YLR285W / NNT1

S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR285W / NNT1

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:-2.88|P-value:9.60E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.11|P-value:3.96E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.22|P-value:2.55E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.66|P-value:3.82E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.85|P-value:1.62E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-5.27|P-value:6.41E-9 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.04|P-value:5.21E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:2.88|P-value:9.32E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.08|P-value:4.44E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.18|P-value:2.89E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.65|P-value:2.57E-7 ID:SGTC_1293|Compound:1000-1278|FD-Score:5.06|P-value:2.30E-8 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.05|P-value:5.92E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:-4.30|P-value:1.76E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.84|P-value:1.65E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:-2.96|P-value:7.08E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.09|P-value:4.25E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.47|P-value:6.94E-7 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-2.94|P-value:7.66E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.11|P-value:3.84E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-2.94|P-value:7.61E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.80|P-value:2.01E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-3.20|P-value:2.76E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-2.90|P-value:8.86E-4 ID:SGTC_1747|Compound:st037496|FD-Score:4.87|P-value:7.31E-8 ID:SGTC_1781|Compound:st038725|FD-Score:2.89|P-value:9.04E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.36|P-value:1.25E-6 ID:SGTC_1919|Compound:st067113|FD-Score:3.97|P-value:9.05E-6 ID:SGTC_2056|Compound:5235370|FD-Score:4.12|P-value:4.31E-6 ID:SGTC_2071|Compound:5230951|FD-Score:-2.92|P-value:8.02E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.06|P-value:5.80E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.45|P-value:9.78E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-3.03|P-value:5.31E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.02|P-value:5.46E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.18|P-value:3.16E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:2.95|P-value:7.10E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.16|P-value:3.19E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.05|P-value:4.99E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.94|P-value:4.74E-8 ID:SGTC_2827|Compound:7993847|FD-Score:4.15|P-value:3.73E-6 ID:SGTC_3009|Compound:9080819|FD-Score:4.50|P-value:5.71E-7 ID:SGTC_3017|Compound:9080681|FD-Score:3.01|P-value:5.79E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.02|P-value:5.59E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.77|P-value:1.28E-7 ID:SGTC_3262|Compound:9137218|FD-Score:2.97|P-value:6.53E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.87|P-value:9.79E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-2.88|P-value:9.60E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.11|P-value:3.96E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.22|P-value:2.55E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.66|P-value:3.82E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.85|P-value:1.62E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-5.27|P-value:6.41E-9 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.04|P-value:5.21E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:2.88|P-value:9.32E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.08|P-value:4.44E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.18|P-value:2.89E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.65|P-value:2.57E-7 ID:SGTC_1293|Compound:1000-1278|FD-Score:5.06|P-value:2.30E-8 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.05|P-value:5.92E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:-4.30|P-value:1.76E-6 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.84|P-value:1.65E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:-2.96|P-value:7.08E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.09|P-value:4.25E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.47|P-value:6.94E-7 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-2.94|P-value:7.66E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.11|P-value:3.84E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-2.94|P-value:7.61E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.80|P-value:2.01E-5 ID:SGTC_1740|Compound:st038286|FD-Score:-3.20|P-value:2.76E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-2.90|P-value:8.86E-4 ID:SGTC_1747|Compound:st037496|FD-Score:4.87|P-value:7.31E-8 ID:SGTC_1781|Compound:st038725|FD-Score:2.89|P-value:9.04E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.36|P-value:1.25E-6 ID:SGTC_1919|Compound:st067113|FD-Score:3.97|P-value:9.05E-6 ID:SGTC_2056|Compound:5235370|FD-Score:4.12|P-value:4.31E-6 ID:SGTC_2071|Compound:5230951|FD-Score:-2.92|P-value:8.02E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.06|P-value:5.80E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.45|P-value:9.78E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-3.03|P-value:5.31E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.02|P-value:5.46E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.18|P-value:3.16E-6 ID:SGTC_2661|Compound:dactinomycin|FD-Score:2.95|P-value:7.10E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.16|P-value:3.19E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.05|P-value:4.99E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.94|P-value:4.74E-8 ID:SGTC_2827|Compound:7993847|FD-Score:4.15|P-value:3.73E-6 ID:SGTC_3009|Compound:9080819|FD-Score:4.50|P-value:5.71E-7 ID:SGTC_3017|Compound:9080681|FD-Score:3.01|P-value:5.79E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.02|P-value:5.59E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.77|P-value:1.28E-7 ID:SGTC_3262|Compound:9137218|FD-Score:2.97|P-value:6.53E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.87|P-value:9.79E-4

Top fitness defect scores for YLR285W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1293 1000-1278 5.06 195.0 µM 2.30E-8 1 2.10E-7
2 SGTC_2802 7925815 4.94 54.5 µM 4.74E-8 19 3.91E-7
3 SGTC_1747 st037496 4.87 66.6 µM 7.31E-8 7 5.67E-7
4 SGTC_3210 9128157 4.77 49.5 µM 1.28E-7 29 9.21E-7
5 SGTC_1176 0848-0131 4.65 83.3 µM 2.57E-7 Golgi 11 1.68E-6
6 SGTC_3009 9080819 4.50 71.4 µM 5.71E-7 8 3.34E-6
7 SGTC_2607 solasodine 4.18 47.4 µM 3.16E-6 51 1.46E-5
8 SGTC_2827 7993847 4.15 71.4 µM 3.73E-6 18 1.68E-5
9 SGTC_2056 5235370 4.12 200.0 µM 4.31E-6 34 1.91E-5
10 SGTC_2126 5251174 4.06 33.9 µM 5.80E-6 30 2.47E-5
11 SGTC_1350 1495-0454 4.05 146.0 µM 5.92E-6 22 2.51E-5
12 SGTC_1919 st067113 3.97 52.3 µM 9.05E-6 TSC3-RPN4 27 3.62E-5
13 SGTC_358 0075-0058 3.85 9.4 µM 1.62E-5 66 5.99E-5
14 SGTC_1363 1636-0063 3.84 10.4 µM 1.65E-5 Golgi 30 6.10E-5
15 SGTC_1735 st034310 3.80 56.8 µM 2.01E-5 Golgi 32 7.20E-5
16 SGTC_265 mycophenolic acid 3.66 32.9 µM 3.82E-5 RPP1 & pyrimidine depletion 27 1.26E-4
17 SGTC_2329 6138490 3.45 200.0 µM 9.78E-5 52 2.83E-4
18 SGTC_185 k048-0037 3.22 25.5 µM 2.55E-4 RSC & ERG11 26 6.48E-4
19 SGTC_936 3005-4620 3.18 401.0 µM 2.89E-4 59 7.24E-4
20 SGTC_2764 methyldopa 3.16 94.7 µM 3.19E-4 53 7.89E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.231 7.72E-42 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.179 1.92E-25 YNL339C YRF1-6 hom Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
0.178 3.29E-25 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.170 3.11E-23 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.164 1.17E-21 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.161 8.62E-21 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.160 1.02E-20 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.157 5.92E-20 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.156 1.12E-19 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.156 1.19E-19 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.154 3.08E-19 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.153 4.34E-19 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.152 9.39E-19 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.145 3.63E-17 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.144 5.98E-17 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies