YLR338W_d / OPI9

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR338W / OPI9

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:-6.55|P-value:1.30E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.85|P-value:2.16E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:6.27|P-value:4.55E-7 ID:SGTC_79|Compound:0052-0007|FD-Score:4.00|P-value:8.69E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:5.08|P-value:3.46E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:6.17|P-value:6.64E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.46|P-value:2.29E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.92|P-value:5.73E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.94|P-value:9.74E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:6.77|P-value:5.56E-8 ID:SGTC_394|Compound:menadione|FD-Score:4.74|P-value:1.02E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.88|P-value:6.54E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-5.27|P-value:1.72E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.00|P-value:8.59E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:6.30|P-value:3.97E-7 ID:SGTC_497|Compound:capsazepine|FD-Score:-4.20|P-value:4.72E-4 ID:SGTC_500|Compound:h-89|FD-Score:4.15|P-value:5.80E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-8.41|P-value:1.98E-11 ID:SGTC_505|Compound:gw-5074|FD-Score:6.70|P-value:7.50E-8 ID:SGTC_550|Compound:4123-0385|FD-Score:4.01|P-value:8.43E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.33|P-value:1.49E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.97|P-value:8.93E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.88|P-value:6.67E-5 ID:SGTC_593|Compound:1203-0218|FD-Score:4.33|P-value:3.50E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:5.67|P-value:4.47E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:4.91|P-value:6.09E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:5.19|P-value:2.38E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.60|P-value:5.82E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:4.28|P-value:4.06E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:5.09|P-value:3.31E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-6.14|P-value:7.02E-7 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.99|P-value:8.88E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.72|P-value:1.10E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.98|P-value:8.73E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.01|P-value:8.47E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.19|P-value:5.17E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.29|P-value:3.90E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.28|P-value:4.01E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.74|P-value:1.01E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.43|P-value:2.30E-7 ID:SGTC_1636|Compound:st007707|FD-Score:4.50|P-value:2.13E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.00|P-value:8.77E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.60|P-value:1.58E-4 ID:SGTC_1711|Compound:st032263|FD-Score:5.11|P-value:3.18E-5 ID:SGTC_1824|Compound:st053723|FD-Score:8.41|P-value:2.11E-11 ID:SGTC_2022|Compound:5136654|FD-Score:4.25|P-value:4.39E-4 ID:SGTC_2027|Compound:5150920|FD-Score:4.13|P-value:6.06E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.48|P-value:2.23E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-4.37|P-value:2.93E-4 ID:SGTC_2070|Compound:5230947|FD-Score:5.01|P-value:4.37E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.34|P-value:3.35E-4 ID:SGTC_2079|Compound:5212404|FD-Score:4.05|P-value:7.60E-4 ID:SGTC_2133|Compound:5320837|FD-Score:5.78|P-value:2.97E-6 ID:SGTC_2135|Compound:5326629|FD-Score:7.37|P-value:3.86E-9 ID:SGTC_2136|Compound:5328288|FD-Score:6.27|P-value:4.40E-7 ID:SGTC_2189|Compound:6047310|FD-Score:4.14|P-value:6.01E-4 ID:SGTC_2190|Compound:6049624|FD-Score:5.23|P-value:2.06E-5 ID:SGTC_2197|Compound:6588183|FD-Score:4.64|P-value:1.39E-4 ID:SGTC_2200|Compound:6600604|FD-Score:7.33|P-value:4.67E-9 ID:SGTC_2223|Compound:6903751|FD-Score:-4.87|P-value:6.39E-5 ID:SGTC_2246|Compound:7293507|FD-Score:5.57|P-value:6.35E-6 ID:SGTC_2391|Compound:6285546|FD-Score:6.06|P-value:1.03E-6 ID:SGTC_2437|Compound:5741531|FD-Score:4.82|P-value:8.01E-5 ID:SGTC_2460|Compound:5552655|FD-Score:4.31|P-value:3.69E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.26|P-value:4.19E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-5.20|P-value:2.18E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.69|P-value:1.19E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.08|P-value:6.99E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.52|P-value:7.54E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.71|P-value:1.13E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-5.88|P-value:1.90E-6 ID:SGTC_2781|Compound:5567276|FD-Score:6.07|P-value:9.76E-7 ID:SGTC_2841|Compound:9004761|FD-Score:4.70|P-value:1.18E-4 ID:SGTC_2897|Compound:9048598|FD-Score:4.08|P-value:7.03E-4 ID:SGTC_2984|Compound:9022109|FD-Score:4.02|P-value:8.16E-4 ID:SGTC_3034|Compound:9090421|FD-Score:7.21|P-value:8.05E-9 ID:SGTC_3126|Compound:9127922|FD-Score:-4.27|P-value:3.91E-4 ID:SGTC_3155|Compound:9099265|FD-Score:5.69|P-value:4.12E-6 ID:SGTC_3189|Compound:9110682|FD-Score:4.52|P-value:1.99E-4 ID:SGTC_3288|Compound:9119690|FD-Score:7.64|P-value:1.08E-9 ID:SGTC_37|Compound:0566-0070|FD-Score:-6.55|P-value:1.30E-7 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.85|P-value:2.16E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:6.27|P-value:4.55E-7 ID:SGTC_79|Compound:0052-0007|FD-Score:4.00|P-value:8.69E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:5.08|P-value:3.46E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:6.17|P-value:6.64E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.46|P-value:2.29E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:4.92|P-value:5.73E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.94|P-value:9.74E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:6.77|P-value:5.56E-8 ID:SGTC_394|Compound:menadione|FD-Score:4.74|P-value:1.02E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.88|P-value:6.54E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:-5.27|P-value:1.72E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.00|P-value:8.59E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:6.30|P-value:3.97E-7 ID:SGTC_497|Compound:capsazepine|FD-Score:-4.20|P-value:4.72E-4 ID:SGTC_500|Compound:h-89|FD-Score:4.15|P-value:5.80E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:-8.41|P-value:1.98E-11 ID:SGTC_505|Compound:gw-5074|FD-Score:6.70|P-value:7.50E-8 ID:SGTC_550|Compound:4123-0385|FD-Score:4.01|P-value:8.43E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:5.33|P-value:1.49E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.97|P-value:8.93E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.88|P-value:6.67E-5 ID:SGTC_593|Compound:1203-0218|FD-Score:4.33|P-value:3.50E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:5.67|P-value:4.47E-6 ID:SGTC_675|Compound:1309-0189|FD-Score:4.91|P-value:6.09E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:5.19|P-value:2.38E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.60|P-value:5.82E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:4.28|P-value:4.06E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:5.09|P-value:3.31E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-6.14|P-value:7.02E-7 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.99|P-value:8.88E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.72|P-value:1.10E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-3.98|P-value:8.73E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.01|P-value:8.47E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.19|P-value:5.17E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.29|P-value:3.90E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.28|P-value:4.01E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.74|P-value:1.01E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.43|P-value:2.30E-7 ID:SGTC_1636|Compound:st007707|FD-Score:4.50|P-value:2.13E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.00|P-value:8.77E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.60|P-value:1.58E-4 ID:SGTC_1711|Compound:st032263|FD-Score:5.11|P-value:3.18E-5 ID:SGTC_1824|Compound:st053723|FD-Score:8.41|P-value:2.11E-11 ID:SGTC_2022|Compound:5136654|FD-Score:4.25|P-value:4.39E-4 ID:SGTC_2027|Compound:5150920|FD-Score:4.13|P-value:6.06E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.48|P-value:2.23E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-4.37|P-value:2.93E-4 ID:SGTC_2070|Compound:5230947|FD-Score:5.01|P-value:4.37E-5 ID:SGTC_2077|Compound:5212015|FD-Score:4.34|P-value:3.35E-4 ID:SGTC_2079|Compound:5212404|FD-Score:4.05|P-value:7.60E-4 ID:SGTC_2133|Compound:5320837|FD-Score:5.78|P-value:2.97E-6 ID:SGTC_2135|Compound:5326629|FD-Score:7.37|P-value:3.86E-9 ID:SGTC_2136|Compound:5328288|FD-Score:6.27|P-value:4.40E-7 ID:SGTC_2189|Compound:6047310|FD-Score:4.14|P-value:6.01E-4 ID:SGTC_2190|Compound:6049624|FD-Score:5.23|P-value:2.06E-5 ID:SGTC_2197|Compound:6588183|FD-Score:4.64|P-value:1.39E-4 ID:SGTC_2200|Compound:6600604|FD-Score:7.33|P-value:4.67E-9 ID:SGTC_2223|Compound:6903751|FD-Score:-4.87|P-value:6.39E-5 ID:SGTC_2246|Compound:7293507|FD-Score:5.57|P-value:6.35E-6 ID:SGTC_2391|Compound:6285546|FD-Score:6.06|P-value:1.03E-6 ID:SGTC_2437|Compound:5741531|FD-Score:4.82|P-value:8.01E-5 ID:SGTC_2460|Compound:5552655|FD-Score:4.31|P-value:3.69E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.26|P-value:4.19E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-5.20|P-value:2.18E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.69|P-value:1.19E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:4.08|P-value:6.99E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.52|P-value:7.54E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.71|P-value:1.13E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-5.88|P-value:1.90E-6 ID:SGTC_2781|Compound:5567276|FD-Score:6.07|P-value:9.76E-7 ID:SGTC_2841|Compound:9004761|FD-Score:4.70|P-value:1.18E-4 ID:SGTC_2897|Compound:9048598|FD-Score:4.08|P-value:7.03E-4 ID:SGTC_2984|Compound:9022109|FD-Score:4.02|P-value:8.16E-4 ID:SGTC_3034|Compound:9090421|FD-Score:7.21|P-value:8.05E-9 ID:SGTC_3126|Compound:9127922|FD-Score:-4.27|P-value:3.91E-4 ID:SGTC_3155|Compound:9099265|FD-Score:5.69|P-value:4.12E-6 ID:SGTC_3189|Compound:9110682|FD-Score:4.52|P-value:1.99E-4 ID:SGTC_3288|Compound:9119690|FD-Score:7.64|P-value:1.08E-9

Top fitness defect scores for YLR338W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1824 st053723 8.41 68.6 µM 2.11E-11 7 1.98E-17
2 SGTC_3288 9119690 7.64 36.2 µM 1.08E-9 4 1.12E-14
3 SGTC_2135 5326629 7.37 150.4 µM 3.86E-9 RPP1 & pyrimidine depletion 2 8.72E-14
4 SGTC_2200 6600604 7.33 21.9 µM 4.67E-9 tubulin folding & SWR complex 18 1.18E-13
5 SGTC_3034 9090421 7.21 49.5 µM 8.05E-9 60S ribosome export 1 2.84E-13
6 SGTC_358 0075-0058 6.77 9.4 µM 5.56E-8 11 6.34E-12
7 SGTC_505 gw-5074 6.70 63.9 µM 7.50E-8 22 1.03E-11
8 SGTC_1635 st007035 6.43 42.4 µM 2.30E-7 130 6.21E-11
9 SGTC_481 bay k-8644 6.30 50.0 µM 3.97E-7 6 1.49E-10
10 SGTC_2136 5328288 6.27 199.3 µM 4.40E-7 3 1.75E-10
11 SGTC_43 0570-0105 6.27 72.5 µM 4.55E-7 ERG2 33 1.85E-10
12 SGTC_161 4065-0411 6.17 162.2 µM 6.64E-7 25 3.40E-10
13 SGTC_2781 5567276 6.07 71.4 µM 9.76E-7 14 6.30E-10
14 SGTC_2391 6285546 6.06 200.0 µM 1.03E-6 1 6.85E-10
15 SGTC_2133 5320837 5.78 200.0 µM 2.97E-6 ERG2 5 3.75E-9
16 SGTC_3155 9099265 5.69 49.5 µM 4.12E-6 6 6.33E-9
17 SGTC_595 3909-8003 5.67 73.7 µM 4.47E-6 2 7.21E-9
18 SGTC_908 3448-7491 5.60 47.7 µM 5.82E-6 mitochondrial stress 59 1.10E-8
19 SGTC_2246 7293507 5.57 91.6 µM 6.35E-6 12 1.26E-8
20 SGTC_2600 tangeritin 5.52 88.0 µM 7.54E-6 9 1.66E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.250 1.23E-48 YDR129C SAC6 hom Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.240 5.06E-45 YLR370C ARC18 hom Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.226 4.34E-40 YOR035C SHE4 hom Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
0.138 9.66E-16 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.130 3.77E-14 YGL012W ERG4 hom C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
0.121 2.17E-12 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.120 3.52E-12 YML122C_d YML122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.119 4.33E-12 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
0.113 4.71E-11 YDR137W RGP1 hom Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
0.103 2.24E-9 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.102 2.90E-9 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.102 3.18E-9 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
0.100 6.76E-9 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.097 2.09E-8 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.096 2.32E-8 YLR230W_d YLR230W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity