YLR275W / SMD2

Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR275W / SMD2

Click on Significant Values for Screen Details ID:SGTC_175|Compound:3793-3120|FD-Score:3.84|P-value:4.29E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:7.84|P-value:4.68E-12 ID:SGTC_625|Compound:k213-0058|FD-Score:4.33|P-value:8.54E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:4.67|P-value:2.52E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:8.87|P-value:5.83E-15 ID:SGTC_654|Compound:1124-0271|FD-Score:3.65|P-value:7.76E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:6.58|P-value:5.31E-9 ID:SGTC_691|Compound:1548-0686|FD-Score:6.06|P-value:7.12E-8 ID:SGTC_708|Compound:3448-5400|FD-Score:4.82|P-value:1.43E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:5.80|P-value:2.34E-7 ID:SGTC_770|Compound:0389-1121|FD-Score:5.02|P-value:6.46E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:4.61|P-value:3.15E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:8.16|P-value:6.43E-13 ID:SGTC_831|Compound:k061-1017|FD-Score:5.31|P-value:2.02E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:5.65|P-value:4.58E-7 ID:SGTC_859|Compound:0439-0102|FD-Score:4.66|P-value:2.64E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:3.75|P-value:5.78E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-4.15|P-value:1.34E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-4.89|P-value:9.04E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:-6.31|P-value:1.67E-8 ID:SGTC_1153|Compound:4055-0057|FD-Score:6.01|P-value:8.86E-8 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.24|P-value:1.18E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:4.83|P-value:1.39E-5 ID:SGTC_1655|Compound:st012546|FD-Score:4.67|P-value:2.56E-5 ID:SGTC_1783|Compound:st039459|FD-Score:4.89|P-value:1.07E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.81|P-value:4.77E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.97|P-value:2.86E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.64|P-value:7.04E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.95|P-value:2.65E-4 ID:SGTC_2056|Compound:5235370|FD-Score:6.78|P-value:1.84E-9 ID:SGTC_2127|Compound:5253358|FD-Score:8.51|P-value:6.83E-14 ID:SGTC_2331|Compound:7980721|FD-Score:5.75|P-value:2.92E-7 ID:SGTC_2335|Compound:9018011|FD-Score:4.00|P-value:2.65E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.51|P-value:8.65E-7 ID:SGTC_2351|Compound:9026858|FD-Score:-3.54|P-value:9.37E-4 ID:SGTC_2353|Compound:9059630|FD-Score:8.63|P-value:2.99E-14 ID:SGTC_2373|Compound:9071805|FD-Score:4.12|P-value:1.75E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.70|P-value:2.28E-5 ID:SGTC_2440|Compound:5628896|FD-Score:-3.97|P-value:2.43E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.88|P-value:1.16E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:4.61|P-value:3.20E-5 ID:SGTC_2805|Compound:7950783|FD-Score:7.05|P-value:4.38E-10 ID:SGTC_2833|Compound:9001315|FD-Score:3.88|P-value:3.85E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.81|P-value:4.80E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.68|P-value:6.16E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.65|P-value:2.68E-5 ID:SGTC_3033|Compound:9090887|FD-Score:3.71|P-value:6.46E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.66|P-value:7.47E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.84|P-value:4.29E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:7.84|P-value:4.68E-12 ID:SGTC_625|Compound:k213-0058|FD-Score:4.33|P-value:8.54E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:4.67|P-value:2.52E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:8.87|P-value:5.83E-15 ID:SGTC_654|Compound:1124-0271|FD-Score:3.65|P-value:7.76E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:6.58|P-value:5.31E-9 ID:SGTC_691|Compound:1548-0686|FD-Score:6.06|P-value:7.12E-8 ID:SGTC_708|Compound:3448-5400|FD-Score:4.82|P-value:1.43E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:5.80|P-value:2.34E-7 ID:SGTC_770|Compound:0389-1121|FD-Score:5.02|P-value:6.46E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:4.61|P-value:3.15E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:8.16|P-value:6.43E-13 ID:SGTC_831|Compound:k061-1017|FD-Score:5.31|P-value:2.02E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:5.65|P-value:4.58E-7 ID:SGTC_859|Compound:0439-0102|FD-Score:4.66|P-value:2.64E-5 ID:SGTC_999|Compound:4022-0066|FD-Score:3.75|P-value:5.78E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:-4.15|P-value:1.34E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-4.89|P-value:9.04E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:-6.31|P-value:1.67E-8 ID:SGTC_1153|Compound:4055-0057|FD-Score:6.01|P-value:8.86E-8 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.24|P-value:1.18E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:4.83|P-value:1.39E-5 ID:SGTC_1655|Compound:st012546|FD-Score:4.67|P-value:2.56E-5 ID:SGTC_1783|Compound:st039459|FD-Score:4.89|P-value:1.07E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.81|P-value:4.77E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.97|P-value:2.86E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.64|P-value:7.04E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.95|P-value:2.65E-4 ID:SGTC_2056|Compound:5235370|FD-Score:6.78|P-value:1.84E-9 ID:SGTC_2127|Compound:5253358|FD-Score:8.51|P-value:6.83E-14 ID:SGTC_2331|Compound:7980721|FD-Score:5.75|P-value:2.92E-7 ID:SGTC_2335|Compound:9018011|FD-Score:4.00|P-value:2.65E-4 ID:SGTC_2344|Compound:7990960|FD-Score:5.51|P-value:8.65E-7 ID:SGTC_2351|Compound:9026858|FD-Score:-3.54|P-value:9.37E-4 ID:SGTC_2353|Compound:9059630|FD-Score:8.63|P-value:2.99E-14 ID:SGTC_2373|Compound:9071805|FD-Score:4.12|P-value:1.75E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.70|P-value:2.28E-5 ID:SGTC_2440|Compound:5628896|FD-Score:-3.97|P-value:2.43E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.88|P-value:1.16E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:4.61|P-value:3.20E-5 ID:SGTC_2805|Compound:7950783|FD-Score:7.05|P-value:4.38E-10 ID:SGTC_2833|Compound:9001315|FD-Score:3.88|P-value:3.85E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.81|P-value:4.80E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-3.68|P-value:6.16E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.65|P-value:2.68E-5 ID:SGTC_3033|Compound:9090887|FD-Score:3.71|P-value:6.46E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.66|P-value:7.47E-4

Top fitness defect scores for YLR275W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_644 1498-1197 8.87 63.3 µM 5.83E-15 1 3.56E-19 3.57
2 SGTC_2353 9059630 8.63 146.7 µM 2.99E-14 1 3.05E-18 4.61
3 SGTC_2127 5253358 8.51 187.9 µM 6.83E-14 1 9.00E-18 3.61
4 SGTC_828 2074-0507 8.16 139.0 µM 6.43E-13 RPP1 & pyrimidine depletion 1 1.70E-16 2.34
5 SGTC_202 3594-0513 7.84 34.8 µM 4.68E-12 PDR1 2 2.30E-15 1.60
6 SGTC_2805 7950783 7.05 58.4 µM 4.38E-10 2 8.86E-13 1.55
7 SGTC_2056 5235370 6.78 200.0 µM 1.84E-9 2 5.81E-12 2.22
8 SGTC_667 1498-1044 6.58 59.0 µM 5.31E-9 RPP1 & pyrimidine depletion 2 2.33E-11 1.26
9 SGTC_691 1548-0686 6.06 185.0 µM 7.12E-8 4 6.98E-10 1.18
10 SGTC_1153 4055-0057 6.01 267.0 µM 8.86E-8 1 9.30E-10 1.01
11 SGTC_718 1130-0073 5.80 349.0 µM 2.34E-7 2 3.32E-9 1.19
12 SGTC_2331 7980721 5.75 200.0 µM 2.92E-7 5 4.42E-9 0.48
13 SGTC_832 4083-0019 5.65 164.0 µM 4.58E-7 translation 11 7.98E-9 0.08
14 SGTC_2344 7990960 5.51 77.0 µM 8.65E-7 21 1.83E-8 0.11
15 SGTC_831 k061-1017 5.31 217.0 µM 2.02E-6 translation 1 5.57E-8 0.48
16 SGTC_770 0389-1121 5.02 67.2 µM 6.46E-6 RPP1 & pyrimidine depletion 2 2.54E-7 0.10
17 SGTC_1783 st039459 4.89 87.5 µM 1.07E-5 Golgi 6 4.92E-7 0.12
18 SGTC_2621 lithochol-11-enic acid 4.88 100.0 µM 1.16E-5 3 5.42E-7 0.04
19 SGTC_1449 4112-4002 4.83 201.0 µM 1.39E-5 RPP1 & pyrimidine depletion 3 6.87E-7 0.74
20 SGTC_708 3448-5400 4.82 146.0 µM 1.43E-5 9 7.16E-7 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 3.13E-22 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.132 2.03E-14 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.128 1.14E-13 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.105 1.19E-9 YHR010W RPL27A hom Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication
0.101 5.50E-9 YLR265C NEJ1 hom Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p
0.099 8.44E-9 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.097 2.10E-8 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.095 3.85E-8 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.094 5.85E-8 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.093 6.44E-8 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.093 7.45E-8 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.091 1.41E-7 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.091 1.46E-7 YAR028W_p YAR028W_p hom Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.085 7.67E-7 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
0.085 7.83E-7 YCR090C_p YCR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene