YLR308W / CDA2

Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR308W / CDA2

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:-3.30|P-value:3.86E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.13|P-value:7.13E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.12|P-value:1.34E-5 ID:SGTC_456|Compound:gingerol|FD-Score:-3.76|P-value:6.40E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:3.20|P-value:5.61E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.35|P-value:3.26E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.79|P-value:5.68E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.65|P-value:1.03E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.71|P-value:7.97E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:4.75|P-value:6.84E-7 ID:SGTC_986|Compound:1493-0483|FD-Score:5.21|P-value:5.66E-8 ID:SGTC_987|Compound:1497-1013|FD-Score:8.12|P-value:6.80E-17 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.06|P-value:9.38E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.22|P-value:8.66E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.22|P-value:8.93E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.92|P-value:3.25E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.20|P-value:9.64E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:4.64|P-value:1.16E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.05|P-value:1.89E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.46|P-value:2.17E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.24|P-value:4.83E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.20|P-value:5.67E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.48|P-value:1.99E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.18|P-value:6.07E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-3.42|P-value:2.44E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.42|P-value:2.51E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.19|P-value:5.89E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.30|P-value:3.87E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.27|P-value:4.32E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.07|P-value:9.07E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.22|P-value:5.27E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-5.39|P-value:2.07E-8 ID:SGTC_3016|Compound:9080866|FD-Score:-3.16|P-value:6.47E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.30|P-value:3.89E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.84|P-value:4.65E-5 ID:SGTC_3112|Compound:9123419|FD-Score:3.65|P-value:1.00E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.78|P-value:6.01E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.06|P-value:9.10E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-3.30|P-value:3.86E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.13|P-value:7.13E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.12|P-value:1.34E-5 ID:SGTC_456|Compound:gingerol|FD-Score:-3.76|P-value:6.40E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:3.20|P-value:5.61E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.35|P-value:3.26E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.79|P-value:5.68E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.65|P-value:1.03E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.71|P-value:7.97E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:4.75|P-value:6.84E-7 ID:SGTC_986|Compound:1493-0483|FD-Score:5.21|P-value:5.66E-8 ID:SGTC_987|Compound:1497-1013|FD-Score:8.12|P-value:6.80E-17 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.06|P-value:9.38E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.22|P-value:8.66E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.22|P-value:8.93E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.92|P-value:3.25E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.20|P-value:9.64E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:4.64|P-value:1.16E-6 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.05|P-value:1.89E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.46|P-value:2.17E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.24|P-value:4.83E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.20|P-value:5.67E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.48|P-value:1.99E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.18|P-value:6.07E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-3.42|P-value:2.44E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.42|P-value:2.51E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.19|P-value:5.89E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.30|P-value:3.87E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.27|P-value:4.32E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.07|P-value:9.07E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.22|P-value:5.27E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-5.39|P-value:2.07E-8 ID:SGTC_3016|Compound:9080866|FD-Score:-3.16|P-value:6.47E-4 ID:SGTC_3062|Compound:9077494|FD-Score:3.30|P-value:3.89E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.84|P-value:4.65E-5 ID:SGTC_3112|Compound:9123419|FD-Score:3.65|P-value:1.00E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.78|P-value:6.01E-5 ID:SGTC_3158|Compound:9100007|FD-Score:-3.06|P-value:9.10E-4

Top fitness defect scores for YLR308W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_987 1497-1013 8.12 404.0 µM 6.80E-17 1 2.25E-16
2 SGTC_986 1493-0483 5.21 84.0 µM 5.66E-8 3 9.32E-8
3 SGTC_979 1426-2828 4.75 121.0 µM 6.84E-7 10 1.04E-6
4 SGTC_1427 4048-4900 4.64 550.0 nM 1.16E-6 19 1.73E-6
5 SGTC_1165 k072-0275 4.22 30.3 µM 8.93E-6 35 1.24E-5
6 SGTC_1313 1220-0047 4.20 237.0 µM 9.64E-6 31 1.34E-5
7 SGTC_1557 sumaresinolic acid 4.05 42.3 µM 1.89E-5 19 2.57E-5
8 SGTC_1176 0848-0131 3.92 83.3 µM 3.25E-5 Golgi 22 4.34E-5
9 SGTC_3091 9116372 3.84 49.5 µM 4.65E-5 16 6.13E-5
10 SGTC_576 1073-0113 3.79 22.7 µM 5.68E-5 redox potentiating 68 7.44E-5
11 SGTC_3148 9097893 3.78 49.5 µM 6.01E-5 42 7.86E-5
12 SGTC_692 k241-0027 3.71 77.8 µM 7.97E-5 12 1.03E-4
13 SGTC_3112 9123419 3.65 49.5 µM 1.00E-4 RPP1 & pyrimidine depletion 20 1.29E-4
14 SGTC_654 1124-0271 3.65 80.9 µM 1.03E-4 34 1.32E-4
15 SGTC_2267 7931562 3.48 200.0 µM 1.99E-4 34 2.50E-4
16 SGTC_1638 st008370 3.46 60.6 µM 2.17E-4 ergosterol biosynthesis 46 2.72E-4
17 SGTC_192 3455-0609 3.44 60.9 µM 2.32E-4 25 2.90E-4
18 SGTC_547 1120-0019 3.35 610.0 nM 3.26E-4 azole & statin 49 4.04E-4
19 SGTC_2330 7979373 3.30 200.0 µM 3.87E-4 60S ribosome export 56 4.76E-4
20 SGTC_3062 9077494 3.30 49.5 µM 3.89E-4 mitochondrial response to ROS 53 4.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.31E-11 YDR102C_d YDR102C_d hom Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
0.096 2.78E-8 YNL303W_d YNL303W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.093 6.16E-8 YNR064C YNR064C hom Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
0.085 7.30E-7 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.085 9.34E-7 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
0.076 1.17E-5 YLR250W SSP120 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.075 1.24E-5 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.073 2.54E-5 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.070 4.81E-5 YLR218C COA4 hom Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors
0.069 6.13E-5 YGR224W AZR1 hom Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole
0.069 7.06E-5 YDR425W SNX41 hom Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p
0.068 8.12E-5 YNL245C CWC25 het Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p
0.067 9.94E-5 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.067 1.01E-4 YNL080C EOS1 hom Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene
0.065 1.59E-4 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters