YLR290C_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR290C / YLR290C

Click on Significant Values for Screen Details ID:SGTC_285|Compound:1486-1325|FD-Score:2.75|P-value:9.49E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:2.76|P-value:9.05E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:2.77|P-value:8.57E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.51|P-value:3.78E-5 ID:SGTC_398|Compound:bronopol|FD-Score:-3.03|P-value:3.73E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.13|P-value:2.44E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.58|P-value:1.24E-7 ID:SGTC_408|Compound:cantharidin|FD-Score:-2.83|P-value:7.95E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-2.80|P-value:9.12E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.82|P-value:9.88E-6 ID:SGTC_991|Compound:3996-0057|FD-Score:-2.83|P-value:7.96E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:4.08|P-value:2.08E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.01|P-value:3.97E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.20|P-value:1.84E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.46|P-value:5.65E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:2.88|P-value:5.70E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.33|P-value:1.04E-4 ID:SGTC_1637|Compound:st007924|FD-Score:2.98|P-value:3.86E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.19|P-value:1.88E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.25|P-value:1.48E-4 ID:SGTC_1851|Compound:st056236|FD-Score:2.85|P-value:6.32E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.46|P-value:5.63E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:2.94|P-value:4.45E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.04|P-value:3.55E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-2.93|P-value:5.40E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.98|P-value:4.51E-6 ID:SGTC_2104|Compound:5389443|FD-Score:2.83|P-value:6.83E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.52|P-value:3.59E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-4.01|P-value:3.86E-6 ID:SGTC_2265|Compound:7929201|FD-Score:-4.61|P-value:1.28E-7 ID:SGTC_2268|Compound:7933382|FD-Score:-3.02|P-value:3.88E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.77|P-value:8.56E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.16|P-value:1.82E-4 ID:SGTC_2678|Compound:equilin|FD-Score:2.74|P-value:9.59E-4 ID:SGTC_2886|Compound:9058944|FD-Score:3.03|P-value:3.04E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.10|P-value:2.73E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.13|P-value:2.38E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.84|P-value:7.79E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.13|P-value:2.05E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.28|P-value:1.27E-4 ID:SGTC_3287|Compound:9117173|FD-Score:5.97|P-value:8.82E-12 ID:SGTC_3295|Compound:9122362|FD-Score:-2.92|P-value:5.74E-4 ID:SGTC_3297|Compound:9117502|FD-Score:4.54|P-value:1.57E-7 ID:SGTC_285|Compound:1486-1325|FD-Score:2.75|P-value:9.49E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:2.76|P-value:9.05E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:2.77|P-value:8.57E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.51|P-value:3.78E-5 ID:SGTC_398|Compound:bronopol|FD-Score:-3.03|P-value:3.73E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.13|P-value:2.44E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.58|P-value:1.24E-7 ID:SGTC_408|Compound:cantharidin|FD-Score:-2.83|P-value:7.95E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-2.80|P-value:9.12E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.82|P-value:9.88E-6 ID:SGTC_991|Compound:3996-0057|FD-Score:-2.83|P-value:7.96E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:4.08|P-value:2.08E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.01|P-value:3.97E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.20|P-value:1.84E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.46|P-value:5.65E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:2.88|P-value:5.70E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.33|P-value:1.04E-4 ID:SGTC_1637|Compound:st007924|FD-Score:2.98|P-value:3.86E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.19|P-value:1.88E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.25|P-value:1.48E-4 ID:SGTC_1851|Compound:st056236|FD-Score:2.85|P-value:6.32E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.46|P-value:5.63E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:2.94|P-value:4.45E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.04|P-value:3.55E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-2.93|P-value:5.40E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.98|P-value:4.51E-6 ID:SGTC_2104|Compound:5389443|FD-Score:2.83|P-value:6.83E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.52|P-value:3.59E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-4.01|P-value:3.86E-6 ID:SGTC_2265|Compound:7929201|FD-Score:-4.61|P-value:1.28E-7 ID:SGTC_2268|Compound:7933382|FD-Score:-3.02|P-value:3.88E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.77|P-value:8.56E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.16|P-value:1.82E-4 ID:SGTC_2678|Compound:equilin|FD-Score:2.74|P-value:9.59E-4 ID:SGTC_2886|Compound:9058944|FD-Score:3.03|P-value:3.04E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.10|P-value:2.73E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.13|P-value:2.38E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.84|P-value:7.79E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.13|P-value:2.05E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-3.28|P-value:1.27E-4 ID:SGTC_3287|Compound:9117173|FD-Score:5.97|P-value:8.82E-12 ID:SGTC_3295|Compound:9122362|FD-Score:-2.92|P-value:5.74E-4 ID:SGTC_3297|Compound:9117502|FD-Score:4.54|P-value:1.57E-7

Top fitness defect scores for YLR290C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3287 9117173 5.97 37.1 µM 8.82E-12 60S ribosome export 1 1.17E-9
2 SGTC_402 epigallocatechin gallate 4.58 10.0 µM 1.24E-7 10 2.35E-6
3 SGTC_3297 9117502 4.54 71.4 µM 1.57E-7 5 2.83E-6
4 SGTC_1004 4084-0029 4.08 199.0 µM 2.08E-6 11 2.23E-5
5 SGTC_2246 7293507 3.52 91.6 µM 3.59E-5 39 2.17E-4
6 SGTC_373 0844-0104 3.51 25.9 µM 3.78E-5 ERAD & cell cycle 68 2.27E-4
7 SGTC_2588 indole-3-carbinol 3.16 100.0 µM 1.82E-4 93 7.99E-4
8 SGTC_2999 9069765 3.13 71.4 µM 2.05E-4 amide catabolism 68 8.79E-4
9 SGTC_2886 9058944 3.03 52.0 µM 3.04E-4 11 0.00120
10 SGTC_1637 st007924 2.98 17.4 µM 3.86E-4 66 0.00146
11 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 2.94 62.6 µM 4.45E-4 TSC3-RPN4 49 0.00164
12 SGTC_1219 1469-0211 2.88 33.1 µM 5.70E-4 51 0.00199
13 SGTC_1851 st056236 2.85 18.9 µM 6.32E-4 64 0.00217
14 SGTC_2104 5389443 2.83 200.0 µM 6.83E-4 74 0.00231
15 SGTC_2583 asiatic acid 2.77 100.0 µM 8.56E-4 87 0.00276
16 SGTC_372 0155-0182 2.77 15.9 µM 8.57E-4 mitochondrial response to ROS 94 0.00277
17 SGTC_314 1671-0008 2.76 2.7 µM 9.05E-4 130 0.00289
18 SGTC_285 1486-1325 2.75 46.0 µM 9.49E-4 71 0.00300
19 SGTC_2678 equilin 2.74 100.0 µM 9.59E-4 78 0.00303
20 SGTC_1248 0469-0687 2.71 58.6 µM 0.00111 111 0.00341

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 6.50E-18 YPR178W PRP4 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.140 4.07E-16 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
0.126 2.75E-13 YGR003W CUL3 hom Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3
0.126 3.05E-13 YLR450W HMG2 hom HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at the nuclear periphery upon DNA replication stress
0.121 1.78E-12 YNR071C_p YNR071C_p hom Putative aldose 1-epimerase
0.116 1.77E-11 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.110 1.59E-10 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.109 2.42E-10 YLR410W VIP1 hom Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1
0.103 2.19E-9 YER091C MET6 hom Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
0.101 4.53E-9 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.100 5.72E-9 YBR216C YBP1 hom Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication
0.098 1.49E-8 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.094 5.66E-8 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.093 7.23E-8 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.087 4.58E-7 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)