YLR295C / ATP14

Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR295C / ATP14

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.91|P-value:5.72E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.82|P-value:3.25E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.35|P-value:6.55E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:4.65|P-value:1.64E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.65|P-value:5.53E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.47|P-value:9.80E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.78|P-value:8.80E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:7.67|P-value:3.30E-12 ID:SGTC_211|Compound:3455-0679|FD-Score:3.60|P-value:6.41E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.95|P-value:2.11E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.18|P-value:1.02E-16 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.39|P-value:4.32E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:7.47|P-value:1.15E-11 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.46|P-value:9.20E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.97|P-value:1.76E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.85|P-value:2.94E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.63|P-value:5.38E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.38|P-value:4.51E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.87|P-value:2.69E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.48|P-value:9.39E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-4.41|P-value:3.60E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.22|P-value:7.97E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.72|P-value:4.39E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.93|P-value:2.23E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-5.05|P-value:2.78E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:5.82|P-value:9.54E-8 ID:SGTC_978|Compound:1416-0512|FD-Score:-4.26|P-value:6.37E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.54|P-value:7.84E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.56|P-value:7.34E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.91|P-value:2.37E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.18|P-value:5.74E-11 ID:SGTC_1722|Compound:st034304|FD-Score:4.17|P-value:9.70E-5 ID:SGTC_1742|Compound:st038235|FD-Score:5.70|P-value:1.70E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.40|P-value:3.73E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.72|P-value:4.46E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.88|P-value:2.59E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.21|P-value:1.59E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.93|P-value:2.25E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-5.45|P-value:4.75E-7 ID:SGTC_2048|Compound:5246248|FD-Score:-3.50|P-value:8.10E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.61|P-value:6.30E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.11|P-value:1.10E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.57|P-value:2.18E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.81|P-value:8.62E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.54|P-value:7.82E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-4.53|P-value:2.34E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.07|P-value:1.38E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.71|P-value:1.17E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-3.96|P-value:1.82E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.42|P-value:3.92E-5 ID:SGTC_2465|Compound:5809242|FD-Score:3.71|P-value:4.56E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.81|P-value:8.59E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.64|P-value:5.77E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.83|P-value:3.09E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.79|P-value:3.53E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.18|P-value:8.65E-5 ID:SGTC_2818|Compound:7996756|FD-Score:3.50|P-value:8.83E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.23|P-value:7.93E-5 ID:SGTC_2826|Compound:7992541|FD-Score:3.52|P-value:8.33E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.72|P-value:4.38E-4 ID:SGTC_3115|Compound:9123671|FD-Score:4.50|P-value:2.88E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.34|P-value:4.84E-5 ID:SGTC_3287|Compound:9117173|FD-Score:-4.48|P-value:2.82E-5 ID:SGTC_3329|Compound:9141233|FD-Score:-3.59|P-value:6.11E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.91|P-value:5.72E-6 ID:SGTC_19|Compound:0279-0214|FD-Score:3.82|P-value:3.25E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.35|P-value:6.55E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:4.65|P-value:1.64E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.65|P-value:5.53E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.47|P-value:9.80E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.78|P-value:8.80E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:7.67|P-value:3.30E-12 ID:SGTC_211|Compound:3455-0679|FD-Score:3.60|P-value:6.41E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.95|P-value:2.11E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.18|P-value:1.02E-16 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.39|P-value:4.32E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:7.47|P-value:1.15E-11 ID:SGTC_352|Compound:k048-0007|FD-Score:-3.46|P-value:9.20E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.97|P-value:1.76E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.85|P-value:2.94E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.63|P-value:5.38E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:4.38|P-value:4.51E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:3.87|P-value:2.69E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.48|P-value:9.39E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-4.41|P-value:3.60E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.22|P-value:7.97E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.72|P-value:4.39E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.93|P-value:2.23E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-5.05|P-value:2.78E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:5.82|P-value:9.54E-8 ID:SGTC_978|Compound:1416-0512|FD-Score:-4.26|P-value:6.37E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.54|P-value:7.84E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.56|P-value:7.34E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.91|P-value:2.37E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-7.18|P-value:5.74E-11 ID:SGTC_1722|Compound:st034304|FD-Score:4.17|P-value:9.70E-5 ID:SGTC_1742|Compound:st038235|FD-Score:5.70|P-value:1.70E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.40|P-value:3.73E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.72|P-value:4.46E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.88|P-value:2.59E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:5.21|P-value:1.59E-6 ID:SGTC_2016|Compound:5121758|FD-Score:3.93|P-value:2.25E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-5.45|P-value:4.75E-7 ID:SGTC_2048|Compound:5246248|FD-Score:-3.50|P-value:8.10E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.61|P-value:6.30E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.11|P-value:1.10E-4 ID:SGTC_2134|Compound:5324836|FD-Score:4.57|P-value:2.18E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.81|P-value:8.62E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.54|P-value:7.82E-4 ID:SGTC_2308|Compound:7584454|FD-Score:-4.53|P-value:2.34E-5 ID:SGTC_2314|Compound:7727897|FD-Score:4.07|P-value:1.38E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.71|P-value:1.17E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-3.96|P-value:1.82E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.42|P-value:3.92E-5 ID:SGTC_2465|Compound:5809242|FD-Score:3.71|P-value:4.56E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:4.81|P-value:8.59E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.64|P-value:5.77E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.83|P-value:3.09E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.79|P-value:3.53E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.18|P-value:8.65E-5 ID:SGTC_2818|Compound:7996756|FD-Score:3.50|P-value:8.83E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.23|P-value:7.93E-5 ID:SGTC_2826|Compound:7992541|FD-Score:3.52|P-value:8.33E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.72|P-value:4.38E-4 ID:SGTC_3115|Compound:9123671|FD-Score:4.50|P-value:2.88E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.34|P-value:4.84E-5 ID:SGTC_3287|Compound:9117173|FD-Score:-4.48|P-value:2.82E-5 ID:SGTC_3329|Compound:9141233|FD-Score:-3.59|P-value:6.11E-4

Top fitness defect scores for YLR295C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.18 5.3 µM 1.02E-16 211 2.13E-20
2 SGTC_173 1273-0061 7.67 2.7 µM 3.30E-12 mitochondrial stress 75 8.52E-15
3 SGTC_310 1273-0058 7.47 1.1 µM 1.15E-11 mitochondrial stress 103 4.00E-14
4 SGTC_28 pentachloropyridine N-oxide 6.35 1.6 µM 6.55E-9 TSC3-RPN4 13 1.05E-10
5 SGTC_943 3253-1379 5.82 105.0 µM 9.54E-8 6 2.91E-9
6 SGTC_1742 st038235 5.70 28.9 µM 1.70E-7 mitochondrial stress 53 5.95E-9
7 SGTC_1883 5-benzylidenerhodanine 5.21 20.0 µM 1.59E-6 TRP & mitochondrial translation 25 9.48E-8
8 SGTC_10 0279-0212 4.91 42.6 µM 5.72E-6 TRP & mitochondrial translation 66 4.61E-7
9 SGTC_2503 beta-caryophyllene alcohol 4.81 24.7 µM 8.59E-6 4 7.63E-7
10 SGTC_2232 chlorophetanol 4.81 41.5 µM 8.62E-6 TRP & mitochondrial translation 86 7.67E-7
11 SGTC_58 0957-0393 4.65 9.0 µM 1.64E-5 cell wall 319 1.70E-6
12 SGTC_2134 5324836 4.57 1.5 µM 2.18E-5 11 2.42E-6
13 SGTC_3115 9123671 4.50 49.5 µM 2.88E-5 2 3.40E-6
14 SGTC_2460 5552655 4.42 174.2 µM 3.92E-5 amide catabolism 20 4.99E-6
15 SGTC_275 trichlorophene 4.39 5.7 µM 4.32E-5 mitochondrial stress 203 5.61E-6
16 SGTC_744 1594-0068 4.38 283.0 µM 4.51E-5 amide catabolism 19 5.92E-6
17 SGTC_2821 7996764 4.23 71.4 µM 7.93E-5 30 1.19E-5
18 SGTC_767 0929-0023 4.22 86.0 µM 7.97E-5 TRP & mitochondrial translation 59 1.20E-5
19 SGTC_1722 st034304 4.17 3.6 µM 9.70E-5 mitochondrial processes 19 1.52E-5
20 SGTC_2314 7727897 4.07 200.0 µM 1.38E-4 18 2.36E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.409 2.06E-135 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.401 1.20E-129 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.390 3.26E-122 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.389 7.39E-121 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.388 9.45E-121 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.388 5.12E-121 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.387 5.07E-120 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.385 4.82E-119 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.380 5.65E-116 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.379 2.81E-115 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.378 1.84E-114 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.375 1.07E-112 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.374 4.01E-112 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.371 7.52E-110 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.368 7.27E-108 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated