YLR336C / SGD1

Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR336C / SGD1

Click on Significant Values for Screen Details ID:SGTC_90|Compound:0870-0863|FD-Score:3.43|P-value:1.18E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.37|P-value:1.50E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.11|P-value:4.29E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.16|P-value:3.48E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.29|P-value:2.11E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:2.99|P-value:6.76E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.55|P-value:7.12E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:-2.96|P-value:7.61E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-2.95|P-value:7.93E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.34|P-value:1.72E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.28|P-value:2.18E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.34|P-value:1.58E-6 ID:SGTC_919|Compound:tnp00227|FD-Score:4.37|P-value:1.38E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.09|P-value:4.69E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.33|P-value:1.75E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.32|P-value:1.83E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.87|P-value:1.65E-5 ID:SGTC_1730|Compound:st033808|FD-Score:-4.33|P-value:1.73E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.90|P-value:1.46E-5 ID:SGTC_1906|Compound:st060206|FD-Score:4.84|P-value:1.04E-7 ID:SGTC_1952|Compound:st077036|FD-Score:3.13|P-value:3.88E-4 ID:SGTC_2152|Compound:5568786|FD-Score:4.24|P-value:2.75E-6 ID:SGTC_2185|Compound:6113692|FD-Score:3.06|P-value:5.19E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.84|P-value:1.87E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.54|P-value:7.28E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.31|P-value:1.89E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.71|P-value:3.41E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-4.19|P-value:3.53E-6 ID:SGTC_3001|Compound:9076041|FD-Score:3.26|P-value:2.33E-4 ID:SGTC_3014|Compound:9081533|FD-Score:4.14|P-value:4.57E-6 ID:SGTC_3199|Compound:9111318|FD-Score:3.40|P-value:1.34E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.11|P-value:4.19E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.05|P-value:5.29E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.43|P-value:1.18E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.37|P-value:1.50E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.11|P-value:4.29E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.16|P-value:3.48E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.29|P-value:2.11E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:2.99|P-value:6.76E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.55|P-value:7.12E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:-2.96|P-value:7.61E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-2.95|P-value:7.93E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:-3.34|P-value:1.72E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.28|P-value:2.18E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.34|P-value:1.58E-6 ID:SGTC_919|Compound:tnp00227|FD-Score:4.37|P-value:1.38E-6 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.09|P-value:4.69E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.33|P-value:1.75E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.32|P-value:1.83E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.87|P-value:1.65E-5 ID:SGTC_1730|Compound:st033808|FD-Score:-4.33|P-value:1.73E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.90|P-value:1.46E-5 ID:SGTC_1906|Compound:st060206|FD-Score:4.84|P-value:1.04E-7 ID:SGTC_1952|Compound:st077036|FD-Score:3.13|P-value:3.88E-4 ID:SGTC_2152|Compound:5568786|FD-Score:4.24|P-value:2.75E-6 ID:SGTC_2185|Compound:6113692|FD-Score:3.06|P-value:5.19E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.84|P-value:1.87E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.54|P-value:7.28E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.31|P-value:1.89E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.71|P-value:3.41E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-4.19|P-value:3.53E-6 ID:SGTC_3001|Compound:9076041|FD-Score:3.26|P-value:2.33E-4 ID:SGTC_3014|Compound:9081533|FD-Score:4.14|P-value:4.57E-6 ID:SGTC_3199|Compound:9111318|FD-Score:3.40|P-value:1.34E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.11|P-value:4.19E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.05|P-value:5.29E-4

Top fitness defect scores for YLR336C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1906 st060206 4.84 94.7 µM 1.04E-7 1 6.47E-7 0.63
2 SGTC_919 tnp00227 4.37 403.6 nM 1.38E-6 RNA pol III & RNase P/MRP 10 6.23E-6 0.10
3 SGTC_884 0851-0618 4.34 334.0 µM 1.58E-6 5 6.98E-6 0.66
4 SGTC_2152 5568786 4.24 200.0 µM 2.75E-6 2 1.14E-5 0.41
5 SGTC_3014 9081533 4.14 49.5 µM 4.57E-6 1 1.77E-5 0.24
6 SGTC_1788 fluconazole 3.90 20.0 µM 1.46E-5 azole & statin 8 4.89E-5 0.01
7 SGTC_1267 0828-0272 3.87 9.5 µM 1.65E-5 6 5.44E-5 0.28
8 SGTC_2359 9039622 3.84 200.0 µM 1.87E-5 endomembrane recycling 4 6.07E-5 0.20
9 SGTC_2736 butenafine 3.71 14.7 µM 3.41E-5 7 1.03E-4 0.09
10 SGTC_376 3970-0862 3.55 59.1 µM 7.12E-5 12 1.96E-4 0.09
11 SGTC_90 0870-0863 3.43 4.6 µM 1.18E-4 8 3.05E-4 0.00
12 SGTC_3199 9111318 3.40 49.5 µM 1.34E-4 12 3.41E-4 0.07
13 SGTC_1007 4101-0031 3.33 70.0 µM 1.75E-4 9 4.30E-4 0.22
14 SGTC_1184 1269-1718 3.32 139.0 µM 1.83E-4 10 4.47E-4 0.16
15 SGTC_2478 5763493 3.31 32.3 µM 1.89E-4 9 4.61E-4 0.03
16 SGTC_114 0364-0001 3.29 490.3 µM 2.11E-4 16 5.08E-4 0.07
17 SGTC_661 1304-0007 3.28 33.6 µM 2.18E-4 13 5.21E-4 0.06
18 SGTC_3001 9076041 3.26 71.4 µM 2.33E-4 11 5.54E-4 0.20
19 SGTC_1952 st077036 3.13 64.1 µM 3.88E-4 18 8.65E-4 0.04
20 SGTC_3313 9133968 3.11 57.0 µM 4.19E-4 4 9.26E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 9.11E-17 YGR043C NQM1 hom Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift
0.135 4.45E-15 YDL057W_p YDL057W_p hom Putative protein of unknown function; YDL057W is not an essential gene
0.130 5.12E-14 YJL116C NCA3 hom Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication
0.117 9.66E-12 YBR018C GAL7 hom Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
0.099 8.03E-9 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.099 8.38E-9 YPR023C EAF3 hom Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
0.099 9.29E-9 YGR277C CAB4 het Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved
0.091 1.51E-7 YDL046W NPC2 hom Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
0.090 1.88E-7 YIL058W_d YIL058W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 5.17E-7 YLR018C POM34 hom Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.086 6.87E-7 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.085 8.60E-7 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.085 9.32E-7 YER161C SPT2 hom Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
0.083 1.34E-6 YKL065C YET1 hom Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.082 2.10E-6 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein