YLR285C-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR285C-A / YLR285C-A

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.09|P-value:5.79E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.08|P-value:5.87E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.02|P-value:7.52E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.99|P-value:8.10E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:2.99|P-value:8.33E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.02|P-value:7.43E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:-3.26|P-value:3.26E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.38|P-value:2.05E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.99|P-value:1.38E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.71|P-value:4.71E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.25|P-value:3.10E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.14|P-value:4.73E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.55|P-value:9.53E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.19|P-value:3.87E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.26|P-value:3.21E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.17|P-value:5.74E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:3.56|P-value:9.04E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-6.37|P-value:1.25E-11 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.13|P-value:5.02E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.60|P-value:8.29E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.28|P-value:2.82E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.07|P-value:9.44E-6 ID:SGTC_1916|Compound:st067606|FD-Score:3.88|P-value:2.23E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.68|P-value:5.50E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.60|P-value:7.71E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.42|P-value:1.60E-4 ID:SGTC_2349|Compound:9023730|FD-Score:2.96|P-value:9.18E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.25|P-value:3.14E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.50|P-value:1.17E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.46|P-value:1.35E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.16|P-value:4.36E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.55|P-value:9.37E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.30|P-value:2.61E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.41|P-value:1.82E-4 ID:SGTC_2819|Compound:7996655|FD-Score:5.18|P-value:2.68E-8 ID:SGTC_2825|Compound:7998094|FD-Score:4.80|P-value:2.27E-7 ID:SGTC_2839|Compound:9003951|FD-Score:3.06|P-value:6.35E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-4.94|P-value:1.16E-7 ID:SGTC_2854|Compound:9024559|FD-Score:3.67|P-value:5.55E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-3.60|P-value:8.29E-5 ID:SGTC_3107|Compound:9121808|FD-Score:3.04|P-value:6.87E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.04|P-value:6.97E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.50|P-value:1.22E-6 ID:SGTC_3269|Compound:9137823|FD-Score:-3.67|P-value:6.21E-5 ID:SGTC_3278|Compound:9139605|FD-Score:3.66|P-value:6.03E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:3.09|P-value:5.79E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.08|P-value:5.87E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.02|P-value:7.52E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:2.99|P-value:8.10E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:2.99|P-value:8.33E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.02|P-value:7.43E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:-3.26|P-value:3.26E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.38|P-value:2.05E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.99|P-value:1.38E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.71|P-value:4.71E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.25|P-value:3.10E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.14|P-value:4.73E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.55|P-value:9.53E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.19|P-value:3.87E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.26|P-value:3.21E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.17|P-value:5.74E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:3.56|P-value:9.04E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:-6.37|P-value:1.25E-11 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.13|P-value:5.02E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.60|P-value:8.29E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.28|P-value:2.82E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.07|P-value:9.44E-6 ID:SGTC_1916|Compound:st067606|FD-Score:3.88|P-value:2.23E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.68|P-value:5.50E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.60|P-value:7.71E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.42|P-value:1.60E-4 ID:SGTC_2349|Compound:9023730|FD-Score:2.96|P-value:9.18E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.25|P-value:3.14E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.50|P-value:1.17E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.46|P-value:1.35E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.16|P-value:4.36E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.55|P-value:9.37E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.30|P-value:2.61E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.41|P-value:1.82E-4 ID:SGTC_2819|Compound:7996655|FD-Score:5.18|P-value:2.68E-8 ID:SGTC_2825|Compound:7998094|FD-Score:4.80|P-value:2.27E-7 ID:SGTC_2839|Compound:9003951|FD-Score:3.06|P-value:6.35E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-4.94|P-value:1.16E-7 ID:SGTC_2854|Compound:9024559|FD-Score:3.67|P-value:5.55E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-3.60|P-value:8.29E-5 ID:SGTC_3107|Compound:9121808|FD-Score:3.04|P-value:6.87E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.04|P-value:6.97E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.50|P-value:1.22E-6 ID:SGTC_3269|Compound:9137823|FD-Score:-3.67|P-value:6.21E-5 ID:SGTC_3278|Compound:9139605|FD-Score:3.66|P-value:6.03E-5

Top fitness defect scores for YLR285C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2819 7996655 5.18 46.4 µM 2.68E-8 8 1.14E-7
2 SGTC_2825 7998094 4.80 58.4 µM 2.27E-7 fatty acid desaturase (OLE1) 17 7.96E-7
3 SGTC_1074 carmofur 4.17 3.8 µM 5.74E-6 exosome 16 1.51E-5
4 SGTC_1385 3091-4834 4.07 14.1 µM 9.44E-6 RPP1 & pyrimidine depletion 20 2.37E-5
5 SGTC_555 4296-0685 3.99 37.0 µM 1.38E-5 ergosterol biosynthesis 7 3.36E-5
6 SGTC_1916 st067606 3.88 49.2 µM 2.23E-5 41 5.18E-5
7 SGTC_650 1328-0195 3.71 38.0 µM 4.71E-5 23 1.03E-4
8 SGTC_2001 4023502 3.68 57.7 µM 5.50E-5 mitochondrial processes 27 1.18E-4
9 SGTC_2854 9024559 3.67 71.4 µM 5.55E-5 32 1.19E-4
10 SGTC_3278 9139605 3.66 49.5 µM 6.03E-5 24 1.28E-4
11 SGTC_2114 5491910 3.60 81.2 µM 7.71E-5 20 1.61E-4
12 SGTC_1123 mangostin 3.56 811.3 nM 9.04E-5 mitochondrial response to ROS 51 1.86E-4
13 SGTC_2572 astragaloside iv 3.55 100.0 µM 9.37E-5 42 1.92E-4
14 SGTC_909 3448-9333 3.55 149.0 µM 9.53E-5 28 1.95E-4
15 SGTC_2427 5545055 3.50 42.8 µM 1.17E-4 31 2.35E-4
16 SGTC_2535 4',4'-dimethoxydalbergione 3.46 51.2 µM 1.35E-4 DNA damage response 30 2.68E-4
17 SGTC_2337 9009472 3.42 200.0 µM 1.60E-4 54 3.12E-4
18 SGTC_2813 7971799 3.30 71.4 µM 2.61E-4 45 4.89E-4
19 SGTC_1314 1222-0010 3.28 41.1 µM 2.82E-4 32 5.24E-4
20 SGTC_760 0568-0725 3.25 82.9 µM 3.10E-4 29 5.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.70E-16 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.142 1.70E-16 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.109 2.39E-10 YGL138C_p YGL138C_p hom Putative protein of unknown function; has no significant sequence similarity to any known protein
0.108 3.00E-10 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.102 3.53E-9 YDL054C MCH1 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.095 4.16E-8 YDR352W YPQ2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
0.094 5.23E-8 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.092 8.24E-8 YBR147W RTC2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter
0.091 1.39E-7 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.086 6.91E-7 YCL009C ILV6 hom Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
0.085 7.34E-7 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.083 1.64E-6 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.68E-6 YLR141W RRN5 het Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
0.081 2.54E-6 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.080 3.50E-6 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability