YLR342W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR342W-A / YLR342W-A

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:5.12|P-value:4.19E-7 ID:SGTC_95|Compound:0471-0001|FD-Score:6.26|P-value:8.90E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.31|P-value:8.92E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.47|P-value:3.99E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.84|P-value:1.42E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.62|P-value:2.40E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.75|P-value:1.50E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.23|P-value:9.13E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.30|P-value:7.15E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.89|P-value:8.75E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:-5.17|P-value:4.77E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.39|P-value:5.24E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.28|P-value:1.83E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.34|P-value:6.35E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.58|P-value:2.78E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.77|P-value:1.36E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.52|P-value:3.37E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.62|P-value:2.41E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.26|P-value:8.21E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.75|P-value:1.48E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.80|P-value:1.23E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.89|P-value:8.62E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:4.18|P-value:2.81E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.42|P-value:6.17E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.63|P-value:2.30E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-4.20|P-value:3.42E-5 ID:SGTC_2883|Compound:9059145|FD-Score:-3.54|P-value:4.15E-4 ID:SGTC_3115|Compound:9123671|FD-Score:-3.59|P-value:3.40E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:5.12|P-value:4.19E-7 ID:SGTC_95|Compound:0471-0001|FD-Score:6.26|P-value:8.90E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.31|P-value:8.92E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.47|P-value:3.99E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.84|P-value:1.42E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.62|P-value:2.40E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.75|P-value:1.50E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.23|P-value:9.13E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.30|P-value:7.15E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.89|P-value:8.75E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:-5.17|P-value:4.77E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.39|P-value:5.24E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.28|P-value:1.83E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.34|P-value:6.35E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.58|P-value:2.78E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.77|P-value:1.36E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.52|P-value:3.37E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.62|P-value:2.41E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.26|P-value:8.21E-4 ID:SGTC_1930|Compound:st074634|FD-Score:3.75|P-value:1.48E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.80|P-value:1.23E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.89|P-value:8.62E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:4.18|P-value:2.81E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.42|P-value:6.17E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.63|P-value:2.30E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-4.20|P-value:3.42E-5 ID:SGTC_2883|Compound:9059145|FD-Score:-3.54|P-value:4.15E-4 ID:SGTC_3115|Compound:9123671|FD-Score:-3.59|P-value:3.40E-4

Top fitness defect scores for YLR342W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_95 0471-0001 6.26 561.1 µM 8.90E-10 3 1.91E-10
2 SGTC_35 0133-0054 5.12 64.1 µM 4.19E-7 11 1.53E-7
3 SGTC_1207 2099-0101 4.28 141.0 µM 1.83E-5 9 9.20E-6
4 SGTC_2495 cafestol 4.18 54.5 µM 2.81E-5 Golgi 22 1.46E-5
5 SGTC_2335 9018011 3.89 154.2 µM 8.62E-5 28 4.91E-5
6 SGTC_841 0251-0215 3.89 91.2 µM 8.75E-5 74 4.99E-5
7 SGTC_2154 5570129 3.80 200.0 µM 1.23E-4 20 7.22E-5
8 SGTC_1470 k295-0292 3.77 231.0 µM 1.36E-4 16 8.02E-5
9 SGTC_1930 st074634 3.75 34.3 µM 1.48E-4 RNA pol III & RNase P/MRP 42 8.79E-5
10 SGTC_271 rotenone 3.75 740.0 µM 1.50E-4 33 8.96E-5
11 SGTC_2764 methyldopa 3.63 94.7 µM 2.30E-4 24 1.42E-4
12 SGTC_236 1509-0011 3.62 5.3 µM 2.40E-4 406 1.49E-4
13 SGTC_1825 st052143 3.62 62.6 µM 2.41E-4 23 1.49E-4
14 SGTC_1460 k062-0059 3.58 9.2 µM 2.78E-4 Golgi 23 1.74E-4
15 SGTC_1664 st014217 3.52 9.0 µM 3.37E-4 60S ribosome export 20 2.15E-4
16 SGTC_126 0417-1624 3.47 672.5 µM 3.99E-4 DNA intercalators 50 2.57E-4
17 SGTC_1098 clofazimine 3.39 15.1 µM 5.24E-4 heme biosynthesis & mitochondrial translocase 50 3.45E-4
18 SGTC_1319 1306-0155 3.34 43.7 µM 6.35E-4 58 4.25E-4
19 SGTC_554 4483-2211 3.30 187.0 µM 7.15E-4 35 4.82E-4
20 SGTC_1833 st055984 3.26 71.0 µM 8.21E-4 37 5.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.10E-12 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.120 3.31E-12 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.116 1.87E-11 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.115 2.56E-11 YHL005C_d YHL005C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W
0.109 2.65E-10 YHR160C PEX18 hom Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
0.106 7.19E-10 YNL172W APC1 het Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress
0.103 2.34E-9 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.098 1.30E-8 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.097 1.80E-8 YKL208W CBT1 hom Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
0.097 1.81E-8 YIL108W YIL108W hom Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress
0.096 2.48E-8 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.095 3.05E-8 YNL052W COX5A hom Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication
0.095 3.92E-8 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.095 4.06E-8 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.094 4.71E-8 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1