YLR311C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR311C / YLR311C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.27|P-value:1.35E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.14|P-value:9.19E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.22|P-value:7.06E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.78|P-value:1.01E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.58|P-value:2.17E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.21|P-value:8.07E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.81|P-value:1.12E-6 ID:SGTC_448|Compound:monastrol|FD-Score:3.54|P-value:2.48E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:4.90|P-value:7.23E-7 ID:SGTC_883|Compound:0850-0245|FD-Score:3.19|P-value:8.44E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.87|P-value:6.97E-5 ID:SGTC_917|Compound:harmaline|FD-Score:5.03|P-value:3.62E-7 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.18|P-value:8.11E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.44|P-value:3.58E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.75|P-value:1.49E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.34|P-value:8.86E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.26|P-value:6.85E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.58|P-value:2.19E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.01|P-value:4.12E-7 ID:SGTC_1378|Compound:2093-0007|FD-Score:5.59|P-value:1.85E-8 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.70|P-value:1.37E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.31|P-value:1.13E-5 ID:SGTC_1610|Compound:st001799|FD-Score:-3.34|P-value:4.66E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.72|P-value:1.27E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.05|P-value:3.34E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.71|P-value:1.31E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.32|P-value:5.43E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.19|P-value:7.85E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.01|P-value:3.97E-5 ID:SGTC_1902|Compound:st060212|FD-Score:3.15|P-value:9.88E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.55|P-value:2.43E-4 ID:SGTC_2062|Compound:5245942|FD-Score:5.54|P-value:2.38E-8 ID:SGTC_2298|Compound:7976326|FD-Score:-3.42|P-value:3.50E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.72|P-value:1.17E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.99|P-value:4.38E-5 ID:SGTC_2986|Compound:9022445|FD-Score:-4.58|P-value:2.87E-6 ID:SGTC_6|Compound:0844-0013|FD-Score:4.27|P-value:1.35E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.14|P-value:9.19E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.22|P-value:7.06E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.78|P-value:1.01E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.58|P-value:2.17E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:3.21|P-value:8.07E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.81|P-value:1.12E-6 ID:SGTC_448|Compound:monastrol|FD-Score:3.54|P-value:2.48E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:4.90|P-value:7.23E-7 ID:SGTC_883|Compound:0850-0245|FD-Score:3.19|P-value:8.44E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.87|P-value:6.97E-5 ID:SGTC_917|Compound:harmaline|FD-Score:5.03|P-value:3.62E-7 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.18|P-value:8.11E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.44|P-value:3.58E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.75|P-value:1.49E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.34|P-value:8.86E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.26|P-value:6.85E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.58|P-value:2.19E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:5.01|P-value:4.12E-7 ID:SGTC_1378|Compound:2093-0007|FD-Score:5.59|P-value:1.85E-8 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.70|P-value:1.37E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.31|P-value:1.13E-5 ID:SGTC_1610|Compound:st001799|FD-Score:-3.34|P-value:4.66E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.72|P-value:1.27E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.05|P-value:3.34E-5 ID:SGTC_1726|Compound:st035556|FD-Score:3.71|P-value:1.31E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.32|P-value:5.43E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.19|P-value:7.85E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.01|P-value:3.97E-5 ID:SGTC_1902|Compound:st060212|FD-Score:3.15|P-value:9.88E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.55|P-value:2.43E-4 ID:SGTC_2062|Compound:5245942|FD-Score:5.54|P-value:2.38E-8 ID:SGTC_2298|Compound:7976326|FD-Score:-3.42|P-value:3.50E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.72|P-value:1.17E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.99|P-value:4.38E-5 ID:SGTC_2986|Compound:9022445|FD-Score:-4.58|P-value:2.87E-6

Top fitness defect scores for YLR311C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1378 2093-0007 5.59 380.0 nM 1.85E-8 3 1.13E-8
2 SGTC_2062 5245942 5.54 200.0 µM 2.38E-8 1 1.47E-8
3 SGTC_917 harmaline 5.03 728.1 nM 3.62E-7 ergosterol biosynthesis 10 2.41E-7
4 SGTC_1375 2910-0797 5.01 186.0 µM 4.12E-7 12 2.75E-7
5 SGTC_868 0527-0199 4.90 213.0 µM 7.23E-7 fatty acid desaturase (OLE1) 17 4.91E-7
6 SGTC_367 0335-0881 4.81 7.1 µM 1.12E-6 ubiquinone biosynthesis & proteasome 48 7.72E-7
7 SGTC_1064 honokiol 4.75 6.8 µM 1.49E-6 13 1.04E-6
8 SGTC_1580 hydrocortisone 21-hemisuccinate 4.31 43.2 µM 1.13E-5 18 8.33E-6
9 SGTC_6 0844-0013 4.27 19.8 µM 1.35E-5 65 9.97E-6
10 SGTC_1713 st033146 4.05 12.8 µM 3.34E-5 23 2.53E-5
11 SGTC_1743 st037606 4.01 46.4 µM 3.97E-5 22 3.02E-5
12 SGTC_2404 5161160 3.99 200.0 µM 4.38E-5 18 3.34E-5
13 SGTC_885 0865-0106 3.87 16.8 µM 6.97E-5 TSC3-RPN4 29 5.38E-5
14 SGTC_132 0417-1715 3.78 25.8 µM 1.01E-4 RPP1 & pyrimidine depletion 26 7.92E-5
15 SGTC_1675 st018485 3.72 24.5 µM 1.27E-4 60S ribosome export 34 1.00E-4
16 SGTC_1726 st035556 3.71 14.6 µM 1.31E-4 44 1.03E-4
17 SGTC_1524 corynanthine 3.70 62.1 µM 1.37E-4 25 1.08E-4
18 SGTC_152 4469-0003 3.58 551.2 µM 2.17E-4 33 1.73E-4
19 SGTC_1372 2752-0194 3.58 270.0 µM 2.19E-4 27 1.74E-4
20 SGTC_1915 st067105 3.55 30.6 µM 2.43E-4 RNA pol III & RNase P/MRP 63 1.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 8.90E-11 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.111 9.74E-11 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.109 2.81E-10 YDL043C PRP11 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.108 4.05E-10 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.104 1.36E-9 YJL170C ASG7 hom Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor
0.104 1.82E-9 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.095 3.01E-8 YPR027C_p YPR027C_p hom Putative protein of unknown function
0.095 3.63E-8 YOR223W YOR223W hom Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3
0.094 4.56E-8 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.093 6.78E-8 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.093 7.86E-8 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
0.092 9.04E-8 YLR128W DCN1 hom Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
0.091 1.36E-7 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.090 1.55E-7 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.090 2.02E-7 YJL162C JJJ2 hom Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein