YLR287C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR287C / YLR287C

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-4.24|P-value:2.64E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:4.11|P-value:5.27E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:-2.97|P-value:7.10E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.86|P-value:1.82E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.28|P-value:2.24E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.95|P-value:1.15E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.50|P-value:7.15E-7 ID:SGTC_427|Compound:1354-0053|FD-Score:-5.37|P-value:4.26E-9 ID:SGTC_521|Compound:r062-0005|FD-Score:5.33|P-value:5.57E-9 ID:SGTC_651|Compound:3253-0966|FD-Score:3.92|P-value:1.38E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.97|P-value:7.17E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.56|P-value:5.22E-7 ID:SGTC_944|Compound:3370-0224|FD-Score:4.02|P-value:8.21E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-5.62|P-value:8.29E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:-5.11|P-value:2.04E-8 ID:SGTC_983|Compound:1491-0821|FD-Score:3.13|P-value:4.01E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:2.97|P-value:7.37E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.29|P-value:2.10E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.21|P-value:2.90E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.55|P-value:7.33E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:5.09|P-value:2.49E-8 ID:SGTC_1605|Compound:st000082|FD-Score:4.51|P-value:6.76E-7 ID:SGTC_1634|Compound:st006576|FD-Score:2.90|P-value:9.38E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-3.55|P-value:7.01E-5 ID:SGTC_1706|Compound:st031321|FD-Score:3.04|P-value:5.78E-4 ID:SGTC_1726|Compound:st035556|FD-Score:2.96|P-value:7.76E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.07|P-value:5.05E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-5.08|P-value:2.51E-8 ID:SGTC_1865|Compound:st057639|FD-Score:-4.66|P-value:2.90E-7 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.00|P-value:6.62E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.53|P-value:7.50E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.65|P-value:4.73E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.86|P-value:1.78E-5 ID:SGTC_2366|Compound:9070441|FD-Score:4.02|P-value:8.28E-6 ID:SGTC_2397|Compound:5161689|FD-Score:2.94|P-value:8.20E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.07|P-value:5.04E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.09|P-value:4.62E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.85|P-value:1.81E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.18|P-value:3.15E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.27|P-value:2.30E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.17|P-value:3.38E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.27|P-value:2.36E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.19|P-value:3.18E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.10|P-value:4.32E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-3.82|P-value:2.09E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.20|P-value:3.46E-6 ID:SGTC_2924|Compound:9010168|FD-Score:-5.24|P-value:9.43E-9 ID:SGTC_2928|Compound:9011484|FD-Score:-3.00|P-value:6.51E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.37|P-value:1.57E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.72|P-value:2.17E-7 ID:SGTC_2940|Compound:9060638|FD-Score:3.09|P-value:4.67E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.27|P-value:2.35E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-2.97|P-value:7.21E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.80|P-value:2.40E-5 ID:SGTC_3150|Compound:9097574|FD-Score:2.92|P-value:8.96E-4 ID:SGTC_3160|Compound:9100216|FD-Score:3.02|P-value:6.19E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.59|P-value:5.91E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.24|P-value:2.64E-6 ID:SGTC_350|Compound:k064-0020|FD-Score:4.11|P-value:5.27E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:-2.97|P-value:7.10E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.86|P-value:1.82E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.28|P-value:2.24E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.95|P-value:1.15E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.50|P-value:7.15E-7 ID:SGTC_427|Compound:1354-0053|FD-Score:-5.37|P-value:4.26E-9 ID:SGTC_521|Compound:r062-0005|FD-Score:5.33|P-value:5.57E-9 ID:SGTC_651|Compound:3253-0966|FD-Score:3.92|P-value:1.38E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.97|P-value:7.17E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.56|P-value:5.22E-7 ID:SGTC_944|Compound:3370-0224|FD-Score:4.02|P-value:8.21E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:-5.62|P-value:8.29E-10 ID:SGTC_951|Compound:1171-0579|FD-Score:-5.11|P-value:2.04E-8 ID:SGTC_983|Compound:1491-0821|FD-Score:3.13|P-value:4.01E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:2.97|P-value:7.37E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.29|P-value:2.10E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.21|P-value:2.90E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.55|P-value:7.33E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:5.09|P-value:2.49E-8 ID:SGTC_1605|Compound:st000082|FD-Score:4.51|P-value:6.76E-7 ID:SGTC_1634|Compound:st006576|FD-Score:2.90|P-value:9.38E-4 ID:SGTC_1697|Compound:st025554|FD-Score:-3.55|P-value:7.01E-5 ID:SGTC_1706|Compound:st031321|FD-Score:3.04|P-value:5.78E-4 ID:SGTC_1726|Compound:st035556|FD-Score:2.96|P-value:7.76E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.07|P-value:5.05E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-5.08|P-value:2.51E-8 ID:SGTC_1865|Compound:st057639|FD-Score:-4.66|P-value:2.90E-7 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.00|P-value:6.62E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-3.53|P-value:7.50E-5 ID:SGTC_2355|Compound:9061122|FD-Score:3.65|P-value:4.73E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.86|P-value:1.78E-5 ID:SGTC_2366|Compound:9070441|FD-Score:4.02|P-value:8.28E-6 ID:SGTC_2397|Compound:5161689|FD-Score:2.94|P-value:8.20E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.07|P-value:5.04E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-3.09|P-value:4.62E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.85|P-value:1.81E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.18|P-value:3.15E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.27|P-value:2.30E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.17|P-value:3.38E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.27|P-value:2.36E-4 ID:SGTC_2790|Compound:5423970|FD-Score:3.19|P-value:3.18E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.10|P-value:4.32E-4 ID:SGTC_2903|Compound:5923464|FD-Score:-3.82|P-value:2.09E-5 ID:SGTC_2920|Compound:7982904|FD-Score:4.20|P-value:3.46E-6 ID:SGTC_2924|Compound:9010168|FD-Score:-5.24|P-value:9.43E-9 ID:SGTC_2928|Compound:9011484|FD-Score:-3.00|P-value:6.51E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.37|P-value:1.57E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.72|P-value:2.17E-7 ID:SGTC_2940|Compound:9060638|FD-Score:3.09|P-value:4.67E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.27|P-value:2.35E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-2.97|P-value:7.21E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.80|P-value:2.40E-5 ID:SGTC_3150|Compound:9097574|FD-Score:2.92|P-value:8.96E-4 ID:SGTC_3160|Compound:9100216|FD-Score:3.02|P-value:6.19E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.59|P-value:5.91E-5

Top fitness defect scores for YLR287C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_521 r062-0005 5.33 13.8 µM 5.57E-9 4 4.83E-8
2 SGTC_1572 epiandrosterone 5.09 68.9 µM 2.49E-8 16 1.79E-7
3 SGTC_2938 9059746 4.72 27.3 µM 2.17E-7 fatty acid desaturase (OLE1) 25 1.19E-6
4 SGTC_788 1182-0090 4.56 188.0 µM 5.22E-7 endomembrane recycling 60 2.56E-6
5 SGTC_1605 st000082 4.51 49.1 µM 6.76E-7 60S ribosome export 5 3.22E-6
6 SGTC_423 5-fluorouracil 4.50 457.0 µM 7.15E-7 exosome 13 3.38E-6
7 SGTC_2920 7982904 4.20 15.8 µM 3.46E-6 17 1.34E-5
8 SGTC_350 k064-0020 4.11 19.8 µM 5.27E-6 heme requiring 25 1.94E-5
9 SGTC_944 3370-0224 4.02 231.0 µM 8.21E-6 21 2.87E-5
10 SGTC_2366 9070441 4.02 60.6 µM 8.28E-6 27 2.89E-5
11 SGTC_651 3253-0966 3.92 34.4 µM 1.38E-5 calcium & mitochondrial duress 34 4.51E-5
12 SGTC_2357 9067248 3.86 200.0 µM 1.78E-5 19 5.65E-5
13 SGTC_387 norethindrone acetate 3.86 66.7 µM 1.82E-5 17 5.76E-5
14 SGTC_3147 9097027 3.80 49.5 µM 2.40E-5 29 7.33E-5
15 SGTC_2355 9061122 3.65 103.1 µM 4.73E-5 17 1.33E-4
16 SGTC_1569 carminic acid 3.55 40.6 µM 7.33E-5 31 1.95E-4
17 SGTC_2930 9013230 3.37 14.9 µM 1.57E-4 heme biosynthesis & mitochondrial translocase 62 3.81E-4
18 SGTC_1563 conessine 3.29 56.1 µM 2.10E-4 35 4.94E-4
19 SGTC_392 N-ethylmaleimide 3.28 8.3 µM 2.24E-4 RNA pol III & RNase P/MRP 32 5.22E-4
20 SGTC_2536 dehydroabietamide 3.27 32.0 µM 2.30E-4 68 5.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 2.38E-17 YDR306C_p YDR306C_p hom F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
0.118 7.67E-12 YLR394W CST9 hom SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
0.107 4.65E-10 YGR201C_p YGR201C_p hom Putative protein of unknown function
0.106 8.57E-10 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.101 3.96E-9 YBL002W HTB2 hom Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.092 8.80E-8 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
0.091 1.17E-7 YMR059W SEN15 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.090 1.93E-7 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.089 2.24E-7 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.089 2.80E-7 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.088 3.18E-7 YDL239C ADY3 hom Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication
0.083 1.29E-6 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.082 1.98E-6 YML086C ALO1 hom D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
0.081 2.31E-6 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.081 2.72E-6 YDR142C PEX7 hom Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)