YLR312W-A / MRPL15

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR312W-A / MRPL15

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:4.85|P-value:1.30E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.76|P-value:1.34E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.22|P-value:9.01E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.59|P-value:2.48E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.80|P-value:1.15E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.89|P-value:7.99E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.23|P-value:8.62E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.03|P-value:5.42E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:3.64|P-value:2.13E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.68|P-value:1.77E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.26|P-value:9.36E-13 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:-3.60|P-value:2.35E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:-3.30|P-value:6.72E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.67|P-value:1.89E-8 ID:SGTC_324|Compound:1315-0088|FD-Score:3.81|P-value:1.10E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:-3.23|P-value:8.64E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.26|P-value:7.85E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.29|P-value:7.09E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.87|P-value:8.49E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.42|P-value:4.47E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.22|P-value:9.01E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.69|P-value:1.73E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.57|P-value:2.65E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-6.01|P-value:2.66E-9 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.43|P-value:8.88E-6 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.54|P-value:2.99E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.34|P-value:1.28E-5 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.22|P-value:9.16E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.98|P-value:6.88E-7 ID:SGTC_1709|Compound:st033179|FD-Score:3.95|P-value:6.44E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-4.30|P-value:1.48E-5 ID:SGTC_2004|Compound:4023728|FD-Score:-3.25|P-value:7.94E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-4.27|P-value:1.67E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-4.03|P-value:4.50E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.78|P-value:1.24E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.42|P-value:4.61E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.61|P-value:2.31E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.59|P-value:4.28E-6 ID:SGTC_2264|Compound:7948757|FD-Score:4.15|P-value:2.86E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.41|P-value:4.67E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.29|P-value:7.10E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.58|P-value:2.56E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.37|P-value:5.34E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.40|P-value:1.02E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.41|P-value:9.57E-6 ID:SGTC_2852|Compound:9023854|FD-Score:3.21|P-value:9.28E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.40|P-value:4.97E-4 ID:SGTC_3121|Compound:9125696|FD-Score:3.38|P-value:5.20E-4 ID:SGTC_3135|Compound:9127742|FD-Score:4.31|P-value:1.46E-5 ID:SGTC_3212|Compound:9128307|FD-Score:6.51|P-value:1.38E-10 ID:SGTC_3285|Compound:9112818|FD-Score:3.26|P-value:7.97E-4 ID:SGTC_3348|Compound:9149464|FD-Score:4.11|P-value:3.41E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.85|P-value:1.30E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.76|P-value:1.34E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.22|P-value:9.01E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.59|P-value:2.48E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.80|P-value:1.15E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.89|P-value:7.99E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.23|P-value:8.62E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.03|P-value:5.42E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:3.64|P-value:2.13E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.68|P-value:1.77E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.26|P-value:9.36E-13 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:-3.60|P-value:2.35E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:-3.30|P-value:6.72E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.67|P-value:1.89E-8 ID:SGTC_324|Compound:1315-0088|FD-Score:3.81|P-value:1.10E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:-3.23|P-value:8.64E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-3.26|P-value:7.85E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.29|P-value:7.09E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.87|P-value:8.49E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.42|P-value:4.47E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.22|P-value:9.01E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.69|P-value:1.73E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.57|P-value:2.65E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-6.01|P-value:2.66E-9 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.43|P-value:8.88E-6 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.54|P-value:2.99E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.34|P-value:1.28E-5 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.22|P-value:9.16E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.98|P-value:6.88E-7 ID:SGTC_1709|Compound:st033179|FD-Score:3.95|P-value:6.44E-5 ID:SGTC_1749|Compound:st037932|FD-Score:-4.30|P-value:1.48E-5 ID:SGTC_2004|Compound:4023728|FD-Score:-3.25|P-value:7.94E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-4.27|P-value:1.67E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-4.03|P-value:4.50E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.78|P-value:1.24E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.42|P-value:4.61E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.61|P-value:2.31E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.59|P-value:4.28E-6 ID:SGTC_2264|Compound:7948757|FD-Score:4.15|P-value:2.86E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.41|P-value:4.67E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.29|P-value:7.10E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.58|P-value:2.56E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.37|P-value:5.34E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.40|P-value:1.02E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.41|P-value:9.57E-6 ID:SGTC_2852|Compound:9023854|FD-Score:3.21|P-value:9.28E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.40|P-value:4.97E-4 ID:SGTC_3121|Compound:9125696|FD-Score:3.38|P-value:5.20E-4 ID:SGTC_3135|Compound:9127742|FD-Score:4.31|P-value:1.46E-5 ID:SGTC_3212|Compound:9128307|FD-Score:6.51|P-value:1.38E-10 ID:SGTC_3285|Compound:9112818|FD-Score:3.26|P-value:7.97E-4 ID:SGTC_3348|Compound:9149464|FD-Score:4.11|P-value:3.41E-5

Top fitness defect scores for YLR312W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 7.26 5.3 µM 9.36E-13 263 1.87E-13
2 SGTC_3212 9128307 6.51 49.5 µM 1.38E-10 12 3.75E-11
3 SGTC_310 1273-0058 5.67 1.1 µM 1.89E-8 mitochondrial stress 152 6.96E-9
4 SGTC_173 1273-0061 5.03 2.7 µM 5.42E-7 mitochondrial stress 148 2.46E-7
5 SGTC_1574 spiramycin 4.98 23.7 µM 6.88E-7 11 3.16E-7
6 SGTC_63 0099-0242 4.85 26.7 µM 1.30E-6 mitochondrial stress 62 6.22E-7
7 SGTC_2250 alverine citrate 4.59 130.0 µM 4.28E-6 117 2.20E-6
8 SGTC_1011 4112-3381 4.43 17.4 µM 8.88E-6 28 4.77E-6
9 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 4.41 100.0 µM 9.57E-6 17 5.16E-6
10 SGTC_2598 perillyl alcohol 4.40 100.0 µM 1.02E-5 20 5.53E-6
11 SGTC_1123 mangostin 4.34 811.3 nM 1.28E-5 mitochondrial response to ROS 29 7.03E-6
12 SGTC_3135 9127742 4.31 49.5 µM 1.46E-5 14 8.11E-6
13 SGTC_2264 7948757 4.15 110.8 µM 2.86E-5 10 1.65E-5
14 SGTC_3348 9149464 4.11 3.5 µM 3.41E-5 11 1.99E-5
15 SGTC_1709 st033179 3.95 39.1 µM 6.44E-5 14 3.90E-5
16 SGTC_324 1315-0088 3.81 19.6 µM 1.10E-4 RSC & ERG11 11 6.89E-5
17 SGTC_141 0443-0274 3.80 32.3 µM 1.15E-4 mitochondrial response to ROS 44 7.20E-5
18 SGTC_2093 5331342 3.78 194.4 µM 1.24E-4 28 7.84E-5
19 SGTC_118 0083-0097 3.76 135.3 µM 1.34E-4 translation 157 8.49E-5
20 SGTC_979 1426-2828 3.69 121.0 µM 1.73E-4 22 1.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.283 9.55E-63 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.275 3.40E-59 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.254 2.01E-50 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.243 3.95E-46 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.240 3.31E-45 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.237 4.60E-44 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.237 4.64E-44 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.235 1.92E-43 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.230 2.12E-41 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.229 4.87E-41 YPR099C_d YPR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W
0.229 5.85E-41 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.228 1.35E-40 YKL138C MRPL31 hom Mitochondrial ribosomal protein of the large subunit
0.226 6.08E-40 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.225 7.02E-40 YKR085C MRPL20 hom Mitochondrial ribosomal protein of the large subunit
0.224 3.37E-39 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase