YLR284C / ECI1

Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR284C / ECI1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:4.09|P-value:3.78E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:4.13|P-value:3.20E-5 ID:SGTC_185|Compound:k048-0037|FD-Score:3.50|P-value:3.52E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:5.89|P-value:6.56E-9 ID:SGTC_365|Compound:0121-0052|FD-Score:-5.02|P-value:7.61E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:3.76|P-value:1.34E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:4.80|P-value:1.70E-6 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.24|P-value:2.07E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.32|P-value:6.55E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.99|P-value:5.73E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.20|P-value:9.66E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.99|P-value:5.60E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:3.49|P-value:3.60E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:5.75|P-value:1.39E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.52|P-value:7.76E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.20|P-value:9.47E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.20|P-value:9.63E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.47|P-value:3.88E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.80|P-value:1.16E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.59|P-value:2.55E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.15|P-value:2.98E-5 ID:SGTC_1659|Compound:st012954|FD-Score:4.65|P-value:3.53E-6 ID:SGTC_1678|Compound:st019265|FD-Score:4.34|P-value:1.34E-5 ID:SGTC_1736|Compound:st036774|FD-Score:-3.27|P-value:9.07E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.68|P-value:3.08E-6 ID:SGTC_1781|Compound:st038725|FD-Score:3.85|P-value:9.59E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.62|P-value:2.29E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-4.52|P-value:7.79E-6 ID:SGTC_1791|Compound:st048313|FD-Score:3.79|P-value:1.21E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.28|P-value:7.50E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.07|P-value:4.11E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-4.43|P-value:1.13E-5 ID:SGTC_1885|Compound:st057546|FD-Score:5.76|P-value:1.29E-8 ID:SGTC_1901|Compound:st060216|FD-Score:5.56|P-value:3.84E-8 ID:SGTC_1907|Compound:st060210|FD-Score:-3.35|P-value:6.84E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-4.29|P-value:2.02E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-3.71|P-value:1.97E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-4.60|P-value:5.29E-6 ID:SGTC_1966|Compound:st070145|FD-Score:-3.42|P-value:5.45E-4 ID:SGTC_1972|Compound:st070201|FD-Score:-3.58|P-value:3.17E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.31|P-value:6.62E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.86|P-value:1.64E-6 ID:SGTC_2269|Compound:7935389|FD-Score:4.13|P-value:3.21E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-4.93|P-value:1.16E-6 ID:SGTC_2274|Compound:7947094|FD-Score:4.66|P-value:3.31E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-4.23|P-value:2.67E-5 ID:SGTC_2382|Compound:9035899|FD-Score:4.53|P-value:5.89E-6 ID:SGTC_2396|Compound:5342950|FD-Score:-3.24|P-value:9.87E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.43|P-value:4.44E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.59|P-value:2.52E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.92|P-value:7.36E-5 ID:SGTC_2700|Compound:st077718|FD-Score:3.29|P-value:7.15E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.32|P-value:6.49E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.94|P-value:8.31E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.94|P-value:6.74E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.56|P-value:2.85E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.81|P-value:1.11E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.98|P-value:5.79E-5 ID:SGTC_3299|Compound:9121982|FD-Score:4.01|P-value:5.13E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.63|P-value:2.22E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.09|P-value:3.78E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:4.13|P-value:3.20E-5 ID:SGTC_185|Compound:k048-0037|FD-Score:3.50|P-value:3.52E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:5.89|P-value:6.56E-9 ID:SGTC_365|Compound:0121-0052|FD-Score:-5.02|P-value:7.61E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:3.76|P-value:1.34E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:4.80|P-value:1.70E-6 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.24|P-value:2.07E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.32|P-value:6.55E-4 ID:SGTC_448|Compound:monastrol|FD-Score:3.99|P-value:5.73E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.20|P-value:9.66E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.99|P-value:5.60E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:3.49|P-value:3.60E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:5.75|P-value:1.39E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.52|P-value:7.76E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.20|P-value:9.47E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.20|P-value:9.63E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.47|P-value:3.88E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.80|P-value:1.16E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.59|P-value:2.55E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.15|P-value:2.98E-5 ID:SGTC_1659|Compound:st012954|FD-Score:4.65|P-value:3.53E-6 ID:SGTC_1678|Compound:st019265|FD-Score:4.34|P-value:1.34E-5 ID:SGTC_1736|Compound:st036774|FD-Score:-3.27|P-value:9.07E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.68|P-value:3.08E-6 ID:SGTC_1781|Compound:st038725|FD-Score:3.85|P-value:9.59E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.62|P-value:2.29E-4 ID:SGTC_1784|Compound:st039334|FD-Score:-4.52|P-value:7.79E-6 ID:SGTC_1791|Compound:st048313|FD-Score:3.79|P-value:1.21E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.28|P-value:7.50E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.07|P-value:4.11E-5 ID:SGTC_1860|Compound:st056228|FD-Score:-4.43|P-value:1.13E-5 ID:SGTC_1885|Compound:st057546|FD-Score:5.76|P-value:1.29E-8 ID:SGTC_1901|Compound:st060216|FD-Score:5.56|P-value:3.84E-8 ID:SGTC_1907|Compound:st060210|FD-Score:-3.35|P-value:6.84E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-4.29|P-value:2.02E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-3.71|P-value:1.97E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-4.60|P-value:5.29E-6 ID:SGTC_1966|Compound:st070145|FD-Score:-3.42|P-value:5.45E-4 ID:SGTC_1972|Compound:st070201|FD-Score:-3.58|P-value:3.17E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.31|P-value:6.62E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.86|P-value:1.64E-6 ID:SGTC_2269|Compound:7935389|FD-Score:4.13|P-value:3.21E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-4.93|P-value:1.16E-6 ID:SGTC_2274|Compound:7947094|FD-Score:4.66|P-value:3.31E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-4.23|P-value:2.67E-5 ID:SGTC_2382|Compound:9035899|FD-Score:4.53|P-value:5.89E-6 ID:SGTC_2396|Compound:5342950|FD-Score:-3.24|P-value:9.87E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.43|P-value:4.44E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.59|P-value:2.52E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.92|P-value:7.36E-5 ID:SGTC_2700|Compound:st077718|FD-Score:3.29|P-value:7.15E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.32|P-value:6.49E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.94|P-value:8.31E-5 ID:SGTC_2908|Compound:7930301|FD-Score:3.94|P-value:6.74E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.56|P-value:2.85E-4 ID:SGTC_3136|Compound:9095672|FD-Score:3.81|P-value:1.11E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.98|P-value:5.79E-5 ID:SGTC_3299|Compound:9121982|FD-Score:4.01|P-value:5.13E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.63|P-value:2.22E-4

Top fitness defect scores for YLR284C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_364 0083-0097 5.89 67.7 µM 6.56E-9 6 1.99E-9
2 SGTC_1885 st057546 5.76 99.9 µM 1.29E-8 2 4.10E-9
3 SGTC_820 1582-0060 5.75 59.9 µM 1.39E-8 8 4.46E-9
4 SGTC_1901 st060216 5.56 58.6 µM 3.84E-8 7 1.33E-8
5 SGTC_371 0195-0006 4.80 7.4 µM 1.70E-6 8 7.76E-7
6 SGTC_1779 st039427 4.68 55.0 µM 3.08E-6 11 1.47E-6
7 SGTC_2274 7947094 4.66 46.1 µM 3.31E-6 14 1.58E-6
8 SGTC_1659 st012954 4.65 42.1 µM 3.53E-6 5 1.70E-6
9 SGTC_2382 9035899 4.53 200.0 µM 5.89E-6 60S ribosome export 10 2.94E-6
10 SGTC_1678 st019265 4.34 80.2 µM 1.34E-5 60S ribosome export 13 7.11E-6
11 SGTC_387 norethindrone acetate 4.24 66.7 µM 2.07E-5 8 1.13E-5
12 SGTC_1565 sinapyl alcohol 4.15 95.1 µM 2.98E-5 24 1.67E-5
13 SGTC_147 4466-0538 4.13 29.2 µM 3.20E-5 ergosterol biosynthesis 16 1.81E-5
14 SGTC_2269 7935389 4.13 174.4 µM 3.21E-5 tubulin folding & SWR complex 23 1.81E-5
15 SGTC_64 000l-0018 4.09 272.1 µM 3.78E-5 ubiquinone biosynthesis & proteasome 142 2.15E-5
16 SGTC_1849 st056239 4.07 19.2 µM 4.11E-5 RPP1 & pyrimidine depletion 22 2.36E-5
17 SGTC_3299 9121982 4.01 43.1 µM 5.13E-5 26 2.99E-5
18 SGTC_560 2332-1943 3.99 155.0 µM 5.60E-5 9 3.28E-5
19 SGTC_448 monastrol 3.99 171.0 µM 5.73E-5 10 3.36E-5
20 SGTC_3181 9108277 3.98 49.5 µM 5.79E-5 iron homeostasis 15 3.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.76E-8 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.091 1.49E-7 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.088 3.43E-7 YPL064C CWC27 hom Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress
0.081 2.62E-6 YOL038W PRE6 het Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
0.080 3.07E-6 YOR377W ATF1 hom Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism
0.080 3.35E-6 YNL087W TCB2 hom ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud
0.076 9.21E-6 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.076 9.24E-6 YNL035C YNL035C hom Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress
0.072 2.78E-5 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.072 2.97E-5 YBL058W SHP1 hom UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
0.071 4.29E-5 YER034W YER034W hom Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress
0.070 4.70E-5 YPL223C GRE1 hom Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
0.070 5.47E-5 YOR053W_d YOR053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
0.069 6.83E-5 YDL033C SLM3 hom tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.068 8.38E-5 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress