YLR282C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR282C / YLR282C

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.55|P-value:8.32E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.67|P-value:5.18E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.31|P-value:2.33E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:4.80|P-value:1.77E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:3.31|P-value:2.18E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.16|P-value:3.93E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:4.89|P-value:1.07E-7 ID:SGTC_559|Compound:1550-0661|FD-Score:3.59|P-value:7.07E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:2.91|P-value:9.86E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.52|P-value:7.95E-7 ID:SGTC_611|Compound:3453-1652|FD-Score:3.88|P-value:1.89E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:3.04|P-value:6.14E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:2.99|P-value:7.54E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.06|P-value:6.25E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.24|P-value:2.88E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.33|P-value:2.21E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.29|P-value:2.36E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:2.99|P-value:7.63E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.33|P-value:2.19E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.47|P-value:1.15E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.21|P-value:3.49E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.51|P-value:9.60E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.56|P-value:7.83E-5 ID:SGTC_1636|Compound:st007707|FD-Score:2.94|P-value:9.00E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.03|P-value:6.37E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.31|P-value:2.25E-4 ID:SGTC_2069|Compound:5228469|FD-Score:4.75|P-value:2.30E-7 ID:SGTC_2081|Compound:5214970|FD-Score:5.13|P-value:2.59E-8 ID:SGTC_2174|Compound:5790901|FD-Score:-2.96|P-value:8.72E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.25|P-value:2.97E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.08|P-value:5.37E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.68|P-value:4.71E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-2.94|P-value:9.46E-4 ID:SGTC_2306|Compound:7482397|FD-Score:5.73|P-value:6.37E-10 ID:SGTC_2346|Compound:9031566|FD-Score:-3.60|P-value:7.05E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.43|P-value:1.34E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.48|P-value:1.10E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.31|P-value:2.37E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.30|P-value:2.29E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.22|P-value:3.16E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.22|P-value:3.12E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.05|P-value:6.07E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-3.02|P-value:7.13E-4 ID:SGTC_2895|Compound:9054447|FD-Score:3.03|P-value:6.53E-4 ID:SGTC_2913|Compound:7966556|FD-Score:2.96|P-value:8.36E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.34|P-value:1.94E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.81|P-value:2.83E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-3.74|P-value:3.89E-5 ID:SGTC_2985|Compound:9022375|FD-Score:4.55|P-value:7.12E-7 ID:SGTC_2987|Compound:9018338|FD-Score:-5.07|P-value:4.13E-8 ID:SGTC_3272|Compound:9137413|FD-Score:-3.14|P-value:4.49E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.07|P-value:7.96E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:3.55|P-value:8.32E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.67|P-value:5.18E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.31|P-value:2.33E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:4.80|P-value:1.77E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:3.31|P-value:2.18E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.16|P-value:3.93E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:4.89|P-value:1.07E-7 ID:SGTC_559|Compound:1550-0661|FD-Score:3.59|P-value:7.07E-5 ID:SGTC_605|Compound:1315-0399|FD-Score:2.91|P-value:9.86E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:4.52|P-value:7.95E-7 ID:SGTC_611|Compound:3453-1652|FD-Score:3.88|P-value:1.89E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:3.04|P-value:6.14E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:2.99|P-value:7.54E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:-3.06|P-value:6.25E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.24|P-value:2.88E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.33|P-value:2.21E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.29|P-value:2.36E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:2.99|P-value:7.63E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.33|P-value:2.19E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.47|P-value:1.15E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-3.21|P-value:3.49E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.51|P-value:9.60E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.56|P-value:7.83E-5 ID:SGTC_1636|Compound:st007707|FD-Score:2.94|P-value:9.00E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.03|P-value:6.37E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.31|P-value:2.25E-4 ID:SGTC_2069|Compound:5228469|FD-Score:4.75|P-value:2.30E-7 ID:SGTC_2081|Compound:5214970|FD-Score:5.13|P-value:2.59E-8 ID:SGTC_2174|Compound:5790901|FD-Score:-2.96|P-value:8.72E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.25|P-value:2.97E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.08|P-value:5.37E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.68|P-value:4.71E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-2.94|P-value:9.46E-4 ID:SGTC_2306|Compound:7482397|FD-Score:5.73|P-value:6.37E-10 ID:SGTC_2346|Compound:9031566|FD-Score:-3.60|P-value:7.05E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.43|P-value:1.34E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.48|P-value:1.10E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.31|P-value:2.37E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.30|P-value:2.29E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.22|P-value:3.16E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.22|P-value:3.12E-4 ID:SGTC_2826|Compound:7992541|FD-Score:3.05|P-value:6.07E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-3.02|P-value:7.13E-4 ID:SGTC_2895|Compound:9054447|FD-Score:3.03|P-value:6.53E-4 ID:SGTC_2913|Compound:7966556|FD-Score:2.96|P-value:8.36E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.34|P-value:1.94E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.81|P-value:2.83E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-3.74|P-value:3.89E-5 ID:SGTC_2985|Compound:9022375|FD-Score:4.55|P-value:7.12E-7 ID:SGTC_2987|Compound:9018338|FD-Score:-5.07|P-value:4.13E-8 ID:SGTC_3272|Compound:9137413|FD-Score:-3.14|P-value:4.49E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.07|P-value:7.96E-6

Top fitness defect scores for YLR282C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2306 7482397 5.73 179.5 µM 6.37E-10 RPP1 & pyrimidine depletion 3 5.17E-9
2 SGTC_2081 5214970 5.13 32.3 µM 2.59E-8 8 1.42E-7
3 SGTC_516 3992-2719 4.89 87.3 µM 1.07E-7 8 5.02E-7
4 SGTC_99 0109-0120 4.80 622.8 µM 1.77E-7 5 7.88E-7
5 SGTC_2069 5228469 4.75 200.0 µM 2.30E-7 4 9.98E-7
6 SGTC_2985 9022375 4.55 71.4 µM 7.12E-7 RPP1 & pyrimidine depletion 18 2.74E-6
7 SGTC_610 4215-0184 4.52 155.0 µM 7.95E-7 exosome 6 3.02E-6
8 SGTC_2651 1327-0036 4.31 5.0 µM 2.37E-6 141 8.02E-6
9 SGTC_3278 9139605 4.07 49.5 µM 7.96E-6 12 2.37E-5
10 SGTC_611 3453-1652 3.88 23.7 µM 1.89E-5 22 5.14E-5
11 SGTC_2259 7964009 3.68 200.0 µM 4.71E-5 superoxide 39 1.17E-4
12 SGTC_559 1550-0661 3.59 158.0 µM 7.07E-5 14 1.68E-4
13 SGTC_1412 3909-8563 3.56 178.0 µM 7.83E-5 15 1.84E-4
14 SGTC_16 erodoxin 3.55 22.8 µM 8.32E-5 unfolded protein response 78 1.94E-4
15 SGTC_1381 2324-0066 3.51 62.1 µM 9.60E-5 42 2.21E-4
16 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.48 100.0 µM 1.10E-4 53 2.48E-4
17 SGTC_1299 1079-1439 3.47 3.7 µM 1.15E-4 TSC3-RPN4 23 2.59E-4
18 SGTC_2606 farnesol 3.43 9.8 µM 1.34E-4 39 2.98E-4
19 SGTC_2969 9091408 3.34 28.7 µM 1.94E-4 55 4.14E-4
20 SGTC_173 1273-0061 3.31 2.7 µM 2.18E-4 mitochondrial stress 214 4.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.15E-13 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.116 1.62E-11 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.113 5.27E-11 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.107 4.44E-10 YBR039W ATP3 hom Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.096 2.53E-8 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.094 4.23E-8 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.089 2.30E-7 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.089 2.34E-7 YJL123C MTC1 hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1
0.088 3.77E-7 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.087 5.11E-7 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.082 2.03E-6 YML079W_p YML079W_p hom Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm
0.082 1.94E-6 YGL248W PDE1 hom Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
0.081 2.84E-6 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.080 3.64E-6 YAL033W POP5 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.080 3.96E-6 YER154W OXA1 hom Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals