YLR343W / GAS2

1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR343W / GAS2

Click on Significant Values for Screen Details ID:SGTC_227|Compound:fluconazole|FD-Score:-3.04|P-value:3.48E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.25|P-value:1.41E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.36|P-value:5.55E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:2.92|P-value:3.76E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-4.41|P-value:3.75E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:3.04|P-value:2.30E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:2.71|P-value:8.73E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.72|P-value:1.58E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:4.68|P-value:4.09E-8 ID:SGTC_722|Compound:3534-0461|FD-Score:2.69|P-value:9.54E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-2.81|P-value:8.72E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.49|P-value:2.37E-7 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.58|P-value:1.95E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:2.71|P-value:8.64E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.25|P-value:9.37E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.83|P-value:9.21E-6 ID:SGTC_1603|Compound:st002045|FD-Score:3.49|P-value:2.99E-5 ID:SGTC_1610|Compound:st001799|FD-Score:3.23|P-value:1.03E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.22|P-value:1.05E-4 ID:SGTC_1923|Compound:st058458|FD-Score:2.72|P-value:8.45E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.22|P-value:1.61E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.78|P-value:1.19E-5 ID:SGTC_2035|Compound:5154463|FD-Score:2.88|P-value:4.56E-4 ID:SGTC_2037|Compound:5169046|FD-Score:2.93|P-value:3.60E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.41|P-value:2.14E-7 ID:SGTC_2159|Compound:5658611|FD-Score:2.70|P-value:9.13E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-3.08|P-value:2.88E-4 ID:SGTC_2355|Compound:9061122|FD-Score:2.95|P-value:3.37E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.07|P-value:3.05E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.32|P-value:6.79E-5 ID:SGTC_2434|Compound:5670830|FD-Score:-2.78|P-value:9.77E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.64|P-value:1.48E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:2.81|P-value:5.85E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.36|P-value:5.55E-5 ID:SGTC_2678|Compound:equilin|FD-Score:3.25|P-value:9.05E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.68|P-value:1.21E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.22|P-value:1.06E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.30|P-value:4.19E-7 ID:SGTC_2896|Compound:9052656|FD-Score:3.05|P-value:2.23E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.09|P-value:1.87E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.05|P-value:3.35E-4 ID:SGTC_3029|Compound:9088683|FD-Score:2.96|P-value:3.18E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.04|P-value:2.28E-4 ID:SGTC_3045|Compound:9092950|FD-Score:2.82|P-value:5.79E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.06|P-value:2.09E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.35|P-value:5.92E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-3.12|P-value:2.52E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.70|P-value:1.69E-5 ID:SGTC_3207|Compound:9114163|FD-Score:4.55|P-value:8.99E-8 ID:SGTC_3208|Compound:9114115|FD-Score:-3.58|P-value:3.14E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.13|P-value:1.55E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.04|P-value:3.48E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.25|P-value:1.41E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.36|P-value:5.55E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:2.92|P-value:3.76E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-4.41|P-value:3.75E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:3.04|P-value:2.30E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:2.71|P-value:8.73E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.72|P-value:1.58E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:4.68|P-value:4.09E-8 ID:SGTC_722|Compound:3534-0461|FD-Score:2.69|P-value:9.54E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-2.81|P-value:8.72E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.49|P-value:2.37E-7 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.58|P-value:1.95E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:2.71|P-value:8.64E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.25|P-value:9.37E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.83|P-value:9.21E-6 ID:SGTC_1603|Compound:st002045|FD-Score:3.49|P-value:2.99E-5 ID:SGTC_1610|Compound:st001799|FD-Score:3.23|P-value:1.03E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.22|P-value:1.05E-4 ID:SGTC_1923|Compound:st058458|FD-Score:2.72|P-value:8.45E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.22|P-value:1.61E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.78|P-value:1.19E-5 ID:SGTC_2035|Compound:5154463|FD-Score:2.88|P-value:4.56E-4 ID:SGTC_2037|Compound:5169046|FD-Score:2.93|P-value:3.60E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.41|P-value:2.14E-7 ID:SGTC_2159|Compound:5658611|FD-Score:2.70|P-value:9.13E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-3.08|P-value:2.88E-4 ID:SGTC_2355|Compound:9061122|FD-Score:2.95|P-value:3.37E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.07|P-value:3.05E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.32|P-value:6.79E-5 ID:SGTC_2434|Compound:5670830|FD-Score:-2.78|P-value:9.77E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.64|P-value:1.48E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:2.81|P-value:5.85E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.36|P-value:5.55E-5 ID:SGTC_2678|Compound:equilin|FD-Score:3.25|P-value:9.05E-5 ID:SGTC_2789|Compound:5281112|FD-Score:3.68|P-value:1.21E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.22|P-value:1.06E-4 ID:SGTC_2799|Compound:7812892|FD-Score:4.30|P-value:4.19E-7 ID:SGTC_2896|Compound:9052656|FD-Score:3.05|P-value:2.23E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.09|P-value:1.87E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.05|P-value:3.35E-4 ID:SGTC_3029|Compound:9088683|FD-Score:2.96|P-value:3.18E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.04|P-value:2.28E-4 ID:SGTC_3045|Compound:9092950|FD-Score:2.82|P-value:5.79E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.06|P-value:2.09E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.35|P-value:5.92E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-3.12|P-value:2.52E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.70|P-value:1.69E-5 ID:SGTC_3207|Compound:9114163|FD-Score:4.55|P-value:8.99E-8 ID:SGTC_3208|Compound:9114115|FD-Score:-3.58|P-value:3.14E-5 ID:SGTC_3329|Compound:9141233|FD-Score:3.13|P-value:1.55E-4

Top fitness defect scores for YLR343W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_616 4092-0450 4.68 108.0 µM 4.09E-8 3 1.43E-6
2 SGTC_3207 9114163 4.55 49.5 µM 8.99E-8 19 2.63E-6
3 SGTC_2119 5528445 4.41 120.6 µM 2.14E-7 9 5.16E-6
4 SGTC_2799 7812892 4.30 81.8 µM 4.19E-7 superoxide 23 8.70E-6
5 SGTC_2789 5281112 3.68 71.4 µM 1.21E-5 46 1.19E-4
6 SGTC_2455 5377712 3.64 9.8 µM 1.48E-5 27 1.39E-4
7 SGTC_1173 0443-0020 3.58 122.0 µM 1.95E-5 TSC3-RPN4 51 1.72E-4
8 SGTC_1603 st002045 3.49 67.8 µM 2.99E-5 TSC3-RPN4 29 2.40E-4
9 SGTC_2633 5,7-dihydroxyisoflavone 3.36 100.0 µM 5.55E-5 52 3.89E-4
10 SGTC_269 exalamide 3.36 29.0 µM 5.55E-5 ergosterol biosynthesis 32 3.90E-4
11 SGTC_3150 9097574 3.35 49.5 µM 5.92E-5 21 4.10E-4
12 SGTC_2428 5615643 3.32 7.8 µM 6.79E-5 48 4.56E-4
13 SGTC_2678 equilin 3.25 100.0 µM 9.05E-5 41 5.70E-4
14 SGTC_1524 corynanthine 3.25 62.1 µM 9.37E-5 44 5.86E-4
15 SGTC_1610 st001799 3.23 48.1 µM 1.03E-4 34 6.29E-4
16 SGTC_1913 st060213 3.22 96.1 µM 1.05E-4 72 6.40E-4
17 SGTC_2796 7949634 3.22 45.5 µM 1.06E-4 51 6.44E-4
18 SGTC_3329 9141233 3.13 27.6 µM 1.55E-4 34 8.68E-4
19 SGTC_3010 9080089 3.09 71.4 µM 1.87E-4 52 0.00101
20 SGTC_3058 9093861 3.06 49.5 µM 2.09E-4 60 0.00109

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 5.85E-15 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.123 8.16E-13 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.118 6.65E-12 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.115 2.24E-11 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.111 1.10E-10 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.110 2.11E-10 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.105 1.22E-9 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.102 4.00E-9 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.100 6.37E-9 YJR124C_p YJR124C_p hom Putative protein of unknown function; expression induced under calcium shortage
0.097 1.78E-8 YCR048W ARE1 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication
0.096 2.90E-8 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.093 8.26E-8 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.092 8.92E-8 YML099C ARG81 hom Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
0.089 2.27E-7 YDR307W_p PMT7_p hom Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation
0.088 3.27E-7 YOL163W_p YOL163W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family