YLR298C / YHC1

Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR298C / YHC1

Click on Significant Values for Screen Details ID:SGTC_107|Compound:0358-0022|FD-Score:2.99|P-value:8.62E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.45|P-value:1.55E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.12|P-value:5.38E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.90|P-value:2.19E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.05|P-value:7.31E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:2.95|P-value:9.98E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.11|P-value:5.67E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.00|P-value:8.90E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.38|P-value:2.05E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.00|P-value:8.54E-4 ID:SGTC_1706|Compound:st031321|FD-Score:3.09|P-value:6.12E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.33|P-value:2.59E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.04|P-value:7.28E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.46|P-value:1.51E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.13|P-value:5.18E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.07|P-value:6.75E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.43|P-value:1.62E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.00|P-value:8.52E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.41|P-value:1.90E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.00|P-value:8.52E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.13|P-value:5.33E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.14|P-value:5.21E-4 ID:SGTC_2838|Compound:9002687|FD-Score:2.99|P-value:8.76E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.05|P-value:7.30E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.55|P-value:1.05E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.17|P-value:4.46E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.17|P-value:4.65E-4 ID:SGTC_2987|Compound:9018338|FD-Score:2.96|P-value:9.66E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.01|P-value:8.11E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.42|P-value:1.71E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.51|P-value:1.28E-4 ID:SGTC_3222|Compound:9128301|FD-Score:2.99|P-value:8.70E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-3.98|P-value:1.68E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.23|P-value:3.83E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.47|P-value:1.40E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:2.99|P-value:8.62E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.45|P-value:1.55E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.12|P-value:5.38E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:3.90|P-value:2.19E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.05|P-value:7.31E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:2.95|P-value:9.98E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.11|P-value:5.67E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.00|P-value:8.90E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.38|P-value:2.05E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.00|P-value:8.54E-4 ID:SGTC_1706|Compound:st031321|FD-Score:3.09|P-value:6.12E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.33|P-value:2.59E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.04|P-value:7.28E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.46|P-value:1.51E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.13|P-value:5.18E-4 ID:SGTC_2263|Compound:7948595|FD-Score:-3.07|P-value:6.75E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.43|P-value:1.62E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.00|P-value:8.52E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.41|P-value:1.90E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.00|P-value:8.52E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.13|P-value:5.33E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.14|P-value:5.21E-4 ID:SGTC_2838|Compound:9002687|FD-Score:2.99|P-value:8.76E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.05|P-value:7.30E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.55|P-value:1.05E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.17|P-value:4.46E-4 ID:SGTC_2972|Compound:9093619|FD-Score:-3.17|P-value:4.65E-4 ID:SGTC_2987|Compound:9018338|FD-Score:2.96|P-value:9.66E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.01|P-value:8.11E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.42|P-value:1.71E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.51|P-value:1.28E-4 ID:SGTC_3222|Compound:9128301|FD-Score:2.99|P-value:8.70E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-3.98|P-value:1.68E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.23|P-value:3.83E-4 ID:SGTC_3312|Compound:9133330|FD-Score:3.47|P-value:1.40E-4

Top fitness defect scores for YLR298C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_543 3844-1095 3.90 191.0 µM 2.19E-5 ERG2 7 4.71E-5 0.13
2 SGTC_3312 9133330 3.47 71.4 µM 1.40E-4 8 2.60E-4 0.31
3 SGTC_113 0099-0221 3.45 2.5 µM 1.55E-4 6 2.85E-4 0.07
4 SGTC_2394 5221648 3.43 200.0 µM 1.62E-4 9 2.97E-4 0.03
5 SGTC_3141 9094609 3.42 49.5 µM 1.71E-4 iron homeostasis 21 3.11E-4 0.03
6 SGTC_1305 1181-0477 3.38 144.0 µM 2.05E-4 10 3.68E-4 0.05
7 SGTC_2971 9092186 3.17 9.9 µM 4.46E-4 ergosterol biosynthesis 15 7.52E-4 0.03
8 SGTC_2098 5376439 3.13 882.5 nM 5.18E-4 12 8.64E-4 0.19
9 SGTC_2697 mebhydrolin 3.13 72.4 µM 5.33E-4 NEO1 14 8.87E-4 0.02
10 SGTC_453 enantio-paf c16 3.12 10.0 µM 5.38E-4 33 8.95E-4 0.03
11 SGTC_1007 4101-0031 3.11 70.0 µM 5.67E-4 10 9.39E-4 0.00
12 SGTC_1706 st031321 3.09 10.0 µM 6.12E-4 TSC3-RPN4 5 0.00101 0.06
13 SGTC_1940 st075990 3.04 51.1 µM 7.28E-4 60S ribosome export 12 0.00118 0.00
14 SGTC_3067 9117431 3.01 49.5 µM 8.11E-4 24 0.00131 0.00
15 SGTC_2648 atorvastatin 3.00 78.7 µM 8.52E-4 azole & statin 15 0.00137 0.01
16 SGTC_2395 5646831 3.00 180.2 µM 8.52E-4 12 0.00137 0.03
17 SGTC_1348 1493-0373 3.00 93.8 µM 8.54E-4 12 0.00137 0.07
18 SGTC_107 0358-0022 2.99 2.7 µM 8.62E-4 SWF1 & branched chain AA biosynthesis 9 0.00138 0.14
19 SGTC_3222 9128301 2.99 49.5 µM 8.70E-4 60S ribosome export 21 0.00139 0.08
20 SGTC_2838 9002687 2.99 71.4 µM 8.76E-4 fatty acid desaturase (OLE1) 34 0.00140 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 1.74E-45 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.146 1.88E-17 YLR037C PAU23 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.117 1.21E-11 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.104 1.52E-9 YGL198W YIP4 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.104 1.76E-9 YMR039C SUB1 hom Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress
0.103 2.62E-9 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.099 8.53E-9 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.099 9.35E-9 YDL134C PPH21 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
0.095 3.69E-8 YGR030C POP6 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.093 7.72E-8 YER182W_p FMP10_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.093 7.88E-8 YNL042W BOP3 hom Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury
0.092 8.34E-8 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.092 1.08E-7 YBR062C_p YBR062C_p hom Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.
0.091 1.22E-7 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.091 1.50E-7 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function