|P-value:4.89E-7 ID:SGTC_2455|Compound:5377712|FD-Score:3.26|P-value:3.49E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.14|P-value:5.33E-4 ID:SGTC_2678|Compound:equilin|FD-Score:4.09|P-value:1.06E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.76|P-value:4.62E-5 ID:SGTC_2849|Compound:9019321|FD-Score:5.43|P-value:9.00E-9 ID:SGTC_2874|Compound:9043904|FD-Score:3.47|P-value:1.52E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.09|P-value:6.53E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.56|P-value:1.06E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.63|P-value:7.83E-7 ID:SGTC_2975|Compound:9084847|FD-Score:7.15|P-value:6.42E-14 ID:SGTC_2993|Compound:9054257|FD-Score:3.09|P-value:6.54E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.28|P-value:3.23E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.11|P-value:7.40E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.43|P-value:2.26E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-4.28|P-value:5.81E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-3.34|P-value:3.14E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.20|P-value:5.31E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.99|P-value:1.69E-5 ID:SGTC_3252|Compound:9135871|FD-Score:3.59|P-value:9.65E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:3.53|P-value:1.22E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.09|P-value:6.45E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:4.26|P-value:4.97E-6 ID:SGTC_379|Compound:3970-0972|FD-Score:3.19|P-value:4.54E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.12|P-value:6.97E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.47|P-value:1.57E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.08|P-value:6.77E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.88|P-value:2.83E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.30|P-value:3.70E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.76|P-value:4.66E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:3.16|P-value:5.12E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:-3.18|P-value:5.81E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:3.31|P-value:2.87E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.34|P-value:2.60E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.04|P-value:1.36E-5 ID:SGTC_810|Compound:3825-7150|FD-Score:3.38|P-value:2.22E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.00|P-value:8.96E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.59|P-value:9.70E-5 ID:SGTC_1158|Compound:4092-0494|FD-Score:-3.40|P-value:2.54E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.20|P-value:4.34E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:6.51|P-value:7.75E-12 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.63|P-value:7.58E-7 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.39|P-value:2.56E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:-3.32|P-value:3.46E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:3.34|P-value:2.54E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.62|P-value:8.34E-7 ID:SGTC_1472|Compound:k841-0093|FD-Score:4.24|P-value:5.43E-6 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:-3.09|P-value:7.96E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.19|P-value:4.56E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.82|P-value:4.60E-5 ID:SGTC_1820|Compound:st053765|FD-Score:-3.11|P-value:7.48E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:5.54|P-value:4.72E-9 ID:SGTC_1901|Compound:st060216|FD-Score:-3.43|P-value:2.21E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.92|P-value:1.68E-7 ID:SGTC_2104|Compound:5389443|FD-Score:3.34|P-value:2.56E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.11|P-value:5.97E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.24|P-value:3.76E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.42|P-value:2.33E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.41|P-value:2.45E-4 ID:SGTC_2402|Compound:5553605|FD-Score:4.72|P-value:4.89E-7 ID:SGTC_2455|Compound:5377712|FD-Score:3.26|P-value:3.49E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.14|P-value:5.33E-4 ID:SGTC_2678|Compound:equilin|FD-Score:4.09|P-value:1.06E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.76|P-value:4.62E-5 ID:SGTC_2849|Compound:9019321|FD-Score:5.43|P-value:9.00E-9 ID:SGTC_2874|Compound:9043904|FD-Score:3.47|P-value:1.52E-4 ID:SGTC_2888|Compound:9058547|FD-Score:3.09|P-value:6.53E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.56|P-value:1.06E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.63|P-value:7.83E-7 ID:SGTC_2975|Compound:9084847|FD-Score:7.15|P-value:6.42E-14 ID:SGTC_2993|Compound:9054257|FD-Score:3.09|P-value:6.54E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.28|P-value:3.23E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.11|P-value:7.40E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.43|P-value:2.26E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-4.28|P-value:5.81E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-3.34|P-value:3.14E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.20|P-value:5.31E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.99|P-value:1.69E-5 ID:SGTC_3252|Compound:9135871|FD-Score:3.59|P-value:9.65E-5

Top fitness defect scores for YLR266C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2975 9084847 7.15 53.7 µM 6.42E-14 2 4.23E-13
2 SGTC_1229 0139-0193 6.51 12.2 µM 7.75E-12 RSC complex & mRNA processing 2 3.77E-11
3 SGTC_1894 3',6'-dihydroxyflavone 5.54 78.7 µM 4.72E-9 4 1.54E-8
4 SGTC_2849 9019321 5.43 13.0 µM 9.00E-9 11 2.81E-8
5 SGTC_2057 5236571 4.92 38.3 µM 1.68E-7 RPP1 & pyrimidine depletion 13 4.36E-7
6 SGTC_2402 5553605 4.72 200.0 µM 4.89E-7 9 1.19E-6
7 SGTC_1352 1496-0991 4.63 99.0 µM 7.58E-7 tubulin folding & SWR complex 16 1.79E-6
8 SGTC_2971 9092186 4.63 9.9 µM 7.83E-7 ergosterol biosynthesis 17 1.84E-6
9 SGTC_1465 k213-0056 4.62 144.0 µM 8.34E-7 DNA intercalators 13 1.96E-6
10 SGTC_306 1672-3436 4.26 11.6 µM 4.97E-6 Golgi 12 1.04E-5
11 SGTC_1472 k841-0093 4.24 193.0 µM 5.43E-6 13 1.13E-5
12 SGTC_2678 equilin 4.09 100.0 µM 1.06E-5 21 2.12E-5
13 SGTC_722 3534-0461 4.04 190.0 µM 1.36E-5 PDR1 33 2.68E-5
14 SGTC_3250 9135583 3.99 49.5 µM 1.69E-5 11 3.28E-5
15 SGTC_518 1021-0119 3.88 62.6 µM 2.83E-5 ERG2 47 5.32E-5
16 SGTC_2816 7982706 3.76 58.4 µM 4.62E-5 azole & statin 59 8.41E-5
17 SGTC_534 k292-0788 3.76 63.4 µM 4.66E-5 mitochondrial processes 32 8.48E-5
18 SGTC_3252 9135871 3.59 49.5 µM 9.65E-5 17 1.68E-4
19 SGTC_965 1291-5240 3.59 308.0 µM 9.70E-5 40 1.68E-4
20 SGTC_2948 9070189 3.56 9.4 µM 1.06E-4 plasma membrane duress 49 1.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.27E-9 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.098 1.24E-8 YCR105W ADH7 hom NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
0.087 4.40E-7 YKL163W PIR3 hom O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication
0.079 4.79E-6 YOR341W RPA190 het RNA polymerase I largest subunit A190
0.079 5.17E-6 YEL025C_p YEL025C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.078 6.01E-6 YGR278W CWC22 het Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein
0.076 9.48E-6 YOR337W TEA1 hom Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein
0.076 1.03E-5 YJR133W XPT1 hom Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.076 1.12E-5 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.076 1.16E-5 YOR284W HUA2 hom Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
0.075 1.40E-5 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.073 2.06E-5 YOL005C RPB11 het RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
0.072 2.87E-5 YER038W-A_d YER038W-A_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
0.072 2.87E-5 YOL113W SKM1 hom Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth
0.070 5.17E-5 YBR131W CCZ1 hom Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway