YLR324W / PEX30

Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR324W / PEX30

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.43|P-value:4.45E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:3.89|P-value:2.92E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:12.00|P-value:1.20E-26 ID:SGTC_67|Compound:0335-0847|FD-Score:4.45|P-value:4.17E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:6.90|P-value:4.91E-10 ID:SGTC_103|Compound:0844-0104|FD-Score:5.53|P-value:4.86E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:6.99|P-value:3.01E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:10.10|P-value:2.41E-19 ID:SGTC_116|Compound:0155-0182|FD-Score:3.57|P-value:7.99E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.94|P-value:2.15E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.84|P-value:9.22E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.59|P-value:2.48E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.02|P-value:1.87E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:6.43|P-value:6.29E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:-5.49|P-value:4.96E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:6.70|P-value:1.49E-9 ID:SGTC_182|Compound:3448-4371|FD-Score:-6.69|P-value:1.23E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.92|P-value:2.32E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.33|P-value:1.18E-6 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.80|P-value:3.92E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.28|P-value:7.67E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:4.16|P-value:1.15E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.00|P-value:4.82E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:4.79|P-value:1.11E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:8.98|P-value:8.54E-16 ID:SGTC_566|Compound:0958-0068|FD-Score:5.71|P-value:2.18E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:4.87|P-value:8.32E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:5.18|P-value:2.26E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:3.56|P-value:8.32E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:18.90|P-value:1.13E-63 ID:SGTC_769|Compound:0302-0231|FD-Score:7.08|P-value:1.79E-10 ID:SGTC_794|Compound:k038-0031|FD-Score:4.73|P-value:1.42E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:9.34|P-value:6.29E-17 ID:SGTC_823|Compound:0417-1665|FD-Score:4.60|P-value:2.32E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:4.54|P-value:2.90E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.52|P-value:9.22E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:10.90|P-value:2.42E-22 ID:SGTC_949|Compound:1165-0505|FD-Score:3.52|P-value:9.45E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.60|P-value:7.31E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.59|P-value:7.45E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.83|P-value:3.09E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.74|P-value:4.20E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.51|P-value:9.66E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.80|P-value:3.89E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:6.43|P-value:6.01E-9 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.91|P-value:2.41E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.72|P-value:4.97E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:14.00|P-value:1.45E-35 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.39|P-value:5.15E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:5.34|P-value:1.13E-6 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.02|P-value:1.89E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.66|P-value:6.07E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:-4.05|P-value:1.51E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.83|P-value:3.57E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.24|P-value:8.70E-5 ID:SGTC_1728|Compound:st035614|FD-Score:11.90|P-value:1.54E-26 ID:SGTC_1754|Compound:st042065|FD-Score:7.79|P-value:2.46E-12 ID:SGTC_1760|Compound:st045453|FD-Score:4.82|P-value:9.85E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.69|P-value:5.47E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.30|P-value:1.37E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.11|P-value:3.09E-6 ID:SGTC_1945|Compound:st075991|FD-Score:3.80|P-value:3.90E-4 ID:SGTC_1949|Compound:st076024|FD-Score:5.62|P-value:3.22E-7 ID:SGTC_1982|Compound:st072467|FD-Score:3.61|P-value:7.04E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.28|P-value:1.49E-6 ID:SGTC_2444|Compound:5485484|FD-Score:5.33|P-value:1.20E-6 ID:SGTC_2446|Compound:5162541|FD-Score:4.13|P-value:1.29E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.70|P-value:5.40E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:9.45|P-value:2.63E-17 ID:SGTC_2557|Compound:derrustone|FD-Score:3.51|P-value:9.67E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.38|P-value:5.35E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:3.92|P-value:2.66E-4 ID:SGTC_2694|Compound:st077685|FD-Score:6.31|P-value:1.13E-8 ID:SGTC_2696|Compound:st077691|FD-Score:3.65|P-value:6.26E-4 ID:SGTC_2713|Compound:st079149|FD-Score:5.38|P-value:9.72E-7 ID:SGTC_2858|Compound:9025781|FD-Score:7.69|P-value:4.60E-12 ID:SGTC_2867|Compound:9039098|FD-Score:3.76|P-value:4.50E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.15|P-value:2.53E-6 ID:SGTC_2920|Compound:7982904|FD-Score:-6.31|P-value:9.43E-9 ID:SGTC_3037|Compound:9091026|FD-Score:5.76|P-value:1.69E-7 ID:SGTC_3284|Compound:9108171|FD-Score:3.84|P-value:3.44E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-4.45|P-value:3.58E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.43|P-value:4.45E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:3.89|P-value:2.92E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:12.00|P-value:1.20E-26 ID:SGTC_67|Compound:0335-0847|FD-Score:4.45|P-value:4.17E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:6.90|P-value:4.91E-10 ID:SGTC_103|Compound:0844-0104|FD-Score:5.53|P-value:4.86E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:6.99|P-value:3.01E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:10.10|P-value:2.41E-19 ID:SGTC_116|Compound:0155-0182|FD-Score:3.57|P-value:7.99E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.94|P-value:2.15E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.84|P-value:9.22E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.59|P-value:2.48E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:4.02|P-value:1.87E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:6.43|P-value:6.29E-9 ID:SGTC_176|Compound:1486-1328|FD-Score:-5.49|P-value:4.96E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:6.70|P-value:1.49E-9 ID:SGTC_182|Compound:3448-4371|FD-Score:-6.69|P-value:1.23E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.92|P-value:2.32E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.33|P-value:1.18E-6 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.80|P-value:3.92E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.28|P-value:7.67E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:4.16|P-value:1.15E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:5.00|P-value:4.82E-6 ID:SGTC_496|Compound:calpeptin|FD-Score:4.79|P-value:1.11E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:8.98|P-value:8.54E-16 ID:SGTC_566|Compound:0958-0068|FD-Score:5.71|P-value:2.18E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:4.87|P-value:8.32E-6 ID:SGTC_709|Compound:3807-1509|FD-Score:5.18|P-value:2.26E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:3.56|P-value:8.32E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:18.90|P-value:1.13E-63 ID:SGTC_769|Compound:0302-0231|FD-Score:7.08|P-value:1.79E-10 ID:SGTC_794|Compound:k038-0031|FD-Score:4.73|P-value:1.42E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:9.34|P-value:6.29E-17 ID:SGTC_823|Compound:0417-1665|FD-Score:4.60|P-value:2.32E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:4.54|P-value:2.90E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.52|P-value:9.22E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:10.90|P-value:2.42E-22 ID:SGTC_949|Compound:1165-0505|FD-Score:3.52|P-value:9.45E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.60|P-value:7.31E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.59|P-value:7.45E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.83|P-value:3.09E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.74|P-value:4.20E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.51|P-value:9.66E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.80|P-value:3.89E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:6.43|P-value:6.01E-9 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.91|P-value:2.41E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.72|P-value:4.97E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:14.00|P-value:1.45E-35 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.39|P-value:5.15E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:5.34|P-value:1.13E-6 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.02|P-value:1.89E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.66|P-value:6.07E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:-4.05|P-value:1.51E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.83|P-value:3.57E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.24|P-value:8.70E-5 ID:SGTC_1728|Compound:st035614|FD-Score:11.90|P-value:1.54E-26 ID:SGTC_1754|Compound:st042065|FD-Score:7.79|P-value:2.46E-12 ID:SGTC_1760|Compound:st045453|FD-Score:4.82|P-value:9.85E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.69|P-value:5.47E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.30|P-value:1.37E-6 ID:SGTC_1803|Compound:st050068|FD-Score:5.11|P-value:3.09E-6 ID:SGTC_1945|Compound:st075991|FD-Score:3.80|P-value:3.90E-4 ID:SGTC_1949|Compound:st076024|FD-Score:5.62|P-value:3.22E-7 ID:SGTC_1982|Compound:st072467|FD-Score:3.61|P-value:7.04E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.28|P-value:1.49E-6 ID:SGTC_2444|Compound:5485484|FD-Score:5.33|P-value:1.20E-6 ID:SGTC_2446|Compound:5162541|FD-Score:4.13|P-value:1.29E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.70|P-value:5.40E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:9.45|P-value:2.63E-17 ID:SGTC_2557|Compound:derrustone|FD-Score:3.51|P-value:9.67E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.38|P-value:5.35E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:3.92|P-value:2.66E-4 ID:SGTC_2694|Compound:st077685|FD-Score:6.31|P-value:1.13E-8 ID:SGTC_2696|Compound:st077691|FD-Score:3.65|P-value:6.26E-4 ID:SGTC_2713|Compound:st079149|FD-Score:5.38|P-value:9.72E-7 ID:SGTC_2858|Compound:9025781|FD-Score:7.69|P-value:4.60E-12 ID:SGTC_2867|Compound:9039098|FD-Score:3.76|P-value:4.50E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.15|P-value:2.53E-6 ID:SGTC_2920|Compound:7982904|FD-Score:-6.31|P-value:9.43E-9 ID:SGTC_3037|Compound:9091026|FD-Score:5.76|P-value:1.69E-7 ID:SGTC_3284|Compound:9108171|FD-Score:3.84|P-value:3.44E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-4.45|P-value:3.58E-5

Top fitness defect scores for YLR324W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_743 1275-0778 18.90 158.0 µM 1.13E-63 excess fatty acid 3 3.05E-80
2 SGTC_1255 0566-0045 14.00 221.0 µM 1.45E-35 excess fatty acid 2 1.26E-44
3 SGTC_64 000l-0018 12.00 272.1 µM 1.20E-26 ubiquinone biosynthesis & proteasome 30 2.48E-33
4 SGTC_1728 st035614 11.90 33.8 µM 1.54E-26 1 3.40E-33
5 SGTC_922 1866-0035 10.90 480.0 µM 2.42E-22 excess fatty acid 6 7.01E-28
6 SGTC_115 0527-0192 10.10 112.0 µM 2.41E-19 5 4.39E-24
7 SGTC_2541 muurolladie-3-one 9.45 83.1 µM 2.63E-17 excess fatty acid 1 1.66E-21
8 SGTC_795 0685-0265 9.34 78.0 µM 6.29E-17 excess fatty acid 2 5.02E-21
9 SGTC_541 4513-1321 8.98 94.0 µM 8.54E-16 1 1.36E-19
10 SGTC_1754 st042065 7.79 16.1 µM 2.46E-12 NEO1-PIK1 59 3.25E-15
11 SGTC_2858 9025781 7.69 9.0 µM 4.60E-12 sphingolipid biosynthesis & PDR1 30 7.16E-15
12 SGTC_769 0302-0231 7.08 76.0 µM 1.79E-10 5 7.31E-13
13 SGTC_114 0364-0001 6.99 490.3 µM 3.01E-10 6 1.42E-12
14 SGTC_86 0417-1630 6.90 471.9 µM 4.91E-10 ubiquinone biosynthesis & proteasome 73 2.63E-12
15 SGTC_178 4092-0806 6.70 87.5 µM 1.49E-9 ergosterol depletion effects on membrane 29 1.06E-11
16 SGTC_1196 1588-0294 6.43 184.0 µM 6.01E-9 1 6.22E-11
17 SGTC_165 k038-0023 6.43 64.4 µM 6.29E-9 ubiquinone biosynthesis & proteasome 19 6.59E-11
18 SGTC_2694 st077685 6.31 81.9 µM 1.13E-8 endomembrane recycling 7 1.38E-10
19 SGTC_3037 9091026 5.76 49.5 µM 1.69E-7 NEO1-PIK1 53 4.19E-9
20 SGTC_566 0958-0068 5.71 16.5 µM 2.18E-7 RSC & ERG11 6 5.80E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.608 0 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.339 3.83E-91 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.301 2.69E-71 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.246 2.30E-47 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.245 4.06E-47 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.228 9.58E-41 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.223 5.20E-39 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.215 1.77E-36 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.214 5.63E-36 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.213 6.82E-36 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.212 1.93E-35 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.210 1.25E-34 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.208 4.65E-34 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.205 4.25E-33 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.204 6.84E-33 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance