YLR330W / CHS5

Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR330W / CHS5

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:13.60|P-value:8.31E-30 ID:SGTC_138|Compound:0850-0259|FD-Score:5.99|P-value:3.88E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.78|P-value:4.14E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:5.85|P-value:7.13E-7 ID:SGTC_259|Compound:usnic acid|FD-Score:3.83|P-value:8.02E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:5.75|P-value:1.04E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.86|P-value:7.43E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:6.11|P-value:2.30E-7 ID:SGTC_332|Compound:4112-0506|FD-Score:4.84|P-value:3.28E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:-4.31|P-value:1.66E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:11.30|P-value:6.81E-21 ID:SGTC_354|Compound:2783-3500|FD-Score:5.10|P-value:1.29E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:6.11|P-value:2.36E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.04|P-value:4.35E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.72|P-value:1.49E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:8.01|P-value:1.83E-11 ID:SGTC_515|Compound:4092-1064|FD-Score:4.39|P-value:1.49E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.74|P-value:1.31E-8 ID:SGTC_526|Compound:4469-0568|FD-Score:4.95|P-value:2.23E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:9.38|P-value:4.56E-15 ID:SGTC_658|Compound:3253-0951|FD-Score:4.57|P-value:8.27E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:3.83|P-value:7.99E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:5.79|P-value:9.07E-7 ID:SGTC_863|Compound:0466-0191|FD-Score:11.90|P-value:5.21E-23 ID:SGTC_928|Compound:2764-0428|FD-Score:4.01|P-value:4.77E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.18|P-value:2.89E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.10|P-value:3.66E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.79|P-value:3.89E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.11|P-value:3.52E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-4.25|P-value:1.99E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.56|P-value:2.27E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.06|P-value:1.53E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.04|P-value:4.36E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.68|P-value:5.80E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:5.15|P-value:1.07E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.14|P-value:3.27E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.73|P-value:9.26E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.76|P-value:9.89E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.92|P-value:5.50E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.59|P-value:2.66E-8 ID:SGTC_1712|Compound:st032288|FD-Score:4.89|P-value:2.80E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.77|P-value:4.24E-5 ID:SGTC_1760|Compound:st045453|FD-Score:5.83|P-value:7.53E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.89|P-value:6.82E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.92|P-value:6.19E-4 ID:SGTC_1801|Compound:st050089|FD-Score:7.93|P-value:2.96E-11 ID:SGTC_1803|Compound:st050068|FD-Score:11.40|P-value:1.98E-21 ID:SGTC_1848|Compound:st056003|FD-Score:4.20|P-value:2.69E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.03|P-value:1.70E-5 ID:SGTC_1933|Compound:st074711|FD-Score:4.88|P-value:2.90E-5 ID:SGTC_1936|Compound:st074407|FD-Score:4.35|P-value:1.69E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.55|P-value:8.85E-5 ID:SGTC_2021|Compound:4019055|FD-Score:6.28|P-value:1.11E-7 ID:SGTC_2036|Compound:5160441|FD-Score:4.70|P-value:5.41E-5 ID:SGTC_2124|Compound:5246320|FD-Score:4.92|P-value:2.54E-5 ID:SGTC_2210|Compound:7115885|FD-Score:4.80|P-value:3.83E-5 ID:SGTC_2274|Compound:7947094|FD-Score:4.22|P-value:2.53E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.28|P-value:9.51E-10 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-5.06|P-value:1.29E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:13.10|P-value:1.05E-27 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:8.60|P-value:6.04E-13 ID:SGTC_2610|Compound:ononetin|FD-Score:-4.02|P-value:4.09E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:10.50|P-value:2.41E-18 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.37|P-value:7.27E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.90|P-value:6.04E-9 ID:SGTC_2756|Compound:carbadox|FD-Score:11.50|P-value:1.23E-21 ID:SGTC_2797|Compound:7859098|FD-Score:5.03|P-value:1.68E-5 ID:SGTC_2798|Compound:7813637|FD-Score:5.07|P-value:1.49E-5 ID:SGTC_2816|Compound:7982706|FD-Score:6.58|P-value:2.79E-8 ID:SGTC_2817|Compound:7995342|FD-Score:5.21|P-value:8.89E-6 ID:SGTC_2821|Compound:7996764|FD-Score:5.16|P-value:1.06E-5 ID:SGTC_2838|Compound:9002687|FD-Score:4.47|P-value:1.15E-4 ID:SGTC_2912|Compound:7964298|FD-Score:6.73|P-value:1.42E-8 ID:SGTC_2915|Compound:7971052|FD-Score:-4.36|P-value:1.42E-4 ID:SGTC_2925|Compound:9010536|FD-Score:7.42|P-value:4.44E-10 ID:SGTC_2991|Compound:9074669|FD-Score:5.71|P-value:1.24E-6 ID:SGTC_2993|Compound:9054257|FD-Score:5.66|P-value:1.50E-6 ID:SGTC_3037|Compound:9091026|FD-Score:5.11|P-value:1.27E-5 ID:SGTC_3152|Compound:9099253|FD-Score:6.79|P-value:1.04E-8 ID:SGTC_3236|Compound:9132701|FD-Score:4.20|P-value:2.70E-4 ID:SGTC_3266|Compound:9136860|FD-Score:6.05|P-value:3.07E-7 ID:SGTC_3304|Compound:9125678|FD-Score:3.96|P-value:5.65E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.91|P-value:6.37E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.32|P-value:1.88E-4 ID:SGTC_3321|Compound:9137793|FD-Score:7.83|P-value:5.08E-11 ID:SGTC_3350|Compound:9150499|FD-Score:4.25|P-value:2.31E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:13.60|P-value:8.31E-30 ID:SGTC_138|Compound:0850-0259|FD-Score:5.99|P-value:3.88E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.78|P-value:4.14E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:5.85|P-value:7.13E-7 ID:SGTC_259|Compound:usnic acid|FD-Score:3.83|P-value:8.02E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:5.75|P-value:1.04E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.86|P-value:7.43E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:6.11|P-value:2.30E-7 ID:SGTC_332|Compound:4112-0506|FD-Score:4.84|P-value:3.28E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:-4.31|P-value:1.66E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:11.30|P-value:6.81E-21 ID:SGTC_354|Compound:2783-3500|FD-Score:5.10|P-value:1.29E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:6.11|P-value:2.36E-7 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:4.04|P-value:4.35E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.72|P-value:1.49E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:8.01|P-value:1.83E-11 ID:SGTC_515|Compound:4092-1064|FD-Score:4.39|P-value:1.49E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.74|P-value:1.31E-8 ID:SGTC_526|Compound:4469-0568|FD-Score:4.95|P-value:2.23E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:9.38|P-value:4.56E-15 ID:SGTC_658|Compound:3253-0951|FD-Score:4.57|P-value:8.27E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:3.83|P-value:7.99E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:5.79|P-value:9.07E-7 ID:SGTC_863|Compound:0466-0191|FD-Score:11.90|P-value:5.21E-23 ID:SGTC_928|Compound:2764-0428|FD-Score:4.01|P-value:4.77E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.18|P-value:2.89E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.10|P-value:3.66E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.79|P-value:3.89E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.11|P-value:3.52E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-4.25|P-value:1.99E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.56|P-value:2.27E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.06|P-value:1.53E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.04|P-value:4.36E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.68|P-value:5.80E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:5.15|P-value:1.07E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.14|P-value:3.27E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.73|P-value:9.26E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:3.76|P-value:9.89E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-3.92|P-value:5.50E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.59|P-value:2.66E-8 ID:SGTC_1712|Compound:st032288|FD-Score:4.89|P-value:2.80E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.77|P-value:4.24E-5 ID:SGTC_1760|Compound:st045453|FD-Score:5.83|P-value:7.53E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.89|P-value:6.82E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.92|P-value:6.19E-4 ID:SGTC_1801|Compound:st050089|FD-Score:7.93|P-value:2.96E-11 ID:SGTC_1803|Compound:st050068|FD-Score:11.40|P-value:1.98E-21 ID:SGTC_1848|Compound:st056003|FD-Score:4.20|P-value:2.69E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.03|P-value:1.70E-5 ID:SGTC_1933|Compound:st074711|FD-Score:4.88|P-value:2.90E-5 ID:SGTC_1936|Compound:st074407|FD-Score:4.35|P-value:1.69E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.55|P-value:8.85E-5 ID:SGTC_2021|Compound:4019055|FD-Score:6.28|P-value:1.11E-7 ID:SGTC_2036|Compound:5160441|FD-Score:4.70|P-value:5.41E-5 ID:SGTC_2124|Compound:5246320|FD-Score:4.92|P-value:2.54E-5 ID:SGTC_2210|Compound:7115885|FD-Score:4.80|P-value:3.83E-5 ID:SGTC_2274|Compound:7947094|FD-Score:4.22|P-value:2.53E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.28|P-value:9.51E-10 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-5.06|P-value:1.29E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:13.10|P-value:1.05E-27 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:8.60|P-value:6.04E-13 ID:SGTC_2610|Compound:ononetin|FD-Score:-4.02|P-value:4.09E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:10.50|P-value:2.41E-18 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.37|P-value:7.27E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.90|P-value:6.04E-9 ID:SGTC_2756|Compound:carbadox|FD-Score:11.50|P-value:1.23E-21 ID:SGTC_2797|Compound:7859098|FD-Score:5.03|P-value:1.68E-5 ID:SGTC_2798|Compound:7813637|FD-Score:5.07|P-value:1.49E-5 ID:SGTC_2816|Compound:7982706|FD-Score:6.58|P-value:2.79E-8 ID:SGTC_2817|Compound:7995342|FD-Score:5.21|P-value:8.89E-6 ID:SGTC_2821|Compound:7996764|FD-Score:5.16|P-value:1.06E-5 ID:SGTC_2838|Compound:9002687|FD-Score:4.47|P-value:1.15E-4 ID:SGTC_2912|Compound:7964298|FD-Score:6.73|P-value:1.42E-8 ID:SGTC_2915|Compound:7971052|FD-Score:-4.36|P-value:1.42E-4 ID:SGTC_2925|Compound:9010536|FD-Score:7.42|P-value:4.44E-10 ID:SGTC_2991|Compound:9074669|FD-Score:5.71|P-value:1.24E-6 ID:SGTC_2993|Compound:9054257|FD-Score:5.66|P-value:1.50E-6 ID:SGTC_3037|Compound:9091026|FD-Score:5.11|P-value:1.27E-5 ID:SGTC_3152|Compound:9099253|FD-Score:6.79|P-value:1.04E-8 ID:SGTC_3236|Compound:9132701|FD-Score:4.20|P-value:2.70E-4 ID:SGTC_3266|Compound:9136860|FD-Score:6.05|P-value:3.07E-7 ID:SGTC_3304|Compound:9125678|FD-Score:3.96|P-value:5.65E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.91|P-value:6.37E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.32|P-value:1.88E-4 ID:SGTC_3321|Compound:9137793|FD-Score:7.83|P-value:5.08E-11 ID:SGTC_3350|Compound:9150499|FD-Score:4.25|P-value:2.31E-4

Top fitness defect scores for YLR330W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 13.60 9.0 µM 8.31E-30 cell wall 36 1.11E-42
2 SGTC_2584 androsterone 13.10 48.7 µM 1.05E-27 cell wall 10 1.28E-39
3 SGTC_863 0466-0191 11.90 129.0 µM 5.21E-23 cell wall 7 8.86E-33
4 SGTC_2756 carbadox 11.50 75.1 µM 1.23E-21 3 8.83E-31
5 SGTC_1803 st050068 11.40 52.4 µM 1.98E-21 NEO1-PIK1 19 1.77E-30
6 SGTC_351 caspofungin 11.30 25.0 nM 6.81E-21 cell wall 3 1.07E-29
7 SGTC_2619 obliquin 10.50 87.9 µM 2.41E-18 cell wall 19 5.47E-26
8 SGTC_528 3492-0019 9.38 172.0 µM 4.56E-15 calcium & mitochondrial duress 44 3.21E-21
9 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 8.60 70.0 µM 6.04E-13 redox potentiating 15 3.90E-18
10 SGTC_514 4466-0038 8.01 2.6 nM 1.83E-11 cell wall 39 5.56E-16
11 SGTC_1801 st050089 7.93 28.4 µM 2.96E-11 NEO1-PIK1 27 1.12E-15
12 SGTC_3321 9137793 7.83 26.8 µM 5.08E-11 cell wall 11 2.44E-15
13 SGTC_2925 9010536 7.42 32.5 µM 4.44E-10 azole & statin 7 5.69E-14
14 SGTC_2582 agaric acid 7.28 100.0 µM 9.51E-10 redox potentiating 120 1.72E-13
15 SGTC_2752 diclazuril 6.90 33.1 µM 6.04E-9 47 2.51E-12
16 SGTC_3152 9099253 6.79 49.5 µM 1.04E-8 NEO1-PIK1 42 5.54E-12
17 SGTC_525 k781-2675 6.74 26.7 µM 1.31E-8 redox potentiating 19 7.70E-12
18 SGTC_2912 7964298 6.73 10.9 µM 1.42E-8 cell wall 37 8.71E-12
19 SGTC_445 e6 berbamine 6.72 66.0 µM 1.49E-8 NEO1-PIK1 19 9.27E-12
20 SGTC_1687 st020778 6.59 55.4 µM 2.66E-8 97 2.16E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.398 2.15E-127 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.360 2.87E-103 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.354 1.21E-99 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.354 1.49E-99 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.348 3.31E-96 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.346 9.02E-95 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.346 9.43E-95 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.339 4.67E-91 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.328 8.31E-85 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.320 1.29E-80 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.318 1.03E-79 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.316 8.61E-79 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.312 8.64E-77 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.312 1.31E-76 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.310 8.36E-76 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria