YLR268W / SEC22

R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR268W / SEC22

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:6.30|P-value:6.67E-7 ID:SGTC_52|Compound:0329-0193|FD-Score:4.25|P-value:5.73E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:6.02|P-value:1.92E-6 ID:SGTC_57|Compound:miconazole|FD-Score:-9.26|P-value:4.44E-13 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.16|P-value:6.49E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.93|P-value:7.85E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-4.34|P-value:3.93E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.09|P-value:8.77E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.42|P-value:3.60E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.70|P-value:6.10E-6 ID:SGTC_263|Compound:alizarin|FD-Score:5.21|P-value:3.27E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:5.73|P-value:5.56E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.32|P-value:4.16E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.27|P-value:8.71E-11 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:6.20|P-value:1.01E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:5.39|P-value:1.77E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.84|P-value:9.07E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.72|P-value:4.97E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:-4.06|P-value:8.48E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.76|P-value:1.09E-7 ID:SGTC_537|Compound:1334-0398|FD-Score:5.34|P-value:2.09E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:6.44|P-value:3.85E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:5.29|P-value:2.49E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:5.95|P-value:2.56E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:5.14|P-value:4.08E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:4.24|P-value:5.78E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:13.50|P-value:1.64E-25 ID:SGTC_763|Compound:3453-1109|FD-Score:-5.55|P-value:8.89E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:6.82|P-value:8.40E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:6.62|P-value:1.87E-7 ID:SGTC_805|Compound:3852-0218|FD-Score:8.35|P-value:7.15E-11 ID:SGTC_828|Compound:2074-0507|FD-Score:4.61|P-value:2.05E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.48|P-value:3.01E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.87|P-value:9.66E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:6.48|P-value:3.27E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:13.00|P-value:8.85E-24 ID:SGTC_1048|Compound:3161-0300|FD-Score:6.71|P-value:1.33E-7 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.35|P-value:4.28E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.73|P-value:9.99E-12 ID:SGTC_1162|Compound:k048-0130|FD-Score:7.24|P-value:1.35E-8 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.11|P-value:4.55E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.33|P-value:4.05E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:5.25|P-value:2.87E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.58|P-value:2.25E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.63|P-value:1.98E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.48|P-value:4.63E-9 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.21|P-value:6.38E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.21|P-value:6.36E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.93|P-value:7.80E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.21|P-value:9.50E-7 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.55|P-value:2.43E-4 ID:SGTC_1530|Compound:rhein|FD-Score:4.38|P-value:3.94E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.25|P-value:5.74E-4 ID:SGTC_1624|Compound:st003710|FD-Score:5.81|P-value:4.20E-6 ID:SGTC_1687|Compound:st020778|FD-Score:8.16|P-value:1.85E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.56|P-value:8.62E-6 ID:SGTC_1797|Compound:st048695|FD-Score:5.64|P-value:7.67E-6 ID:SGTC_1801|Compound:st050089|FD-Score:5.85|P-value:3.66E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.33|P-value:4.59E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.41|P-value:6.38E-9 ID:SGTC_2059|Compound:5238311|FD-Score:5.25|P-value:2.85E-5 ID:SGTC_2077|Compound:5212015|FD-Score:5.75|P-value:5.21E-6 ID:SGTC_2085|Compound:5307070|FD-Score:5.31|P-value:2.38E-5 ID:SGTC_2153|Compound:5569715|FD-Score:4.48|P-value:3.02E-4 ID:SGTC_2173|Compound:5763948|FD-Score:5.14|P-value:4.11E-5 ID:SGTC_2223|Compound:6903751|FD-Score:4.59|P-value:2.22E-4 ID:SGTC_2385|Compound:9074692|FD-Score:9.06|P-value:1.75E-12 ID:SGTC_2424|Compound:5537928|FD-Score:5.29|P-value:2.53E-5 ID:SGTC_2440|Compound:5628896|FD-Score:4.87|P-value:9.56E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.16|P-value:7.15E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.26|P-value:5.57E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.14|P-value:4.09E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.90|P-value:8.67E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:9.19|P-value:8.72E-13 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:5.44|P-value:1.50E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:5.21|P-value:3.22E-5 ID:SGTC_2748|Compound:diazoxide|FD-Score:4.63|P-value:1.96E-4 ID:SGTC_2784|Compound:7567673|FD-Score:11.80|P-value:4.55E-20 ID:SGTC_2788|Compound:5282734|FD-Score:-4.23|P-value:5.35E-4 ID:SGTC_2790|Compound:5423970|FD-Score:6.13|P-value:1.31E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.38|P-value:4.03E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.75|P-value:1.20E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-5.67|P-value:5.93E-6 ID:SGTC_2934|Compound:9036370|FD-Score:6.91|P-value:5.82E-8 ID:SGTC_2968|Compound:9090663|FD-Score:5.18|P-value:3.57E-5 ID:SGTC_3013|Compound:9080133|FD-Score:4.38|P-value:3.94E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-5.40|P-value:1.48E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.48|P-value:3.03E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-5.33|P-value:1.90E-5 ID:SGTC_3141|Compound:9094609|FD-Score:8.35|P-value:7.41E-11 ID:SGTC_3142|Compound:9086498|FD-Score:5.40|P-value:1.75E-5 ID:SGTC_3161|Compound:9100388|FD-Score:4.63|P-value:1.95E-4 ID:SGTC_3188|Compound:9110789|FD-Score:4.33|P-value:4.62E-4 ID:SGTC_3189|Compound:9110682|FD-Score:7.97|P-value:4.65E-10 ID:SGTC_3190|Compound:9110366|FD-Score:-5.18|P-value:3.09E-5 ID:SGTC_3194|Compound:9111903|FD-Score:-6.71|P-value:1.10E-7 ID:SGTC_3200|Compound:9114385|FD-Score:-4.80|P-value:1.02E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.54|P-value:2.52E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:6.30|P-value:6.67E-7 ID:SGTC_52|Compound:0329-0193|FD-Score:4.25|P-value:5.73E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:6.02|P-value:1.92E-6 ID:SGTC_57|Compound:miconazole|FD-Score:-9.26|P-value:4.44E-13 ID:SGTC_101|Compound:0490-5701|FD-Score:-4.16|P-value:6.49E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:4.93|P-value:7.85E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-4.34|P-value:3.93E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.09|P-value:8.77E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:4.42|P-value:3.60E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.70|P-value:6.10E-6 ID:SGTC_263|Compound:alizarin|FD-Score:5.21|P-value:3.27E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:5.73|P-value:5.56E-6 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.32|P-value:4.16E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.27|P-value:8.71E-11 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:6.20|P-value:1.01E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:5.39|P-value:1.77E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.84|P-value:9.07E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.72|P-value:4.97E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:-4.06|P-value:8.48E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.76|P-value:1.09E-7 ID:SGTC_537|Compound:1334-0398|FD-Score:5.34|P-value:2.09E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:6.44|P-value:3.85E-7 ID:SGTC_562|Compound:3772-2733|FD-Score:5.29|P-value:2.49E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:5.95|P-value:2.56E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:5.14|P-value:4.08E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:4.24|P-value:5.78E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:13.50|P-value:1.64E-25 ID:SGTC_763|Compound:3453-1109|FD-Score:-5.55|P-value:8.89E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:6.82|P-value:8.40E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:6.62|P-value:1.87E-7 ID:SGTC_805|Compound:3852-0218|FD-Score:8.35|P-value:7.15E-11 ID:SGTC_828|Compound:2074-0507|FD-Score:4.61|P-value:2.05E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.48|P-value:3.01E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:4.87|P-value:9.66E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:6.48|P-value:3.27E-7 ID:SGTC_1026|Compound:k007-1105|FD-Score:13.00|P-value:8.85E-24 ID:SGTC_1048|Compound:3161-0300|FD-Score:6.71|P-value:1.33E-7 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.35|P-value:4.28E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.73|P-value:9.99E-12 ID:SGTC_1162|Compound:k048-0130|FD-Score:7.24|P-value:1.35E-8 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.11|P-value:4.55E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.33|P-value:4.05E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:5.25|P-value:2.87E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.58|P-value:2.25E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.63|P-value:1.98E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.48|P-value:4.63E-9 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.21|P-value:6.38E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:4.21|P-value:6.36E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.93|P-value:7.80E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.21|P-value:9.50E-7 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.55|P-value:2.43E-4 ID:SGTC_1530|Compound:rhein|FD-Score:4.38|P-value:3.94E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.25|P-value:5.74E-4 ID:SGTC_1624|Compound:st003710|FD-Score:5.81|P-value:4.20E-6 ID:SGTC_1687|Compound:st020778|FD-Score:8.16|P-value:1.85E-10 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.56|P-value:8.62E-6 ID:SGTC_1797|Compound:st048695|FD-Score:5.64|P-value:7.67E-6 ID:SGTC_1801|Compound:st050089|FD-Score:5.85|P-value:3.66E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.33|P-value:4.59E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:7.41|P-value:6.38E-9 ID:SGTC_2059|Compound:5238311|FD-Score:5.25|P-value:2.85E-5 ID:SGTC_2077|Compound:5212015|FD-Score:5.75|P-value:5.21E-6 ID:SGTC_2085|Compound:5307070|FD-Score:5.31|P-value:2.38E-5 ID:SGTC_2153|Compound:5569715|FD-Score:4.48|P-value:3.02E-4 ID:SGTC_2173|Compound:5763948|FD-Score:5.14|P-value:4.11E-5 ID:SGTC_2223|Compound:6903751|FD-Score:4.59|P-value:2.22E-4 ID:SGTC_2385|Compound:9074692|FD-Score:9.06|P-value:1.75E-12 ID:SGTC_2424|Compound:5537928|FD-Score:5.29|P-value:2.53E-5 ID:SGTC_2440|Compound:5628896|FD-Score:4.87|P-value:9.56E-5 ID:SGTC_2485|Compound:5633444|FD-Score:4.16|P-value:7.15E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.26|P-value:5.57E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.14|P-value:4.09E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.90|P-value:8.67E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:9.19|P-value:8.72E-13 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:5.44|P-value:1.50E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:5.21|P-value:3.22E-5 ID:SGTC_2748|Compound:diazoxide|FD-Score:4.63|P-value:1.96E-4 ID:SGTC_2784|Compound:7567673|FD-Score:11.80|P-value:4.55E-20 ID:SGTC_2788|Compound:5282734|FD-Score:-4.23|P-value:5.35E-4 ID:SGTC_2790|Compound:5423970|FD-Score:6.13|P-value:1.31E-6 ID:SGTC_2791|Compound:5663188|FD-Score:4.38|P-value:4.03E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.75|P-value:1.20E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-5.67|P-value:5.93E-6 ID:SGTC_2934|Compound:9036370|FD-Score:6.91|P-value:5.82E-8 ID:SGTC_2968|Compound:9090663|FD-Score:5.18|P-value:3.57E-5 ID:SGTC_3013|Compound:9080133|FD-Score:4.38|P-value:3.94E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-5.40|P-value:1.48E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.48|P-value:3.03E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-5.33|P-value:1.90E-5 ID:SGTC_3141|Compound:9094609|FD-Score:8.35|P-value:7.41E-11 ID:SGTC_3142|Compound:9086498|FD-Score:5.40|P-value:1.75E-5 ID:SGTC_3161|Compound:9100388|FD-Score:4.63|P-value:1.95E-4 ID:SGTC_3188|Compound:9110789|FD-Score:4.33|P-value:4.62E-4 ID:SGTC_3189|Compound:9110682|FD-Score:7.97|P-value:4.65E-10 ID:SGTC_3190|Compound:9110366|FD-Score:-5.18|P-value:3.09E-5 ID:SGTC_3194|Compound:9111903|FD-Score:-6.71|P-value:1.10E-7 ID:SGTC_3200|Compound:9114385|FD-Score:-4.80|P-value:1.02E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.54|P-value:2.52E-4

Top fitness defect scores for YLR268W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_733 4069-0007 13.50 56.1 µM 1.64E-25 ERAD & cell cycle 7 7.99E-42
2 SGTC_1026 k007-1105 13.00 30.6 µM 8.85E-24 ERAD & cell cycle 6 6.61E-39
3 SGTC_2784 7567673 11.80 72.7 µM 4.55E-20 iron homeostasis 1 1.17E-32
4 SGTC_2666 tannic acid 9.19 100.0 µM 8.72E-13 iron homeostasis 3 2.05E-20
5 SGTC_2385 9074692 9.06 200.0 µM 1.75E-12 4 6.60E-20
6 SGTC_1161 k007-0610 8.73 110.0 µM 9.99E-12 ERAD & cell cycle 20 1.22E-18
7 SGTC_805 3852-0218 8.35 479.0 µM 7.15E-11 ERAD & cell cycle 10 3.32E-17
8 SGTC_3141 9094609 8.35 49.5 µM 7.41E-11 iron homeostasis 3 3.53E-17
9 SGTC_1687 st020778 8.16 55.4 µM 1.85E-10 68 1.64E-16
10 SGTC_3189 9110682 7.97 49.5 µM 4.65E-10 2 7.67E-16
11 SGTC_1306 1185-0270 7.48 9.0 µM 4.63E-9 Golgi 21 3.61E-14
12 SGTC_1877 wortmannin 7.41 25.0 µM 6.38E-9 28 6.15E-14
13 SGTC_1162 k048-0130 7.24 20.1 µM 1.35E-8 Golgi 7 2.17E-13
14 SGTC_2934 9036370 6.91 36.9 µM 5.82E-8 6 2.48E-12
15 SGTC_770 0389-1121 6.82 67.2 µM 8.40E-8 RPP1 & pyrimidine depletion 2 4.59E-12
16 SGTC_525 k781-2675 6.76 26.7 µM 1.09E-7 redox potentiating 18 7.09E-12
17 SGTC_1048 3161-0300 6.71 24.5 µM 1.33E-7 2 9.90E-12
18 SGTC_788 1182-0090 6.62 188.0 µM 1.87E-7 endomembrane recycling 27 1.74E-11
19 SGTC_970 1315-0089 6.48 19.5 µM 3.27E-7 RSC & ERG11 4 4.45E-11
20 SGTC_543 3844-1095 6.44 191.0 µM 3.85E-7 ERG2 14 5.83E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.250 4.40E-49 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.232 2.69E-42 YNR052C POP2 hom RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
0.229 4.40E-41 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.216 9.33E-37 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.211 4.91E-35 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.208 3.57E-34 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.207 6.67E-34 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.206 2.37E-33 YDL041W_d YDL041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
0.204 6.57E-33 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.200 1.53E-31 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.200 1.62E-31 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.198 7.42E-31 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.193 2.11E-29 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.193 2.26E-29 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.189 3.11E-28 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif