YLR329W / REC102

Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR329W / REC102

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.87|P-value:1.25E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.45|P-value:5.48E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.43|P-value:1.31E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.43|P-value:5.09E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.63|P-value:2.93E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:-4.56|P-value:6.43E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.75|P-value:2.86E-6 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-4.45|P-value:1.03E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.31|P-value:7.67E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.17|P-value:3.93E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.71|P-value:2.21E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.51|P-value:4.47E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.59|P-value:2.90E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.42|P-value:1.40E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.52|P-value:3.82E-4 ID:SGTC_1724|Compound:st037281|FD-Score:7.78|P-value:7.23E-14 ID:SGTC_1783|Compound:st039459|FD-Score:3.78|P-value:1.70E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.54|P-value:8.31E-6 ID:SGTC_1940|Compound:st075990|FD-Score:4.54|P-value:8.36E-6 ID:SGTC_2273|Compound:7815444|FD-Score:3.41|P-value:6.33E-4 ID:SGTC_2276|Compound:7947513|FD-Score:5.61|P-value:5.15E-8 ID:SGTC_2284|Compound:7945075|FD-Score:-3.53|P-value:3.65E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.40|P-value:5.66E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.45|P-value:4.82E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-7.60|P-value:1.96E-13 ID:SGTC_2394|Compound:5221648|FD-Score:3.94|P-value:9.30E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.45|P-value:5.43E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.69|P-value:2.09E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.41|P-value:6.14E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.24|P-value:2.92E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.95|P-value:9.13E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.87|P-value:1.25E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.45|P-value:5.48E-4 ID:SGTC_394|Compound:menadione|FD-Score:4.43|P-value:1.31E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.43|P-value:5.09E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.63|P-value:2.93E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:-4.56|P-value:6.43E-6 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.75|P-value:2.86E-6 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-4.45|P-value:1.03E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.31|P-value:7.67E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.17|P-value:3.93E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.71|P-value:2.21E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.51|P-value:4.47E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-3.59|P-value:2.90E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.42|P-value:1.40E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-3.52|P-value:3.82E-4 ID:SGTC_1724|Compound:st037281|FD-Score:7.78|P-value:7.23E-14 ID:SGTC_1783|Compound:st039459|FD-Score:3.78|P-value:1.70E-4 ID:SGTC_1812|Compound:st052057|FD-Score:4.54|P-value:8.31E-6 ID:SGTC_1940|Compound:st075990|FD-Score:4.54|P-value:8.36E-6 ID:SGTC_2273|Compound:7815444|FD-Score:3.41|P-value:6.33E-4 ID:SGTC_2276|Compound:7947513|FD-Score:5.61|P-value:5.15E-8 ID:SGTC_2284|Compound:7945075|FD-Score:-3.53|P-value:3.65E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.40|P-value:5.66E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.45|P-value:4.82E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-7.60|P-value:1.96E-13 ID:SGTC_2394|Compound:5221648|FD-Score:3.94|P-value:9.30E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.45|P-value:5.43E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.69|P-value:2.09E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.41|P-value:6.14E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.24|P-value:2.92E-5 ID:SGTC_2795|Compound:7780010|FD-Score:3.95|P-value:9.13E-5

Top fitness defect scores for YLR329W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1724 st037281 7.78 8.3 µM 7.23E-14 3 3.54E-15
2 SGTC_2276 7947513 5.61 42.1 µM 5.15E-8 6 1.02E-8
3 SGTC_1812 st052057 4.54 4.3 µM 8.31E-6 calcium & mitochondrial duress 14 2.79E-6
4 SGTC_1940 st075990 4.54 51.1 µM 8.36E-6 60S ribosome export 9 2.81E-6
5 SGTC_394 menadione 4.43 8.3 µM 1.31E-5 superoxide 20 4.61E-6
6 SGTC_1718 roemerine 4.42 11.9 µM 1.40E-5 redox potentiating 36 4.94E-6
7 SGTC_2635 hydroquinidine 4.24 100.0 µM 2.92E-5 18 1.11E-5
8 SGTC_1189 1431-2119 4.17 7.3 µM 3.93E-5 20 1.55E-5
9 SGTC_2795 7780010 3.95 54.5 µM 9.13E-5 28 3.92E-5
10 SGTC_2394 5221648 3.94 200.0 µM 9.30E-5 21 4.00E-5
11 SGTC_6 0844-0013 3.87 19.8 µM 1.25E-4 97 5.55E-5
12 SGTC_1783 st039459 3.78 87.5 µM 1.70E-4 Golgi 25 7.75E-5
13 SGTC_1325 1431-0015 3.71 227.0 µM 2.21E-4 Golgi 24 1.04E-4
14 SGTC_1073 triclabendazole 3.63 3.1 µM 2.93E-4 36 1.42E-4
15 SGTC_1575 cyproterone acetate 3.51 48.0 µM 4.47E-4 34 2.26E-4
16 SGTC_2405 ticlatone 3.45 3.5 µM 5.43E-4 88 2.79E-4
17 SGTC_120 rhodamine 6G 3.45 52.3 µM 5.48E-4 mitochondrial processes 54 2.82E-4
18 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.41 3.7 µM 6.14E-4 138 3.20E-4
19 SGTC_2273 7815444 3.41 169.1 µM 6.33E-4 44 3.31E-4
20 SGTC_1555 citronellol 3.25 128.0 µM 0.00105 13 5.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 1.32E-33 YGR144W THI4 hom Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents
0.135 3.81E-15 YDR520C_p URC2_p hom Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
0.134 7.17E-15 YMR145C NDE1 hom Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
0.133 1.33E-14 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.130 4.94E-14 YBR220C_p YBR220C_p hom Putative protein of unknown function; YBR220C is not an essential gene
0.122 1.31E-12 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.117 1.03E-11 YER073W ALD5 hom Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
0.116 1.50E-11 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.105 1.26E-9 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.103 2.41E-9 YOL007C CSI2 hom Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
0.103 2.69E-9 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.098 1.46E-8 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.097 2.11E-8 YDL195W SEC31 het Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
0.096 2.90E-8 YOR331C_d YOR331C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W
0.096 3.03E-8 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele