YLR281C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR281C / YLR281C

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:-3.44|P-value:1.31E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.04|P-value:5.87E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-2.96|P-value:8.54E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-2.99|P-value:7.68E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.01|P-value:9.48E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.28|P-value:2.47E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.77|P-value:2.95E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:3.02|P-value:6.39E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.21|P-value:3.13E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.97|P-value:1.28E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:2.93|P-value:9.02E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.70|P-value:3.98E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.30|P-value:2.33E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.04|P-value:6.37E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.14|P-value:4.02E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.23|P-value:3.22E-6 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.45|P-value:1.05E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.93|P-value:8.86E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.34|P-value:1.88E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.47|P-value:1.10E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.08|P-value:5.51E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.46|P-value:1.20E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.12|P-value:4.44E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-2.92|P-value:9.68E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.64|P-value:5.50E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-3.57|P-value:7.66E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.77|P-value:2.89E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.51|P-value:9.17E-5 ID:SGTC_2478|Compound:5763493|FD-Score:-3.02|P-value:6.81E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.26|P-value:2.89E-6 ID:SGTC_2817|Compound:7995342|FD-Score:3.82|P-value:2.36E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-3.20|P-value:3.41E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.13|P-value:5.31E-6 ID:SGTC_2864|Compound:9034755|FD-Score:5.36|P-value:5.57E-9 ID:SGTC_2958|Compound:9077254|FD-Score:3.40|P-value:1.45E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.54|P-value:6.71E-7 ID:SGTC_3101|Compound:9120531|FD-Score:-3.02|P-value:6.82E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.63|P-value:5.40E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:-3.44|P-value:1.31E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.04|P-value:5.87E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-2.96|P-value:8.54E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-2.99|P-value:7.68E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.01|P-value:9.48E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.28|P-value:2.47E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.77|P-value:2.95E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:3.02|P-value:6.39E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.21|P-value:3.13E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.97|P-value:1.28E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:2.93|P-value:9.02E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.70|P-value:3.98E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.30|P-value:2.33E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.04|P-value:6.37E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.14|P-value:4.02E-4 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.23|P-value:3.22E-6 ID:SGTC_1210|Compound:3013-0140|FD-Score:4.45|P-value:1.05E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.93|P-value:8.86E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.34|P-value:1.88E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.47|P-value:1.10E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.08|P-value:5.51E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.46|P-value:1.20E-4 ID:SGTC_1978|Compound:st071761|FD-Score:3.12|P-value:4.44E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-2.92|P-value:9.68E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.64|P-value:5.50E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-3.57|P-value:7.66E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.77|P-value:2.89E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.51|P-value:9.17E-5 ID:SGTC_2478|Compound:5763493|FD-Score:-3.02|P-value:6.81E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.26|P-value:2.89E-6 ID:SGTC_2817|Compound:7995342|FD-Score:3.82|P-value:2.36E-5 ID:SGTC_2819|Compound:7996655|FD-Score:-3.20|P-value:3.41E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.13|P-value:5.31E-6 ID:SGTC_2864|Compound:9034755|FD-Score:5.36|P-value:5.57E-9 ID:SGTC_2958|Compound:9077254|FD-Score:3.40|P-value:1.45E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.54|P-value:6.71E-7 ID:SGTC_3101|Compound:9120531|FD-Score:-3.02|P-value:6.82E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.63|P-value:5.40E-5

Top fitness defect scores for YLR281C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2864 9034755 5.36 47.6 µM 5.57E-9 1 4.09E-8
2 SGTC_2969 9091408 4.54 28.7 µM 6.71E-7 14 2.86E-6
3 SGTC_1210 3013-0140 4.45 750.0 nM 1.05E-6 1 4.24E-6
4 SGTC_2703 st077852 4.26 53.4 µM 2.89E-6 14 1.04E-5
5 SGTC_1084 voriconazole 4.23 435.0 nM 3.22E-6 azole & statin 20 1.15E-5
6 SGTC_2857 9024691 4.13 58.4 µM 5.31E-6 21 1.79E-5
7 SGTC_363 0455-0021 4.01 3.1 µM 9.48E-6 azole & statin 65 2.99E-5
8 SGTC_2817 7995342 3.82 71.4 µM 2.36E-5 30 6.72E-5
9 SGTC_2350 9023895 3.77 38.9 µM 2.89E-5 ergosterol biosynthesis 36 8.05E-5
10 SGTC_705 1124-0212 3.77 310.0 µM 2.95E-5 18 8.20E-5
11 SGTC_936 3005-4620 3.70 401.0 µM 3.98E-5 32 1.07E-4
12 SGTC_3109 9122853 3.63 49.5 µM 5.40E-5 13 1.40E-4
13 SGTC_2362 9071156 3.51 126.0 µM 9.17E-5 18 2.24E-4
14 SGTC_1578 josamycin 3.47 24.2 µM 1.10E-4 22 2.64E-4
15 SGTC_2958 9077254 3.40 16.7 µM 1.45E-4 45 3.38E-4
16 SGTC_1427 4048-4900 3.34 550.0 nM 1.88E-4 49 4.25E-4
17 SGTC_731 3966-0296 3.21 387.0 µM 3.13E-4 41 6.69E-4
18 SGTC_1057 3448-5381 3.14 134.0 µM 4.02E-4 calcium & mitochondrial duress 56 8.35E-4
19 SGTC_1978 st071761 3.12 42.0 µM 4.44E-4 TSC3-RPN4 35 9.13E-4
20 SGTC_31 0508-1974 3.04 57.2 µM 5.87E-4 67 0.00117

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.38E-13 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.118 7.47E-12 YDR263C DIN7 hom Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination
0.114 3.40E-11 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.104 2.07E-9 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.103 2.06E-9 YGL009C LEU1 hom Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
0.096 2.38E-8 YDR153C ENT5 hom Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
0.094 4.51E-8 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.094 4.88E-8 YLR049C_p YLR049C_p hom Putative protein of unknown function
0.094 5.05E-8 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.090 1.68E-7 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.088 2.96E-7 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.088 3.77E-7 YMR271C URA10 hom Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication
0.082 1.95E-6 YBR150C TBS1 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication
0.081 2.49E-6 YOR161C PNS1 hom Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
0.080 3.98E-6 YGL257C MNT2 hom Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans