YLR339C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR339C / YLR339C

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.79|P-value:4.75E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.07|P-value:8.11E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.84|P-value:3.02E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:3.20|P-value:4.95E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:7.63|P-value:1.51E-15 ID:SGTC_158|Compound:k038-0087|FD-Score:4.36|P-value:3.52E-6 ID:SGTC_246|Compound:cycloheximide|FD-Score:6.17|P-value:9.24E-11 ID:SGTC_405|Compound:ebelactone b|FD-Score:-4.13|P-value:7.46E-6 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.88|P-value:3.19E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.80|P-value:2.49E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.98|P-value:2.05E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:-2.97|P-value:8.77E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.19|P-value:7.96E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.13|P-value:7.44E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.61|P-value:7.49E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:6.47|P-value:1.16E-11 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.50|P-value:1.60E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.45|P-value:1.96E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.16|P-value:5.80E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.05|P-value:6.60E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.16|P-value:8.90E-6 ID:SGTC_1591|Compound:genipin|FD-Score:3.61|P-value:1.00E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.28|P-value:2.80E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.41|P-value:1.71E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.90|P-value:2.96E-5 ID:SGTC_1719|Compound:st032227|FD-Score:6.54|P-value:7.09E-12 ID:SGTC_1745|Compound:st081495|FD-Score:4.81|P-value:3.44E-7 ID:SGTC_1771|Compound:st048882|FD-Score:-3.48|P-value:1.29E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-3.53|P-value:1.05E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.30|P-value:2.59E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.82|P-value:4.26E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-2.97|P-value:9.05E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.44|P-value:2.05E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.80|P-value:4.63E-5 ID:SGTC_2333|Compound:9017922|FD-Score:-3.02|P-value:7.58E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.48|P-value:1.75E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.38|P-value:2.50E-4 ID:SGTC_2369|Compound:9071472|FD-Score:4.01|P-value:1.80E-5 ID:SGTC_2376|Compound:9072922|FD-Score:3.42|P-value:2.19E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.65|P-value:8.53E-5 ID:SGTC_2382|Compound:9035899|FD-Score:5.57|P-value:4.47E-9 ID:SGTC_2394|Compound:5221648|FD-Score:-3.35|P-value:2.18E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.27|P-value:2.93E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.52|P-value:1.44E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.98|P-value:2.07E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.07|P-value:7.97E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.30|P-value:3.48E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.29|P-value:2.75E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.23|P-value:4.48E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.49|P-value:1.24E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-4.02|P-value:1.27E-5 ID:SGTC_2794|Compound:7785382|FD-Score:-4.19|P-value:5.55E-6 ID:SGTC_2884|Compound:9058502|FD-Score:-3.48|P-value:1.28E-4 ID:SGTC_2885|Compound:9057732|FD-Score:5.59|P-value:3.98E-9 ID:SGTC_2897|Compound:9048598|FD-Score:-3.94|P-value:1.82E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.92|P-value:2.75E-5 ID:SGTC_3030|Compound:9087619|FD-Score:-3.24|P-value:3.29E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.23|P-value:4.56E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.55|P-value:1.29E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-2.97|P-value:8.83E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.99|P-value:1.42E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.73|P-value:6.20E-5 ID:SGTC_3242|Compound:9133940|FD-Score:3.11|P-value:7.08E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-2.95|P-value:9.56E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-4.03|P-value:1.16E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:3.79|P-value:4.75E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:3.07|P-value:8.11E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.84|P-value:3.02E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:3.20|P-value:4.95E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:7.63|P-value:1.51E-15 ID:SGTC_158|Compound:k038-0087|FD-Score:4.36|P-value:3.52E-6 ID:SGTC_246|Compound:cycloheximide|FD-Score:6.17|P-value:9.24E-11 ID:SGTC_405|Compound:ebelactone b|FD-Score:-4.13|P-value:7.46E-6 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.88|P-value:3.19E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.80|P-value:2.49E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.98|P-value:2.05E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:-2.97|P-value:8.77E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.19|P-value:7.96E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.13|P-value:7.44E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.61|P-value:7.49E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:6.47|P-value:1.16E-11 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.50|P-value:1.60E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.45|P-value:1.96E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.16|P-value:5.80E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.05|P-value:6.60E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.16|P-value:8.90E-6 ID:SGTC_1591|Compound:genipin|FD-Score:3.61|P-value:1.00E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.28|P-value:2.80E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.41|P-value:1.71E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.90|P-value:2.96E-5 ID:SGTC_1719|Compound:st032227|FD-Score:6.54|P-value:7.09E-12 ID:SGTC_1745|Compound:st081495|FD-Score:4.81|P-value:3.44E-7 ID:SGTC_1771|Compound:st048882|FD-Score:-3.48|P-value:1.29E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-3.53|P-value:1.05E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.30|P-value:2.59E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.82|P-value:4.26E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-2.97|P-value:9.05E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.44|P-value:2.05E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.80|P-value:4.63E-5 ID:SGTC_2333|Compound:9017922|FD-Score:-3.02|P-value:7.58E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.48|P-value:1.75E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.38|P-value:2.50E-4 ID:SGTC_2369|Compound:9071472|FD-Score:4.01|P-value:1.80E-5 ID:SGTC_2376|Compound:9072922|FD-Score:3.42|P-value:2.19E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.65|P-value:8.53E-5 ID:SGTC_2382|Compound:9035899|FD-Score:5.57|P-value:4.47E-9 ID:SGTC_2394|Compound:5221648|FD-Score:-3.35|P-value:2.18E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.27|P-value:2.93E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.52|P-value:1.44E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.98|P-value:2.07E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:3.07|P-value:7.97E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.30|P-value:3.48E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.29|P-value:2.75E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.23|P-value:4.48E-4 ID:SGTC_2787|Compound:5284540|FD-Score:-3.49|P-value:1.24E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-4.02|P-value:1.27E-5 ID:SGTC_2794|Compound:7785382|FD-Score:-4.19|P-value:5.55E-6 ID:SGTC_2884|Compound:9058502|FD-Score:-3.48|P-value:1.28E-4 ID:SGTC_2885|Compound:9057732|FD-Score:5.59|P-value:3.98E-9 ID:SGTC_2897|Compound:9048598|FD-Score:-3.94|P-value:1.82E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.92|P-value:2.75E-5 ID:SGTC_3030|Compound:9087619|FD-Score:-3.24|P-value:3.29E-4 ID:SGTC_3039|Compound:9090270|FD-Score:3.23|P-value:4.56E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.55|P-value:1.29E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-2.97|P-value:8.83E-4 ID:SGTC_3129|Compound:9127257|FD-Score:-3.99|P-value:1.42E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.73|P-value:6.20E-5 ID:SGTC_3242|Compound:9133940|FD-Score:3.11|P-value:7.08E-4 ID:SGTC_3274|Compound:9138298|FD-Score:-2.95|P-value:9.56E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-4.03|P-value:1.16E-5

Top fitness defect scores for YLR339C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_142 0335-0849 7.63 62.7 µM 1.51E-15 ubiquinone biosynthesis & proteasome 6 1.21E-14 0.11
2 SGTC_1719 st032227 6.54 49.2 µM 7.09E-12 1 3.17E-11 0.74
3 SGTC_1132 3456-3614 6.47 2.5 µM 1.16E-11 tubulin folding & SWR complex 2 5.00E-11 1.35
4 SGTC_246 cycloheximide 6.17 667.0 µM 9.24E-11 3 3.47E-10 0.83
5 SGTC_2885 9057732 5.59 52.0 µM 3.98E-9 1 1.16E-8 0.99
6 SGTC_2382 9035899 5.57 200.0 µM 4.47E-9 60S ribosome export 2 1.29E-8 0.23
7 SGTC_86 0417-1630 4.84 471.9 µM 3.02E-7 ubiquinone biosynthesis & proteasome 17 6.61E-7 0.03
8 SGTC_1745 st081495 4.81 74.0 µM 3.44E-7 RNA processing & uracil transport 21 7.46E-7 0.26
9 SGTC_158 k038-0087 4.36 26.4 µM 3.52E-6 ubiquinone biosynthesis & proteasome 29 6.57E-6 0.14
10 SGTC_914 3820-6779 4.19 408.0 µM 7.96E-6 3 1.41E-5 0.12
11 SGTC_1514 1189-1591 4.16 158.0 µM 8.90E-6 4 1.56E-5 0.10
12 SGTC_2369 9071472 4.01 200.0 µM 1.80E-5 3 3.03E-5 0.26
13 SGTC_501 nsc-95397 3.98 161.0 µM 2.05E-5 8 3.41E-5 0.20
14 SGTC_2595 hexamethylquercetagetin 3.98 100.0 µM 2.07E-5 4 3.45E-5 0.06
15 SGTC_2998 9066762 3.92 71.4 µM 2.75E-5 RPP1 & pyrimidine depletion 11 4.51E-5 0.19
16 SGTC_1681 tripelennamine 3.90 100.0 µM 2.96E-5 8 4.82E-5 0.13
17 SGTC_420 mitomycin C 3.88 81.9 mM 3.19E-5 3 5.18E-5 0.33
18 SGTC_2012 4023501 3.82 200.0 µM 4.26E-5 13 6.78E-5 0.07
19 SGTC_2145 5634607 3.80 200.0 µM 4.63E-5 3 7.33E-5 0.24
20 SGTC_64 000l-0018 3.79 272.1 µM 4.75E-5 ubiquinone biosynthesis & proteasome 50 7.51E-5 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.224 3.07E-39 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.210 1.26E-34 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.206 2.07E-33 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.196 2.70E-30 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.192 3.88E-29 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.191 9.01E-29 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.188 4.47E-28 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.188 4.11E-28 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.186 1.39E-27 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.181 4.07E-26 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.181 4.76E-26 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.177 5.57E-25 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.170 4.53E-23 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.169 5.99E-23 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.168 1.47E-22 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis