YLR286C / CTS1

Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR286C / CTS1

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.65|P-value:1.54E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.40|P-value:6.38E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.86|P-value:6.96E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:3.61|P-value:1.84E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.22|P-value:7.13E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.39|P-value:7.56E-6 ID:SGTC_443|Compound:clozapine|FD-Score:4.12|P-value:2.44E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.38|P-value:6.81E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.20|P-value:7.65E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.81|P-value:8.59E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:3.40|P-value:3.81E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.29|P-value:9.14E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.00|P-value:4.01E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.40|P-value:3.79E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:4.30|P-value:1.13E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:3.62|P-value:1.74E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.55|P-value:3.82E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.56|P-value:3.59E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.13|P-value:4.15E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.54|P-value:2.78E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.19|P-value:1.84E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.44|P-value:6.19E-6 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.38|P-value:4.10E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.72|P-value:2.02E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.39|P-value:1.44E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.20|P-value:7.56E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-4.01|P-value:6.75E-5 ID:SGTC_1748|Compound:st037455|FD-Score:5.92|P-value:3.15E-9 ID:SGTC_1752|Compound:st044819|FD-Score:-4.68|P-value:4.00E-6 ID:SGTC_1855|Compound:st056195|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.82|P-value:8.19E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-4.00|P-value:7.04E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.34|P-value:4.76E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.23|P-value:2.85E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-5.02|P-value:8.34E-7 ID:SGTC_1948|Compound:st076329|FD-Score:4.32|P-value:1.06E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.99|P-value:4.24E-5 ID:SGTC_2150|Compound:5556613|FD-Score:3.42|P-value:3.62E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.85|P-value:7.30E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.18|P-value:1.87E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.76|P-value:1.03E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.32|P-value:5.09E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.60|P-value:1.91E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.30|P-value:5.48E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.65|P-value:1.57E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.43|P-value:4.82E-8 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.05|P-value:3.42E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.06|P-value:5.53E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-7.77|P-value:4.31E-14 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.90|P-value:7.28E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.98|P-value:4.88E-7 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.80|P-value:8.91E-5 ID:SGTC_2861|Compound:9024595|FD-Score:4.71|P-value:1.80E-6 ID:SGTC_2870|Compound:9038528|FD-Score:3.41|P-value:3.77E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.28|P-value:2.31E-5 ID:SGTC_2938|Compound:9059746|FD-Score:5.51|P-value:3.22E-8 ID:SGTC_2960|Compound:9079389|FD-Score:3.67|P-value:1.45E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.46|P-value:3.13E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-3.49|P-value:4.68E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-4.84|P-value:1.93E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-7.64|P-value:1.14E-13 ID:SGTC_3141|Compound:9094609|FD-Score:-4.04|P-value:6.13E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.13|P-value:9.59E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.65|P-value:1.54E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.40|P-value:6.38E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.86|P-value:6.96E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:3.61|P-value:1.84E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.22|P-value:7.13E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.39|P-value:7.56E-6 ID:SGTC_443|Compound:clozapine|FD-Score:4.12|P-value:2.44E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.38|P-value:6.81E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.20|P-value:7.65E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.81|P-value:8.59E-5 ID:SGTC_640|Compound:3381-0960|FD-Score:3.40|P-value:3.81E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.29|P-value:9.14E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.00|P-value:4.01E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:3.40|P-value:3.79E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:4.30|P-value:1.13E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:3.62|P-value:1.74E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.55|P-value:3.82E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.56|P-value:3.59E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.13|P-value:4.15E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.54|P-value:2.78E-8 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.19|P-value:1.84E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.44|P-value:6.19E-6 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.38|P-value:4.10E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.72|P-value:2.02E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-4.39|P-value:1.44E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.20|P-value:7.56E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-4.01|P-value:6.75E-5 ID:SGTC_1748|Compound:st037455|FD-Score:5.92|P-value:3.15E-9 ID:SGTC_1752|Compound:st044819|FD-Score:-4.68|P-value:4.00E-6 ID:SGTC_1855|Compound:st056195|FD-Score:3.29|P-value:5.67E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.82|P-value:8.19E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-4.00|P-value:7.04E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.34|P-value:4.76E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.23|P-value:2.85E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-5.02|P-value:8.34E-7 ID:SGTC_1948|Compound:st076329|FD-Score:4.32|P-value:1.06E-5 ID:SGTC_1988|Compound:st071872|FD-Score:3.99|P-value:4.24E-5 ID:SGTC_2150|Compound:5556613|FD-Score:3.42|P-value:3.62E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.85|P-value:7.30E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.18|P-value:1.87E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.76|P-value:1.03E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.32|P-value:5.09E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.60|P-value:1.91E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.30|P-value:5.48E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.65|P-value:1.57E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.43|P-value:4.82E-8 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.05|P-value:3.42E-7 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.06|P-value:5.53E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-7.77|P-value:4.31E-14 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.90|P-value:7.28E-7 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.98|P-value:4.88E-7 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.80|P-value:8.91E-5 ID:SGTC_2861|Compound:9024595|FD-Score:4.71|P-value:1.80E-6 ID:SGTC_2870|Compound:9038528|FD-Score:3.41|P-value:3.77E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-4.28|P-value:2.31E-5 ID:SGTC_2938|Compound:9059746|FD-Score:5.51|P-value:3.22E-8 ID:SGTC_2960|Compound:9079389|FD-Score:3.67|P-value:1.45E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.46|P-value:3.13E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-3.49|P-value:4.68E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-4.84|P-value:1.93E-6 ID:SGTC_3138|Compound:9097216|FD-Score:-7.64|P-value:1.14E-13 ID:SGTC_3141|Compound:9094609|FD-Score:-4.04|P-value:6.13E-5 ID:SGTC_3324|Compound:9138759|FD-Score:3.13|P-value:9.59E-4

Top fitness defect scores for YLR286C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1748 st037455 5.92 53.6 µM 3.15E-9 5 1.57E-9
2 SGTC_1132 3456-3614 5.54 2.5 µM 2.78E-8 tubulin folding & SWR complex 12 1.55E-8
3 SGTC_2938 9059746 5.51 27.3 µM 3.22E-8 fatty acid desaturase (OLE1) 17 1.80E-8
4 SGTC_2489 cantharidin 5.43 73.4 µM 4.82E-8 cell wall signaling 15 2.76E-8
5 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.05 3.7 µM 3.42E-7 31 2.16E-7
6 SGTC_2629 bisabolol 4.98 100.0 µM 4.88E-7 10 3.13E-7
7 SGTC_2581 avocatin a 4.90 64.0 µM 7.28E-7 sphingolipid biosynthesis & PDR1 36 4.77E-7
8 SGTC_2861 9024595 4.71 19.5 µM 1.80E-6 1 1.23E-6
9 SGTC_1251 0490-5699 4.44 265.0 µM 6.19E-6 18 4.50E-6
10 SGTC_405 ebelactone b 4.39 50.0 µM 7.56E-6 6 5.54E-6
11 SGTC_1948 st076329 4.32 66.6 µM 1.06E-5 18 7.91E-6
12 SGTC_855 0428-0020 4.30 25.0 µM 1.13E-5 Golgi 16 8.41E-6
13 SGTC_1246 0422-0085 4.19 105.0 µM 1.84E-5 23 1.41E-5
14 SGTC_2407 paclitaxel 4.18 400.0 µM 1.87E-5 27 1.43E-5
15 SGTC_443 clozapine 4.12 122.0 µM 2.44E-5 NEO1-PIK1 9 1.89E-5
16 SGTC_763 3453-1109 4.00 128.0 µM 4.01E-5 14 3.18E-5
17 SGTC_1988 st071872 3.99 53.4 µM 4.24E-5 10 3.37E-5
18 SGTC_353 1988-1175 3.86 58.3 µM 6.96E-5 unfolded protein response 28 5.65E-5
19 SGTC_2311 7694451 3.85 200.0 µM 7.30E-5 19 5.94E-5
20 SGTC_1878 temozolomide 3.82 1.0 mM 8.19E-5 9 6.70E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 6.52E-17 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.119 4.52E-12 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.116 1.78E-11 YER085C_p YER085C_p hom Putative protein of unknown function
0.105 9.06E-10 YHR006W STP2 hom Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication
0.105 9.10E-10 YOL017W ESC8 hom Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication
0.105 9.53E-10 YDR327W_d YDR327W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1
0.102 3.64E-9 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.099 1.07E-8 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.093 7.74E-8 YJL097W PHS1 het Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking
0.091 1.34E-7 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.091 1.36E-7 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.091 1.43E-7 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.087 4.10E-7 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.085 7.56E-7 YKL012W PRP40 het U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
0.082 1.84E-6 YGL108C YGL108C hom Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress