YLR272C / YCS4

Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR272C / YCS4

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-5.38|P-value:5.18E-9 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.08|P-value:5.62E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:5.78|P-value:2.20E-10 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.58|P-value:7.27E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.48|P-value:8.20E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:3.50|P-value:7.54E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.60|P-value:6.55E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.79|P-value:1.10E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.48|P-value:1.09E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.65|P-value:3.87E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:2.96|P-value:6.40E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.36|P-value:1.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.78|P-value:3.05E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.05|P-value:4.58E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:2.99|P-value:5.87E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:2.89|P-value:8.39E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.32|P-value:2.13E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.00|P-value:7.42E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.97|P-value:8.20E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:5.00|P-value:3.36E-8 ID:SGTC_1591|Compound:genipin|FD-Score:-4.24|P-value:3.28E-6 ID:SGTC_1594|Compound:piperine|FD-Score:-3.34|P-value:2.02E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.53|P-value:6.42E-5 ID:SGTC_1656|Compound:st012921|FD-Score:2.99|P-value:5.93E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.02|P-value:5.23E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.75|P-value:2.40E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-3.45|P-value:1.28E-4 ID:SGTC_1885|Compound:st057546|FD-Score:2.95|P-value:6.65E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.92|P-value:5.40E-8 ID:SGTC_2084|Compound:5306078|FD-Score:3.70|P-value:3.01E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-3.14|P-value:4.39E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.48|P-value:6.23E-7 ID:SGTC_2141|Compound:5621638|FD-Score:3.27|P-value:1.95E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.22|P-value:2.34E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.42|P-value:1.42E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.77|P-value:3.14E-5 ID:SGTC_2415|Compound:st077333|FD-Score:7.97|P-value:4.59E-18 ID:SGTC_2446|Compound:5162541|FD-Score:-3.60|P-value:6.82E-5 ID:SGTC_2447|Compound:5741742|FD-Score:3.42|P-value:1.04E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-2.96|P-value:8.75E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.93|P-value:1.48E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.90|P-value:8.00E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.26|P-value:2.72E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.29|P-value:2.46E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.46|P-value:1.20E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.23|P-value:3.52E-6 ID:SGTC_2868|Compound:9035608|FD-Score:-3.21|P-value:3.34E-4 ID:SGTC_3014|Compound:9081533|FD-Score:2.95|P-value:6.66E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.66|P-value:3.62E-5 ID:SGTC_3066|Compound:9117245|FD-Score:-3.18|P-value:3.77E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.48|P-value:7.98E-5 ID:SGTC_3235|Compound:9132602|FD-Score:2.89|P-value:8.32E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.01|P-value:5.39E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-2.94|P-value:9.24E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.38|P-value:5.18E-9 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.08|P-value:5.62E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:5.78|P-value:2.20E-10 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.58|P-value:7.27E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.48|P-value:8.20E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:3.50|P-value:7.54E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.60|P-value:6.55E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.79|P-value:1.10E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.48|P-value:1.09E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.65|P-value:3.87E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:2.96|P-value:6.40E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.36|P-value:1.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.78|P-value:3.05E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.05|P-value:4.58E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:2.99|P-value:5.87E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:2.89|P-value:8.39E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.32|P-value:2.13E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.00|P-value:7.42E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.97|P-value:8.20E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:5.00|P-value:3.36E-8 ID:SGTC_1591|Compound:genipin|FD-Score:-4.24|P-value:3.28E-6 ID:SGTC_1594|Compound:piperine|FD-Score:-3.34|P-value:2.02E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.53|P-value:6.42E-5 ID:SGTC_1656|Compound:st012921|FD-Score:2.99|P-value:5.93E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.02|P-value:5.23E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.75|P-value:2.40E-5 ID:SGTC_1847|Compound:st056231|FD-Score:-3.45|P-value:1.28E-4 ID:SGTC_1885|Compound:st057546|FD-Score:2.95|P-value:6.65E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.92|P-value:5.40E-8 ID:SGTC_2084|Compound:5306078|FD-Score:3.70|P-value:3.01E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-3.14|P-value:4.39E-4 ID:SGTC_2138|Compound:5575593|FD-Score:4.48|P-value:6.23E-7 ID:SGTC_2141|Compound:5621638|FD-Score:3.27|P-value:1.95E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.22|P-value:2.34E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.42|P-value:1.42E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.77|P-value:3.14E-5 ID:SGTC_2415|Compound:st077333|FD-Score:7.97|P-value:4.59E-18 ID:SGTC_2446|Compound:5162541|FD-Score:-3.60|P-value:6.82E-5 ID:SGTC_2447|Compound:5741742|FD-Score:3.42|P-value:1.04E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-2.96|P-value:8.75E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.93|P-value:1.48E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.90|P-value:8.00E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.26|P-value:2.72E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.29|P-value:2.46E-4 ID:SGTC_2801|Compound:7907800|FD-Score:-3.46|P-value:1.20E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.23|P-value:3.52E-6 ID:SGTC_2868|Compound:9035608|FD-Score:-3.21|P-value:3.34E-4 ID:SGTC_3014|Compound:9081533|FD-Score:2.95|P-value:6.66E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.66|P-value:3.62E-5 ID:SGTC_3066|Compound:9117245|FD-Score:-3.18|P-value:3.77E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.48|P-value:7.98E-5 ID:SGTC_3235|Compound:9132602|FD-Score:2.89|P-value:8.32E-4 ID:SGTC_3244|Compound:9134489|FD-Score:3.01|P-value:5.39E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-2.94|P-value:9.24E-4

Top fitness defect scores for YLR272C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2415 st077333 7.97 57.7 µM 4.59E-18 1 8.22E-16 1.98
2 SGTC_72 0744-0168 5.78 198.4 µM 2.20E-10 RPP1 & pyrimidine depletion 2 3.76E-9 0.61
3 SGTC_1562 morin hydrate 5.00 59.1 µM 3.36E-8 3 2.93E-7 0.22
4 SGTC_1894 3',6'-dihydroxyflavone 4.92 78.7 µM 5.40E-8 2 4.43E-7 0.60
5 SGTC_807 1315-0151 4.79 48.0 µM 1.10E-7 3 8.21E-7 0.59
6 SGTC_2138 5575593 4.48 77.7 µM 6.23E-7 2 3.69E-6 1.03
7 SGTC_1707 st032323 3.75 6.3 µM 2.40E-5 DNA damage response 33 8.77E-5 0.00
8 SGTC_2084 5306078 3.70 60.6 µM 3.01E-5 4 1.07E-4 0.04
9 SGTC_3018 9082602 3.66 49.5 µM 3.62E-5 10 1.25E-4 0.19
10 SGTC_829 1635-0120 3.65 117.0 µM 3.87E-5 DNA damage response 50 1.33E-4 0.00
11 SGTC_1625 st003711 3.53 30.1 µM 6.42E-5 calcium & mitochondrial duress 3 2.06E-4 0.26
12 SGTC_322 k048-0136 3.50 19.3 µM 7.54E-5 RSC & ERG11 13 2.37E-4 0.01
13 SGTC_3152 9099253 3.48 49.5 µM 7.98E-5 NEO1-PIK1 33 2.49E-4 0.04
14 SGTC_102 gallobenzophenone 3.48 83.6 µM 8.20E-5 redox potentiating 7 2.54E-4 0.11
15 SGTC_2447 5741742 3.42 33.8 µM 1.04E-4 12 3.12E-4 0.16
16 SGTC_942 3253-1115 3.36 227.0 µM 1.36E-4 15 3.96E-4 0.00
17 SGTC_2141 5621638 3.27 7.7 µM 1.95E-4 tubulin folding & SWR complex 4 5.40E-4 0.02
18 SGTC_2156 5649887 3.22 115.0 µM 2.34E-4 RPP1 & pyrimidine depletion 26 6.32E-4 0.06
19 SGTC_1169 aniline yellow 3.05 25.8 µM 4.58E-4 6 0.00113 2.63E-4
20 SGTC_1697 st025554 3.02 27.7 µM 5.23E-4 9 0.00127 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 2.50E-30 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.165 6.65E-22 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.144 5.15E-17 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.143 6.92E-17 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.143 1.03E-16 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.133 8.85E-15 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.127 1.57E-13 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.127 1.69E-13 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.127 1.87E-13 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.118 5.78E-12 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.112 8.05E-11 YBR263W SHM1 hom Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
0.112 8.57E-11 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.111 1.30E-10 YLR011W LOT6 hom FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
0.109 2.08E-10 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.109 2.78E-10 YDR413C_d YDR413C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing