YLR312C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR312C / YLR312C

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:-3.33|P-value:8.67E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.39|P-value:1.02E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:4.02|P-value:4.65E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:3.23|P-value:8.27E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.87|P-value:1.32E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.42|P-value:6.44E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.58|P-value:2.46E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.93|P-value:6.61E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.48|P-value:3.50E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.74|P-value:1.40E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.92|P-value:1.12E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:-4.13|P-value:5.02E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:-4.10|P-value:5.50E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.41|P-value:1.59E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:-4.73|P-value:3.99E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:-4.39|P-value:1.74E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.17|P-value:0.00100 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.48|P-value:5.37E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.52|P-value:3.09E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-5.10|P-value:7.17E-7 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.73|P-value:1.42E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.56|P-value:4.99E-6 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.45|P-value:3.85E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.58|P-value:2.47E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.69|P-value:2.61E-4 ID:SGTC_1897|Compound:st060201|FD-Score:4.15|P-value:2.77E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.57|P-value:4.61E-6 ID:SGTC_1919|Compound:st067113|FD-Score:3.74|P-value:1.36E-4 ID:SGTC_1966|Compound:st070145|FD-Score:4.67|P-value:3.02E-6 ID:SGTC_1984|Compound:st072354|FD-Score:3.25|P-value:7.55E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:4.55|P-value:5.09E-6 ID:SGTC_2054|Compound:5233173|FD-Score:3.72|P-value:1.49E-4 ID:SGTC_2255|Compound:7941087|FD-Score:-3.41|P-value:6.69E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-4.64|P-value:5.75E-6 ID:SGTC_2279|Compound:7948423|FD-Score:-4.60|P-value:7.09E-6 ID:SGTC_2474|Compound:5321570|FD-Score:3.84|P-value:9.33E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-3.61|P-value:3.43E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.69|P-value:2.78E-6 ID:SGTC_2997|Compound:9067075|FD-Score:3.34|P-value:5.76E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.42|P-value:6.61E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.84|P-value:9.35E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.48|P-value:3.51E-4 ID:SGTC_3159|Compound:9100096|FD-Score:5.74|P-value:1.46E-8 ID:SGTC_3263|Compound:9137018|FD-Score:-3.77|P-value:1.95E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.28|P-value:6.96E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:-3.33|P-value:8.67E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:4.39|P-value:1.02E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:4.02|P-value:4.65E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:3.23|P-value:8.27E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.46|P-value:3.79E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.87|P-value:1.32E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.42|P-value:6.44E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.58|P-value:2.46E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.93|P-value:6.61E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.48|P-value:3.50E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.74|P-value:1.40E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.92|P-value:1.12E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:-4.13|P-value:5.02E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:-4.10|P-value:5.50E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:-4.41|P-value:1.59E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:-4.73|P-value:3.99E-6 ID:SGTC_1005|Compound:4092-0690|FD-Score:-4.39|P-value:1.74E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.17|P-value:0.00100 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.48|P-value:5.37E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.52|P-value:3.09E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-5.10|P-value:7.17E-7 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.73|P-value:1.42E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.56|P-value:4.99E-6 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.45|P-value:3.85E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.58|P-value:2.47E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-3.69|P-value:2.61E-4 ID:SGTC_1897|Compound:st060201|FD-Score:4.15|P-value:2.77E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.57|P-value:4.61E-6 ID:SGTC_1919|Compound:st067113|FD-Score:3.74|P-value:1.36E-4 ID:SGTC_1966|Compound:st070145|FD-Score:4.67|P-value:3.02E-6 ID:SGTC_1984|Compound:st072354|FD-Score:3.25|P-value:7.55E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:4.55|P-value:5.09E-6 ID:SGTC_2054|Compound:5233173|FD-Score:3.72|P-value:1.49E-4 ID:SGTC_2255|Compound:7941087|FD-Score:-3.41|P-value:6.69E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-4.64|P-value:5.75E-6 ID:SGTC_2279|Compound:7948423|FD-Score:-4.60|P-value:7.09E-6 ID:SGTC_2474|Compound:5321570|FD-Score:3.84|P-value:9.33E-5 ID:SGTC_2810|Compound:7959871|FD-Score:-3.61|P-value:3.43E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.69|P-value:2.78E-6 ID:SGTC_2997|Compound:9067075|FD-Score:3.34|P-value:5.76E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.42|P-value:6.61E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.84|P-value:9.35E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.48|P-value:3.51E-4 ID:SGTC_3159|Compound:9100096|FD-Score:5.74|P-value:1.46E-8 ID:SGTC_3263|Compound:9137018|FD-Score:-3.77|P-value:1.95E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.28|P-value:6.96E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.73|P-value:1.46E-4

Top fitness defect scores for YLR312C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3159 9100096 5.74 49.5 µM 1.46E-8 4 4.88E-9
2 SGTC_2906 7926292 4.69 26.4 µM 2.78E-6 12 1.39E-6
3 SGTC_1966 st070145 4.67 16.1 µM 3.02E-6 12 1.52E-6
4 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.57 70.1 µM 4.61E-6 11 2.40E-6
5 SGTC_1265 0819-1001 4.56 68.8 µM 4.99E-6 12 2.61E-6
6 SGTC_2039 Aminomethylbenzodioxan 4.55 200.0 µM 5.09E-6 2 2.67E-6
7 SGTC_65 0798-0905 4.39 35.0 µM 1.02E-5 calcium & mitochondrial duress 68 5.61E-6
8 SGTC_1897 st060201 4.15 15.0 µM 2.77E-5 mitochondrial processes 14 1.65E-5
9 SGTC_69 0096-0274 4.02 206.7 µM 4.65E-5 mitochondrial processes 38 2.87E-5
10 SGTC_620 0109-0052 3.93 432.0 µM 6.61E-5 19 4.19E-5
11 SGTC_2474 5321570 3.84 43.3 µM 9.33E-5 16 6.07E-5
12 SGTC_3047 9092122 3.84 49.5 µM 9.35E-5 22 6.08E-5
13 SGTC_1919 st067113 3.74 52.3 µM 1.36E-4 TSC3-RPN4 34 9.07E-5
14 SGTC_921 1561-0023 3.74 372.0 µM 1.40E-4 19 9.38E-5
15 SGTC_1212 0520-0165 3.73 585.0 µM 1.42E-4 40 9.55E-5
16 SGTC_3349 9149703 3.73 23.0 µM 1.46E-4 19 9.77E-5
17 SGTC_2054 5233173 3.72 129.0 µM 1.49E-4 mitochondrial response to ROS 64 1.00E-4
18 SGTC_541 4513-1321 3.58 94.0 µM 2.46E-4 31 1.71E-4
19 SGTC_1492 4158-0558 3.58 28.5 µM 2.47E-4 60S ribosome export 23 1.72E-4
20 SGTC_1168 k815-0004 3.52 80.5 µM 3.09E-4 DNA damage response 25 2.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.70E-10 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.092 7.97E-8 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.085 7.58E-7 YBR089C-A NHP6B hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication
0.083 1.61E-6 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.078 5.55E-6 YOL129W VPS68 hom Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
0.078 6.66E-6 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.075 1.31E-5 YHR181W SVP26 hom Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
0.073 2.47E-5 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.073 2.55E-5 YOR348C PUT4 hom Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
0.072 2.68E-5 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.072 3.30E-5 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.070 5.32E-5 YBR242W_p YBR242W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
0.069 5.78E-5 YKL103C APE1 hom Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress
0.069 6.36E-5 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.068 7.86E-5 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene