YLR278C_p

Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR278C / YLR278C

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-3.76|P-value:1.65E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.32|P-value:7.58E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.58|P-value:3.29E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.61|P-value:3.03E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.44|P-value:5.40E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.25|P-value:9.95E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.51|P-value:4.02E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-3.69|P-value:2.11E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.36|P-value:6.65E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.33|P-value:1.93E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.65|P-value:4.90E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:5.08|P-value:6.81E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.42|P-value:5.44E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.86|P-value:1.74E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.51|P-value:4.04E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.31|P-value:2.04E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:8.41|P-value:5.56E-16 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.84|P-value:2.03E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.44|P-value:5.29E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.91|P-value:9.96E-5 ID:SGTC_1712|Compound:st032288|FD-Score:7.11|P-value:6.51E-12 ID:SGTC_1725|Compound:st036284|FD-Score:-3.52|P-value:3.85E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.83|P-value:1.35E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.68|P-value:2.31E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.77|P-value:1.69E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.70|P-value:3.82E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.15|P-value:3.94E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.32|P-value:7.62E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.77|P-value:1.58E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.63|P-value:2.76E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.30|P-value:8.64E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.46|P-value:5.05E-4 ID:SGTC_3109|Compound:9122853|FD-Score:4.72|P-value:3.54E-6 ID:SGTC_3192|Compound:9110362|FD-Score:3.39|P-value:6.37E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.38|P-value:6.11E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.41|P-value:5.55E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.76|P-value:1.65E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-3.32|P-value:7.58E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.58|P-value:3.29E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.61|P-value:3.03E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.44|P-value:5.40E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.25|P-value:9.95E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.51|P-value:4.02E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-3.69|P-value:2.11E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.36|P-value:6.65E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.33|P-value:1.93E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.65|P-value:4.90E-6 ID:SGTC_1046|Compound:2001-0062|FD-Score:5.08|P-value:6.81E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.42|P-value:5.44E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.86|P-value:1.74E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.51|P-value:4.04E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.31|P-value:2.04E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:8.41|P-value:5.56E-16 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.84|P-value:2.03E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.44|P-value:5.29E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.91|P-value:9.96E-5 ID:SGTC_1712|Compound:st032288|FD-Score:7.11|P-value:6.51E-12 ID:SGTC_1725|Compound:st036284|FD-Score:-3.52|P-value:3.85E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.83|P-value:1.35E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.68|P-value:2.31E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.77|P-value:1.69E-4 ID:SGTC_2364|Compound:9055074|FD-Score:4.70|P-value:3.82E-6 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.15|P-value:3.94E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.32|P-value:7.62E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.77|P-value:1.58E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.63|P-value:2.76E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.30|P-value:8.64E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.46|P-value:5.05E-4 ID:SGTC_3109|Compound:9122853|FD-Score:4.72|P-value:3.54E-6 ID:SGTC_3192|Compound:9110362|FD-Score:3.39|P-value:6.37E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.38|P-value:6.11E-4 ID:SGTC_3310|Compound:9130229|FD-Score:-3.41|P-value:5.55E-4

Top fitness defect scores for YLR278C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1134 3477-0009 8.41 42.5 µM 5.56E-16 2 1.97E-17
2 SGTC_1712 st032288 7.11 53.4 µM 6.51E-12 calcium & mitochondrial duress 53 5.87E-13
3 SGTC_1046 2001-0062 5.08 216.0 µM 6.81E-7 4 1.93E-7
4 SGTC_1187 1391-0724 4.84 117.0 µM 2.03E-6 amide catabolism 7 6.40E-7
5 SGTC_3109 9122853 4.72 49.5 µM 3.54E-6 1 1.18E-6
6 SGTC_2364 9055074 4.70 200.0 µM 3.82E-6 10 1.28E-6
7 SGTC_920 mycophenolic acid 4.65 780.4 nM 4.90E-6 13 1.69E-6
8 SGTC_915 methyl methanesulfonate (MMS) 4.33 110.0 mM 1.93E-5 DNA damage response 34 7.60E-6
9 SGTC_1109 tnp00067 4.31 928.3 nM 2.04E-5 7 8.08E-6
10 SGTC_2536 dehydroabietamide 4.15 32.0 µM 3.94E-5 29 1.67E-5
11 SGTC_1465 k213-0056 3.91 144.0 µM 9.96E-5 DNA intercalators 23 4.60E-5
12 SGTC_1733 st037357 3.83 54.9 µM 1.35E-4 60S ribosome export 34 6.42E-5
13 SGTC_2173 5763948 3.77 167.0 µM 1.69E-4 tubulin folding & SWR complex 17 8.20E-5
14 SGTC_1778 st046819 3.68 58.9 µM 2.31E-4 33 1.16E-4
15 SGTC_2750 bromebric acid 3.63 70.2 µM 2.76E-4 42 1.41E-4
16 SGTC_514 4466-0038 3.61 2.6 nM 3.03E-4 cell wall 174 1.56E-4
17 SGTC_445 e6 berbamine 3.58 66.0 µM 3.29E-4 NEO1-PIK1 136 1.71E-4
18 SGTC_3059 1327-0034 3.46 3.0 µM 5.05E-4 70 2.73E-4
19 SGTC_1368 1852-0141 3.44 284.0 µM 5.29E-4 ERG2 55 2.87E-4
20 SGTC_775 4577-0580 3.44 57.3 µM 5.40E-4 15 2.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 1.01E-16 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.133 9.88E-15 YDR053W_d YDR053W_d het Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex
0.133 1.04E-14 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.124 5.69E-13 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.122 1.06E-12 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.121 1.97E-12 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.116 1.50E-11 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.113 5.05E-11 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.110 1.68E-10 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.109 2.17E-10 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.108 3.38E-10 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.108 3.68E-10 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.107 4.23E-10 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.102 3.45E-9 YER120W SCS2 hom Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
0.102 3.55E-9 YDL212W SHR3 het Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface