YLR327C / TMA10

Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR327C / TMA10

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:3.49|P-value:2.19E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:3.79|P-value:6.68E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.19|P-value:6.69E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-3.54|P-value:1.71E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.33|P-value:3.98E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.33|P-value:3.68E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.13|P-value:8.32E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.93|P-value:3.46E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.18|P-value:6.88E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.07|P-value:9.36E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.55|P-value:1.76E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.33|P-value:3.80E-4 ID:SGTC_1695|Compound:st026914|FD-Score:-3.13|P-value:7.76E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.81|P-value:5.87E-5 ID:SGTC_1930|Compound:st074634|FD-Score:4.78|P-value:7.22E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:8.67|P-value:1.13E-18 ID:SGTC_2248|Compound:tofa|FD-Score:8.22|P-value:5.82E-17 ID:SGTC_2251|Compound:lansoprazole|FD-Score:11.70|P-value:2.62E-32 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.19|P-value:1.22E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.26|P-value:5.13E-4 ID:SGTC_2329|Compound:6138490|FD-Score:14.10|P-value:6.52E-46 ID:SGTC_2363|Compound:9053361|FD-Score:5.19|P-value:8.54E-8 ID:SGTC_2403|Compound:6032726|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.55|P-value:1.11E-8 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.44|P-value:2.72E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.62|P-value:1.32E-4 ID:SGTC_2830|Compound:7992007|FD-Score:7.79|P-value:1.96E-15 ID:SGTC_2833|Compound:9001315|FD-Score:7.03|P-value:7.13E-13 ID:SGTC_2931|Compound:9014674|FD-Score:3.37|P-value:3.53E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-4.71|P-value:9.37E-7 ID:SGTC_2945|Compound:9067681|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-5.18|P-value:7.96E-8 ID:SGTC_3016|Compound:9080866|FD-Score:3.26|P-value:5.11E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.49|P-value:2.19E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:3.79|P-value:6.68E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:3.19|P-value:6.69E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-3.54|P-value:1.71E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.33|P-value:3.98E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.33|P-value:3.68E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.13|P-value:8.32E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.93|P-value:3.46E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.18|P-value:6.88E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.07|P-value:9.36E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.55|P-value:1.76E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.33|P-value:3.80E-4 ID:SGTC_1695|Compound:st026914|FD-Score:-3.13|P-value:7.76E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.81|P-value:5.87E-5 ID:SGTC_1930|Compound:st074634|FD-Score:4.78|P-value:7.22E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:8.67|P-value:1.13E-18 ID:SGTC_2248|Compound:tofa|FD-Score:8.22|P-value:5.82E-17 ID:SGTC_2251|Compound:lansoprazole|FD-Score:11.70|P-value:2.62E-32 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.19|P-value:1.22E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.26|P-value:5.13E-4 ID:SGTC_2329|Compound:6138490|FD-Score:14.10|P-value:6.52E-46 ID:SGTC_2363|Compound:9053361|FD-Score:5.19|P-value:8.54E-8 ID:SGTC_2403|Compound:6032726|FD-Score:3.59|P-value:1.49E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.55|P-value:1.11E-8 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.44|P-value:2.72E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.62|P-value:1.32E-4 ID:SGTC_2830|Compound:7992007|FD-Score:7.79|P-value:1.96E-15 ID:SGTC_2833|Compound:9001315|FD-Score:7.03|P-value:7.13E-13 ID:SGTC_2931|Compound:9014674|FD-Score:3.37|P-value:3.53E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-4.71|P-value:9.37E-7 ID:SGTC_2945|Compound:9067681|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-5.18|P-value:7.96E-8 ID:SGTC_3016|Compound:9080866|FD-Score:3.26|P-value:5.11E-4

Top fitness defect scores for YLR327C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2329 6138490 14.10 200.0 µM 6.52E-46 1 3.65E-45
2 SGTC_2251 lansoprazole 11.70 556.0 µM 2.62E-32 1 8.43E-32
3 SGTC_2247 cerulenin 8.67 830.0 nM 1.13E-18 2 2.12E-18
4 SGTC_2248 tofa 8.22 1.1 µM 5.82E-17 sphingolipid biosynthesis & PDR1 10 1.02E-16
5 SGTC_2830 7992007 7.79 71.4 µM 1.96E-15 2 3.24E-15
6 SGTC_2833 9001315 7.03 45.5 µM 7.13E-13 amide catabolism 10 1.06E-12
7 SGTC_2566 crystal violet carbinol 5.55 226.0 nM 1.11E-8 13 1.41E-8
8 SGTC_2363 9053361 5.19 176.0 µM 8.54E-8 Golgi 12 1.05E-7
9 SGTC_817 1391-0715 4.93 46.0 µM 3.46E-7 6 4.16E-7
10 SGTC_1930 st074634 4.78 34.3 µM 7.22E-7 RNA pol III & RNase P/MRP 20 8.59E-7
11 SGTC_2252 omeprazole 4.19 400.0 µM 1.22E-5 6 1.38E-5
12 SGTC_106 0092-0003 3.79 11.6 µM 6.68E-5 copper-dependent oxidative stress 20 7.40E-5
13 SGTC_2945 9067681 3.63 61.8 µM 1.31E-4 20 1.44E-4
14 SGTC_2815 7968870 3.62 71.4 µM 1.32E-4 33 1.45E-4
15 SGTC_2403 6032726 3.59 181.2 µM 1.49E-4 47 1.64E-4
16 SGTC_1261 0712-0010 3.55 12.7 µM 1.76E-4 RNA processing & uracil transport 35 1.92E-4
17 SGTC_95 0471-0001 3.49 561.1 µM 2.19E-4 40 2.39E-4
18 SGTC_2597 laccaic acid a 3.44 100.0 µM 2.72E-4 52 2.95E-4
19 SGTC_2931 9014674 3.37 55.7 µM 3.53E-4 45 3.82E-4
20 SGTC_662 k832-1615 3.33 104.0 µM 3.98E-4 45 4.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 7.86E-23 YDR531W CAB1 het Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element
0.138 1.00E-15 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.137 1.82E-15 YBL074C AAR2 het Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
0.137 2.07E-15 YGL157W ARI1 hom NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
0.132 1.77E-14 YKL216W URA1 hom Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
0.128 1.47E-13 YOR177C MPC54 hom Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
0.126 3.07E-13 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.126 3.08E-13 YMR158W-B_d YMR158W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C
0.118 8.88E-12 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.117 1.49E-11 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.115 2.49E-11 YIL086C_d YIL086C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.114 3.79E-11 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.111 1.13E-10 YKR048C NAP1 hom Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress
0.108 3.41E-10 YBR180W DTR1 hom Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation
0.107 6.49E-10 YDR445C_d YDR445C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data