YLR307W / CDA1

Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR307W / CDA1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:-4.14|P-value:1.08E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:-2.90|P-value:4.55E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-2.79|P-value:7.23E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.22|P-value:1.15E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:5.51|P-value:1.46E-10 ID:SGTC_424|Compound:splitomicin|FD-Score:-2.76|P-value:8.16E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.00|P-value:3.01E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.87|P-value:5.08E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.41|P-value:4.92E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:2.86|P-value:5.32E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.12|P-value:1.85E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.23|P-value:1.08E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.88|P-value:4.49E-6 ID:SGTC_934|Compound:2950-0684|FD-Score:4.35|P-value:3.14E-7 ID:SGTC_1006|Compound:4099-6547|FD-Score:-2.93|P-value:4.08E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.19|P-value:1.29E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.04|P-value:1.89E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.61|P-value:1.81E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.87|P-value:5.22E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.73|P-value:8.73E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.14|P-value:1.64E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.23|P-value:1.07E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.06|P-value:1.74E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.14|P-value:1.62E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:2.91|P-value:4.35E-4 ID:SGTC_1602|Compound:st001878|FD-Score:2.82|P-value:6.34E-4 ID:SGTC_1616|Compound:st002734|FD-Score:2.76|P-value:8.01E-4 ID:SGTC_1634|Compound:st006576|FD-Score:2.82|P-value:6.18E-4 ID:SGTC_1745|Compound:st081495|FD-Score:2.81|P-value:6.53E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.57|P-value:2.19E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-2.86|P-value:5.46E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.01|P-value:2.90E-4 ID:SGTC_2310|Compound:7668677|FD-Score:2.94|P-value:3.77E-4 ID:SGTC_2318|Compound:6029776|FD-Score:2.79|P-value:6.87E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.20|P-value:1.23E-4 ID:SGTC_2339|Compound:9000433|FD-Score:2.74|P-value:8.39E-4 ID:SGTC_2435|Compound:5706476|FD-Score:5.69|P-value:3.81E-11 ID:SGTC_2470|Compound:5664817|FD-Score:-2.78|P-value:7.39E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.09|P-value:2.07E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.08|P-value:2.19E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:2.86|P-value:5.34E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:2.92|P-value:4.16E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.84|P-value:1.53E-8 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.40|P-value:5.04E-5 ID:SGTC_2854|Compound:9024559|FD-Score:5.75|P-value:2.28E-11 ID:SGTC_2975|Compound:9084847|FD-Score:3.68|P-value:1.29E-5 ID:SGTC_3003|Compound:9075612|FD-Score:2.73|P-value:8.79E-4 ID:SGTC_3162|Compound:9099653|FD-Score:2.76|P-value:7.97E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:-4.14|P-value:1.08E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:-2.90|P-value:4.55E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-2.79|P-value:7.23E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.22|P-value:1.15E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:5.51|P-value:1.46E-10 ID:SGTC_424|Compound:splitomicin|FD-Score:-2.76|P-value:8.16E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.00|P-value:3.01E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.87|P-value:5.08E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.41|P-value:4.92E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:2.86|P-value:5.32E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.12|P-value:1.85E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.23|P-value:1.08E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.88|P-value:4.49E-6 ID:SGTC_934|Compound:2950-0684|FD-Score:4.35|P-value:3.14E-7 ID:SGTC_1006|Compound:4099-6547|FD-Score:-2.93|P-value:4.08E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.19|P-value:1.29E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.04|P-value:1.89E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.61|P-value:1.81E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.87|P-value:5.22E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.73|P-value:8.73E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.14|P-value:1.64E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.23|P-value:1.07E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.06|P-value:1.74E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.14|P-value:1.62E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:2.91|P-value:4.35E-4 ID:SGTC_1602|Compound:st001878|FD-Score:2.82|P-value:6.34E-4 ID:SGTC_1616|Compound:st002734|FD-Score:2.76|P-value:8.01E-4 ID:SGTC_1634|Compound:st006576|FD-Score:2.82|P-value:6.18E-4 ID:SGTC_1745|Compound:st081495|FD-Score:2.81|P-value:6.53E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.57|P-value:2.19E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-2.86|P-value:5.46E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.01|P-value:2.90E-4 ID:SGTC_2310|Compound:7668677|FD-Score:2.94|P-value:3.77E-4 ID:SGTC_2318|Compound:6029776|FD-Score:2.79|P-value:6.87E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.20|P-value:1.23E-4 ID:SGTC_2339|Compound:9000433|FD-Score:2.74|P-value:8.39E-4 ID:SGTC_2435|Compound:5706476|FD-Score:5.69|P-value:3.81E-11 ID:SGTC_2470|Compound:5664817|FD-Score:-2.78|P-value:7.39E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.09|P-value:2.07E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.08|P-value:2.19E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:2.86|P-value:5.34E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:2.92|P-value:4.16E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.84|P-value:1.53E-8 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.40|P-value:5.04E-5 ID:SGTC_2854|Compound:9024559|FD-Score:5.75|P-value:2.28E-11 ID:SGTC_2975|Compound:9084847|FD-Score:3.68|P-value:1.29E-5 ID:SGTC_3003|Compound:9075612|FD-Score:2.73|P-value:8.79E-4 ID:SGTC_3162|Compound:9099653|FD-Score:2.76|P-value:7.97E-4

Top fitness defect scores for YLR307W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2854 9024559 5.75 71.4 µM 2.28E-11 4 4.37E-9
2 SGTC_2435 5706476 5.69 10.6 µM 3.81E-11 6 6.47E-9
3 SGTC_344 k064-0035 5.51 6.4 µM 1.46E-10 60S ribosome export 4 1.82E-8
4 SGTC_2756 carbadox 4.84 75.1 µM 1.53E-8 36 6.54E-7
5 SGTC_934 2950-0684 4.35 338.0 µM 3.14E-7 15 6.70E-6
6 SGTC_1014 4130-3005 4.04 69.3 µM 1.89E-6 17 2.68E-5
7 SGTC_2975 9084847 3.68 53.7 µM 1.29E-5 31 1.18E-4
8 SGTC_1871 st057448 3.57 67.3 µM 2.19E-5 38 1.79E-4
9 SGTC_2757 clomiphene 3.40 4.2 µM 5.04E-5 fatty acid desaturase (OLE1) 66 3.41E-4
10 SGTC_1428 4049-0204 3.23 61.7 µM 1.07E-4 33 6.13E-4
11 SGTC_834 0312-0008 3.23 75.7 µM 1.08E-4 NEO1 71 6.15E-4
12 SGTC_2334 9017922 3.20 200.0 µM 1.23E-4 46 6.79E-4
13 SGTC_1010 4112-3296 3.19 15.2 µM 1.29E-4 47 7.05E-4
14 SGTC_1464 k208-0027 3.14 110.0 µM 1.62E-4 48 8.41E-4
15 SGTC_1355 1499-0035 3.14 1.7 µM 1.64E-4 55 8.53E-4
16 SGTC_2255 7941087 3.01 197.4 µM 2.90E-4 79 0.00132
17 SGTC_2310 7668677 2.94 200.0 µM 3.77E-4 97 0.00163
18 SGTC_2642 cholecalciferol 2.92 100.0 µM 4.16E-4 50 0.00176
19 SGTC_1600 coumarin 106 2.91 71.1 µM 4.35E-4 75 0.00182
20 SGTC_563 tetrahydrosecaminediol 2.87 614.0 µM 5.08E-4 amide catabolism 68 0.00205

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 2.14E-15 YPR111W DBF20 hom Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs
0.136 2.60E-15 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.130 5.38E-14 YBL019W APN2 hom Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.129 5.96E-14 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.122 1.37E-12 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.121 1.85E-12 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.121 2.00E-12 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.119 4.39E-12 YDR026C NSI1 hom RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
0.116 1.52E-11 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.116 1.94E-11 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.111 1.22E-10 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.111 1.43E-10 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110 1.66E-10 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.108 4.17E-10 YMR135W-A_d YMR135W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104 1.37E-9 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data