YLR270W / DCS1

Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR270W / DCS1

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:3.56|P-value:3.50E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:6.94|P-value:1.81E-11 ID:SGTC_68|Compound:0986-0284|FD-Score:4.97|P-value:1.11E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:3.71|P-value:2.04E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.40|P-value:8.20E-33 ID:SGTC_253|Compound:dyclonine|FD-Score:4.10|P-value:4.71E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.50|P-value:4.33E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.29|P-value:2.31E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:3.39|P-value:6.35E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.72|P-value:1.79E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.13|P-value:4.13E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.65|P-value:2.58E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.65|P-value:4.13E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.86|P-value:1.19E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.74|P-value:1.63E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.25|P-value:8.87E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:4.22|P-value:2.98E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.97|P-value:7.87E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:4.04|P-value:5.89E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:3.32|P-value:7.95E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.46|P-value:4.89E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.51|P-value:8.65E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.99|P-value:7.26E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.60|P-value:2.77E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.61|P-value:2.98E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:5.33|P-value:1.86E-7 ID:SGTC_979|Compound:1426-2828|FD-Score:6.18|P-value:1.86E-9 ID:SGTC_985|Compound:1493-0307|FD-Score:-5.50|P-value:6.82E-8 ID:SGTC_1139|Compound:k015-0024|FD-Score:-4.56|P-value:6.12E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.01|P-value:6.63E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:-6.75|P-value:4.99E-11 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.05|P-value:5.67E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.76|P-value:1.70E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.43|P-value:4.93E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.82|P-value:2.14E-6 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.71|P-value:2.08E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.83|P-value:1.17E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.93|P-value:9.31E-5 ID:SGTC_1623|Compound:st003709|FD-Score:4.32|P-value:1.92E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-5.02|P-value:7.24E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-4.04|P-value:5.30E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-4.36|P-value:1.46E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.48|P-value:2.69E-10 ID:SGTC_1719|Compound:st032227|FD-Score:4.35|P-value:1.69E-5 ID:SGTC_1722|Compound:st034304|FD-Score:5.64|P-value:3.78E-8 ID:SGTC_1723|Compound:st034307|FD-Score:3.70|P-value:2.18E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.19|P-value:3.38E-12 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.53|P-value:6.99E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.75|P-value:3.03E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.47|P-value:4.84E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.65|P-value:2.57E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.72|P-value:7.46E-11 ID:SGTC_2295|Compound:7971645|FD-Score:4.02|P-value:6.37E-5 ID:SGTC_2296|Compound:7971656|FD-Score:4.81|P-value:2.26E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-3.34|P-value:6.70E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.67|P-value:2.16E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.59|P-value:3.21E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.07|P-value:5.39E-5 ID:SGTC_2326|Compound:6164455|FD-Score:5.87|P-value:1.09E-8 ID:SGTC_2526|Compound:patulin|FD-Score:3.67|P-value:2.41E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.73|P-value:1.69E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.87|P-value:2.32E-11 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.56|P-value:3.15E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.68|P-value:2.34E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.93|P-value:1.34E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.80|P-value:1.30E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-6.45|P-value:3.25E-10 ID:SGTC_2896|Compound:9052656|FD-Score:-7.00|P-value:9.89E-12 ID:SGTC_2900|Compound:5328528|FD-Score:3.94|P-value:8.90E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.84|P-value:1.15E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-3.95|P-value:7.33E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-4.04|P-value:5.36E-5 ID:SGTC_3174|Compound:9107204|FD-Score:-5.11|P-value:4.73E-7 ID:SGTC_3193|Compound:9111931|FD-Score:5.71|P-value:2.55E-8 ID:SGTC_3197|Compound:9113331|FD-Score:-4.04|P-value:5.17E-5 ID:SGTC_3274|Compound:9138298|FD-Score:3.58|P-value:3.32E-4 ID:SGTC_3340|Compound:9146634|FD-Score:-3.44|P-value:4.76E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.25|P-value:9.04E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:3.56|P-value:3.50E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:6.94|P-value:1.81E-11 ID:SGTC_68|Compound:0986-0284|FD-Score:4.97|P-value:1.11E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:3.71|P-value:2.04E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.40|P-value:8.20E-33 ID:SGTC_253|Compound:dyclonine|FD-Score:4.10|P-value:4.71E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.50|P-value:4.33E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.29|P-value:2.31E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:3.39|P-value:6.35E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.72|P-value:1.79E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.13|P-value:4.13E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.65|P-value:2.58E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.65|P-value:4.13E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.86|P-value:1.19E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.74|P-value:1.63E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.25|P-value:8.87E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:4.22|P-value:2.98E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.97|P-value:7.87E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:4.04|P-value:5.89E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:3.32|P-value:7.95E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.46|P-value:4.89E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.51|P-value:8.65E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:3.99|P-value:7.26E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.60|P-value:2.77E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.61|P-value:2.98E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:5.33|P-value:1.86E-7 ID:SGTC_979|Compound:1426-2828|FD-Score:6.18|P-value:1.86E-9 ID:SGTC_985|Compound:1493-0307|FD-Score:-5.50|P-value:6.82E-8 ID:SGTC_1139|Compound:k015-0024|FD-Score:-4.56|P-value:6.12E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.01|P-value:6.63E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:-6.75|P-value:4.99E-11 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.05|P-value:5.67E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.76|P-value:1.70E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.43|P-value:4.93E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.82|P-value:2.14E-6 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.71|P-value:2.08E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.83|P-value:1.17E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.93|P-value:9.31E-5 ID:SGTC_1623|Compound:st003709|FD-Score:4.32|P-value:1.92E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-5.02|P-value:7.24E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-4.04|P-value:5.30E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-4.36|P-value:1.46E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.48|P-value:2.69E-10 ID:SGTC_1719|Compound:st032227|FD-Score:4.35|P-value:1.69E-5 ID:SGTC_1722|Compound:st034304|FD-Score:5.64|P-value:3.78E-8 ID:SGTC_1723|Compound:st034307|FD-Score:3.70|P-value:2.18E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.19|P-value:3.38E-12 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.53|P-value:6.99E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.75|P-value:3.03E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.47|P-value:4.84E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.65|P-value:2.57E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.72|P-value:7.46E-11 ID:SGTC_2295|Compound:7971645|FD-Score:4.02|P-value:6.37E-5 ID:SGTC_2296|Compound:7971656|FD-Score:4.81|P-value:2.26E-6 ID:SGTC_2300|Compound:7976697|FD-Score:-3.34|P-value:6.70E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-3.67|P-value:2.16E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.59|P-value:3.21E-4 ID:SGTC_2325|Compound:6158266|FD-Score:4.07|P-value:5.39E-5 ID:SGTC_2326|Compound:6164455|FD-Score:5.87|P-value:1.09E-8 ID:SGTC_2526|Compound:patulin|FD-Score:3.67|P-value:2.41E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.73|P-value:1.69E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-6.87|P-value:2.32E-11 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.56|P-value:3.15E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.68|P-value:2.34E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.93|P-value:1.34E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.80|P-value:1.30E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-6.45|P-value:3.25E-10 ID:SGTC_2896|Compound:9052656|FD-Score:-7.00|P-value:9.89E-12 ID:SGTC_2900|Compound:5328528|FD-Score:3.94|P-value:8.90E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.84|P-value:1.15E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-3.95|P-value:7.33E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-4.04|P-value:5.36E-5 ID:SGTC_3174|Compound:9107204|FD-Score:-5.11|P-value:4.73E-7 ID:SGTC_3193|Compound:9111931|FD-Score:5.71|P-value:2.55E-8 ID:SGTC_3197|Compound:9113331|FD-Score:-4.04|P-value:5.17E-5 ID:SGTC_3274|Compound:9138298|FD-Score:3.58|P-value:3.32E-4 ID:SGTC_3340|Compound:9146634|FD-Score:-3.44|P-value:4.76E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.25|P-value:9.04E-4

Top fitness defect scores for YLR270W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 12.40 5.3 µM 8.20E-33 141 8.47E-36
2 SGTC_1742 st038235 7.19 28.9 µM 3.38E-12 mitochondrial stress 25 3.13E-13
3 SGTC_63 0099-0242 6.94 26.7 µM 1.81E-11 mitochondrial stress 18 1.96E-12
4 SGTC_2250 alverine citrate 6.72 130.0 µM 7.46E-11 37 9.28E-12
5 SGTC_979 1426-2828 6.18 121.0 µM 1.86E-9 3 3.14E-10
6 SGTC_2326 6164455 5.87 177.6 µM 1.09E-8 mitochondrial processes 3 2.17E-9
7 SGTC_3193 9111931 5.71 49.5 µM 2.55E-8 3 5.51E-9
8 SGTC_1722 st034304 5.64 3.6 µM 3.78E-8 mitochondrial processes 9 8.46E-9
9 SGTC_977 1348-1378 5.33 135.0 µM 1.86E-7 6 4.82E-8
10 SGTC_310 1273-0058 5.29 1.1 µM 2.31E-7 mitochondrial stress 169 6.14E-8
11 SGTC_68 0986-0284 4.97 82.8 µM 1.11E-6 33 3.42E-7
12 SGTC_2730 imipramine 4.93 71.3 µM 1.34E-6 4 4.19E-7
13 SGTC_1402 3909-7673 4.82 35.9 µM 2.14E-6 10 7.02E-7
14 SGTC_2296 7971656 4.81 126.5 µM 2.26E-6 24 7.42E-7
15 SGTC_2232 chlorophetanol 4.75 41.5 µM 3.03E-6 TRP & mitochondrial translation 88 1.02E-6
16 SGTC_717 1532-0246 4.51 73.2 µM 8.65E-6 Golgi 18 3.23E-6
17 SGTC_1719 st032227 4.35 49.2 µM 1.69E-5 15 6.73E-6
18 SGTC_1623 st003709 4.32 20.3 µM 1.92E-5 calcium & mitochondrial duress 54 7.71E-6
19 SGTC_596 1155-0152 4.22 116.0 µM 2.98E-5 TRP & mitochondrial translation 31 1.25E-5
20 SGTC_432 NS 1619 4.13 61.3 µM 4.13E-5 24 1.78E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.425 1.52E-147 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.408 6.31E-134 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.402 7.46E-131 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.399 3.68E-128 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.397 7.05E-127 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.391 6.67E-123 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.385 5.04E-119 YDR114C_p YDR114C_p hom Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
0.379 4.47E-115 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.374 3.14E-112 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.371 5.58E-110 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.371 6.51E-110 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.366 5.08E-107 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.364 6.70E-106 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.362 1.69E-104 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.359 1.87E-102 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress