Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR289W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.107 | 5.13E-10 | YDR196C | CAB5 | het | Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies |
0.101 | 4.50E-9 | YGR154C | GTO1 | hom | Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization |
0.096 | 2.87E-8 | YNL179C_d | YNL179C_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance |
0.091 | 1.18E-7 | YLL048C | YBT1 | hom | Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters |
0.090 | 1.69E-7 | YCL022C_d | YCL022C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W |
0.089 | 2.22E-7 | YLL041C | SDH2 | hom | Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain |
0.089 | 2.31E-7 | YOL057W | YOL057W | hom | Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers |
0.088 | 3.62E-7 | YNL055C | POR1 | hom | Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication |
0.085 | 9.41E-7 | YLR215C | CDC123 | het | Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein |
0.081 | 2.44E-6 | YKL077W_p | YKL077W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole |
0.079 | 4.06E-6 | YBR259W | YBR259W | hom | Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress |
0.078 | 5.40E-6 | YLR180W | SAM1 | hom | S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication |
0.078 | 6.39E-6 | YDR513W | GRX2 | hom | Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication |
0.077 | 9.00E-6 | YGR256W | GND2 | hom | 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication |
0.076 | 1.06E-5 | YPR180W | AOS1 | het | Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |