YLR296W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR296W / YLR296W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.19|P-value:6.18E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:5.50|P-value:1.32E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:-4.19|P-value:1.05E-5 ID:SGTC_459|Compound:nigericin|FD-Score:5.73|P-value:3.29E-9 ID:SGTC_555|Compound:4296-0685|FD-Score:3.81|P-value:5.87E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:4.36|P-value:5.19E-6 ID:SGTC_723|Compound:4182-0001|FD-Score:3.12|P-value:8.13E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.15|P-value:7.17E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.26|P-value:8.26E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.29|P-value:4.13E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.32|P-value:3.86E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.40|P-value:2.78E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.16|P-value:6.89E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.20|P-value:6.14E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:-3.50|P-value:1.87E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:-3.05|P-value:9.64E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.06|P-value:9.97E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-3.35|P-value:3.31E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.07|P-value:9.65E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.51|P-value:1.92E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.79|P-value:6.27E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.72|P-value:8.42E-5 ID:SGTC_2100|Compound:5377183|FD-Score:4.67|P-value:1.17E-6 ID:SGTC_2176|Compound:5809774|FD-Score:-4.14|P-value:1.27E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-3.81|P-value:5.38E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-3.32|P-value:3.73E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.19|P-value:1.10E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.46|P-value:2.34E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.11|P-value:8.20E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.80|P-value:5.73E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-5.06|P-value:1.41E-7 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.87|P-value:3.68E-7 ID:SGTC_2783|Compound:7738165|FD-Score:5.25|P-value:5.26E-8 ID:SGTC_2865|Compound:9030313|FD-Score:3.20|P-value:6.02E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.22|P-value:5.65E-4 ID:SGTC_2974|Compound:9094440|FD-Score:5.93|P-value:9.64E-10 ID:SGTC_3141|Compound:9094609|FD-Score:4.38|P-value:4.57E-6 ID:SGTC_3335|Compound:9143315|FD-Score:-3.05|P-value:9.60E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.19|P-value:6.18E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:5.50|P-value:1.32E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:-4.19|P-value:1.05E-5 ID:SGTC_459|Compound:nigericin|FD-Score:5.73|P-value:3.29E-9 ID:SGTC_555|Compound:4296-0685|FD-Score:3.81|P-value:5.87E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:4.36|P-value:5.19E-6 ID:SGTC_723|Compound:4182-0001|FD-Score:3.12|P-value:8.13E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.15|P-value:7.17E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:4.26|P-value:8.26E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.29|P-value:4.13E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.32|P-value:3.86E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.40|P-value:2.78E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:3.16|P-value:6.89E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.20|P-value:6.14E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:-3.50|P-value:1.87E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:-3.05|P-value:9.64E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.06|P-value:9.97E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-3.35|P-value:3.31E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.07|P-value:9.65E-4 ID:SGTC_1966|Compound:st070145|FD-Score:3.51|P-value:1.92E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.79|P-value:6.27E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.72|P-value:8.42E-5 ID:SGTC_2100|Compound:5377183|FD-Score:4.67|P-value:1.17E-6 ID:SGTC_2176|Compound:5809774|FD-Score:-4.14|P-value:1.27E-5 ID:SGTC_2268|Compound:7933382|FD-Score:-3.81|P-value:5.38E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-3.32|P-value:3.73E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.19|P-value:1.10E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.46|P-value:2.34E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.11|P-value:8.20E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.80|P-value:5.73E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-5.06|P-value:1.41E-7 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.87|P-value:3.68E-7 ID:SGTC_2783|Compound:7738165|FD-Score:5.25|P-value:5.26E-8 ID:SGTC_2865|Compound:9030313|FD-Score:3.20|P-value:6.02E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.22|P-value:5.65E-4 ID:SGTC_2974|Compound:9094440|FD-Score:5.93|P-value:9.64E-10 ID:SGTC_3141|Compound:9094609|FD-Score:4.38|P-value:4.57E-6 ID:SGTC_3335|Compound:9143315|FD-Score:-3.05|P-value:9.60E-4

Top fitness defect scores for YLR296W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2974 9094440 5.93 9.7 µM 9.64E-10 ergosterol biosynthesis 14 1.52E-9
2 SGTC_459 nigericin 5.73 15.3 µM 3.29E-9 36 5.02E-9
3 SGTC_379 3970-0972 5.50 5.9 µM 1.32E-8 tubulin folding & SWR complex 6 1.95E-8
4 SGTC_2783 7738165 5.25 71.4 µM 5.26E-8 9 7.48E-8
5 SGTC_2100 5377183 4.67 190.0 µM 1.17E-6 60S ribosome export 4 1.54E-6
6 SGTC_3141 9094609 4.38 49.5 µM 4.57E-6 iron homeostasis 29 5.82E-6
7 SGTC_590 k048-0076 4.36 22.4 µM 5.19E-6 RSC & ERG11 7 6.59E-6
8 SGTC_752 1896-0090 4.26 130.0 µM 8.26E-6 TSC3-RPN4 12 1.04E-5
9 SGTC_2413 inermin 4.19 26.1 µM 1.10E-5 45 1.38E-5
10 SGTC_555 4296-0685 3.81 37.0 µM 5.87E-5 ergosterol biosynthesis 11 7.03E-5
11 SGTC_2061 5245884 3.79 81.0 µM 6.27E-5 tubulin folding & SWR complex 26 7.49E-5
12 SGTC_2081 5214970 3.72 32.3 µM 8.42E-5 29 9.99E-5
13 SGTC_1966 st070145 3.51 16.1 µM 1.92E-4 35 2.24E-4
14 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.46 3.7 µM 2.34E-4 134 2.72E-4
15 SGTC_1243 0416-0003 3.32 5.7 µM 3.86E-4 PDR1 61 4.42E-4
16 SGTC_2904 7225135 3.22 42.0 µM 5.65E-4 18 6.42E-4
17 SGTC_2865 9030313 3.20 52.0 µM 6.02E-4 35 6.82E-4
18 SGTC_1435 4092-0789 3.20 56.7 µM 6.14E-4 plasma membrane duress 37 6.96E-4
19 SGTC_6 0844-0013 3.19 19.8 µM 6.18E-4 174 7.00E-4
20 SGTC_1352 1496-0991 3.16 99.0 µM 6.89E-4 tubulin folding & SWR complex 54 7.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.42E-15 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.130 4.94E-14 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.125 4.39E-13 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.116 1.73E-11 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.110 2.01E-10 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.104 1.43E-9 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.103 2.47E-9 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.101 5.50E-9 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.097 1.78E-8 YGL177W_d YGL177W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.63E-8 YDR046C BAP3 hom Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication
0.093 6.38E-8 YML067C ERV41 hom Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
0.091 1.25E-7 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.090 2.03E-7 YKR064W OAF3 hom Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.089 2.39E-7 YBR235W VHC1 hom Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
0.087 4.71E-7 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles