YLR321C / SFH1

Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR321C / SFH1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:6.03|P-value:8.77E-7 ID:SGTC_39|Compound:0986-0283|FD-Score:-5.20|P-value:1.89E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.52|P-value:1.20E-7 ID:SGTC_93|Compound:0109-0045|FD-Score:5.32|P-value:1.25E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:6.57|P-value:9.89E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:5.64|P-value:3.90E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:6.54|P-value:1.10E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:5.80|P-value:2.19E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:4.28|P-value:3.51E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:5.90|P-value:1.50E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:8.71|P-value:2.57E-12 ID:SGTC_288|Compound:1315-0019|FD-Score:5.14|P-value:2.33E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:4.52|P-value:1.73E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.98|P-value:8.01E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:5.06|P-value:3.08E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:4.40|P-value:2.45E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.83|P-value:6.48E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:4.18|P-value:4.65E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.93|P-value:9.18E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.36|P-value:2.78E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:8.50|P-value:8.47E-12 ID:SGTC_590|Compound:k048-0076|FD-Score:4.82|P-value:6.76E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:5.59|P-value:4.81E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:5.52|P-value:6.17E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:4.01|P-value:7.37E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:6.81|P-value:3.39E-8 ID:SGTC_839|Compound:0122-0028|FD-Score:5.28|P-value:1.46E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.33|P-value:2.97E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:6.34|P-value:2.53E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:4.23|P-value:4.03E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.23|P-value:4.01E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.42|P-value:2.33E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.00|P-value:7.58E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.21|P-value:1.81E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.63|P-value:4.09E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.34|P-value:2.57E-7 ID:SGTC_1194|Compound:1488-0194|FD-Score:-4.47|P-value:1.98E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.15|P-value:5.07E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.96|P-value:8.45E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:6.27|P-value:3.41E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:9.62|P-value:1.30E-14 ID:SGTC_1274|Compound:0865-0114|FD-Score:6.53|P-value:1.16E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:11.10|P-value:8.73E-19 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.14|P-value:5.25E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.79|P-value:7.47E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:-4.58|P-value:1.44E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:7.13|P-value:7.97E-9 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.52|P-value:1.71E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.42|P-value:1.87E-7 ID:SGTC_1691|Compound:st019933|FD-Score:-4.18|P-value:4.70E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.37|P-value:1.05E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.97|P-value:8.40E-4 ID:SGTC_1773|Compound:st048542|FD-Score:5.30|P-value:1.34E-5 ID:SGTC_1783|Compound:st039459|FD-Score:6.48|P-value:1.44E-7 ID:SGTC_1915|Compound:st067105|FD-Score:5.84|P-value:1.84E-6 ID:SGTC_1936|Compound:st074407|FD-Score:5.30|P-value:1.32E-5 ID:SGTC_2001|Compound:4023502|FD-Score:4.08|P-value:6.15E-4 ID:SGTC_2006|Compound:4011487|FD-Score:6.91|P-value:2.23E-8 ID:SGTC_2109|Compound:5483026|FD-Score:5.00|P-value:3.77E-5 ID:SGTC_2111|Compound:5486399|FD-Score:7.17|P-value:6.81E-9 ID:SGTC_2186|Compound:6124449|FD-Score:4.10|P-value:5.77E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.71|P-value:9.42E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.04|P-value:6.90E-4 ID:SGTC_2534|Compound:helenine|FD-Score:5.51|P-value:6.35E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.35|P-value:2.81E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.94|P-value:8.99E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.31|P-value:3.23E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.47|P-value:2.02E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.69|P-value:1.01E-4 ID:SGTC_2830|Compound:7992007|FD-Score:5.05|P-value:3.19E-5 ID:SGTC_2912|Compound:7964298|FD-Score:7.61|P-value:8.50E-10 ID:SGTC_2955|Compound:9076254|FD-Score:-4.40|P-value:2.44E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.95|P-value:4.41E-5 ID:SGTC_2974|Compound:9094440|FD-Score:7.43|P-value:1.98E-9 ID:SGTC_3154|Compound:9100113|FD-Score:4.41|P-value:2.39E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.56|P-value:1.08E-9 ID:SGTC_22|Compound:0964-0034|FD-Score:6.03|P-value:8.77E-7 ID:SGTC_39|Compound:0986-0283|FD-Score:-5.20|P-value:1.89E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.52|P-value:1.20E-7 ID:SGTC_93|Compound:0109-0045|FD-Score:5.32|P-value:1.25E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:6.57|P-value:9.89E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:5.64|P-value:3.90E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:6.54|P-value:1.10E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:5.80|P-value:2.19E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:4.28|P-value:3.51E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:5.90|P-value:1.50E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:8.71|P-value:2.57E-12 ID:SGTC_288|Compound:1315-0019|FD-Score:5.14|P-value:2.33E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:4.52|P-value:1.73E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.98|P-value:8.01E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:5.06|P-value:3.08E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:4.40|P-value:2.45E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.83|P-value:6.48E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:4.18|P-value:4.65E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.93|P-value:9.18E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.36|P-value:2.78E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:8.50|P-value:8.47E-12 ID:SGTC_590|Compound:k048-0076|FD-Score:4.82|P-value:6.76E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:5.59|P-value:4.81E-6 ID:SGTC_673|Compound:1082-0474|FD-Score:5.52|P-value:6.17E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:4.01|P-value:7.37E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:6.81|P-value:3.39E-8 ID:SGTC_839|Compound:0122-0028|FD-Score:5.28|P-value:1.46E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.33|P-value:2.97E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:6.34|P-value:2.53E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:4.23|P-value:4.03E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.23|P-value:4.01E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.42|P-value:2.33E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.00|P-value:7.58E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.21|P-value:1.81E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.63|P-value:4.09E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:6.34|P-value:2.57E-7 ID:SGTC_1194|Compound:1488-0194|FD-Score:-4.47|P-value:1.98E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.15|P-value:5.07E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.96|P-value:8.45E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:6.27|P-value:3.41E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:9.62|P-value:1.30E-14 ID:SGTC_1274|Compound:0865-0114|FD-Score:6.53|P-value:1.16E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:11.10|P-value:8.73E-19 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.14|P-value:5.25E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.79|P-value:7.47E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:-4.58|P-value:1.44E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:7.13|P-value:7.97E-9 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.52|P-value:1.71E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.42|P-value:1.87E-7 ID:SGTC_1691|Compound:st019933|FD-Score:-4.18|P-value:4.70E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.37|P-value:1.05E-5 ID:SGTC_1731|Compound:st035964|FD-Score:3.97|P-value:8.40E-4 ID:SGTC_1773|Compound:st048542|FD-Score:5.30|P-value:1.34E-5 ID:SGTC_1783|Compound:st039459|FD-Score:6.48|P-value:1.44E-7 ID:SGTC_1915|Compound:st067105|FD-Score:5.84|P-value:1.84E-6 ID:SGTC_1936|Compound:st074407|FD-Score:5.30|P-value:1.32E-5 ID:SGTC_2001|Compound:4023502|FD-Score:4.08|P-value:6.15E-4 ID:SGTC_2006|Compound:4011487|FD-Score:6.91|P-value:2.23E-8 ID:SGTC_2109|Compound:5483026|FD-Score:5.00|P-value:3.77E-5 ID:SGTC_2111|Compound:5486399|FD-Score:7.17|P-value:6.81E-9 ID:SGTC_2186|Compound:6124449|FD-Score:4.10|P-value:5.77E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.71|P-value:9.42E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.04|P-value:6.90E-4 ID:SGTC_2534|Compound:helenine|FD-Score:5.51|P-value:6.35E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.35|P-value:2.81E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:3.94|P-value:8.99E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.31|P-value:3.23E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.47|P-value:2.02E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.69|P-value:1.01E-4 ID:SGTC_2830|Compound:7992007|FD-Score:5.05|P-value:3.19E-5 ID:SGTC_2912|Compound:7964298|FD-Score:7.61|P-value:8.50E-10 ID:SGTC_2955|Compound:9076254|FD-Score:-4.40|P-value:2.44E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.95|P-value:4.41E-5 ID:SGTC_2974|Compound:9094440|FD-Score:7.43|P-value:1.98E-9 ID:SGTC_3154|Compound:9100113|FD-Score:4.41|P-value:2.39E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.56|P-value:1.08E-9

Top fitness defect scores for YLR321C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1374 2889-5571 11.10 141.0 µM 8.73E-19 RSC complex & mRNA processing 11 8.24E-29 0.30
2 SGTC_1239 0337-0584 9.62 35.4 µM 1.30E-14 unfolded protein response 5 3.43E-22 0.06
3 SGTC_268 camptothecin 8.71 39.6 µM 2.57E-12 DNA damage response 11 1.48E-18 0.68
4 SGTC_586 0957-0265 8.50 8.2 µM 8.47E-12 cell wall 13 9.74E-18 0.35
5 SGTC_2912 7964298 7.61 10.9 µM 8.50E-10 cell wall 19 1.42E-14 0.62
6 SGTC_3304 9125678 7.56 46.1 µM 1.08E-9 14 2.08E-14 0.04
7 SGTC_2974 9094440 7.43 9.7 µM 1.98E-9 ergosterol biosynthesis 5 5.40E-14 0.43
8 SGTC_2111 5486399 7.17 200.0 µM 6.81E-9 11 3.79E-13 0.36
9 SGTC_1493 4348-0038 7.13 111.0 µM 7.97E-9 RSC complex & mRNA processing 9 4.87E-13 0.17
10 SGTC_2006 4011487 6.91 200.0 µM 2.23E-8 endomembrane recycling 8 2.46E-12 0.05
11 SGTC_829 1635-0120 6.81 117.0 µM 3.39E-8 DNA damage response 24 4.78E-12 0.01
12 SGTC_138 0850-0259 6.57 40.9 µM 9.89E-8 cell wall 27 2.58E-11 0.18
13 SGTC_203 k066-0004 6.54 30.9 µM 1.10E-7 RSC & ERG11 4 3.03E-11 0.64
14 SGTC_1274 0865-0114 6.53 173.0 µM 1.16E-7 2 3.33E-11 1.27
15 SGTC_58 0957-0393 6.52 9.0 µM 1.20E-7 cell wall 25 3.48E-11 0.17
16 SGTC_1783 st039459 6.48 87.5 µM 1.44E-7 Golgi 1 4.64E-11 0.91
17 SGTC_1652 st011932 6.42 78.0 µM 1.87E-7 RSC complex & mRNA processing 21 7.01E-11 0.02
18 SGTC_928 2764-0428 6.34 58.7 µM 2.53E-7 cell wall 7 1.13E-10 0.61
19 SGTC_1133 3473-0247 6.34 50.0 µM 2.57E-7 RSC complex & mRNA processing 19 1.16E-10 0.16
20 SGTC_1229 0139-0193 6.27 12.2 µM 3.41E-7 RSC complex & mRNA processing 6 1.81E-10 0.14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.520 7.47E-232 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.482 3.18E-195 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.474 7.73E-188 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.463 3.00E-178 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.439 9.20E-158 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.420 1.51E-143 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.404 1.22E-131 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.389 2.58E-121 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.388 4.71E-121 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.383 5.31E-117 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.365 2.05E-106 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.352 6.84E-98 YJL039C NUP192 het Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205
0.340 9.86E-92 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.339 4.43E-91 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.318 1.41E-79 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components