YLR316C / TAD3

Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR316C / TAD3

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.38|P-value:2.72E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.38|P-value:2.74E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.53|P-value:1.55E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.66|P-value:9.09E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.34|P-value:2.62E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.31|P-value:2.99E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.17|P-value:5.02E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.04|P-value:9.42E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.49|P-value:1.76E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.11|P-value:7.42E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.04|P-value:9.42E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.68|P-value:6.91E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:-3.03|P-value:8.17E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.78|P-value:5.42E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.29|P-value:3.83E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.38|P-value:2.71E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.23|P-value:4.81E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.65|P-value:9.46E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.00|P-value:2.11E-5 ID:SGTC_2070|Compound:5230947|FD-Score:3.35|P-value:3.11E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.22|P-value:4.18E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.13|P-value:6.90E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.72|P-value:7.04E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-4.83|P-value:2.78E-7 ID:SGTC_2517|Compound:totarol|FD-Score:-4.50|P-value:1.56E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.42|P-value:1.90E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.25|P-value:6.63E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.03|P-value:8.11E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-5.34|P-value:1.67E-8 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.30|P-value:3.04E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.05|P-value:1.69E-5 ID:SGTC_3233|Compound:9132340|FD-Score:4.85|P-value:3.43E-7 ID:SGTC_3238|Compound:9133470|FD-Score:-3.21|P-value:4.25E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.23|P-value:4.83E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.68|P-value:8.18E-5 ID:SGTC_3255|Compound:9139072|FD-Score:3.23|P-value:4.84E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.38|P-value:2.72E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:3.38|P-value:2.74E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.53|P-value:1.55E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.66|P-value:9.09E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.34|P-value:2.62E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.31|P-value:2.99E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.17|P-value:5.02E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.04|P-value:9.42E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.49|P-value:1.76E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.11|P-value:7.42E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.04|P-value:9.42E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.68|P-value:6.91E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:-3.03|P-value:8.17E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.78|P-value:5.42E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.29|P-value:3.83E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.38|P-value:2.71E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.23|P-value:4.81E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.65|P-value:9.46E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:4.00|P-value:2.11E-5 ID:SGTC_2070|Compound:5230947|FD-Score:3.35|P-value:3.11E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.22|P-value:4.18E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.13|P-value:6.90E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.72|P-value:7.04E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-4.83|P-value:2.78E-7 ID:SGTC_2517|Compound:totarol|FD-Score:-4.50|P-value:1.56E-6 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.42|P-value:1.90E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.25|P-value:6.63E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.03|P-value:8.11E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-5.34|P-value:1.67E-8 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.30|P-value:3.04E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.05|P-value:1.69E-5 ID:SGTC_3233|Compound:9132340|FD-Score:4.85|P-value:3.43E-7 ID:SGTC_3238|Compound:9133470|FD-Score:-3.21|P-value:4.25E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.23|P-value:4.83E-4 ID:SGTC_3248|Compound:9135562|FD-Score:3.68|P-value:8.18E-5 ID:SGTC_3255|Compound:9139072|FD-Score:3.23|P-value:4.84E-4

Top fitness defect scores for YLR316C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3233 9132340 4.85 49.5 µM 3.43E-7 4 6.32E-7 0.32
2 SGTC_165 k038-0023 4.66 64.4 µM 9.09E-7 ubiquinone biosynthesis & proteasome 17 1.60E-6 0.15
3 SGTC_2588 indole-3-carbinol 4.25 100.0 µM 6.63E-6 5 1.05E-5 0.19
4 SGTC_3078 9116413 4.05 49.5 µM 1.69E-5 unfolded protein response 5 2.56E-5 0.24
5 SGTC_1965 Pectolinarigenin 4.00 58.4 µM 2.11E-5 RPP1 & pyrimidine depletion 4 3.17E-5 0.19
6 SGTC_1692 fluoroquinolonic acid 3.78 71.0 µM 5.42E-5 3 7.76E-5 0.59
7 SGTC_2510 benzyl isothiocyanate 3.72 8.3 µM 7.04E-5 26 9.95E-5 0.05
8 SGTC_3248 9135562 3.68 49.5 µM 8.18E-5 2 1.15E-4 0.28
9 SGTC_1949 st076024 3.65 69.1 µM 9.46E-5 7 1.32E-4 0.03
10 SGTC_128 0906-2981 3.53 13.4 µM 1.55E-4 12 2.10E-4 0.06
11 SGTC_999 4022-0066 3.49 22.7 µM 1.76E-4 Golgi 21 2.38E-4 0.19
12 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 3.46 39.7 µM 2.04E-4 2 2.74E-4 0.03
13 SGTC_1783 st039459 3.38 87.5 µM 2.71E-4 Golgi 14 3.59E-4 0.13
14 SGTC_6 0844-0013 3.38 19.8 µM 2.72E-4 18 3.60E-4 0.02
15 SGTC_66 0109-0187 3.38 42.4 µM 2.74E-4 9 3.62E-4 0.01
16 SGTC_2070 5230947 3.35 200.0 µM 3.11E-4 6 4.09E-4 0.02
17 SGTC_1707 st032323 3.29 6.3 µM 3.83E-4 DNA damage response 40 4.98E-4 0.03
18 SGTC_1909 st060837 3.23 51.5 µM 4.81E-4 14 6.19E-4 0.10
19 SGTC_3247 9135149 3.23 49.5 µM 4.83E-4 DNA damage response 34 6.22E-4 0.00
20 SGTC_3255 9139072 3.23 49.5 µM 4.84E-4 4 6.23E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 7.72E-16 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.120 2.90E-12 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.112 9.47E-11 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.110 1.83E-10 YLR366W_d YLR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
0.107 4.81E-10 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.102 3.39E-9 YNL201C PSY2 hom Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3
0.093 6.55E-8 YGL073W HSF1 het Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
0.088 3.14E-7 YFR022W ROG3 hom Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication
0.088 3.19E-7 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.086 5.99E-7 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.086 6.90E-7 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.085 7.30E-7 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.085 8.57E-7 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.085 8.93E-7 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.083 1.48E-6 YCL040W GLK1 hom Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication