YLR287C-A / RPS30A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR287C-A / RPS30A

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.56|P-value:3.19E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.56|P-value:6.52E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:5.81|P-value:1.52E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.64|P-value:3.53E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:3.37|P-value:6.10E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.37|P-value:1.46E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:4.20|P-value:2.91E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.27|P-value:8.45E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.25|P-value:9.01E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:4.67|P-value:4.09E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:6.41|P-value:5.10E-10 ID:SGTC_798|Compound:1287-0182|FD-Score:6.29|P-value:1.04E-9 ID:SGTC_799|Compound:1310-0557|FD-Score:3.23|P-value:9.56E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:10.00|P-value:8.76E-22 ID:SGTC_806|Compound:3966-4455|FD-Score:7.53|P-value:3.86E-13 ID:SGTC_807|Compound:1315-0151|FD-Score:3.91|P-value:9.19E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-4.37|P-value:2.24E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.17|P-value:3.32E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.45|P-value:6.64E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.24|P-value:9.32E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.31|P-value:7.51E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:5.68|P-value:2.97E-8 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.46|P-value:4.52E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.25|P-value:8.98E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.14|P-value:3.75E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.47|P-value:9.44E-6 ID:SGTC_1781|Compound:st038725|FD-Score:3.51|P-value:3.84E-4 ID:SGTC_1862|Compound:st057513|FD-Score:4.33|P-value:1.74E-5 ID:SGTC_1942|Compound:st076330|FD-Score:-4.17|P-value:5.11E-5 ID:SGTC_1963|Compound:st076565|FD-Score:4.10|P-value:4.36E-5 ID:SGTC_1966|Compound:st070145|FD-Score:4.66|P-value:4.23E-6 ID:SGTC_2017|Compound:5132927|FD-Score:3.28|P-value:8.09E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.61|P-value:2.67E-4 ID:SGTC_2210|Compound:7115885|FD-Score:3.60|P-value:2.80E-4 ID:SGTC_2211|Compound:7117706|FD-Score:4.54|P-value:7.09E-6 ID:SGTC_2248|Compound:tofa|FD-Score:4.84|P-value:1.89E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.40|P-value:1.30E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.67|P-value:2.17E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.82|P-value:2.04E-6 ID:SGTC_3029|Compound:9088683|FD-Score:3.34|P-value:6.64E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.36|P-value:9.05E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.56|P-value:3.19E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.56|P-value:6.52E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:5.81|P-value:1.52E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.64|P-value:3.53E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:3.37|P-value:6.10E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.37|P-value:1.46E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:4.20|P-value:2.91E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.27|P-value:8.45E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.25|P-value:9.01E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:4.67|P-value:4.09E-6 ID:SGTC_745|Compound:0469-0705|FD-Score:6.41|P-value:5.10E-10 ID:SGTC_798|Compound:1287-0182|FD-Score:6.29|P-value:1.04E-9 ID:SGTC_799|Compound:1310-0557|FD-Score:3.23|P-value:9.56E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:10.00|P-value:8.76E-22 ID:SGTC_806|Compound:3966-4455|FD-Score:7.53|P-value:3.86E-13 ID:SGTC_807|Compound:1315-0151|FD-Score:3.91|P-value:9.19E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:-4.37|P-value:2.24E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.17|P-value:3.32E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.45|P-value:6.64E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.24|P-value:9.32E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.31|P-value:7.51E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:5.68|P-value:2.97E-8 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.46|P-value:4.52E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.25|P-value:8.98E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.14|P-value:3.75E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.47|P-value:9.44E-6 ID:SGTC_1781|Compound:st038725|FD-Score:3.51|P-value:3.84E-4 ID:SGTC_1862|Compound:st057513|FD-Score:4.33|P-value:1.74E-5 ID:SGTC_1942|Compound:st076330|FD-Score:-4.17|P-value:5.11E-5 ID:SGTC_1963|Compound:st076565|FD-Score:4.10|P-value:4.36E-5 ID:SGTC_1966|Compound:st070145|FD-Score:4.66|P-value:4.23E-6 ID:SGTC_2017|Compound:5132927|FD-Score:3.28|P-value:8.09E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.61|P-value:2.67E-4 ID:SGTC_2210|Compound:7115885|FD-Score:3.60|P-value:2.80E-4 ID:SGTC_2211|Compound:7117706|FD-Score:4.54|P-value:7.09E-6 ID:SGTC_2248|Compound:tofa|FD-Score:4.84|P-value:1.89E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.40|P-value:1.30E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.67|P-value:2.17E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.82|P-value:2.04E-6 ID:SGTC_3029|Compound:9088683|FD-Score:3.34|P-value:6.64E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.36|P-value:9.05E-4

Top fitness defect scores for YLR287C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_800 3448-7362 10.00 155.0 µM 8.76E-22 translation 8 6.15E-24
2 SGTC_806 3966-4455 7.53 5.9 µM 3.86E-13 2 2.52E-14
3 SGTC_745 0469-0705 6.41 296.0 µM 5.10E-10 mitochondrial processes 2 7.32E-11
4 SGTC_798 1287-0182 6.29 476.0 µM 1.04E-9 4 1.61E-10
5 SGTC_154 3389-1638 5.81 511.1 µM 1.52E-8 3 3.15E-9
6 SGTC_1231 0242-0792 5.68 125.0 µM 2.97E-8 2 6.60E-9
7 SGTC_2248 tofa 4.84 1.1 µM 1.89E-6 sphingolipid biosynthesis & PDR1 28 6.51E-7
8 SGTC_3020 9089140 4.82 49.5 µM 2.04E-6 11 7.07E-7
9 SGTC_735 3076-0345 4.67 636.0 µM 4.09E-6 15 1.53E-6
10 SGTC_1966 st070145 4.66 16.1 µM 4.23E-6 13 1.59E-6
11 SGTC_118 0083-0097 4.56 135.3 µM 6.52E-6 translation 82 2.55E-6
12 SGTC_2211 7117706 4.54 200.0 µM 7.09E-6 4 2.80E-6
13 SGTC_1537 2',6'-dihydroxyflavanone 4.47 78.0 µM 9.44E-6 9 3.84E-6
14 SGTC_2597 laccaic acid a 4.40 100.0 µM 1.30E-5 25 5.48E-6
15 SGTC_353 1988-1175 4.37 58.3 µM 1.46E-5 unfolded protein response 18 6.22E-6
16 SGTC_1862 st057513 4.33 3.8 µM 1.74E-5 6 7.53E-6
17 SGTC_357 1325-0123 4.20 420.0 µM 2.91E-5 4 1.33E-5
18 SGTC_1032 k061-1018 4.17 98.7 µM 3.32E-5 15 1.54E-5
19 SGTC_1438 4092-1045 4.14 4.0 µM 3.75E-5 5 1.76E-5
20 SGTC_1963 st076565 4.10 50.3 µM 4.36E-5 7 2.07E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 2.06E-24 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.161 5.18E-21 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.161 7.54E-21 YGL250W RMR1 hom Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus
0.155 1.76E-19 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.136 2.24E-15 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.135 4.00E-15 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.130 4.45E-14 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.129 8.00E-14 YJR055W HIT1 hom Protein of unknown function, required for growth at high temperature
0.124 5.61E-13 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.124 5.83E-13 YDL061C RPS29B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication
0.121 1.91E-12 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.117 9.23E-12 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.116 1.51E-11 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.116 1.69E-11 YPL101W ELP4 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.115 2.04E-11 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication