YLR280C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR280C / YLR280C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.04|P-value:5.98E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.41|P-value:1.43E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.09|P-value:4.92E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:2.99|P-value:7.03E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:4.60|P-value:5.38E-7 ID:SGTC_634|Compound:1611-4317|FD-Score:4.14|P-value:5.64E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.06|P-value:8.58E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.75|P-value:5.69E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.84|P-value:2.28E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.74|P-value:6.05E-5 ID:SGTC_1819|Compound:st053448|FD-Score:4.06|P-value:8.14E-6 ID:SGTC_1828|Compound:st055811|FD-Score:-3.95|P-value:2.40E-5 ID:SGTC_1912|Compound:st060209|FD-Score:-8.28|P-value:4.51E-18 ID:SGTC_1916|Compound:st067606|FD-Score:-7.49|P-value:4.07E-15 ID:SGTC_1917|Compound:st066507|FD-Score:-5.04|P-value:1.01E-7 ID:SGTC_1987|Compound:st072290|FD-Score:-3.48|P-value:1.78E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.16|P-value:6.00E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.26|P-value:3.04E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.16|P-value:3.72E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.49|P-value:1.67E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.12|P-value:4.41E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.84|P-value:3.90E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.68|P-value:4.49E-5 ID:SGTC_2187|Compound:6125751|FD-Score:-4.79|P-value:3.91E-7 ID:SGTC_2200|Compound:6600604|FD-Score:-3.85|P-value:3.68E-5 ID:SGTC_2216|Compound:7189485|FD-Score:3.42|P-value:1.37E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.24|P-value:2.78E-4 ID:SGTC_2228|Compound:7354201|FD-Score:2.98|P-value:7.45E-4 ID:SGTC_2253|Compound:7938677|FD-Score:2.98|P-value:7.43E-4 ID:SGTC_2293|Compound:7624732|FD-Score:2.97|P-value:7.59E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.40|P-value:2.41E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.50|P-value:9.83E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-4.45|P-value:2.31E-6 ID:SGTC_3192|Compound:9110362|FD-Score:3.44|P-value:1.25E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.22|P-value:3.04E-4 ID:SGTC_3258|Compound:9138477|FD-Score:2.92|P-value:9.01E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.93|P-value:8.69E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.04|P-value:5.98E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.41|P-value:1.43E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:3.09|P-value:4.92E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:2.99|P-value:7.03E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:4.60|P-value:5.38E-7 ID:SGTC_634|Compound:1611-4317|FD-Score:4.14|P-value:5.64E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.06|P-value:8.58E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.75|P-value:5.69E-5 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.84|P-value:2.28E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.74|P-value:6.05E-5 ID:SGTC_1819|Compound:st053448|FD-Score:4.06|P-value:8.14E-6 ID:SGTC_1828|Compound:st055811|FD-Score:-3.95|P-value:2.40E-5 ID:SGTC_1912|Compound:st060209|FD-Score:-8.28|P-value:4.51E-18 ID:SGTC_1916|Compound:st067606|FD-Score:-7.49|P-value:4.07E-15 ID:SGTC_1917|Compound:st066507|FD-Score:-5.04|P-value:1.01E-7 ID:SGTC_1987|Compound:st072290|FD-Score:-3.48|P-value:1.78E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.16|P-value:6.00E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.26|P-value:3.04E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.16|P-value:3.72E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.49|P-value:1.67E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.12|P-value:4.41E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.84|P-value:3.90E-5 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.68|P-value:4.49E-5 ID:SGTC_2187|Compound:6125751|FD-Score:-4.79|P-value:3.91E-7 ID:SGTC_2200|Compound:6600604|FD-Score:-3.85|P-value:3.68E-5 ID:SGTC_2216|Compound:7189485|FD-Score:3.42|P-value:1.37E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.24|P-value:2.78E-4 ID:SGTC_2228|Compound:7354201|FD-Score:2.98|P-value:7.45E-4 ID:SGTC_2253|Compound:7938677|FD-Score:2.98|P-value:7.43E-4 ID:SGTC_2293|Compound:7624732|FD-Score:2.97|P-value:7.59E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.40|P-value:2.41E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.50|P-value:9.83E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-4.45|P-value:2.31E-6 ID:SGTC_3192|Compound:9110362|FD-Score:3.44|P-value:1.25E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.22|P-value:3.04E-4 ID:SGTC_3258|Compound:9138477|FD-Score:2.92|P-value:9.01E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.93|P-value:8.69E-4

Top fitness defect scores for YLR280C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_618 k072-0232 4.60 33.2 µM 5.38E-7 60S ribosome export 2 2.09E-6
2 SGTC_2019 4016004 4.26 108.0 µM 3.04E-6 22 1.00E-5
3 SGTC_634 1611-4317 4.14 11.2 µM 5.64E-6 ERG2 12 1.76E-5
4 SGTC_1819 st053448 4.06 58.6 µM 8.14E-6 amide catabolism 18 2.45E-5
5 SGTC_1450 4112-4260 3.84 37.6 µM 2.28E-5 calcium & mitochondrial duress 32 6.22E-5
6 SGTC_2091 4-phenylthiadiazole 3.68 200.0 µM 4.49E-5 22 1.15E-4
7 SGTC_2628 lathosterol 3.50 100.0 µM 9.83E-5 42 2.34E-4
8 SGTC_3192 9110362 3.44 49.5 µM 1.25E-4 mitochondrial processes 19 2.92E-4
9 SGTC_2216 7189485 3.42 200.0 µM 1.37E-4 7 3.16E-4
10 SGTC_181 1447-1644 3.41 8.1 µM 1.43E-4 endomembrane recycling 51 3.28E-4
11 SGTC_2223 6903751 3.24 107.6 µM 2.78E-4 superoxide 24 6.00E-4
12 SGTC_3203 9113543 3.22 49.5 µM 3.04E-4 65 6.50E-4
13 SGTC_2023 5144124 3.16 124.0 µM 3.72E-4 50 7.80E-4
14 SGTC_2037 5169046 3.12 200.0 µM 4.41E-4 60S ribosome export 35 9.09E-4
15 SGTC_281 1672-3440 3.09 14.9 µM 4.92E-4 Golgi 27 0.00100
16 SGTC_6 0844-0013 3.04 19.8 µM 5.98E-4 206 0.00120
17 SGTC_403 arphamenine a 2.99 50.0 µM 7.03E-4 60S ribosome export 57 0.00139
18 SGTC_2253 7938677 2.98 135.8 µM 7.43E-4 49 0.00146
19 SGTC_2228 7354201 2.98 200.0 µM 7.45E-4 endomembrane recycling 15 0.00146
20 SGTC_2293 7624732 2.97 200.0 µM 7.59E-4 67 0.00149

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.209 2.49E-34 YGL145W TIP20 het Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
0.159 2.24E-20 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.144 5.75E-17 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.129 6.42E-14 YPR140W TAZ1 hom Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome
0.121 2.03E-12 YBR217W ATG12 hom Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
0.100 7.21E-9 YLR041W_d YLR041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C
0.099 9.14E-9 YLR456W_p YLR456W_p hom Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication
0.098 1.15E-8 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.098 1.13E-8 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.098 1.33E-8 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.097 1.80E-8 YBR150C TBS1 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication
0.096 2.56E-8 YIL071C PCI8 hom Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
0.095 3.30E-8 YPL111W CAR1 hom Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
0.094 4.91E-8 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.094 5.63E-8 YLR385C SWC7 hom Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin