YLR271W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR271W / YLR271W

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:-3.09|P-value:6.46E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.83|P-value:2.49E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.75|P-value:4.62E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:5.88|P-value:2.60E-10 ID:SGTC_157|Compound:1348-1695|FD-Score:3.10|P-value:4.99E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:7.15|P-value:2.23E-14 ID:SGTC_218|Compound:alverine citrate|FD-Score:12.00|P-value:3.08E-37 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:9.92|P-value:6.51E-26 ID:SGTC_220|Compound:paclitaxel|FD-Score:13.20|P-value:1.87E-44 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.28|P-value:6.46E-23 ID:SGTC_222|Compound:nsc-310342|FD-Score:8.20|P-value:2.66E-18 ID:SGTC_223|Compound:busulfan|FD-Score:13.50|P-value:6.57E-46 ID:SGTC_224|Compound:benfluorex|FD-Score:10.80|P-value:1.71E-30 ID:SGTC_225|Compound:nsc-122657|FD-Score:13.40|P-value:9.74E-46 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.34|P-value:1.95E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.18|P-value:3.68E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.26|P-value:2.72E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.09|P-value:5.27E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:8.65|P-value:3.50E-20 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.14|P-value:5.43E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.05|P-value:6.08E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.82|P-value:3.41E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.27|P-value:3.35E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.63|P-value:5.88E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:3.19|P-value:3.51E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.32|P-value:2.13E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.51|P-value:1.00E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.74|P-value:3.68E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.07|P-value:5.54E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.08|P-value:5.34E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.19|P-value:4.53E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.26|P-value:1.98E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.78|P-value:4.08E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.14|P-value:4.29E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.18|P-value:6.59E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:2.95|P-value:8.62E-4 ID:SGTC_1609|Compound:st001574|FD-Score:4.17|P-value:4.97E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.52|P-value:9.62E-5 ID:SGTC_1710|Compound:st031758|FD-Score:3.38|P-value:1.66E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.06|P-value:7.38E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.57|P-value:7.82E-5 ID:SGTC_2113|Compound:5491891|FD-Score:-3.41|P-value:1.93E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.12|P-value:4.59E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.41|P-value:1.91E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.15|P-value:4.12E-4 ID:SGTC_2382|Compound:9035899|FD-Score:-3.84|P-value:3.13E-5 ID:SGTC_2383|Compound:9036125|FD-Score:3.28|P-value:2.54E-4 ID:SGTC_2395|Compound:5646831|FD-Score:4.25|P-value:3.33E-6 ID:SGTC_2403|Compound:6032726|FD-Score:3.40|P-value:1.54E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.52|P-value:9.37E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.58|P-value:9.54E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-2.99|P-value:9.32E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.99|P-value:1.18E-5 ID:SGTC_2884|Compound:9058502|FD-Score:-3.35|P-value:2.41E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.89|P-value:1.87E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.41|P-value:1.52E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.27|P-value:2.64E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.36|P-value:1.85E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.12|P-value:5.83E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.09|P-value:6.46E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.83|P-value:2.49E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.75|P-value:4.62E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:5.88|P-value:2.60E-10 ID:SGTC_157|Compound:1348-1695|FD-Score:3.10|P-value:4.99E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:7.15|P-value:2.23E-14 ID:SGTC_218|Compound:alverine citrate|FD-Score:12.00|P-value:3.08E-37 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:9.92|P-value:6.51E-26 ID:SGTC_220|Compound:paclitaxel|FD-Score:13.20|P-value:1.87E-44 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.28|P-value:6.46E-23 ID:SGTC_222|Compound:nsc-310342|FD-Score:8.20|P-value:2.66E-18 ID:SGTC_223|Compound:busulfan|FD-Score:13.50|P-value:6.57E-46 ID:SGTC_224|Compound:benfluorex|FD-Score:10.80|P-value:1.71E-30 ID:SGTC_225|Compound:nsc-122657|FD-Score:13.40|P-value:9.74E-46 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.34|P-value:1.95E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.18|P-value:3.68E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.26|P-value:2.72E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.09|P-value:5.27E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:8.65|P-value:3.50E-20 ID:SGTC_804|Compound:1595-0054|FD-Score:-3.14|P-value:5.43E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:3.05|P-value:6.08E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.82|P-value:3.41E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.27|P-value:3.35E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.63|P-value:5.88E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:3.19|P-value:3.51E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.32|P-value:2.13E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.51|P-value:1.00E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.74|P-value:3.68E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.07|P-value:5.54E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.08|P-value:5.34E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.19|P-value:4.53E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.26|P-value:1.98E-8 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.78|P-value:4.08E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.14|P-value:4.29E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-4.18|P-value:6.59E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:2.95|P-value:8.62E-4 ID:SGTC_1609|Compound:st001574|FD-Score:4.17|P-value:4.97E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.52|P-value:9.62E-5 ID:SGTC_1710|Compound:st031758|FD-Score:3.38|P-value:1.66E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.06|P-value:7.38E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.57|P-value:7.82E-5 ID:SGTC_2113|Compound:5491891|FD-Score:-3.41|P-value:1.93E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.12|P-value:4.59E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.41|P-value:1.91E-4 ID:SGTC_2350|Compound:9023895|FD-Score:3.15|P-value:4.12E-4 ID:SGTC_2382|Compound:9035899|FD-Score:-3.84|P-value:3.13E-5 ID:SGTC_2383|Compound:9036125|FD-Score:3.28|P-value:2.54E-4 ID:SGTC_2395|Compound:5646831|FD-Score:4.25|P-value:3.33E-6 ID:SGTC_2403|Compound:6032726|FD-Score:3.40|P-value:1.54E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.52|P-value:9.37E-5 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-3.58|P-value:9.54E-5 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-2.99|P-value:9.32E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.99|P-value:1.18E-5 ID:SGTC_2884|Compound:9058502|FD-Score:-3.35|P-value:2.41E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.89|P-value:1.87E-5 ID:SGTC_2926|Compound:9010726|FD-Score:3.41|P-value:1.52E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.27|P-value:2.64E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.36|P-value:1.85E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.12|P-value:5.83E-4

Top fitness defect scores for YLR271W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_223 busulfan 13.50 5.0 mM 6.57E-46 1 1.44E-41
2 SGTC_225 nsc-122657 13.40 1.0 µM 9.74E-46 1 2.06E-41
3 SGTC_220 paclitaxel 13.20 373.4 µM 1.87E-44 1 2.97E-40
4 SGTC_218 alverine citrate 12.00 93.8 µM 3.08E-37 fatty acid desaturase (OLE1) 3 9.85E-34
5 SGTC_224 benfluorex 10.80 43.9 µM 1.71E-30 1 1.22E-27
6 SGTC_219 mitoxanthrone 9.92 164.4 µM 6.51E-26 DNA intercalators 8 1.68E-23
7 SGTC_221 trifluoperazine 9.28 10.3 µM 6.46E-23 NEO1-PIK1 69 8.52E-21
8 SGTC_773 4358-1457 8.65 44.6 µM 3.50E-20 4 2.51E-18
9 SGTC_222 nsc-310342 8.20 10.7 µM 2.66E-18 1 1.25E-16
10 SGTC_217 ketoconazole 7.15 989.0 nM 2.23E-14 ergosterol depletion effects on membrane 3 4.37E-13
11 SGTC_156 3474-0145 5.88 5.6 µM 2.60E-10 endomembrane recycling 22 2.05E-9
12 SGTC_2395 5646831 4.25 180.2 µM 3.33E-6 17 1.05E-5
13 SGTC_1609 st001574 4.17 46.4 µM 4.97E-6 9 1.51E-5
14 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 3.99 100.0 µM 1.18E-5 24 3.30E-5
15 SGTC_2903 5923464 3.89 63.9 µM 1.87E-5 9 5.00E-5
16 SGTC_89 0302-0250 3.83 142.1 µM 2.49E-5 21 6.45E-5
17 SGTC_1227 3909-8010 3.74 46.6 µM 3.68E-5 26 9.19E-5
18 SGTC_880 0833-0487 3.63 87.2 µM 5.88E-5 mitochondrial processes 19 1.40E-4
19 SGTC_1951 sophoraflavanone G 3.57 9.2 µM 7.82E-5 RNA processing & uracil transport 41 1.81E-4
20 SGTC_2501 sodium tetradecyl sulfate 3.52 13.4 µM 9.37E-5 49 2.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.289 9.18E-65 YGL220W FRA2 hom Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
0.245 9.84E-47 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.234 1.55E-42 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.167 4.31E-22 YHR163W SOL3 hom 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication
0.165 9.32E-22 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.159 3.12E-20 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.153 7.64E-19 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.145 3.31E-17 YLR053C_p YLR053C_p hom Putative protein of unknown function
0.143 8.57E-17 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.143 1.13E-16 YJR001W AVT1 hom Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.123 1.07E-12 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.119 4.48E-12 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.114 4.70E-11 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.113 5.16E-11 YJL132W_p YJL132W_p hom Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
0.107 6.69E-10 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W