YLR299W / ECM38

Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR299W / ECM38

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-3.60|P-value:1.65E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.06|P-value:1.02E-7 ID:SGTC_534|Compound:k292-0788|FD-Score:3.97|P-value:2.14E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.97|P-value:2.21E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.58|P-value:1.10E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.74|P-value:5.65E-5 ID:SGTC_918|Compound:glabranin|FD-Score:4.01|P-value:1.83E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:3.64|P-value:8.58E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:6.54|P-value:1.04E-11 ID:SGTC_977|Compound:1348-1378|FD-Score:3.66|P-value:8.05E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:3.00|P-value:9.40E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.30|P-value:3.29E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.71|P-value:6.48E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.42|P-value:2.06E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.19|P-value:4.78E-4 ID:SGTC_1757|Compound:st041620|FD-Score:4.75|P-value:5.26E-7 ID:SGTC_1759|Compound:st043059|FD-Score:3.08|P-value:7.16E-4 ID:SGTC_1802|Compound:st050112|FD-Score:6.37|P-value:3.34E-11 ID:SGTC_1806|Compound:st050005|FD-Score:-3.59|P-value:1.67E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.68|P-value:1.19E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.10|P-value:6.78E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.24|P-value:4.13E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.72|P-value:6.23E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-4.48|P-value:3.64E-6 ID:SGTC_2289|Compound:7946404|FD-Score:3.51|P-value:1.43E-4 ID:SGTC_2431|Compound:5490079|FD-Score:-4.12|P-value:1.90E-5 ID:SGTC_2436|Compound:5633522|FD-Score:-4.12|P-value:1.83E-5 ID:SGTC_2438|Compound:5259590|FD-Score:-3.30|P-value:4.96E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.00|P-value:1.93E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.62|P-value:9.35E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.57|P-value:1.13E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.44|P-value:1.91E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.39|P-value:2.28E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.09|P-value:6.91E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.89|P-value:5.03E-5 ID:SGTC_3334|Compound:9142812|FD-Score:-3.23|P-value:6.43E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.72|P-value:6.28E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.60|P-value:1.65E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.06|P-value:1.02E-7 ID:SGTC_534|Compound:k292-0788|FD-Score:3.97|P-value:2.14E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.97|P-value:2.21E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.58|P-value:1.10E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.74|P-value:5.65E-5 ID:SGTC_918|Compound:glabranin|FD-Score:4.01|P-value:1.83E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:3.64|P-value:8.58E-5 ID:SGTC_976|Compound:1348-1067|FD-Score:6.54|P-value:1.04E-11 ID:SGTC_977|Compound:1348-1378|FD-Score:3.66|P-value:8.05E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:3.00|P-value:9.40E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.30|P-value:3.29E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.71|P-value:6.48E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.42|P-value:2.06E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.19|P-value:4.78E-4 ID:SGTC_1757|Compound:st041620|FD-Score:4.75|P-value:5.26E-7 ID:SGTC_1759|Compound:st043059|FD-Score:3.08|P-value:7.16E-4 ID:SGTC_1802|Compound:st050112|FD-Score:6.37|P-value:3.34E-11 ID:SGTC_1806|Compound:st050005|FD-Score:-3.59|P-value:1.67E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.68|P-value:1.19E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.10|P-value:6.78E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.24|P-value:4.13E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.72|P-value:6.23E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-4.48|P-value:3.64E-6 ID:SGTC_2289|Compound:7946404|FD-Score:3.51|P-value:1.43E-4 ID:SGTC_2431|Compound:5490079|FD-Score:-4.12|P-value:1.90E-5 ID:SGTC_2436|Compound:5633522|FD-Score:-4.12|P-value:1.83E-5 ID:SGTC_2438|Compound:5259590|FD-Score:-3.30|P-value:4.96E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.00|P-value:1.93E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.62|P-value:9.35E-5 ID:SGTC_2887|Compound:9044784|FD-Score:3.57|P-value:1.13E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.44|P-value:1.91E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.39|P-value:2.28E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.09|P-value:6.91E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.89|P-value:5.03E-5 ID:SGTC_3334|Compound:9142812|FD-Score:-3.23|P-value:6.43E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.72|P-value:6.28E-5

Top fitness defect scores for YLR299W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_976 1348-1067 6.54 47.6 µM 1.04E-11 60S ribosome export 4 3.05E-11
2 SGTC_1802 st050112 6.37 57.9 µM 3.34E-11 1 9.37E-11
3 SGTC_471 1-acyl-paf 5.06 4.0 µM 1.02E-7 DNA intercalators 11 2.11E-7
4 SGTC_1757 st041620 4.75 31.8 µM 5.26E-7 21 1.02E-6
5 SGTC_918 glabranin 4.01 770.7 nM 1.83E-5 31 3.06E-5
6 SGTC_2539 epi(13)torulosol 4.00 80.0 µM 1.93E-5 26 3.23E-5
7 SGTC_534 k292-0788 3.97 63.4 µM 2.14E-5 mitochondrial processes 29 3.57E-5
8 SGTC_589 1227-0070 3.97 34.1 µM 2.21E-5 28 3.67E-5
9 SGTC_904 1141-0088 3.74 396.0 µM 5.65E-5 14 9.04E-5
10 SGTC_2027 5150920 3.72 200.0 µM 6.23E-5 15 9.93E-5
11 SGTC_3349 9149703 3.72 23.0 µM 6.28E-5 20 1.00E-4
12 SGTC_1167 k781-0610 3.71 148.0 µM 6.48E-5 RNA processing & uracil transport 35 1.03E-4
13 SGTC_977 1348-1378 3.66 135.0 µM 8.05E-5 29 1.27E-4
14 SGTC_949 1165-0505 3.64 146.0 µM 8.58E-5 28 1.35E-4
15 SGTC_2588 indole-3-carbinol 3.62 100.0 µM 9.35E-5 60 1.47E-4
16 SGTC_622 1348-1566 3.58 26.3 µM 1.10E-4 29 1.71E-4
17 SGTC_2887 9044784 3.57 58.4 µM 1.13E-4 fatty acid desaturase (OLE1) 49 1.76E-4
18 SGTC_2289 7946404 3.51 165.1 µM 1.43E-4 109 2.20E-4
19 SGTC_2921 7974240 3.44 10.7 µM 1.91E-4 78 2.91E-4
20 SGTC_1256 0570-0116 3.42 285.0 µM 2.06E-4 34 3.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.16E-8 YGR051C_d YGR051C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
0.081 2.40E-6 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.079 4.67E-6 YKR100C SKG1 hom Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
0.078 5.76E-6 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.078 5.78E-6 YKL079W SMY1 hom Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
0.076 1.12E-5 YBR280C SAF1 hom F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
0.076 1.17E-5 YDR319C_p YFT2_p hom Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens
0.075 1.39E-5 YBR206W_d YBR206W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3
0.074 1.61E-5 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.074 1.67E-5 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.073 2.32E-5 YPL245W_p YPL245W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.072 2.71E-5 YBR040W FIG1 hom Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
0.072 2.94E-5 YBR259W YBR259W hom Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress
0.072 3.27E-5 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.070 4.38E-5 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W