YLR305C / STT4

Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR305C / STT4

Click on Significant Values for Screen Details ID:SGTC_144|Compound:4161-2749|FD-Score:-4.30|P-value:8.70E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.04|P-value:3.55E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.48|P-value:3.30E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.96|P-value:4.89E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.73|P-value:1.61E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:5.97|P-value:1.69E-11 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.22|P-value:1.69E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:6.83|P-value:1.71E-14 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.00|P-value:4.10E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.09|P-value:3.04E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-4.07|P-value:3.02E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:-2.86|P-value:7.18E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.08|P-value:3.01E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.13|P-value:2.62E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.64|P-value:2.50E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.63|P-value:2.64E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.15|P-value:5.16E-9 ID:SGTC_1123|Compound:mangostin|FD-Score:-2.83|P-value:8.14E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.41|P-value:7.83E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.53|P-value:4.26E-5 ID:SGTC_1720|Compound:st037298|FD-Score:2.93|P-value:5.83E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.47|P-value:5.98E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-3.61|P-value:2.95E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.14|P-value:2.50E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-4.66|P-value:1.11E-7 ID:SGTC_2118|Compound:5526350|FD-Score:-5.14|P-value:5.33E-9 ID:SGTC_2119|Compound:5528445|FD-Score:2.90|P-value:6.63E-4 ID:SGTC_2135|Compound:5326629|FD-Score:2.92|P-value:5.94E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-2.80|P-value:9.16E-4 ID:SGTC_2204|Compound:7233102|FD-Score:-2.78|P-value:9.65E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.49|P-value:5.15E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.93|P-value:6.62E-6 ID:SGTC_2487|Compound:5918373|FD-Score:2.87|P-value:7.42E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.38|P-value:8.43E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-2.82|P-value:8.41E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-2.90|P-value:6.20E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.58|P-value:3.53E-5 ID:SGTC_2708|Compound:st078559|FD-Score:-4.73|P-value:7.11E-8 ID:SGTC_2714|Compound:st079313|FD-Score:-6.26|P-value:1.74E-12 ID:SGTC_2815|Compound:7968870|FD-Score:4.09|P-value:2.90E-6 ID:SGTC_2855|Compound:9016525|FD-Score:2.87|P-value:7.21E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-2.94|P-value:5.26E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.23|P-value:1.63E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.03|P-value:3.68E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.25|P-value:1.45E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.35|P-value:1.00E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.53|P-value:4.26E-5 ID:SGTC_3015|Compound:9080845|FD-Score:4.19|P-value:1.64E-6 ID:SGTC_3082|Compound:9117008|FD-Score:-3.23|P-value:1.59E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.09|P-value:3.13E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-3.10|P-value:2.84E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.13|P-value:2.64E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.87|P-value:8.94E-6 ID:SGTC_3145|Compound:9085516|FD-Score:-3.23|P-value:1.65E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.80|P-value:1.18E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:-4.30|P-value:8.70E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.04|P-value:3.55E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.48|P-value:3.30E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.96|P-value:4.89E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.73|P-value:1.61E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:5.97|P-value:1.69E-11 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.22|P-value:1.69E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:6.83|P-value:1.71E-14 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.00|P-value:4.10E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.09|P-value:3.04E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-4.07|P-value:3.02E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:-2.86|P-value:7.18E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.08|P-value:3.01E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.13|P-value:2.62E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.64|P-value:2.50E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.63|P-value:2.64E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.15|P-value:5.16E-9 ID:SGTC_1123|Compound:mangostin|FD-Score:-2.83|P-value:8.14E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.41|P-value:7.83E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.53|P-value:4.26E-5 ID:SGTC_1720|Compound:st037298|FD-Score:2.93|P-value:5.83E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.47|P-value:5.98E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-3.61|P-value:2.95E-5 ID:SGTC_1920|Compound:st075728|FD-Score:3.14|P-value:2.50E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-4.66|P-value:1.11E-7 ID:SGTC_2118|Compound:5526350|FD-Score:-5.14|P-value:5.33E-9 ID:SGTC_2119|Compound:5528445|FD-Score:2.90|P-value:6.63E-4 ID:SGTC_2135|Compound:5326629|FD-Score:2.92|P-value:5.94E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-2.80|P-value:9.16E-4 ID:SGTC_2204|Compound:7233102|FD-Score:-2.78|P-value:9.65E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.49|P-value:5.15E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.93|P-value:6.62E-6 ID:SGTC_2487|Compound:5918373|FD-Score:2.87|P-value:7.42E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.38|P-value:8.43E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-2.82|P-value:8.41E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-2.90|P-value:6.20E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.58|P-value:3.53E-5 ID:SGTC_2708|Compound:st078559|FD-Score:-4.73|P-value:7.11E-8 ID:SGTC_2714|Compound:st079313|FD-Score:-6.26|P-value:1.74E-12 ID:SGTC_2815|Compound:7968870|FD-Score:4.09|P-value:2.90E-6 ID:SGTC_2855|Compound:9016525|FD-Score:2.87|P-value:7.21E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-2.94|P-value:5.26E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.23|P-value:1.63E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.03|P-value:3.68E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.25|P-value:1.45E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.35|P-value:1.00E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.53|P-value:4.26E-5 ID:SGTC_3015|Compound:9080845|FD-Score:4.19|P-value:1.64E-6 ID:SGTC_3082|Compound:9117008|FD-Score:-3.23|P-value:1.59E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.09|P-value:3.13E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-3.10|P-value:2.84E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.13|P-value:2.64E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.87|P-value:8.94E-6 ID:SGTC_3145|Compound:9085516|FD-Score:-3.23|P-value:1.65E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.80|P-value:1.18E-5

Top fitness defect scores for YLR305C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_431 k089-0097 6.83 107.0 µM 1.71E-14 iron homeostasis 3 4.20E-12 0.66
2 SGTC_184 1494-0393 5.97 24.7 µM 1.69E-11 9 1.16E-9 0.17
3 SGTC_152 4469-0003 4.48 551.2 µM 3.30E-7 8 3.68E-6 0.13
4 SGTC_3015 9080845 4.19 49.5 µM 1.64E-6 3 1.37E-5 0.54
5 SGTC_2815 7968870 4.09 71.4 µM 2.90E-6 5 2.18E-5 0.10
6 SGTC_2297 7971671 3.93 152.3 µM 6.62E-6 RNA processing & uracil transport 7 4.28E-5 0.23
7 SGTC_3123 9126162 3.87 49.5 µM 8.94E-6 1 5.48E-5 0.27
8 SGTC_2705 st078069 3.58 42.8 µM 3.53E-5 3 1.69E-4 0.02
9 SGTC_1753 st043925 3.47 64.0 µM 5.98E-5 4 2.61E-4 0.01
10 SGTC_1170 0310-0127 3.41 64.8 µM 7.83E-5 16 3.25E-4 0.02
11 SGTC_2991 9074669 3.35 71.4 µM 1.00E-4 azole & statin 32 3.99E-4 0.02
12 SGTC_1920 st075728 3.14 45.7 µM 2.50E-4 12 8.43E-4 0.10
13 SGTC_720 r052-1644 3.13 49.9 µM 2.62E-4 TSC3-RPN4 18 8.76E-4 0.10
14 SGTC_3108 9121785 3.13 49.5 µM 2.64E-4 21 8.82E-4 0.00
15 SGTC_455 paf C-16 3.09 10.0 µM 3.04E-4 12 9.93E-4 0.06
16 SGTC_3089 9117425 3.09 49.5 µM 3.13E-4 6 0.00102 0.06
17 SGTC_1720 st037298 2.93 9.5 µM 5.83E-4 18 0.00170 0.12
18 SGTC_2135 5326629 2.92 150.4 µM 5.94E-4 RPP1 & pyrimidine depletion 15 0.00172 0.16
19 SGTC_2119 5528445 2.90 120.6 µM 6.63E-4 16 0.00189 0.00
20 SGTC_2855 9016525 2.87 58.4 µM 7.21E-4 17 0.00202 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.158 4.27E-20 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.152 8.64E-19 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.142 1.74E-16 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.139 7.55E-16 YPL133C RDS2 hom Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole
0.135 3.29E-15 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.135 4.33E-15 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.133 1.08E-14 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.130 3.80E-14 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.129 6.36E-14 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.125 3.07E-13 YKL214C YRA2 hom Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
0.125 3.13E-13 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.125 3.71E-13 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.124 4.53E-13 YGL061C DUO1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.123 8.65E-13 YMR230W-A_p YMR230W-A_p hom Putative protein of unknown function
0.122 1.30E-12 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential