HIPHOP chemogenomics database

YLR324W / PEX30

Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR324W / PEX30

Click on Significant Values for Screen Details

Top fitness defect scores for YLR324W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_743	1275-0778	18.90	158.0 µM	1.13E-63	excess fatty acid	3	3.05E-80
2	SGTC_1255	0566-0045	14.00	221.0 µM	1.45E-35	excess fatty acid	2	1.26E-44
3	SGTC_64	000l-0018	12.00	272.1 µM	1.20E-26	ubiquinone biosynthesis & proteasome	30	2.48E-33
4	SGTC_1728	st035614	11.90	33.8 µM	1.54E-26		1	3.40E-33
5	SGTC_922	1866-0035	10.90	480.0 µM	2.42E-22	excess fatty acid	6	7.01E-28
6	SGTC_115	0527-0192	10.10	112.0 µM	2.41E-19		5	4.39E-24
7	SGTC_2541	muurolladie-3-one	9.45	83.1 µM	2.63E-17	excess fatty acid	1	1.66E-21
8	SGTC_795	0685-0265	9.34	78.0 µM	6.29E-17	excess fatty acid	2	5.02E-21
9	SGTC_541	4513-1321	8.98	94.0 µM	8.54E-16		1	1.36E-19
10	SGTC_1754	st042065	7.79	16.1 µM	2.46E-12	NEO1-PIK1	59	3.25E-15
11	SGTC_2858	9025781	7.69	9.0 µM	4.60E-12	sphingolipid biosynthesis & PDR1	30	7.16E-15
12	SGTC_769	0302-0231	7.08	76.0 µM	1.79E-10		5	7.31E-13
13	SGTC_114	0364-0001	6.99	490.3 µM	3.01E-10		6	1.42E-12
14	SGTC_86	0417-1630	6.90	471.9 µM	4.91E-10	ubiquinone biosynthesis & proteasome	73	2.63E-12
15	SGTC_178	4092-0806	6.70	87.5 µM	1.49E-9	ergosterol depletion effects on membrane	29	1.06E-11
16	SGTC_1196	1588-0294	6.43	184.0 µM	6.01E-9		1	6.22E-11
17	SGTC_165	k038-0023	6.43	64.4 µM	6.29E-9	ubiquinone biosynthesis & proteasome	19	6.59E-11
18	SGTC_2694	st077685	6.31	81.9 µM	1.13E-8	endomembrane recycling	7	1.38E-10
19	SGTC_3037	9091026	5.76	49.5 µM	1.69E-7	NEO1-PIK1	53	4.19E-9
20	SGTC_566	0958-0068	5.71	16.5 µM	2.18E-7	RSC & ERG11	6	5.80E-9

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.608	0	YDR479C	PEX29	hom	Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.339	3.83E-91	YLL001W	DNM1	hom	Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.301	2.69E-71	YPR024W	YME1	hom	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.246	2.30E-47	YJL168C	SET2	hom	Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.245	4.06E-47	YNR008W	LRO1	hom	Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.228	9.58E-41	YBR246W	RRT2	hom	Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.223	5.20E-39	YBR003W	COQ1	hom	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.215	1.77E-36	YER041W	YEN1	hom	Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.214	5.63E-36	YDL183C	YDL183C	hom	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.213	6.82E-36	YLR020C	YEH2	hom	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.212	1.93E-35	YNR042W_d	YNR042W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.210	1.25E-34	YML034C-A_d	YML034C-A_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.208	4.65E-34	YJL169W_d	YJL169W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.205	4.25E-33	YPR146C_d	YPR146C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.204	6.84E-33	YML034W	SRC1	hom	Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance