YLR267W_p / BOP2

Protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR267W / BOP2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:2.59|P-value:6.24E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.98|P-value:3.86E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:2.72|P-value:3.63E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:2.49|P-value:9.73E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:2.95|P-value:1.23E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.71|P-value:3.75E-9 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.77|P-value:3.49E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:2.53|P-value:8.09E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-6.26|P-value:7.69E-15 ID:SGTC_917|Compound:harmaline|FD-Score:2.73|P-value:3.42E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.05|P-value:5.46E-14 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-2.56|P-value:8.74E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.67|P-value:4.38E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:2.87|P-value:1.76E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:2.74|P-value:3.20E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.47|P-value:1.52E-8 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-2.81|P-value:2.95E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-2.91|P-value:1.83E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.73|P-value:2.32E-9 ID:SGTC_1727|Compound:st034309|FD-Score:-3.85|P-value:1.18E-6 ID:SGTC_2014|Compound:4013930|FD-Score:2.92|P-value:1.42E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-2.57|P-value:8.60E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-5.50|P-value:7.26E-12 ID:SGTC_2127|Compound:5253358|FD-Score:-2.72|P-value:4.40E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.00|P-value:9.48E-5 ID:SGTC_2135|Compound:5326629|FD-Score:4.39|P-value:2.67E-8 ID:SGTC_2242|Compound:6630449|FD-Score:2.95|P-value:1.24E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.80|P-value:1.64E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.97|P-value:1.44E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.27|P-value:3.12E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:2.87|P-value:1.78E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:4.56|P-value:7.77E-9 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.76|P-value:1.59E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:-2.84|P-value:2.63E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:-3.19|P-value:4.81E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-2.90|P-value:1.92E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.54|P-value:5.71E-6 ID:SGTC_2885|Compound:9057732|FD-Score:2.99|P-value:9.94E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-3.03|P-value:1.07E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-2.70|P-value:4.88E-4 ID:SGTC_2913|Compound:7966556|FD-Score:4.21|P-value:9.01E-8 ID:SGTC_2924|Compound:9010168|FD-Score:3.05|P-value:7.44E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.88|P-value:7.62E-7 ID:SGTC_2936|Compound:9038235|FD-Score:-3.31|P-value:2.54E-5 ID:SGTC_3002|Compound:9075603|FD-Score:-2.68|P-value:5.28E-4 ID:SGTC_3066|Compound:9117245|FD-Score:2.80|P-value:2.48E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-2.62|P-value:6.77E-4 ID:SGTC_3262|Compound:9137218|FD-Score:2.93|P-value:1.37E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-2.61|P-value:7.06E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-2.86|P-value:2.38E-4 ID:SGTC_3281|Compound:9140613|FD-Score:2.82|P-value:2.28E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-2.87|P-value:2.22E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.01|P-value:1.16E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.11|P-value:7.24E-5 ID:SGTC_3348|Compound:9149464|FD-Score:2.55|P-value:7.63E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:2.59|P-value:6.24E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.98|P-value:3.86E-7 ID:SGTC_18|Compound:0111-0177|FD-Score:2.72|P-value:3.63E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:2.49|P-value:9.73E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:2.95|P-value:1.23E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-4.71|P-value:3.75E-9 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.77|P-value:3.49E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:2.53|P-value:8.09E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-6.26|P-value:7.69E-15 ID:SGTC_917|Compound:harmaline|FD-Score:2.73|P-value:3.42E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.05|P-value:5.46E-14 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-2.56|P-value:8.74E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.67|P-value:4.38E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:2.87|P-value:1.76E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:2.74|P-value:3.20E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.47|P-value:1.52E-8 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-2.81|P-value:2.95E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-2.91|P-value:1.83E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.73|P-value:2.32E-9 ID:SGTC_1727|Compound:st034309|FD-Score:-3.85|P-value:1.18E-6 ID:SGTC_2014|Compound:4013930|FD-Score:2.92|P-value:1.42E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-2.57|P-value:8.60E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-5.50|P-value:7.26E-12 ID:SGTC_2127|Compound:5253358|FD-Score:-2.72|P-value:4.40E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.00|P-value:9.48E-5 ID:SGTC_2135|Compound:5326629|FD-Score:4.39|P-value:2.67E-8 ID:SGTC_2242|Compound:6630449|FD-Score:2.95|P-value:1.24E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.80|P-value:1.64E-6 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.97|P-value:1.44E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.27|P-value:3.12E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:2.87|P-value:1.78E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:4.56|P-value:7.77E-9 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.76|P-value:1.59E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:-2.84|P-value:2.63E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:-3.19|P-value:4.81E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-2.90|P-value:1.92E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.54|P-value:5.71E-6 ID:SGTC_2885|Compound:9057732|FD-Score:2.99|P-value:9.94E-5 ID:SGTC_2900|Compound:5328528|FD-Score:-3.03|P-value:1.07E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-2.70|P-value:4.88E-4 ID:SGTC_2913|Compound:7966556|FD-Score:4.21|P-value:9.01E-8 ID:SGTC_2924|Compound:9010168|FD-Score:3.05|P-value:7.44E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.88|P-value:7.62E-7 ID:SGTC_2936|Compound:9038235|FD-Score:-3.31|P-value:2.54E-5 ID:SGTC_3002|Compound:9075603|FD-Score:-2.68|P-value:5.28E-4 ID:SGTC_3066|Compound:9117245|FD-Score:2.80|P-value:2.48E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-2.62|P-value:6.77E-4 ID:SGTC_3262|Compound:9137218|FD-Score:2.93|P-value:1.37E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-2.61|P-value:7.06E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-2.86|P-value:2.38E-4 ID:SGTC_3281|Compound:9140613|FD-Score:2.82|P-value:2.28E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-2.87|P-value:2.22E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.01|P-value:1.16E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.11|P-value:7.24E-5 ID:SGTC_3348|Compound:9149464|FD-Score:2.55|P-value:7.63E-4

Top fitness defect scores for YLR267W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1725 st036284 4.73 20.6 µM 2.32E-9 17 1.13E-6
2 SGTC_2722 naftopidil 4.56 47.2 µM 7.77E-9 3 2.52E-6
3 SGTC_1520 flindersine 4.47 88.0 µM 1.52E-8 20 3.93E-6
4 SGTC_2135 5326629 4.39 150.4 µM 2.67E-8 RPP1 & pyrimidine depletion 17 5.72E-6
5 SGTC_2913 7966556 4.21 36.6 µM 9.01E-8 60S ribosome export 5 1.28E-5
6 SGTC_8 0354-0001 3.98 70.0 µM 3.86E-7 76 3.38E-5
7 SGTC_2930 9013230 3.88 14.9 µM 7.62E-7 heme biosynthesis & mitochondrial translocase 40 5.31E-5
8 SGTC_2724 maprotiline 3.76 69.6 µM 1.59E-6 ERG2 19 8.66E-5
9 SGTC_2835 9006588 3.54 71.4 µM 5.71E-6 58 2.04E-4
10 SGTC_2924 9010168 3.05 62.8 µM 7.44E-5 cell wall signaling 80 0.00113
11 SGTC_2133 5320837 3.00 200.0 µM 9.48E-5 ERG2 72 0.00134
12 SGTC_2885 9057732 2.99 52.0 µM 9.94E-5 49 0.00138
13 SGTC_356 1634-0012 2.95 32.5 µM 1.23E-4 74 0.00159
14 SGTC_2242 6630449 2.95 61.3 µM 1.24E-4 Golgi 82 0.00160
15 SGTC_3262 9137218 2.93 49.5 µM 1.37E-4 19 0.00171
16 SGTC_2014 4013930 2.92 200.0 µM 1.42E-4 94 0.00176
17 SGTC_1123 mangostin 2.87 811.3 nM 1.76E-4 mitochondrial response to ROS 92 0.00202
18 SGTC_2563 tomatine 2.87 8.5 µM 1.78E-4 129 0.00204
19 SGTC_3281 9140613 2.82 49.5 µM 2.28E-4 RPP1 & pyrimidine depletion 72 0.00241
20 SGTC_3066 9117245 2.80 49.5 µM 2.48E-4 68 0.00255

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 9.80E-46 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.237 4.56E-44 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.221 2.80E-38 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.221 2.71E-38 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.218 2.65E-37 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.215 1.47E-36 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.214 3.87E-36 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.213 1.04E-35 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.203 1.63E-32 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.202 2.29E-32 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.199 2.59E-31 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.198 4.73E-31 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.198 7.53E-31 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.195 4.22E-30 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.194 6.86E-30 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication