YLR307C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR307C-A / YLR307C-A

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:3.04|P-value:4.21E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-2.82|P-value:9.58E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.18|P-value:2.42E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.59|P-value:3.93E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.36|P-value:1.11E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.86|P-value:1.10E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.57|P-value:4.32E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.55|P-value:4.75E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.45|P-value:7.65E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:2.98|P-value:5.27E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-2.83|P-value:9.50E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.11|P-value:3.21E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:2.91|P-value:7.04E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.99|P-value:5.13E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.25|P-value:1.81E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.14|P-value:2.86E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.02|P-value:4.50E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.45|P-value:7.43E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:-6.89|P-value:1.89E-14 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.45|P-value:7.67E-5 ID:SGTC_1656|Compound:st012921|FD-Score:2.83|P-value:9.47E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.08|P-value:3.57E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.25|P-value:1.82E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-2.94|P-value:6.24E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.55|P-value:4.83E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.00|P-value:4.85E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.40|P-value:9.22E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.44|P-value:7.82E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.23|P-value:1.97E-4 ID:SGTC_2208|Compound:7283366|FD-Score:2.98|P-value:5.38E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.49|P-value:6.19E-5 ID:SGTC_2299|Compound:7976368|FD-Score:3.40|P-value:9.31E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.72|P-value:2.22E-5 ID:SGTC_2363|Compound:9053361|FD-Score:2.85|P-value:8.59E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.25|P-value:1.75E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.98|P-value:6.08E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:-2.88|P-value:7.76E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.50|P-value:6.06E-5 ID:SGTC_2625|Compound:euphol|FD-Score:6.46|P-value:6.60E-13 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.05|P-value:4.05E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.23|P-value:1.98E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.38|P-value:1.02E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.57|P-value:4.36E-5 ID:SGTC_3137|Compound:9097352|FD-Score:2.97|P-value:5.45E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.92|P-value:8.43E-6 ID:SGTC_3145|Compound:9085516|FD-Score:-3.05|P-value:3.97E-4 ID:SGTC_3217|Compound:9129673|FD-Score:6.26|P-value:3.08E-12 ID:SGTC_3303|Compound:9125618|FD-Score:2.91|P-value:6.89E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.36|P-value:1.10E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.04|P-value:4.21E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-2.82|P-value:9.58E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.18|P-value:2.42E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.59|P-value:3.93E-5 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.36|P-value:1.11E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.86|P-value:1.10E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.57|P-value:4.32E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.55|P-value:4.75E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.45|P-value:7.65E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:2.98|P-value:5.27E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-2.83|P-value:9.50E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:-3.11|P-value:3.21E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:2.91|P-value:7.04E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.99|P-value:5.13E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.25|P-value:1.81E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.14|P-value:2.86E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.02|P-value:4.50E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.45|P-value:7.43E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:-6.89|P-value:1.89E-14 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.45|P-value:7.67E-5 ID:SGTC_1656|Compound:st012921|FD-Score:2.83|P-value:9.47E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.08|P-value:3.57E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.25|P-value:1.82E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-2.94|P-value:6.24E-4 ID:SGTC_1847|Compound:st056231|FD-Score:-3.55|P-value:4.83E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.00|P-value:4.85E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.40|P-value:9.22E-5 ID:SGTC_2109|Compound:5483026|FD-Score:3.44|P-value:7.82E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.23|P-value:1.97E-4 ID:SGTC_2208|Compound:7283366|FD-Score:2.98|P-value:5.38E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.49|P-value:6.19E-5 ID:SGTC_2299|Compound:7976368|FD-Score:3.40|P-value:9.31E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.72|P-value:2.22E-5 ID:SGTC_2363|Compound:9053361|FD-Score:2.85|P-value:8.59E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.25|P-value:1.75E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.98|P-value:6.08E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:-2.88|P-value:7.76E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.50|P-value:6.06E-5 ID:SGTC_2625|Compound:euphol|FD-Score:6.46|P-value:6.60E-13 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.05|P-value:4.05E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.23|P-value:1.98E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.38|P-value:1.02E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.57|P-value:4.36E-5 ID:SGTC_3137|Compound:9097352|FD-Score:2.97|P-value:5.45E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-3.92|P-value:8.43E-6 ID:SGTC_3145|Compound:9085516|FD-Score:-3.05|P-value:3.97E-4 ID:SGTC_3217|Compound:9129673|FD-Score:6.26|P-value:3.08E-12 ID:SGTC_3303|Compound:9125618|FD-Score:2.91|P-value:6.89E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.36|P-value:1.10E-4

Top fitness defect scores for YLR307C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2625 euphol 6.46 100.0 µM 6.60E-13 3 5.37E-11
2 SGTC_3217 9129673 6.26 49.5 µM 3.08E-12 5 1.93E-10
3 SGTC_2519 cryptotanshinone 3.98 88.0 µM 6.08E-6 heme biosynthesis & mitochondrial translocase 13 3.41E-5
4 SGTC_359 0081-0058 3.86 15.9 µM 1.10E-5 60S ribosome export 45 5.61E-5
5 SGTC_2303 7774051 3.72 200.0 µM 2.22E-5 26 1.01E-4
6 SGTC_236 1509-0011 3.59 5.3 µM 3.93E-5 408 1.62E-4
7 SGTC_3043 9092303 3.57 49.5 µM 4.36E-5 30 1.77E-4
8 SGTC_2621 lithochol-11-enic acid 3.50 100.0 µM 6.06E-5 42 2.33E-4
9 SGTC_2295 7971645 3.49 200.0 µM 6.19E-5 38 2.37E-4
10 SGTC_1447 4239-0816 3.45 81.9 µM 7.43E-5 51 2.77E-4
11 SGTC_402 epigallocatechin gallate 3.45 10.0 µM 7.65E-5 52 2.83E-4
12 SGTC_2109 5483026 3.44 200.0 µM 7.82E-5 RSC complex & mRNA processing 46 2.89E-4
13 SGTC_2299 7976368 3.40 114.9 µM 9.31E-5 50 3.34E-4
14 SGTC_3038 9091290 3.38 49.5 µM 1.02E-4 34 3.61E-4
15 SGTC_243 5hr heat shock (37°C) + splitomicin 3.36 1.0 µM 1.11E-4 heat shock/prefoldin 78 3.87E-4
16 SGTC_2453 5731132 3.25 22.2 µM 1.75E-4 52 5.67E-4
17 SGTC_1810 st050138 3.25 53.0 µM 1.82E-4 PDR1 28 5.86E-4
18 SGTC_2166 5933061 3.23 31.5 µM 1.97E-4 tubulin folding & SWR complex 71 6.26E-4
19 SGTC_2937 9044753 3.23 11.3 µM 1.98E-4 60S ribosome export 66 6.28E-4
20 SGTC_1206 3978-0017 3.14 132.0 µM 2.86E-4 ERG2 62 8.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 6.13E-23 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.161 5.91E-21 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.153 5.11E-19 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.127 1.79E-13 YGR174C CBP4 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex
0.126 2.95E-13 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.123 1.01E-12 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.121 2.21E-12 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.120 2.86E-12 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.120 2.89E-12 YBR085C-A YBR085C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress
0.119 4.97E-12 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.118 7.95E-12 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.116 1.59E-11 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.113 5.93E-11 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.111 1.23E-10 YPR147C_p YPR147C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
0.109 2.74E-10 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication