YLR279W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR279W / YLR279W

Click on Significant Values for Screen Details ID:SGTC_312|Compound:4092-0653|FD-Score:3.86|P-value:2.16E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:7.45|P-value:5.85E-12 ID:SGTC_320|Compound:4092-0846|FD-Score:5.12|P-value:1.55E-6 ID:SGTC_324|Compound:1315-0088|FD-Score:5.06|P-value:2.00E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:4.57|P-value:1.55E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:4.78|P-value:6.81E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:3.58|P-value:5.51E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.88|P-value:2.03E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.57|P-value:6.19E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.75|P-value:3.15E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.39|P-value:3.11E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:-8.84|P-value:5.27E-16 ID:SGTC_965|Compound:1291-5240|FD-Score:3.74|P-value:3.25E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:4.31|P-value:4.33E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.43|P-value:3.81E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.11|P-value:9.07E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.71|P-value:9.05E-6 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.82|P-value:2.47E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.51|P-value:7.50E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.55|P-value:6.11E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.65|P-value:1.35E-7 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.62|P-value:1.30E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.42|P-value:9.14E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.62|P-value:5.21E-4 ID:SGTC_1611|Compound:st001856|FD-Score:-4.61|P-value:1.45E-5 ID:SGTC_1616|Compound:st002734|FD-Score:3.41|P-value:9.34E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.67|P-value:4.17E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.44|P-value:2.57E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-3.97|P-value:1.59E-4 ID:SGTC_1956|Compound:st077085|FD-Score:4.92|P-value:3.65E-6 ID:SGTC_1967|Compound:st070177|FD-Score:4.16|P-value:7.51E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.63|P-value:5.02E-4 ID:SGTC_2282|Compound:7944268|FD-Score:6.48|P-value:1.81E-9 ID:SGTC_2424|Compound:5537928|FD-Score:5.06|P-value:2.07E-6 ID:SGTC_2439|Compound:5492030|FD-Score:3.90|P-value:1.88E-4 ID:SGTC_2440|Compound:5628896|FD-Score:4.62|P-value:1.29E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.60|P-value:5.63E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.59|P-value:1.43E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.63|P-value:1.22E-5 ID:SGTC_2694|Compound:st077685|FD-Score:4.66|P-value:1.08E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.50|P-value:7.73E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.23|P-value:5.79E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.46|P-value:8.09E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-4.71|P-value:9.76E-6 ID:SGTC_3011|Compound:9081274|FD-Score:4.07|P-value:1.05E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.54|P-value:6.80E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.83|P-value:2.41E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.56|P-value:6.22E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.76|P-value:3.30E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.34|P-value:4.12E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:3.86|P-value:2.16E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:7.45|P-value:5.85E-12 ID:SGTC_320|Compound:4092-0846|FD-Score:5.12|P-value:1.55E-6 ID:SGTC_324|Compound:1315-0088|FD-Score:5.06|P-value:2.00E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:4.57|P-value:1.55E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:4.78|P-value:6.81E-6 ID:SGTC_430|Compound:0958-0115|FD-Score:3.58|P-value:5.51E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.88|P-value:2.03E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.57|P-value:6.19E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.75|P-value:3.15E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.39|P-value:3.11E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:-8.84|P-value:5.27E-16 ID:SGTC_965|Compound:1291-5240|FD-Score:3.74|P-value:3.25E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:4.31|P-value:4.33E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:5.43|P-value:3.81E-7 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.11|P-value:9.07E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.71|P-value:9.05E-6 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.82|P-value:2.47E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.51|P-value:7.50E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.55|P-value:6.11E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.65|P-value:1.35E-7 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.62|P-value:1.30E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.42|P-value:9.14E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.62|P-value:5.21E-4 ID:SGTC_1611|Compound:st001856|FD-Score:-4.61|P-value:1.45E-5 ID:SGTC_1616|Compound:st002734|FD-Score:3.41|P-value:9.34E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.67|P-value:4.17E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.44|P-value:2.57E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-3.97|P-value:1.59E-4 ID:SGTC_1956|Compound:st077085|FD-Score:4.92|P-value:3.65E-6 ID:SGTC_1967|Compound:st070177|FD-Score:4.16|P-value:7.51E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.63|P-value:5.02E-4 ID:SGTC_2282|Compound:7944268|FD-Score:6.48|P-value:1.81E-9 ID:SGTC_2424|Compound:5537928|FD-Score:5.06|P-value:2.07E-6 ID:SGTC_2439|Compound:5492030|FD-Score:3.90|P-value:1.88E-4 ID:SGTC_2440|Compound:5628896|FD-Score:4.62|P-value:1.29E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.60|P-value:5.63E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:4.59|P-value:1.43E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.63|P-value:1.22E-5 ID:SGTC_2694|Compound:st077685|FD-Score:4.66|P-value:1.08E-5 ID:SGTC_2809|Compound:7964133|FD-Score:-3.50|P-value:7.73E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.23|P-value:5.79E-5 ID:SGTC_2980|Compound:9014342|FD-Score:3.46|P-value:8.09E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-4.71|P-value:9.76E-6 ID:SGTC_3011|Compound:9081274|FD-Score:4.07|P-value:1.05E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.54|P-value:6.80E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.83|P-value:2.41E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.56|P-value:6.22E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-3.76|P-value:3.30E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-4.34|P-value:4.12E-5

Top fitness defect scores for YLR279W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_315 k915-0449 7.45 187.0 µM 5.85E-12 11 4.53E-14
2 SGTC_2282 7944268 6.48 200.0 µM 1.81E-9 RPP1 & pyrimidine depletion 4 4.54E-11
3 SGTC_1449 4112-4002 5.65 201.0 µM 1.35E-7 RPP1 & pyrimidine depletion 6 8.13E-9
4 SGTC_1040 k898-0338 5.43 155.0 µM 3.81E-7 5 2.82E-8
5 SGTC_320 4092-0846 5.12 5.3 µM 1.55E-6 ergosterol depletion effects on membrane 23 1.52E-7
6 SGTC_324 1315-0088 5.06 19.6 µM 2.00E-6 RSC & ERG11 3 2.06E-7
7 SGTC_2424 5537928 5.06 59.2 µM 2.07E-6 14 2.14E-7
8 SGTC_1956 st077085 4.92 54.0 µM 3.65E-6 7 4.25E-7
9 SGTC_327 1273-0057 4.78 4.0 µM 6.81E-6 azole & statin 15 8.97E-7
10 SGTC_1253 0550-0034 4.71 176.0 µM 9.05E-6 9 1.26E-6
11 SGTC_2694 st077685 4.66 81.9 µM 1.08E-5 endomembrane recycling 15 1.56E-6
12 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 4.63 100.0 µM 1.22E-5 13 1.80E-6
13 SGTC_2440 5628896 4.62 157.8 µM 1.29E-5 14 1.93E-6
14 SGTC_1455 4262-0120 4.62 131.0 µM 1.30E-5 plasma membrane duress 18 1.95E-6
15 SGTC_2569 tetrandrine 4.59 100.0 µM 1.43E-5 12 2.19E-6
16 SGTC_325 2810-4341 4.57 181.0 µM 1.55E-5 amide catabolism 6 2.41E-6
17 SGTC_1712 st032288 4.44 53.4 µM 2.57E-5 calcium & mitochondrial duress 153 4.40E-6
18 SGTC_920 mycophenolic acid 4.39 780.4 nM 3.11E-5 20 5.55E-6
19 SGTC_983 1491-0821 4.31 12.2 µM 4.33E-5 10 8.22E-6
20 SGTC_2971 9092186 4.23 9.9 µM 5.79E-5 ergosterol biosynthesis 22 1.17E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 1.43E-23 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.117 1.27E-11 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.107 5.64E-10 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.097 1.60E-8 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.087 4.79E-7 YBR102C EXO84 het Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
0.084 1.13E-6 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.084 1.24E-6 YER180C-A SLO1 hom Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
0.083 1.43E-6 YGR198W YPP1 het Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
0.081 2.79E-6 YGL136C MRM2 hom Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
0.081 2.93E-6 YLR303W MET17 hom Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis
0.077 8.90E-6 YOL037C_d YOL037C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W
0.077 9.07E-6 YMR240C CUS1 het Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
0.074 1.98E-5 YMR081C ISF1 hom Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
0.072 2.82E-5 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.072 2.88E-5 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage