YLR347C / KAP95

Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR347C / KAP95

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.45|P-value:4.07E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.33|P-value:6.16E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.93|P-value:7.02E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.53|P-value:3.17E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:5.04|P-value:5.19E-7 ID:SGTC_150|Compound:3970-0969|FD-Score:8.77|P-value:9.46E-18 ID:SGTC_152|Compound:4469-0003|FD-Score:6.97|P-value:7.09E-12 ID:SGTC_155|Compound:k072-0202|FD-Score:3.76|P-value:1.33E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.41|P-value:4.71E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.59|P-value:2.51E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.57|P-value:2.74E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:5.01|P-value:5.99E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:3.55|P-value:2.95E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.95|P-value:6.22E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.38|P-value:5.21E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.36|P-value:5.61E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:4.45|P-value:8.07E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:7.03|P-value:4.63E-12 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.55|P-value:2.95E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.70|P-value:1.65E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.52|P-value:4.28E-8 ID:SGTC_601|Compound:0986-0029|FD-Score:3.60|P-value:2.42E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.98|P-value:5.82E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:-4.01|P-value:4.90E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.72|P-value:1.56E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.42|P-value:4.52E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:5.05|P-value:4.95E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:3.29|P-value:7.04E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.40|P-value:1.00E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:5.43|P-value:7.03E-8 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.20|P-value:2.26E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.88|P-value:8.43E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.44|P-value:8.33E-6 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.59|P-value:2.99E-8 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.25|P-value:8.17E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.38|P-value:5.24E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.28|P-value:7.30E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-6.77|P-value:2.52E-11 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.29|P-value:7.94E-13 ID:SGTC_1912|Compound:st060209|FD-Score:3.70|P-value:1.66E-4 ID:SGTC_1921|Compound:5740136|FD-Score:6.28|P-value:5.54E-10 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.26|P-value:7.84E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-5.13|P-value:3.22E-7 ID:SGTC_2052|Compound:5265182|FD-Score:3.20|P-value:9.63E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.48|P-value:3.75E-4 ID:SGTC_2192|Compound:5915882|FD-Score:6.99|P-value:6.11E-12 ID:SGTC_2194|Compound:5927483|FD-Score:-3.73|P-value:1.49E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.49|P-value:3.63E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.38|P-value:5.24E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.76|P-value:1.33E-4 ID:SGTC_2369|Compound:9071472|FD-Score:4.45|P-value:7.94E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.49|P-value:3.59E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:5.65|P-value:2.21E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.43|P-value:4.36E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.84|P-value:1.37E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.84|P-value:9.78E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.62|P-value:2.48E-8 ID:SGTC_2867|Compound:9039098|FD-Score:3.38|P-value:5.19E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.20|P-value:9.55E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.57|P-value:2.73E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.24|P-value:8.58E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.29|P-value:7.19E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.38|P-value:5.19E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.27|P-value:7.61E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.48|P-value:3.68E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-3.27|P-value:7.51E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.45|P-value:4.07E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.33|P-value:6.16E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.93|P-value:7.02E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.53|P-value:3.17E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:5.04|P-value:5.19E-7 ID:SGTC_150|Compound:3970-0969|FD-Score:8.77|P-value:9.46E-18 ID:SGTC_152|Compound:4469-0003|FD-Score:6.97|P-value:7.09E-12 ID:SGTC_155|Compound:k072-0202|FD-Score:3.76|P-value:1.33E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.41|P-value:4.71E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.59|P-value:2.51E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.57|P-value:2.74E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:5.01|P-value:5.99E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:3.55|P-value:2.95E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.95|P-value:6.22E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.38|P-value:5.21E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.36|P-value:5.61E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:4.45|P-value:8.07E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:7.03|P-value:4.63E-12 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.55|P-value:2.95E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.70|P-value:1.65E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:5.52|P-value:4.28E-8 ID:SGTC_601|Compound:0986-0029|FD-Score:3.60|P-value:2.42E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.98|P-value:5.82E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:-4.01|P-value:4.90E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:3.72|P-value:1.56E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.42|P-value:4.52E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:5.05|P-value:4.95E-7 ID:SGTC_852|Compound:0418-0143|FD-Score:3.29|P-value:7.04E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.40|P-value:1.00E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:5.43|P-value:7.03E-8 ID:SGTC_1252|Compound:0493-0875|FD-Score:-4.20|P-value:2.26E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.88|P-value:8.43E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.44|P-value:8.33E-6 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.59|P-value:2.99E-8 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.25|P-value:8.17E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.38|P-value:5.24E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.28|P-value:7.30E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-6.77|P-value:2.52E-11 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.29|P-value:7.94E-13 ID:SGTC_1912|Compound:st060209|FD-Score:3.70|P-value:1.66E-4 ID:SGTC_1921|Compound:5740136|FD-Score:6.28|P-value:5.54E-10 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.26|P-value:7.84E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-5.13|P-value:3.22E-7 ID:SGTC_2052|Compound:5265182|FD-Score:3.20|P-value:9.63E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.48|P-value:3.75E-4 ID:SGTC_2192|Compound:5915882|FD-Score:6.99|P-value:6.11E-12 ID:SGTC_2194|Compound:5927483|FD-Score:-3.73|P-value:1.49E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.49|P-value:3.63E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.38|P-value:5.24E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.76|P-value:1.33E-4 ID:SGTC_2369|Compound:9071472|FD-Score:4.45|P-value:7.94E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.49|P-value:3.59E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:5.65|P-value:2.21E-8 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.43|P-value:4.36E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.84|P-value:1.37E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.84|P-value:9.78E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.62|P-value:2.48E-8 ID:SGTC_2867|Compound:9039098|FD-Score:3.38|P-value:5.19E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.20|P-value:9.55E-4 ID:SGTC_2988|Compound:9073640|FD-Score:3.57|P-value:2.73E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.24|P-value:8.58E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.29|P-value:7.19E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.38|P-value:5.19E-4 ID:SGTC_3090|Compound:9117696|FD-Score:3.27|P-value:7.61E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.48|P-value:3.68E-4 ID:SGTC_3247|Compound:9135149|FD-Score:-3.27|P-value:7.51E-4

Top fitness defect scores for YLR347C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_150 3970-0969 8.77 77.2 µM 9.46E-18 1 9.17E-19 1.62
2 SGTC_1844 rapamycin 7.29 4.0 nM 7.94E-13 18 1.56E-13 0.20
3 SGTC_377 3970-0964 7.03 33.1 µM 4.63E-12 2 1.02E-12 1.34
4 SGTC_2192 5915882 6.99 198.5 µM 6.11E-12 RNA processing & uracil transport 7 1.37E-12 1.12
5 SGTC_152 4469-0003 6.97 551.2 µM 7.09E-12 2 1.60E-12 1.33
6 SGTC_1921 5740136 6.28 50.0 µM 5.54E-10 TRP & mitochondrial translation 4 1.64E-10 0.56
7 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 5.65 100.0 µM 2.21E-8 60S ribosome export 5 8.21E-9 0.22
8 SGTC_2779 methotrexate 5.62 400.0 µM 2.48E-8 6 9.28E-9 0.25
9 SGTC_1447 4239-0816 5.59 81.9 µM 2.99E-8 2 1.13E-8 0.44
10 SGTC_454 lyso-paf C-16 5.52 6.7 µM 4.28E-8 2 1.66E-8 1.08
11 SGTC_1202 1988-0068 5.43 29.6 µM 7.03E-8 RNA processing & uracil transport 3 2.81E-8 0.16
12 SGTC_845 0330-0138 5.05 4.5 µM 4.95E-7 5 2.23E-7 0.75
13 SGTC_149 3970-0822 5.04 46.1 µM 5.19E-7 tubulin folding & SWR complex 5 2.34E-7 0.48
14 SGTC_214 4373-3496 5.01 70.0 µM 5.99E-7 6 2.73E-7 0.01
15 SGTC_2679 rapamycin 4.84 1.0 nM 1.37E-6 40 6.56E-7 0.01
16 SGTC_2369 9071472 4.45 200.0 µM 7.94E-6 1 4.24E-6 0.26
17 SGTC_376 3970-0862 4.45 59.1 µM 8.07E-6 4 4.31E-6 0.12
18 SGTC_1383 3049-0032 4.44 20.7 µM 8.33E-6 60S ribosome export 7 4.46E-6 0.20
19 SGTC_1055 3448-0672 4.40 86.0 µM 1.00E-5 8 5.41E-6 0.10
20 SGTC_609 0986-0026 3.98 86.3 µM 5.82E-5 calcium & mitochondrial duress 11 3.51E-5 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 3.52E-26 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.180 7.65E-26 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.178 2.75E-25 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.176 8.24E-25 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.170 5.06E-23 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.156 1.15E-19 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.154 2.82E-19 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.148 6.77E-18 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.148 7.34E-18 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.147 9.53E-18 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.146 1.91E-17 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.145 2.49E-17 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.145 2.89E-17 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.144 4.44E-17 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.144 4.98E-17 YDR432W NPL3 hom RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress