YLR344W / RPL26A

Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR344W / RPL26A

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:-3.13|P-value:5.44E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:4.97|P-value:9.38E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:3.09|P-value:5.74E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.08|P-value:5.95E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.05|P-value:6.79E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.94|P-value:1.74E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.51|P-value:1.13E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.72|P-value:4.70E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:5.01|P-value:7.47E-8 ID:SGTC_518|Compound:1021-0119|FD-Score:3.66|P-value:6.06E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.09|P-value:6.46E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.92|P-value:2.20E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.20|P-value:3.92E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.86|P-value:2.87E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:-2.97|P-value:9.72E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.13|P-value:5.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.98|P-value:9.46E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.02|P-value:7.44E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.68|P-value:5.49E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.43|P-value:1.75E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.03|P-value:7.12E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.71|P-value:3.93E-7 ID:SGTC_1924|Compound:st058459|FD-Score:3.02|P-value:7.63E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-6.57|P-value:3.45E-12 ID:SGTC_1931|Compound:st074438|FD-Score:-3.24|P-value:3.66E-4 ID:SGTC_1979|Compound:st071809|FD-Score:2.94|P-value:9.90E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.76|P-value:4.31E-5 ID:SGTC_2030|Compound:5175110|FD-Score:6.42|P-value:8.02E-12 ID:SGTC_2043|Compound:5101342|FD-Score:-3.52|P-value:1.23E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-4.24|P-value:4.94E-6 ID:SGTC_2053|Compound:5265679|FD-Score:-5.47|P-value:5.70E-9 ID:SGTC_2058|Compound:5236698|FD-Score:4.29|P-value:3.34E-6 ID:SGTC_2117|Compound:5521686|FD-Score:3.18|P-value:4.23E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.06|P-value:6.56E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.44|P-value:1.65E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.52|P-value:1.03E-6 ID:SGTC_2342|Compound:7990637|FD-Score:3.05|P-value:6.77E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.67|P-value:6.59E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-4.39|P-value:2.26E-6 ID:SGTC_2355|Compound:9061122|FD-Score:3.74|P-value:4.23E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-5.26|P-value:2.02E-8 ID:SGTC_2369|Compound:9071472|FD-Score:-3.54|P-value:1.11E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.46|P-value:1.39E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-4.56|P-value:9.49E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.47|P-value:1.49E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:7.25|P-value:1.47E-14 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.03|P-value:7.94E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.58|P-value:8.32E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.97|P-value:9.87E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.30|P-value:3.12E-6 ID:SGTC_2761|Compound:levamisole|FD-Score:3.30|P-value:2.58E-4 ID:SGTC_2805|Compound:7950783|FD-Score:5.04|P-value:6.24E-8 ID:SGTC_2809|Compound:7964133|FD-Score:4.08|P-value:8.97E-6 ID:SGTC_2829|Compound:7992743|FD-Score:3.34|P-value:2.28E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-6.01|P-value:1.73E-10 ID:SGTC_2907|Compound:7721985|FD-Score:3.24|P-value:3.27E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.35|P-value:2.43E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.14|P-value:5.24E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.24|P-value:3.62E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.11|P-value:5.41E-4 ID:SGTC_3160|Compound:9100216|FD-Score:3.43|P-value:1.58E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.04|P-value:6.97E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.04|P-value:6.85E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.01|P-value:7.68E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.49|P-value:1.22E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.13|P-value:5.44E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:4.97|P-value:9.38E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:3.09|P-value:5.74E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.08|P-value:5.95E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.05|P-value:6.79E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.94|P-value:1.74E-5 ID:SGTC_321|Compound:4534-3890|FD-Score:3.51|P-value:1.13E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.72|P-value:4.70E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:5.01|P-value:7.47E-8 ID:SGTC_518|Compound:1021-0119|FD-Score:3.66|P-value:6.06E-5 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.09|P-value:6.46E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.92|P-value:2.20E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.20|P-value:3.92E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.86|P-value:2.87E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:-2.97|P-value:9.72E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.13|P-value:5.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.98|P-value:9.46E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.02|P-value:7.44E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.68|P-value:5.49E-5 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.43|P-value:1.75E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.03|P-value:7.12E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.71|P-value:3.93E-7 ID:SGTC_1924|Compound:st058459|FD-Score:3.02|P-value:7.63E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-6.57|P-value:3.45E-12 ID:SGTC_1931|Compound:st074438|FD-Score:-3.24|P-value:3.66E-4 ID:SGTC_1979|Compound:st071809|FD-Score:2.94|P-value:9.90E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.76|P-value:4.31E-5 ID:SGTC_2030|Compound:5175110|FD-Score:6.42|P-value:8.02E-12 ID:SGTC_2043|Compound:5101342|FD-Score:-3.52|P-value:1.23E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-4.24|P-value:4.94E-6 ID:SGTC_2053|Compound:5265679|FD-Score:-5.47|P-value:5.70E-9 ID:SGTC_2058|Compound:5236698|FD-Score:4.29|P-value:3.34E-6 ID:SGTC_2117|Compound:5521686|FD-Score:3.18|P-value:4.23E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.06|P-value:6.56E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.44|P-value:1.65E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.52|P-value:1.03E-6 ID:SGTC_2342|Compound:7990637|FD-Score:3.05|P-value:6.77E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.67|P-value:6.59E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-4.39|P-value:2.26E-6 ID:SGTC_2355|Compound:9061122|FD-Score:3.74|P-value:4.23E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-5.26|P-value:2.02E-8 ID:SGTC_2369|Compound:9071472|FD-Score:-3.54|P-value:1.11E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.46|P-value:1.39E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-4.56|P-value:9.49E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.47|P-value:1.49E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:7.25|P-value:1.47E-14 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.03|P-value:7.94E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.58|P-value:8.32E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.97|P-value:9.87E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.30|P-value:3.12E-6 ID:SGTC_2761|Compound:levamisole|FD-Score:3.30|P-value:2.58E-4 ID:SGTC_2805|Compound:7950783|FD-Score:5.04|P-value:6.24E-8 ID:SGTC_2809|Compound:7964133|FD-Score:4.08|P-value:8.97E-6 ID:SGTC_2829|Compound:7992743|FD-Score:3.34|P-value:2.28E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-6.01|P-value:1.73E-10 ID:SGTC_2907|Compound:7721985|FD-Score:3.24|P-value:3.27E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.35|P-value:2.43E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.14|P-value:5.24E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.24|P-value:3.62E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.11|P-value:5.41E-4 ID:SGTC_3160|Compound:9100216|FD-Score:3.43|P-value:1.58E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.04|P-value:6.97E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.04|P-value:6.85E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.01|P-value:7.68E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.49|P-value:1.22E-4

Top fitness defect scores for YLR344W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2420 aureobasidin a 7.25 50.0 nM 1.47E-14 8 2.10E-13
2 SGTC_2030 5175110 6.42 200.0 µM 8.02E-12 Golgi 3 6.63E-11
3 SGTC_2805 7950783 5.04 58.4 µM 6.24E-8 9 2.36E-7
4 SGTC_431 k089-0097 5.01 107.0 µM 7.47E-8 iron homeostasis 13 2.78E-7
5 SGTC_101 0490-5701 4.97 117.5 µM 9.38E-8 4 3.43E-7
6 SGTC_1745 st081495 4.71 74.0 µM 3.93E-7 RNA processing & uracil transport 51 1.27E-6
7 SGTC_2341 7987486 4.52 176.7 µM 1.03E-6 9 3.05E-6
8 SGTC_2751 anetholtrithion 4.30 17.2 µM 3.12E-6 21 8.42E-6
9 SGTC_2058 5236698 4.29 133.0 µM 3.34E-6 21 8.96E-6
10 SGTC_2809 7964133 4.08 13.0 µM 8.97E-6 60S ribosome export 34 2.21E-5
11 SGTC_189 3970-0742 3.94 2.1 µM 1.74E-5 8 4.04E-5
12 SGTC_2355 9061122 3.74 103.1 µM 4.23E-5 15 9.12E-5
13 SGTC_364 0083-0097 3.72 67.7 µM 4.70E-5 31 1.00E-4
14 SGTC_1507 4075-3230 3.68 155.0 µM 5.49E-5 12 1.16E-4
15 SGTC_518 1021-0119 3.66 62.6 µM 6.06E-5 ERG2 60 1.27E-4
16 SGTC_2429 5902844 3.58 64.4 µM 8.32E-5 38 1.69E-4
17 SGTC_321 4534-3890 3.51 65.3 µM 1.13E-4 RPP1 & pyrimidine depletion 9 2.24E-4
18 SGTC_3296 9122258 3.49 64.0 µM 1.22E-4 redox potentiating 28 2.39E-4
19 SGTC_2395 5646831 3.46 180.2 µM 1.39E-4 44 2.71E-4
20 SGTC_3160 9100216 3.43 49.5 µM 1.58E-4 14 3.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 5.14E-23 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.159 2.57E-20 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.151 1.53E-18 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.138 1.03E-15 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.137 1.48E-15 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.131 2.87E-14 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.129 6.39E-14 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.127 1.71E-13 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.125 3.03E-13 YPL063W TIM50 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
0.119 4.23E-12 YJR050W ISY1 hom Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
0.117 1.11E-11 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.110 1.56E-10 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.110 1.89E-10 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.103 1.87E-9 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.103 2.19E-9 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication