YLR340W / RPP0

Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR340W / RPP0

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.94|P-value:2.86E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.56|P-value:9.26E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:-4.63|P-value:2.38E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:-3.75|P-value:4.85E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:11.90|P-value:1.01E-25 ID:SGTC_448|Compound:monastrol|FD-Score:4.37|P-value:6.75E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.49|P-value:4.38E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.03|P-value:2.14E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:4.09|P-value:1.73E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.91|P-value:3.14E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-4.36|P-value:6.21E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:4.20|P-value:1.22E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.83|P-value:1.11E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:6.73|P-value:1.96E-9 ID:SGTC_994|Compound:3910-0338|FD-Score:3.87|P-value:3.57E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.56|P-value:9.20E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.57|P-value:9.11E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.49|P-value:7.67E-7 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.95|P-value:2.80E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.85|P-value:3.50E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.87|P-value:3.57E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.81|P-value:4.03E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.05|P-value:1.99E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:7.44|P-value:3.71E-11 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-3.95|P-value:2.55E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.59|P-value:8.56E-4 ID:SGTC_1668|Compound:st014914|FD-Score:4.39|P-value:6.10E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-7.98|P-value:1.18E-12 ID:SGTC_1676|Compound:st018489|FD-Score:-4.13|P-value:1.38E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.43|P-value:5.45E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:11.00|P-value:2.44E-22 ID:SGTC_1745|Compound:st081495|FD-Score:4.83|P-value:1.19E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.89|P-value:3.38E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.79|P-value:4.55E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-4.51|P-value:3.61E-5 ID:SGTC_1982|Compound:st072467|FD-Score:4.75|P-value:1.66E-5 ID:SGTC_1983|Compound:st071813|FD-Score:5.96|P-value:9.36E-8 ID:SGTC_1991|Compound:st073000|FD-Score:4.60|P-value:2.86E-5 ID:SGTC_2099|Compound:5377090|FD-Score:8.63|P-value:2.07E-14 ID:SGTC_2186|Compound:6124449|FD-Score:4.37|P-value:6.68E-5 ID:SGTC_2192|Compound:5915882|FD-Score:4.60|P-value:2.92E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:4.14|P-value:1.47E-4 ID:SGTC_2253|Compound:7938677|FD-Score:4.74|P-value:1.72E-5 ID:SGTC_2258|Compound:7960471|FD-Score:4.87|P-value:1.02E-5 ID:SGTC_2282|Compound:7944268|FD-Score:-4.13|P-value:1.39E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.61|P-value:7.42E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.09|P-value:1.61E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.83|P-value:4.12E-4 ID:SGTC_2570|Compound:licareol|FD-Score:6.45|P-value:8.38E-9 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.04|P-value:1.88E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.98|P-value:2.36E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.94|P-value:7.10E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:7.43|P-value:3.95E-11 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.62|P-value:2.70E-5 ID:SGTC_2786|Compound:7743617|FD-Score:5.20|P-value:2.71E-6 ID:SGTC_2788|Compound:5282734|FD-Score:3.65|P-value:7.13E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.10|P-value:1.71E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.85|P-value:3.84E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-5.50|P-value:6.69E-7 ID:SGTC_2952|Compound:9073731|FD-Score:-4.14|P-value:1.36E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.19|P-value:1.24E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.08|P-value:1.81E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.93|P-value:7.30E-6 ID:SGTC_3094|Compound:9117742|FD-Score:-4.07|P-value:1.72E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.08|P-value:1.78E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.57|P-value:9.15E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-3.61|P-value:7.43E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.94|P-value:2.86E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.56|P-value:9.26E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:-4.63|P-value:2.38E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:-3.75|P-value:4.85E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:11.90|P-value:1.01E-25 ID:SGTC_448|Compound:monastrol|FD-Score:4.37|P-value:6.75E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.49|P-value:4.38E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.03|P-value:2.14E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:4.09|P-value:1.73E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.91|P-value:3.14E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-4.36|P-value:6.21E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:4.20|P-value:1.22E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-4.83|P-value:1.11E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:6.73|P-value:1.96E-9 ID:SGTC_994|Compound:3910-0338|FD-Score:3.87|P-value:3.57E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.56|P-value:9.20E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.57|P-value:9.11E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:5.49|P-value:7.67E-7 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.95|P-value:2.80E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.85|P-value:3.50E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.87|P-value:3.57E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:-3.81|P-value:4.03E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.05|P-value:1.99E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:7.44|P-value:3.71E-11 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-3.95|P-value:2.55E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.59|P-value:8.56E-4 ID:SGTC_1668|Compound:st014914|FD-Score:4.39|P-value:6.10E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-7.98|P-value:1.18E-12 ID:SGTC_1676|Compound:st018489|FD-Score:-4.13|P-value:1.38E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.43|P-value:5.45E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:11.00|P-value:2.44E-22 ID:SGTC_1745|Compound:st081495|FD-Score:4.83|P-value:1.19E-5 ID:SGTC_1836|Compound:st055642|FD-Score:3.89|P-value:3.38E-4 ID:SGTC_1862|Compound:st057513|FD-Score:3.79|P-value:4.55E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-4.51|P-value:3.61E-5 ID:SGTC_1982|Compound:st072467|FD-Score:4.75|P-value:1.66E-5 ID:SGTC_1983|Compound:st071813|FD-Score:5.96|P-value:9.36E-8 ID:SGTC_1991|Compound:st073000|FD-Score:4.60|P-value:2.86E-5 ID:SGTC_2099|Compound:5377090|FD-Score:8.63|P-value:2.07E-14 ID:SGTC_2186|Compound:6124449|FD-Score:4.37|P-value:6.68E-5 ID:SGTC_2192|Compound:5915882|FD-Score:4.60|P-value:2.92E-5 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:4.14|P-value:1.47E-4 ID:SGTC_2253|Compound:7938677|FD-Score:4.74|P-value:1.72E-5 ID:SGTC_2258|Compound:7960471|FD-Score:4.87|P-value:1.02E-5 ID:SGTC_2282|Compound:7944268|FD-Score:-4.13|P-value:1.39E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.61|P-value:7.42E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-4.09|P-value:1.61E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.83|P-value:4.12E-4 ID:SGTC_2570|Compound:licareol|FD-Score:6.45|P-value:8.38E-9 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.04|P-value:1.88E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-3.98|P-value:2.36E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.94|P-value:7.10E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:7.43|P-value:3.95E-11 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.62|P-value:2.70E-5 ID:SGTC_2786|Compound:7743617|FD-Score:5.20|P-value:2.71E-6 ID:SGTC_2788|Compound:5282734|FD-Score:3.65|P-value:7.13E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.10|P-value:1.71E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.85|P-value:3.84E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-5.50|P-value:6.69E-7 ID:SGTC_2952|Compound:9073731|FD-Score:-4.14|P-value:1.36E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.19|P-value:1.24E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.08|P-value:1.81E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.93|P-value:7.30E-6 ID:SGTC_3094|Compound:9117742|FD-Score:-4.07|P-value:1.72E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.08|P-value:1.78E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.57|P-value:9.15E-4 ID:SGTC_3328|Compound:9140624|FD-Score:-3.61|P-value:7.43E-4

Top fitness defect scores for YLR340W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_246 cycloheximide 11.90 667.0 µM 1.01E-25 1 6.29E-33 5.35
2 SGTC_1681 tripelennamine 11.00 100.0 µM 2.44E-22 1 1.56E-28 4.15
3 SGTC_2099 5377090 8.63 177.4 µM 2.07E-14 1 3.08E-18 3.72
4 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 7.44 61.9 µM 3.71E-11 1 5.10E-14 2.51
5 SGTC_2628 lathosterol 7.43 100.0 µM 3.95E-11 1 5.51E-14 1.59
6 SGTC_932 2857-0803 6.73 154.0 µM 1.96E-9 2 8.69E-12 1.58
7 SGTC_2570 licareol 6.45 100.0 µM 8.38E-9 1 5.70E-11 1.71
8 SGTC_1983 st071813 5.96 46.9 µM 9.36E-8 RPP1 & pyrimidine depletion 1 1.30E-9 1.25
9 SGTC_1167 k781-0610 5.49 148.0 µM 7.67E-7 RNA processing & uracil transport 1 1.96E-8 0.66
10 SGTC_2786 7743617 5.20 45.5 µM 2.71E-6 2 1.01E-7 0.44
11 SGTC_2258 7960471 4.87 200.0 µM 1.02E-5 1 5.58E-7 0.64
12 SGTC_1745 st081495 4.83 74.0 µM 1.19E-5 RNA processing & uracil transport 20 6.76E-7 0.02
13 SGTC_1982 st072467 4.75 71.9 µM 1.66E-5 4 1.04E-6 0.09
14 SGTC_2253 7938677 4.74 135.8 µM 1.72E-5 2 1.09E-6 0.08
15 SGTC_2750 bromebric acid 4.62 70.2 µM 2.70E-5 3 1.94E-6 0.67
16 SGTC_1991 st073000 4.60 8.9 µM 2.86E-5 NEO1 13 2.10E-6 0.17
17 SGTC_2192 5915882 4.60 198.5 µM 2.92E-5 RNA processing & uracil transport 12 2.16E-6 0.06
18 SGTC_501 nsc-95397 4.49 161.0 µM 4.38E-5 4 3.64E-6 0.15
19 SGTC_1680 diphenhydramine 4.43 100.0 µM 5.45E-5 NEO1 11 4.81E-6 0.16
20 SGTC_1668 st014914 4.39 51.6 µM 6.10E-5 RPP1 & pyrimidine depletion 3 5.57E-6 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 2.33E-14 YLR339C_d YLR339C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
0.088 3.29E-7 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.087 5.18E-7 YPL229W_p YPL229W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication
0.079 5.24E-6 YKL006W RPL14A hom Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication
0.074 1.87E-5 YLR227C ADY4 hom Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
0.072 3.08E-5 YDR352W YPQ2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
0.072 3.50E-5 YJR070C LIA1 hom Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress
0.072 3.48E-5 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.069 5.93E-5 YOL127W RPL25 het Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
0.069 6.70E-5 YCL054W SPB1 het AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
0.069 7.31E-5 YDR078C SHU2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.068 7.62E-5 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.068 9.26E-5 YLR398C SKI2 hom Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
0.067 1.05E-4 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.066 1.29E-4 YCL051W LRE1 hom Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication