HIPHOP chemogenomics database
YLR336C / SGD1 
Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YLR336C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.143 | 9.11E-17 | YGR043C | NQM1 | hom | Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift |
| 0.135 | 4.45E-15 | YDL057W_p | YDL057W_p | hom | Putative protein of unknown function; YDL057W is not an essential gene |
| 0.130 | 5.12E-14 | YJL116C | NCA3 | hom | Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication |
| 0.117 | 9.66E-12 | YBR018C | GAL7 | hom | Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism |
| 0.099 | 8.03E-9 | YJR016C | ILV3 | het | Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids |
| 0.099 | 8.38E-9 | YPR023C | EAF3 | hom | Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition |
| 0.099 | 9.29E-9 | YGR277C | CAB4 | het | Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved |
| 0.091 | 1.51E-7 | YDL046W | NPC2 | hom | Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes |
| 0.090 | 1.88E-7 | YIL058W_d | YIL058W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.087 | 5.17E-7 | YLR018C | POM34 | hom | Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication |
| 0.086 | 6.87E-7 | YDR459C | PFA5 | hom | Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain |
| 0.085 | 8.60E-7 | YDL072C | YET3 | hom | Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress |
| 0.085 | 9.32E-7 | YER161C | SPT2 | hom | Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins |
| 0.083 | 1.34E-6 | YKL065C | YET1 | hom | Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein |
| 0.082 | 2.10E-6 | YDL118W_d | YDL118W_d | hom | Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein |