YLR292C / SEC72

Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR292C / SEC72

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:11.00|P-value:2.60E-24 ID:SGTC_37|Compound:0566-0070|FD-Score:3.40|P-value:8.76E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.11|P-value:1.27E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:3.78|P-value:2.51E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:12.60|P-value:1.75E-31 ID:SGTC_89|Compound:0302-0250|FD-Score:4.33|P-value:3.32E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:9.03|P-value:4.41E-17 ID:SGTC_142|Compound:0335-0849|FD-Score:4.00|P-value:1.18E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:5.65|P-value:9.98E-8 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.52|P-value:5.99E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.40|P-value:2.56E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:-6.64|P-value:4.64E-10 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.57|P-value:1.24E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:3.51|P-value:6.12E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.14|P-value:7.71E-9 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.42|P-value:8.27E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:8.78|P-value:3.17E-16 ID:SGTC_543|Compound:3844-1095|FD-Score:6.10|P-value:1.00E-8 ID:SGTC_635|Compound:k038-0028|FD-Score:5.75|P-value:6.02E-8 ID:SGTC_642|Compound:0335-0876|FD-Score:4.20|P-value:5.61E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:4.10|P-value:8.19E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:4.10|P-value:7.98E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:4.18|P-value:6.02E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.77|P-value:2.49E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.61|P-value:4.42E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.62|P-value:1.07E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:5.01|P-value:1.96E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.59|P-value:4.79E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.50|P-value:6.34E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:9.41|P-value:2.30E-18 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.69|P-value:3.41E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.24|P-value:4.86E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.36|P-value:9.95E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.42|P-value:8.39E-4 ID:SGTC_1751|Compound:st044839|FD-Score:4.34|P-value:3.28E-5 ID:SGTC_1752|Compound:st044819|FD-Score:4.12|P-value:7.46E-5 ID:SGTC_1764|Compound:st044502|FD-Score:4.11|P-value:7.79E-5 ID:SGTC_1901|Compound:st060216|FD-Score:4.44|P-value:2.17E-5 ID:SGTC_1925|Compound:st057770|FD-Score:3.65|P-value:3.96E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.45|P-value:7.25E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.93|P-value:1.48E-4 ID:SGTC_2195|Compound:6536160|FD-Score:4.92|P-value:2.98E-6 ID:SGTC_2302|Compound:7771753|FD-Score:-4.18|P-value:5.63E-5 ID:SGTC_2328|Compound:6201408|FD-Score:5.13|P-value:1.15E-6 ID:SGTC_2348|Compound:9022543|FD-Score:3.84|P-value:2.05E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.61|P-value:1.10E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.53|P-value:5.53E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.11|P-value:7.45E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.56|P-value:5.26E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_2799|Compound:7812892|FD-Score:8.08|P-value:5.02E-14 ID:SGTC_2800|Compound:7887935|FD-Score:4.20|P-value:5.62E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-4.14|P-value:6.63E-5 ID:SGTC_2903|Compound:5923464|FD-Score:3.69|P-value:3.40E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.98|P-value:1.26E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.33|P-value:3.33E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.12|P-value:7.64E-5 ID:SGTC_3103|Compound:9120822|FD-Score:3.88|P-value:1.82E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-5.43|P-value:2.74E-7 ID:SGTC_3217|Compound:9129673|FD-Score:3.95|P-value:1.40E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-4.39|P-value:2.57E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:11.00|P-value:2.60E-24 ID:SGTC_37|Compound:0566-0070|FD-Score:3.40|P-value:8.76E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.11|P-value:1.27E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:3.78|P-value:2.51E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:12.60|P-value:1.75E-31 ID:SGTC_89|Compound:0302-0250|FD-Score:4.33|P-value:3.32E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:9.03|P-value:4.41E-17 ID:SGTC_142|Compound:0335-0849|FD-Score:4.00|P-value:1.18E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:5.65|P-value:9.98E-8 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.52|P-value:5.99E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.40|P-value:2.56E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:-6.64|P-value:4.64E-10 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.57|P-value:1.24E-5 ID:SGTC_408|Compound:cantharidin|FD-Score:3.51|P-value:6.12E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.14|P-value:7.71E-9 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.42|P-value:8.27E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:8.78|P-value:3.17E-16 ID:SGTC_543|Compound:3844-1095|FD-Score:6.10|P-value:1.00E-8 ID:SGTC_635|Compound:k038-0028|FD-Score:5.75|P-value:6.02E-8 ID:SGTC_642|Compound:0335-0876|FD-Score:4.20|P-value:5.61E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:4.10|P-value:8.19E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:4.10|P-value:7.98E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:4.18|P-value:6.02E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.77|P-value:2.49E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.61|P-value:4.42E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.62|P-value:1.07E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:5.01|P-value:1.96E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.59|P-value:4.79E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.50|P-value:6.34E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:9.41|P-value:2.30E-18 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.69|P-value:3.41E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.24|P-value:4.86E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.36|P-value:9.95E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.42|P-value:8.39E-4 ID:SGTC_1751|Compound:st044839|FD-Score:4.34|P-value:3.28E-5 ID:SGTC_1752|Compound:st044819|FD-Score:4.12|P-value:7.46E-5 ID:SGTC_1764|Compound:st044502|FD-Score:4.11|P-value:7.79E-5 ID:SGTC_1901|Compound:st060216|FD-Score:4.44|P-value:2.17E-5 ID:SGTC_1925|Compound:st057770|FD-Score:3.65|P-value:3.96E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.45|P-value:7.25E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.93|P-value:1.48E-4 ID:SGTC_2195|Compound:6536160|FD-Score:4.92|P-value:2.98E-6 ID:SGTC_2302|Compound:7771753|FD-Score:-4.18|P-value:5.63E-5 ID:SGTC_2328|Compound:6201408|FD-Score:5.13|P-value:1.15E-6 ID:SGTC_2348|Compound:9022543|FD-Score:3.84|P-value:2.05E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.61|P-value:1.10E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.53|P-value:5.53E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.11|P-value:7.45E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.56|P-value:5.26E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_2799|Compound:7812892|FD-Score:8.08|P-value:5.02E-14 ID:SGTC_2800|Compound:7887935|FD-Score:4.20|P-value:5.62E-5 ID:SGTC_2803|Compound:7707263|FD-Score:-4.14|P-value:6.63E-5 ID:SGTC_2903|Compound:5923464|FD-Score:3.69|P-value:3.40E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.98|P-value:1.26E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.33|P-value:3.33E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.12|P-value:7.64E-5 ID:SGTC_3103|Compound:9120822|FD-Score:3.88|P-value:1.82E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-5.43|P-value:2.74E-7 ID:SGTC_3217|Compound:9129673|FD-Score:3.95|P-value:1.40E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-4.39|P-value:2.57E-5

Top fitness defect scores for YLR292C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_86 0417-1630 12.60 471.9 µM 1.75E-31 ubiquinone biosynthesis & proteasome 25 9.45E-37
2 SGTC_16 erodoxin 11.00 22.8 µM 2.60E-24 unfolded protein response 10 2.60E-28
3 SGTC_1239 0337-0584 9.41 35.4 µM 2.30E-18 unfolded protein response 8 2.56E-21
4 SGTC_137 0438-0332 9.03 85.4 µM 4.41E-17 ubiquinone biosynthesis & proteasome 30 8.26E-20
5 SGTC_513 4245-1575 8.78 41.7 µM 3.17E-16 unfolded protein response 22 8.39E-19
6 SGTC_2799 7812892 8.08 81.8 µM 5.02E-14 superoxide 3 3.23E-16
7 SGTC_445 e6 berbamine 6.14 66.0 µM 7.71E-9 NEO1-PIK1 27 4.01E-10
8 SGTC_543 3844-1095 6.10 191.0 µM 1.00E-8 ERG2 17 5.43E-10
9 SGTC_635 k038-0028 5.75 24.7 µM 6.02E-8 ubiquinone biosynthesis & proteasome 16 4.47E-9
10 SGTC_158 k038-0087 5.65 26.4 µM 9.98E-8 ubiquinone biosynthesis & proteasome 75 8.09E-9
11 SGTC_2328 6201408 5.13 200.0 µM 1.15E-6 7 1.41E-7
12 SGTC_64 000l-0018 5.11 272.1 µM 1.27E-6 ubiquinone biosynthesis & proteasome 104 1.59E-7
13 SGTC_1144 3486-0183 5.01 12.5 µM 1.96E-6 11 2.65E-7
14 SGTC_2195 6536160 4.92 144.2 µM 2.98E-6 60S ribosome export 2 4.34E-7
15 SGTC_1135 dihydrocapsaicin 4.62 536.7 nM 1.07E-5 19 1.94E-6
16 SGTC_2582 agaric acid 4.61 100.0 µM 1.10E-5 redox potentiating 249 2.01E-6
17 SGTC_1901 st060216 4.44 58.6 µM 2.17E-5 16 4.44E-6
18 SGTC_341 1486-1430 4.40 230.0 µM 2.56E-5 14 5.38E-6
19 SGTC_1751 st044839 4.34 27.2 µM 3.28E-5 Golgi 8 7.20E-6
20 SGTC_89 0302-0250 4.33 142.1 µM 3.32E-5 12 7.30E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.357 1.12E-101 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.333 7.73E-88 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.291 1.37E-66 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.279 4.87E-61 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.278 9.56E-61 YHR079C IRE1 hom Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.276 7.02E-60 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.269 8.47E-57 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.261 2.00E-53 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.254 1.47E-50 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.252 1.10E-49 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.251 2.36E-49 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.251 2.69E-49 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.250 5.30E-49 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.249 1.75E-48 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.247 7.23E-48 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p